Cited by 107Neuroinflammation and Neurodegeneration MechanismsStress Responses and CortisolNeuropeptides and Animal Physiology

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Unraveling the Molecular Details Involved in the Intimate Link between the Immune and Neuroendocrine Systems

Turrin, Nicolas P., Rivest, Serge·2004·Experimental Biology and Medicine

DOI 10.1177/153537020422901003

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Abstract

During systemic infections, the immune system can signal the brain and act on different neuronal circuits via soluble molecules, such as proinflammatory cytokines, that act on the cells forming the blood-brain barrier and the circumventricular organs. These activated cells release prostaglandin of the E(2) type (PGE(2)), which is the endogenous ligand that triggers the pathways involved in the control of autonomic functions necessary to restore homeostasis and provide inhibitory feedback to innate immunity. Among these neurophysiological functions, activation of the circuits that control the plasma release of glucocorticoids is probably the most critical to the survival of the host in the presence of pathogens. This review revisits this issue and describes in depth the molecular details (including the emerging role of Toll-like receptors during inflammation) underlying the influence of circulating inflammatory molecules on the cerebral tissue, focusing on their contribution in the synthesis and action PGE(2) in the brain. We also provide an innovative view supporting the concept of "fast and delayed response" involving the same ligands but different groups of cells, signal transduction pathways, and target genes.

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“An immunogenic insult can also trigger HPA axis activity through immunomodulators traversing the chorus plexus (Kunis et al., 2013) and BBB (Capuron and Miller, 2011; Turrin and Rivest, 2004).”
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Background

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Authors: Turrin, N. P., & Rivest, S.
Affiliations: Centre hospitalier de l'Université Laval (CA)
Corresponding author: Rivest, Serge
ORCID: Rivest, Serge
Venue: Experimental Biology and Medicine
Publisher: Frontiers Media SA
Published: 2004-11
Volume: 229
Issue: 10
Pages: 996-1006
ISSN: 0071-3384 (ISSN-L)
1535-3702
1535-3699
DOI: 10.1177/153537020422901003
OpenAlex: W1760516212
Cited by: 107
References: 99
Citations by year: 2026: 1 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 7
FWCI: 0.77
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Experimental Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: neuroimmune interactions, neuroendocrine system, inflammatory cytokines, prostaglandin E2, blood-brain barrier, circumventricular organs, hypothalamic-pituitary-adrenal axis, Toll-like receptors, systemic infection, inflammation, signal transduction
MeSH terms: Animals, Autonomic Nervous System, Blood-Brain Barrier, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Immune System, Molecular Biology, Neurosecretory Systems, Receptors, Cell Surface, Dinoprostone, Signal Transduction, Cytokines, Inflammation Mediators

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Unraveling the Molecular Details Involved in the Intimate Link between the Immune and Neuroendocrine Systems

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