Manipulating Gut Microbiota Composition to Enhance the Therapeutic Effect of Cancer Immunotherapy

Human gut microbes associated with obesity

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Oncology meets immunology: the cancer-immunity cycle.

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Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

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Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

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Elements of cancer immunity and the cancer–immune set point

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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

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Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

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Commensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy

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First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer

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Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

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Gut flora in health and disease

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The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients

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Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

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Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

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Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

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Adjuvant pembrolizumab versus placebo in resected stage III melanoma

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Dysbiosis and the immune system

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Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

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Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

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CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

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Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

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The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

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PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

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The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

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The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

Gopalakrishnan, V., Helmink, B. A., Spencer, C. N., Reuben, A., & Wargo, J. A. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.015 · Cited by 1,392 · see citing works

Cancer immunotherapy: harnessing the immune system to battle cancer

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Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

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Homeostatic Immunity and the Microbiota

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Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

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Th17 cell induction by adhesion of microbes to intestinal epithelial cells

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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

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Immunological aspects of intestinal mucus and mucins

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Gut microbiota modulation of chemotherapy efficacy and toxicity

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Interaction between the gut microbiome and mucosal immune system

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CAR T Cell Therapy for Solid Tumors

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Microbiota: a key orchestrator of cancer therapy

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Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway

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Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

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Next generation of immune checkpoint therapy in cancer: new developments and challenges

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Helicobacter pylori-induced gastric inflammation and gastric cancer

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Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

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Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors

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Functional specialization of gut CD103 + dendritic cells in the regulation of tissue-selective T cell homing

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Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

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The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation

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Tumor microenvironment participates in metastasis of pancreatic cancer

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The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti–Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC

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Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study

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Immune checkpoints and their inhibition in cancer and infectious diseases

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Higher Fecal Short-Chain Fatty Acid Levels Are Associated with Gut Microbiome Dysbiosis, Obesity, Hypertension and Cardiometabolic Disease Risk Factors

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Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

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Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance

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The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD)

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Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

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Selective Generation of Gut Tropic T Cells in Gut-associated Lymphoid Tissue (GALT)

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Short-chain fatty acids in control of energy metabolism

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Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

Li, A., Yi, M., Qin, S., Song, Y., Chu, Q., & Wu, K. (2019) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-019-0721-x · Cited by 413 · see citing works

Lessons learned from the blockade of immune checkpoints in cancer immunotherapy

Li, X., Shao, C., Shi, Y., & Han, W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0578-4 · Cited by 385 · see citing works

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

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Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

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Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo, J., Grabe, M., Jiang, Q., et al. (2013) · Nature · doi:10.1038/nature12729 · Cited by 326 · see citing works

Gut microbiota in neurodegenerative disorders

Sarkar, S. R., & Banerjee, S. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.01.004 · Cited by 319 · see citing works

Gut Microbiota, Immune System, and Bone

D’Amelio, P., & Sassi, F. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0331-y · Cited by 315 · see citing works

Peyer's patches: organizing B‐cell responses at the intestinal frontier

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Chimeric antigen receptor T cells: a novel therapy for solid tumors

Yu, S., Li, A., Liu, Q., Li, T., Yuan, X., Han, X., & Wu, K. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0444-9 · Cited by 306 · see citing works

The immune system bridges the gut microbiota with systemic energy homeostasis: focus on TLRs, mucosal barrier, and SCFAs

Spiljar, M., Merkler, D., & Trajkovski, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01353 · Cited by 219 · see citing works

Principles of adoptive T cell therapy in cancer

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Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with immune checkpoint inhibitors

Elkrief, A., El Raichani, L., Richard, C., Messaoudene, M., Belkaid, W., Malo, J., Belanger, K., Miller, W., Jamal, R., Letarte, N., et al. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1568812 · Cited by 208 · see citing works

CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia

Wang, J., Chen, S., Xiao, W., Li, W., Wang, L., Yang, S., Wang, W., Xu, L., Liao, S., Liu, W., et al. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0553-5 · Cited by 200 · see citing works

Biofilm Producing Salmonella Typhi: Chronic Colonization and Development of Gallbladder Cancer

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PD-1 blockade therapy in renal cell carcinoma: Current studies and future promises

Massari, F., Santoni, M., Ciccarese, C., Santini, D., Alfieri, S., Martignoni, G., Brunelli, M., Piva, F., Berardi, R., Montironi, R., et al. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2014.12.013 · Cited by 182 · see citing works

Gut microbiome modulates efficacy of immune checkpoint inhibitors

Yi, M., Yu, S., Qin, S., Liu, Q., Xu, H., Zhao, W., Chu, Q., & Wu, K. (2018) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-018-0592-6 · Cited by 179 · see citing works

Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12

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Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy

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The Role of Dietary Nutrients in Inflammatory Bowel Disease

Sugihara, K., Morhardt, T. L., & Kamada, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03183 · Cited by 166 · see citing works

Gut-associated lymphoid tissues for the development of oral vaccines.

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Perinatal Interactions between the Microbiome, Immunity, and Neurodevelopment

Pronovost, G. N., & Hsiao, E. Y. (2019) · Immunity · doi:10.1016/j.immuni.2018.11.016 · Cited by 146 · see citing works

Colorectal cancer vaccines: Tumor-associated antigens vs neoantigens

Wagner, S., Mullins, C. S., & Linnebacher, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i48.5418 · Cited by 144 · see citing works

The role of neoantigen in immune checkpoint blockade therapy

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Evaluation of different 16S rRNA gene V regions for exploring bacterial diversity in a eutrophic freshwater lake

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Microbiota and host immune responses: a love–hate relationship

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The role of Paneth cells and their antimicrobial peptides in innate host defense

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Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer

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