Diabetic peripheral neuropathic pain is a stronger predictor of depression than other diabetic complications and comorbidities
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Aims: To investigate the independent effect on depression of painless diabetic polyneuropathy, painful diabetic polyneuropathy, and general and diabetes-related comorbidities. Methods: In 181 patients, the presence of painless diabetic polyneuropathy, painful diabetic polyneuropathy, comorbidities and depression was assessed using the Michigan Neuropathy Screening Instrument Questionnaire, the Michigan Diabetic Neuropathy Score, nerve conduction studies, the Douleur Neuropathique en 4 Questions, the Charlson Comorbidity Index and the Beck Depression Inventory-II. Results: In all, 46 patients met the criteria of confirmed painless diabetic polyneuropathy and 25 of painful diabetic polyneuropathy. Beck Depression Inventory-II scores indicative of mild–moderate–severe depression were reached in 36 patients (19.7%). In a multiple logistic regression analysis (including age, sex, body mass index, being unemployed, duration, haemoglobin A1c, insulin treatment, systolic blood pressure, nephropathy, retinopathy, Charlson Comorbidity Index and painful diabetic polyneuropathy), female sex (odds ratio: 5.9, p = 0.005) and painful diabetic polyneuropathy (odds ratio: 4.6, p = 0.038) were the only independent predictors of depression. Multiple regression analysis, including Douleur Neuropathique en 4 Questions and Michigan Diabetic Neuropathy Score instead of painful diabetic polyneuropathy, showed that Douleur Neuropathique en 4 Questions, in addition to female sex, was a significant predictor of depressive symptoms severity ( p =0.005). Conclusion: Painful diabetic polyneuropathy is a greater determinant of depression than other diabetes-related complications and comorbidities. Painful symptoms enhance depression severity more than objective insensitivity.
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Individuals with prediabetes or obesity can also develop diabetic peripheral neuropathy.
“Persons with prediabetes and/or obesity may also develop DPN.547,548,553”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [548]
The Clinical and neurological results (p. 4) report higher BMI among patients with diabetic polyneuropathy, supporting the obesity portion only in people who already have diabetes. The paper does not report neuropathy in people with prediabetes or establish that obesity without diabetes is sufficient; prediabetes appears only in a reference title (p. 11). (LLM, conf=0.78)
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Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.51.6.1173 · Cited by 91,542 · see citing works
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532 · see citing works
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965 · see citing works
The Prevalence of Comorbid Depression in Adults With Diabetes
Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1069 · Cited by 3,926 · see citing works
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392 · see citing works
Treede (2008) · doi:10.1212/01.wnl.0000282763.29778.59 · Cited by 2,746 · see citing works
Bouhassira, D., Attal, N., Alchaar, H., Boureau, F., Brochet, B., Bruxelle, J., Cunin, G., Fermanian, J., Giniès, P., Grun-Overdyking, A., et al. (2005) · Pain · doi:10.1016/j.pain.2004.12.010 · Cited by 2,732 · see citing works
Tesfaye, S., Boulton, A. J. M., Dyck, P. J., Freeman, R., Horowitz, M., Kempler, P., Lauria, G., Malik, R. A., Spallone, V., Vinik, A., et al. (2010) · Diabetes Care · doi:10.2337/dc10-1303 · Cited by 2,690 · see citing works
Self-citationDepression and poor glycemic control: a meta-analytic review of the literature.
Lustman, P. J., Anderson, R. J., Freedland, K. E., de Groot, M., Carney, R. M., & Clouse, R. E. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.934 · Cited by 1,854 · see citing works
Association of depression and diabetes complications: a meta-analysis
de Groot, M., Anderson, R., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200107000-00015 · Cited by 1,799 · see citing works
How to measure comorbiditya critical review of available methods
DEGROOT, V, BECKERMAN, H., LANKHORST, G., & BOUTER, L. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00585-1 · Cited by 1,757 · see citing works
Feldman, E. L., Stevens, M. J., Thomas, P. K., Brown, M. B., Canal, N., & Greene, D. A. (1994) · Diabetes Care · doi:10.2337/diacare.17.11.1281 · Cited by 1,291 · see citing works
Epidemiology of depression and diabetes: a systematic review
Roy, T., & Lloyd, C. E. (2012) · Journal of Affective Disorders · doi:10.1016/s0165-0327(12)70004-6 · Cited by 1,229 · see citing works
Katon, W. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00273-7 · Cited by 1,216 · see citing works
for the European Depression in Diabetes (EDID) Research Consortium, Nouwen, A., Winkley, K., Twisk, J., Lloyd, C. E., Peyrot, M., Ismail, K., & Pouwer, F. (2010) · Diabetologia · doi:10.1007/s00125-010-1874-x · Cited by 756 · see citing works
EFNS guidelines on neuropathic pain assessment: revised 2009
Cruccu, G., Sommer, C., Anand, P., Attal, N., Baron, R., Garcı́a-Larrea, L., Haanpää, M. L., Jensen, T. S., Serra, J., & Treede, R. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.02969.x · Cited by 545 · see citing works
Increased mortality of patients with diabetes reporting severe hypoglycemia
McCoy, R. G., Van Houten, H. K., Ziegenfuss, J. Y., Shah, N. D., Wermers, R. A., & Smith, S. A. (2012) · Diabetes Care · doi:10.2337/dc11-2054 · Cited by 539 · see citing works
Gore, M., Brandenburg, N. A., Dukes, E., Hoffman, D. L., Tai, K.-S., & Stacey, B. (2005) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2005.04.009 · Cited by 525 · see citing works
Acker, K. V., Bouhassira, D., Bacquer, D. D., Weiss, S., Matthys, K. E., Rae-Men, H., Mathieu, C., & Colin, I. M. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.11.004 · Cited by 409 · see citing works
Validation of DN4 as a screening tool for neuropathic pain in painful diabetic polyneuropathy
Spallone, V., Morganti, R., D’Amato, C., Greco, C., Cacciotti, L., & Marfia, G. A. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03500.x · Cited by 311 · see citing works
Self-citationDiabetic Peripheral Neuropathy and Depressive Symptoms
Vileikytė, L., Leventhal, H., Gonzalez, J. S., Peyrot, M. F., Rubin, R. R., Ulbrecht, J. S., Garrow, A. P., Waterman, C. G., Cavanagh, P. R., & Boulton, A. J. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.10.2378 · Cited by 286 · see citing works
The Rochester Diabetic Neuropathy Study
Dyck, P. J., Karnes, J. L., O’Brien, P. C., Litchy, W. J., Low, P. A., & Melton, L. J. (1992) · Neurology · doi:10.1212/wnl.42.6.1164 · Cited by 245 · see citing works
Epidemiology of polyneuropathy in diabetes and prediabetes
Ziegler, D., Παπάνας, Ν., Vinik, A. I., & Shaw, J. E. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00001-1 · Cited by 241 · see citing works
Burden of Illness in Painful Diabetic Peripheral Neuropathy: The Patients’ Perspectives
Gore, M. R., Brandenburg, N. A., Hoffman, D. L., Tai, K.-S., & Stacey, B. R. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.04.013 · Cited by 239 · see citing works
Tölle, T. R., Xu, X., & Sadosky, A. (2005) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2005.09.007 · Cited by 199 · see citing works
Sadosky, A., Schaefer, C. P., Mann, R., Bergstrom, F., Baik, R., Parsons, B., Nalamachu, S. R., Nieshoff, E. C., Stacey, Tuchman, et al. (2013) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s37415 · Cited by 165 · see citing works
Pouwer, F., Geelhoed‐Duijvestijn, P. H. L. M., Tack, C. J., Bazelmans, E., Beekman, A. ‐., Heine, R. J., & Snoek, F. J. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02903.x · Cited by 163 · see citing works
Prevalence and Correlates of Depression in Individuals With and Without Type 1 Diabetes
Gendelman, N., Snell‐Bergeon, J. K., McFann, K., Kinney, G. L., Wadwa, R. P., Bishop, F. K., Rewers, M., & Maahs, D. M. (2009) · Diabetes Care · doi:10.2337/dc08-1835 · Cited by 161 · see citing works
Hutter, N., Schnurr, A., & Baumeister, H. (2010) · Diabetologia · doi:10.1007/s00125-010-1873-y · Cited by 155 · see citing works
Depression Predicts All-Cause Mortality
Sullivan, M. D., O’Connor, P. J., Feeney, P. A., Hire, D. G., Simmons, D. L., Raisch, D. W., Fine, L. J., Narayan, K. M. V., Ali, M. K., & Katon, W. J. (2012) · Diabetes Care · doi:10.2337/dc11-1791 · Cited by 149 · see citing works
Vileikyte, L., Peyrot, M., Gonzalez, J. S., Rubin, R. R., Garrow, A. P., Stickings, D., Waterman, C., Ulbrecht, J. S., Cavanagh, P. R., & Boulton, A. J. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1363-2 · Cited by 123 · see citing works
Carney, C. E., Ulmer, C. S., Edinger, J. D., Krystal, A. D., & Knauss, F. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.09.002 · Cited by 114 · see citing works
Lloyd, C. E., Pambianco, G., & Orchard, T. J. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02896.x · Cited by 112 · see citing works
Depression in adults in the T1D Exchange Clinic Registry
Trief, P. M., Xing, D., Foster, N. C., Maahs, D. M., Kittelsrud, J. M., Olson, B. A., Young, L. A., Peters, A. L., Bergenstal, R. M., Miller, K. M., et al. (2014) · Diabetes Care · doi:10.2337/dc13-1867 · Cited by 93 · see citing works
Painful and Painless Diabetic Neuropathy: One Disease or Two?
Spallone, V., & Greco, C. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0387-7 · Cited by 93 · see citing works
Self-citationSymptoms of Depression in Patients With Type II Diabetes Mellitus
Leedom, L. J., Meehan, W. P., Procci, W. R., & Zeidler, A. (1991) · Psychosomatics · doi:10.1016/s0033-3182(91)72066-5 · Cited by 90 · see citing works
Jain, R., Jain, S. B., Raison, C. L., & Maletic, V. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0202-2 · Cited by 78 · see citing works
The contributors of emotional distress in painful diabetic neuropathy
Selvarajah, D., Cash, T., Sankar, A., Thomas, L., Davies, J., Boland, E. G., Gandhi, R. A., Wilkinson, I. D., Wilkinson, N., Emery, C., et al. (2014) · Diabetes and Vascular Disease Research · doi:10.1177/1479164114522135 · Cited by 77 · see citing works
Yoshida, S., Hirai, M., Suzuki, S., Awata, S., & Oka, Y. (2008) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2008.01889.x · Cited by 56 · see citing works
Ell, K., Katon, W. J., Lee, P.-J., Guterman, J. J., & Wu, S. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.05.010 · Cited by 17 · see citing works
A follow-up study of painful diabetic neuropathy: Physical and psychological aspects.
Takahashi, Y., & Hirata, Y. (1983) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.141.463 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507 · see citing works
Gylfadottir, S. S., Christensen, D. H., Nicolaisen, S. K., Andersen, H., Callaghan, B. C., Itani, M., Khan, K. S., Kristensen, A. G., Nielsen, J. S., Sindrup, S. H., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000001744 · Cited by 151 · see citing works
Depression and type 2 diabetes: A causal relationship and mechanistic pathway
Khawagi, W. Y., Al-Kuraishy, H. M., Hussein, N. R., Al-Gareeb, A. I., Atef, E., Elhussieny, O., Alexiou, A. T., Papadakis, M., Jabir, M. S., Alshehri, A. A., et al. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15630 · Cited by 135 · see citing works
Risk factors for neuropathic pain in diabetes mellitus
Hébert, H. L., Veluchamy, A., Torrance, N., & Smith, B. H. (2016) · Pain · doi:10.1097/j.pain.0000000000000785 · Cited by 117 · see citing works
Capece, U., Moffa, S., Improta, I., Giuseppe, G. D., Nista, E. C., CEFALO, C. M. A., Cinti, F., Pontecorvi, A., Gasbarrini, A., Giaccari, A., et al. (2022) · Nutrients · doi:10.3390/nu15010018 · Cited by 96 · see citing works
Truini, A., Spallone, V., Morganti, R., Tamburin, S., Zanette, G., Schenone, A., De Michelis, C., Tugnoli, V., Simioni, V., Manganelli, F., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001378 · Cited by 85 · see citing works
Self-citationNaranjo, C., del Reguero, L., Moratalla, G., Moreno, M. H., Valenzuela, M., & Failde, I. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1653760 · Cited by 83 · see citing works
Incidence of Anxiety and Depression Among Patients with Type 2 Diabetes and the Predicting Factors
Khan, P., Qayyum, N., Malik, F., Khan, T., Khan, M., & Tahir, A. (2019) · Cureus · doi:10.7759/cureus.4254 · Cited by 79 · see citing works
Li, C., Wang, W., Ji, Q., Ran, X., Kuang, H., Yu, X., Fang, H., Yang, J., Liu, J., Xue, Y., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110602 · Cited by 81 · see citing works
Guan, S., Shen, Y., Ge, H., Xiong, W., He, L., Liu, L., Yin, C., Wei, X., & Gao, Y. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00770 · Cited by 60 · see citing works
Naranjo, C., Ortega-Jiménez, P., del Reguero, L., Moratalla, G., & Failde, I. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108236 · Cited by 55 · see citing works
Bai, J.-W., Lovblom, L. E., Cardinez, M., Weisman, A., Farooqi, M. A., Halpern, E. M., Boulet, G., Eldelekli, D., Lovshin, J. A., Lytvyn, Y., et al. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.05.002 · Cited by 51 · see citing works
van Laake-Geelen, C. C. M., Smeets, R. J. E. M., Quadflieg, S. P. A. B., Kleijnen, J., & Verbunt, J. A. (2019) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2019-0001 · Cited by 51 · see citing works
Borbjerg, M. K., Wegeberg, A., Nikontovic, A., Mørch, C. D., Arendt‐Nielsen, L., Ejskjær, N., Brock, C., Vestergaard, P., & Røikjer, J. (2025) · Diabetes Care · doi:10.2337/dc24-2287 · Cited by 51 · see citing works
Quality of life and time since diagnosis of Diabetes Mellitus among the elderly
de Lima, L. R., Funghetto, S. S., Volpe, C. R. G., Santos, W. S., Funez, M. I., & Stival, M. M. (2018) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1981-22562018021.170187 · Cited by 43 · see citing works
Almeida, S. S., Zizzi, F., Cattaneo, A., Comandini, A., Dato, G. D., Lubrano, E., Pellicano, C., Spallone, V., Tongiani, S., & Torta, R. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.542444 · Cited by 42 · see citing works
Self-citationAn Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy
Qureshi, Z., Ali, M. N., & Khalid, M. (2022) · Journal of Diabetes Research · doi:10.1155/2022/9989272 · Cited by 39 · see citing works
Jeong, J., Um, Y. H., Ko, S., Park, J. H., Park, J., Han, K., & Ko, K. S. (2017) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2017.41.4.296 · Cited by 35 · see citing works
Psychosocial Care for People With Diabetic Neuropathy: Time for Action
Pouwer, F., Mizokami‐Stout, K., Reeves, N. D., Pop‐Busui, R., Tesfaye, S. H., Boulton, A. J. M., & Vileikytė, L. (2023) · Diabetes Care · doi:10.2337/dci23-0033 · Cited by 38 · see citing works
Jamal, A., Ahmad, I., Ahamed, N. M. B., Azharuddin, M., Alam, F., & Hussain, M. E. (2019) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-019-00476-1 · Cited by 33 · see citing works
Şahin, S., & Cingil, D. (2020) · Primary care diabetes · doi:10.1016/j.pcd.2020.02.005 · Cited by 31 · see citing works
Alhunayni, N. M., Mohamed, A. E., & Hammad, S. M. (2020) · Psychiatry Journal · doi:10.1155/2020/9174818 · Cited by 31 · see citing works
The characteristics of pain and dysesthesia in patients with diabetic polyneuropathy
Gylfadottir, S. S., Itani, M., Kristensen, A. G., Karlsson, P., Krøigård, T., Bennett, D., Tankişi, H., Andersen, N. T., Jensen, T. S., Sindrup, S. H., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263831 · Cited by 32 · see citing works
Baba, M., Kuroha, M., Ohwada, S., Murayama, E., & Matsui, N. (2020) · Pain and Therapy · doi:10.1007/s40122-020-00156-6 · Cited by 28 · see citing works
Anxiety and depression in small fiber neuropathy
Damci, A., Schruers, K. R. J., Leue, C., Faber, C. G., & Hoeijmakers, J. G. J. (2022) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12514 · Cited by 27 · see citing works
Amorim, D., Puga, S., Bragança, R., Braga, A., Pertovaara, A., Almeida, A., & Pinto‐Ribeiro, F. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.003 · Cited by 26 · see citing works
Huang, L., Zhang, Y., Wang, Y., Shen, X., & Yan, S. (2019) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2019.11.005 · Cited by 27 · see citing works
Ge, H., Sun, M., Wei, X., Zhang, M., Tu, H., Hao, Y., Chen, R., Ye, M., & Gao, Y. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09752-9 · Cited by 24 · see citing works
The Diabetic Foot–Pain–Depression Cycle
Brooks, B. M., Shih, C.-D., Brooks, B. M., Tower, D. E., Tran, T., Simon, J. E., & Armstrong, D. G. (2023) · Journal of the American Podiatric Medical Association · doi:10.7547/22-126 · Cited by 24 · see citing works
Development and Progression of Polyneuropathy Over 5 Years in Patients With Type 2 Diabetes
Brask‐Thomsen, P. K., Itani, M., Karlsson, P., Kristensen, A. G., Krøigård, T., Jensen, T. S., Tankişi, H., Sindrup, S. H., Finnerup, N. B., & Gylfadottir, S. S. (2024) · Neurology · doi:10.1212/wnl.0000000000209652 · Cited by 22 · see citing works
Zhang, Y., Zhang, S., Pan, L., Wang, B., Sun, Y., Gao, L., Wang, L., Cui, L., Zhang, Q., Heng, S., et al. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00281-w · Cited by 21 · see citing works
Zafeiri, M., Tsioutis, C., Kleinaki, Z., Manolopoulos, P. P., Ioannidis, I., & Dimitriadis, G. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0741-6937 · Cited by 22 · see citing works
Freo, U., Brugnatelli, V., Turco, F., & Zanette, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.584649 · Cited by 19 · see citing works
Marcus, J. C., Lasch, K., Wan, Y., Yang, M., Hsu, C., & Merante, D. (2018) · Pain Research and Management · doi:10.1155/2018/2140420 · Cited by 18 · see citing works
The Giant Geriatric Syndromes Are Intensified by Diabetic Complications
Lewandowicz, A., Skowronek, P., Maksymiuk-Kłos, A., & Piątkiewicz, P. (2018) · Gerontology and Geriatric Medicine · doi:10.1177/2333721418817396 · Cited by 15 · see citing works
Bidirectional association between depression and diabetic nephropathy by meta-analysis
Fang, T., Zhang, Q., Wang, Z., & Liu, J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278489 · Cited by 14 · see citing works
Bzowyckyj, A. S. (2020) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13229 · Cited by 12 · see citing works
Zhang, Y., Li, N., Zhao, Y., & Fan, D. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025722 · Cited by 11 · see citing works
de Lima, L. R., Stival, M. M., Funghetto, S. S., Volpe, C. R. G., Rehem, T. C. M. S. B., Santos, W. S., & Funez, M. I. (2018) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-018-0667-5 · Cited by 10 · see citing works
Advances in the pathophysiology and treatment of diabetic peripheral neuropathy
Fridman, V., Elafros, M. A., Eid, S., Reynolds, E. L., McCray, B. A., & Callaghan, B. C. (2026) · BMJ · doi:10.1136/bmj-2024-081217 · Cited by 11 · see citing works
Prospects for the application of transcranial magnetic stimulation in diabetic neuropathy
Xu, X., & Xu, X. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.297062 · Cited by 9 · see citing works
Therapeutic potential of orally applied KB-R7943 in streptozotocin-induced neuropathy in rats
Andreeva-Gateva, P. A., Hristov, M., Strokova-Stoilova, M., Ivanova, N. M., Sabit, Z., Surcheva, S. K., Beliakov, M., Karakashev, G., Sukhov, I. B., Belinskaya, D. A., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27367 · Cited by 7 · see citing works
Zhang, X., Ma, L., Mu, S., & Yin, Y. (2023) · Diabetes Therapy · doi:10.1007/s13300-023-01436-y · Cited by 6 · see citing works
Diabetic Neuropathic Cachexia: A Clinical Case and Review of Literature
Bellelli, A., Santi, D., Simoni, M., & Greco, C. (2022) · Life · doi:10.3390/life12050680 · Cited by 6 · see citing works
Self-citationWu, W., Zeng, C., Wu, C., Wu, T., Pang, J., Zhou, P., & Cao, Y. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150374 · Cited by 6 · see citing works
Reynaud, V., Conforto, I., Givron, P., Clavelou, P., Cornut-Chauvinc, C., Taithe, F., Pereira, B., & Coudeyre, E. (2020) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2020.02.002 · Cited by 6 · see citing works
Neuropathic pain in diabetic polyneuropathy: a 5-year prospective study
Brask‐Thomsen, P. K., Itani, M., Karlsson, P., Kristensen, A. G., Krøigård, T., Jensen, T. S., Tankişi, H., Sindrup, S. H., Finnerup, N. B., & Gylfadottir, S. S. (2025) · Pain · doi:10.1097/j.pain.0000000000003649 · Cited by 5 · see citing works
Shah, N., Tran, E., Aly, M., Phu, V., Laughlin, E., & Malvankar‐Mehta, M. S. (2025) · The International Journal of Psychiatry in Medicine · doi:10.1177/00912174251382653 · Cited by 7 · see citing works
Klee, M., Thomsen, T. H., Enggaard, T. P., Bitsch, M. S., Simonsen, L., Jensen, R., & Biering‐Sørensen, B. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-074372 · Cited by 5 · see citing works
Brooks, B. M., Nettles, A. M., & Brooks, B. M. (2025) · Psychoactives · doi:10.3390/psychoactives4020013 · Cited by 4 · see citing works
Khiro, M. A. K., Alshahrani, A., Jabali, S. H., Alyahya, Y. A., & Alamri, M. (2024) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_1174_23 · Cited by 5 · see citing works
Anxiety and Depression Among Patients with Diabetes in Saudi Arabia and Egypt
Mahmoud, M. R., Aljadani, A., Mahmood, A. A. R., Alshammari, R. F., Shahien, M. M., Ibrahim, S., Khalik, A. A., Alenazi, F., Alreshidi, F. S., Nasr, F. M., et al. (2024) · Healthcare · doi:10.3390/healthcare12212159 · Cited by 6 · see citing works
Benavidez, G. A., Ylitalo, K. R., Lanning, B. A., Asare, M., Meyer, A. R., & Griggs, J. O. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02579-2 · Cited by 4 · see citing works
Kuo, H., Lin, C., Tsai, S., Chen, C., Lyu, R., Chu, C., Ro, L., Liao, M., Chang, H., Weng, Y., et al. (2024) · Journal of Diabetes Investigation · doi:10.1111/jdi.14355 · Cited by 4 · see citing works
Depression among outpatients with diabetic peripheral neuropathy: prevalence and associated factors
Gharaibeh, B. A., Baniyones, A., Abuhammad, S., & Mehrass, A. A.-K. O. (2025) · Future Science OA · doi:10.1080/20565623.2025.2458989 · Cited by 4 · see citing works
Jacob, L., Kaiser, M., & Kostev, K. (2021) · Primary care diabetes · doi:10.1016/j.pcd.2020.12.005 · Cited by 4 · see citing works
DIABETIC POLYNEUROPATHIES: OPTIONS OF THE COURSE AND INFLUENCE ON THE QUALITY OF PATIENTS’ LIFE
Tykhonova, T. M., & Smilka, Y. M. (2019) · PROBLEMS OF ENDOCRINE PATHOLOGY · doi:10.21856/j-pep.2019.3.19 · Cited by 4 · see citing works
Diabetic peripheral neuropathy
Anastasi, J. K., & Klug, C. (2021) · Nursing · doi:10.1097/01.nurse.0000736904.62783.68 · Cited by 4 · see citing works
Vas, P. R. J., & Παπάνας, Ν. (2021) · The Review of Diabetic Studies · doi:10.1900/rds.2021.17.17 · Cited by 3 · see citing works
Öztorun, H. S., GÖZÜKARA, B., Bahşi, R., Turgut, T., Sürmeli, D. M., Coşarderelioğlu, Ç., Atmış, V., Varlı, M., & Aras, S. (2022) · Journal of Health Sciences and Medicine · doi:10.32322/jhsm.1133659 · Cited by 3 · see citing works
Medical and socio-demographic determinants of depressive disorders in diabetic patients
Florek-Łuszczki, M., Choina, P., Kostrzewa-Zabłocka, E., Panasiuk, L., & Dziemidok, P. (2020) · Annals of Agricultural and Environmental Medicine · doi:10.26444/aaem/118529 · Cited by 3 · see citing works
Diabetic complications and poor mental health in the aging population
Bansal, R., Singhal, S., Dewangan, G. C., Kumar, P., Satpathy, S., Kumar, N. K., Dwivedi, S., & Dey, A. (2019) · Journal of Geriatric Mental Health · doi:10.4103/jgmh.jgmh_22_19 · Cited by 3 · see citing works
Fatores preditivos da neuropatia diabética em idosos atendidos na atenção primária
Reis, I., de Lima, L. R., Funez, M. I., Funghetto, S. S., da Costa, M. V. G., Leite, M. M., & Stival, M. M. (2021) · Revista de Enfermagem Referência · doi:10.12707/rv20148 · Cited by 3 · see citing works
Purwata, T. E., Widyadharma, I. P. E., Rudy, M., Soejitno, A., Gotera, W., & Suryana, K. (2021) · Romanian Journal of Neurology · doi:10.37897/rjn.2021.3.12 · Cited by 2 · see citing works
Agreda, J. J. O., Molina, J. V., & Pérez, C. D. R. P. (2022) · Mediciencias UTA (Impresa)/Mediciencias UTA (En línea) · doi:10.31243/mdc.uta.v6i2.1624.2022 · Cited by 2 · see citing works
Characteristics and Treatment of Painful Diabetic Neuropathy
Gylfadottir, S. S., & Finnerup, N. B. (2023) · Contemporary diabetes · doi:10.1007/978-3-031-15613-7_25 · Cited by 2 · see citing works
Wei, B., Liu, Y., Liu, X., & Wei, C. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1519556 · Cited by 2 · see citing works
review on diabetes associated with psychological disorders among elderly people
Dey, A., Goyal, B., Venugopal, S., Srinivasan, P., Sathish, S., & Chitra, B. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns3.8734 · Cited by 1 · see citing works
Diabetic neuropathy: Current issues in diagnosis and prevention
Spallone, V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-88426-6.00016-6 · Cited by 1 · see citing works
Self-citationPasha, R., Quartey, G., Kalteniece, A., Faber, C. G., Lauria, G., Marshall, A. G., Azmi, S., Malik, R. A., Soran, H., & Ferdousi, M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15093215 · Cited by 1 · see citing works
El-Asrar, M. A., Elrassas, H. H., Thabet, R. A., Abdeen, M. S., & Elazab, A. N. M. (2020) · Vulnerable Children and Youth Studies · doi:10.1080/17450128.2020.1822568 · Cited by 1 · see citing works
Was Diabetiker depressiv werden lässt
dk (2016) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-016-8553-x
Living with painful diabetic neuropathy
van Laake‐Geelen, C. C. M. (2021) · doi:10.26481/dis.20210923cg
Gholami, F. (2021) · Bimonthly Journal of Hormozgan University of Medical Sciences · doi:10.34172/hmj.2021.23
Sanyal, S., Ghosh, S., & Dutta, A. (2023) · Homœopathic Links · doi:10.1055/s-0043-1772490
A multimodal approach to the treatment of painful diabetic neuropathy. Case report
Mandra, E. V., & Kim, A. (2024) · Consilium Medicum · doi:10.26442/20751753.2024.11.202819
EsnaAshari, P., Mianehsaz, E., Afarini, M., & Azadchehr, M. J. (2025) · Journal of Diabetes Research · doi:10.1155/jdr/7027972
Ramzan, M. A., Rehman, H., Kumar, B., Ghafoor, A., Maheshwary, N., Asif, W., Anwar, A., & Hashmi, A. A. (2025) · Cureus · doi:10.7759/cureus.88562
Sun, C., Ling, G., Sun, C.-Q., & Feng, X. (2025) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2025.102543
Reginia, A., Mazur, A., Bąba-Kubiś, A., Jabłoński, M., Sołtysiński, M., Samochowiec, J., & Kucharska–Mazur, J. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1741046
Tan, T., Yang, C., Wang, Q. J., Xu, C., Wang, S., Xiao, B., Zhao, J., He, H., & Wang, M. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1728665
ÖKSÜZ, S. B. T., Demirtel, A. A., Apaydın, B., Tumluer, E. B., Günay, M., Bayrak, M. Ç., Saygı, S., Yorulmaz, Z. Z., Emral, R., & Canpolat, A. G. (2026) · Ankara Üniversitesi Tıp Fakültesi Mecmuası · doi:10.65092/autfm.1860563
Fridman, V. (2026) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/cont.0000000000001744
- Authors
- D’Amato, C., Morganti, R., Greco, C., Di Gennaro, F., Cacciotti, L., Longo, S., Mataluni, G., Lauro, D., Marfia, G. A., & Spallone, V.
- Affiliations
- University of Rome Tor Vergata (IT)
- Endocrinology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
- Corresponding author
- Spallone, Vincenza
- Venue
- Diabetes and Vascular Disease Research
- Publisher
- SAGE Publications
- Published
- 2016-07-07
- Volume
- 13
- Issue
- 6
- Pages
- 418-428
- ISSN
- 1479-1641 (ISSN-L)
- 1752-8984
- OpenAlex
- W2460495313
- Cited by
- 83
- References
- 41
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 3 · 2016: 2
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes and Vascular Disease Research (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Funders
- European Association for the Study of Diabetes
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Keywords
- diabetic peripheral neuropathy, painful diabetic polyneuropathy, depression, diabetes complications, comorbidities, sex differences, neuropathic pain, depression severity, diabetic neuropathy screening
- MeSH terms
- Aged, Depression, Diabetic Neuropathies, Female, Humans, Male, Middle Aged, Neurologic Examination, Prognosis, Prospective Studies, Surveys and Questionnaires, Risk Factors, Severity of Illness Index, Comorbidity, Chi-Square Distribution, Logistic Models, Odds Ratio, Risk Assessment, Diabetes Complications
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