Changing views of basal ganglia circuits and circuit disorders
Open accessAbstract
The basal ganglia (BG) have long been considered to play an important role in the control of movement and the pathophysiology of movement disorders, such as Parkinson's disease (PD). Studies over the past decades have considerably broadened this view, indicating that the BG participate in multiple, parallel, largely segregated, cortico-subcortical reentrant pathways involving motor, associative and limbic functions. Research has shown that dysfunction within individual circuits is associated not only with movement disorders, but also with neuropsychiatric disorders. Accordingly, a number of movement disorders and neuropsychiatric disorders such as obsessive compulsive disorder and Tourette's syndrome are viewed as "circuit disorders." We here discuss the changes in our current understanding of the anatomic and functional organization of BG circuits and related circuit disorders.
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Accumulating evidence suggests neuroplasticity within the corticostriatal circuit is impaired under conditions of dopamine denervation.
“However, accumulating evidence suggest that neuroplasticity within this corticostriatal circuit is also impaired under conditions of DA denervation 41–44”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [43]
Exercise can alter the storage and release of glutamate in presynaptic terminals that may improve circuit function and diminish the increased inhibitory drive of the dopamine depleted striatum.
“In addition to its receptors, exercise can also alter the storage and release of glutamate in presynaptic terminals that may also improve circuit function and diminish the increased inhibitory drive of the DA depleted striatum 41–44.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [43]
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- Authors
- DeLong, M., & Wichmann, T.
- Affiliations
- Emory University (US)
- Corresponding author
- DeLong, Mahlon
- Venue
- Clinical EEG and Neuroscience
- Publisher
- SAGE Publications
- Published
- 2010-04
- Volume
- 41
- Issue
- 2
- Pages
- 61-67
- ISSN
- 1550-0594 (ISSN-L)
- 2169-5202
- PMC
- PMC4305332
- OpenAlex
- W2139464784
- Cited by
- 128
- References
- 76
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 5 · 2023: 4 · 2022: 13 · 2021: 9 · 2020: 17 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 12 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical EEG and Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS054976, P50NS071669)
- National Center for Research Resources (P51RR000165)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- basal ganglia, basal ganglia circuitry, movement disorders, Parkinson's disease, neuropsychiatric disorders, obsessive-compulsive disorder, Tourette syndrome, associative functions
- MeSH terms
- Basal Ganglia, Basal Ganglia Diseases, Humans, Models, Neurological, Nerve Net, Parkinson Disease
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