The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase
Open accessAbstract
To explore the role of glucocorticoids in regulation of kinase pathways during innate immune responses, we generated mice with conditional deletion of glucocorticoid receptor (GR) in macrophages (MGRKO). Activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) caused greater mortality and cytokine production in MGRKO mice than in controls. Ex vivo, treatment with dexamethasone (Dex) markedly inhibited LPS-mediated induction of inflammatory genes in control but not GR-deficient macrophages. We show that Dex inhibits p38 MAPK, but not PI3K/Akt, ERK, or JNK, in control macrophages. Associated with p38 inhibition, Dex induced MAP kinase phosphatase-1 (MKP-1) in control, but not MGRKO, macrophages. Consistent with the ex vivo studies, treatment with a p38 MAPK-specific inhibitor resulted in rescue of MGRKO mice from LPS-induced lethality. Taken together, we identify p38 MAPK and its downstream targets as essential for GR-mediated immunosuppression in macrophages.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The single point mutation A458T engineered in GRdim is thus unlikely to fully abrogate the formation of functional GR homodimers (30, 112, 113).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [113]
Citations
Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647
Innate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A. M., Wilson, C. B., Bassetti, M., & Aderem, A. A. (1999) · Nature · doi:10.1038/44605 · Cited by 1,370
Cited by
Sorted by citations
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Mogensen, T. H. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-08 · Cited by 3,296
Coutinho, A. E., & Chapman, K. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.04.005 · Cited by 1,815
Immune regulation by glucocorticoids
Cain, D. W., & Cidlowski, J. A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.1 · Cited by 1,846
11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action
Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887
Essandoh, K., Li, Y., Huo, J., & Fan, G. (2016) · Shock · doi:10.1097/shk.0000000000000604 · Cited by 611
Dual‐specificity MAP kinase phosphatases (MKPs): Shaping the outcome of MAP kinase signalling
Caunt, C. J., & Keyse, S. M. (2013) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08716.x · Cited by 535
One Hormone, Two Actions: Anti- and Pro-Inflammatory Effects of Glucocorticoids
Cruz‐Topete, D., & Cidlowski, J. A. (2014) · NeuroImmunoModulation · doi:10.1159/000362724 · Cited by 481
The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419
The role of the glucocorticoid receptor in inflammation and immunity
Baschant, U., & Tuckermann, J. P. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.058 · Cited by 354
Busillo, J. M., & Cidlowski, J. A. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.005 · Cited by 339
Beck, I. M. E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K. R., Haegeman, G., & De Bosscher, K. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0013 · Cited by 298
Vandevyver, S., Dejager, L., Tuckermann, J., & Libert, C. (2013) · Endocrinology · doi:10.1210/en.2012-2045 · Cited by 296
Anti-inflammatory functions of glucocorticoid-induced genes
Clark, A. R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.04.013 · Cited by 276
Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome
Busillo, J. M., Azzam, K. M., & Cidlowski, J. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.275370 · Cited by 264
Glucocorticoids, developmental ‘programming’ and the risk of affective dysfunction
Seckl, J. R. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67002-2 · Cited by 245
Giles, D. A., Moreno‐Fernandez, M. E., Stankiewicz, T. E., Graspeuntner, S., Cappelletti, M., Wu, D. X.-Y., Mukherjee, R., Chan, C. C., Lawson, M. J., Klarquist, J. S., et al. (2017) · Nature Medicine · doi:10.1038/nm.4346 · Cited by 247
Mechanisms Generating Diversity in Glucocorticoid Receptor Signaling
Revollo, J. R., & Cidlowski, J. A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04986.x · Cited by 220
New dimension of glucocorticoids in cancer treatment
Lin, K., & Wang, L. (2016) · Steroids · doi:10.1016/j.steroids.2016.02.019 · Cited by 204
More Than Suppression: Glucocorticoid Action on Monocytes and Macrophages
Ehrchen, J. M., Roth, J., & Barczyk‐Kahlert, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02028 · Cited by 208
Control of immunity by glucocorticoids in health and disease
Shimba, A., & Ikuta, K. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00827-8 · Cited by 184
Wüst, S., van den Brandt, J., Tischner, D., Kleiman, A., Tuckermann, J. P., Gold, R., Lühder, F., & Reichardt, H. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8434 · Cited by 181
Munhoz, C. D., Sorrells, S. F., Caso, J. R., Scavone, C., & Sapolsky, R. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0303-09.2010 · Cited by 169
Kleiman, A., & Tuckermann, J. P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.009 · Cited by 165
New insights into the cell- and tissue-specificity of glucocorticoid actions
Quatrini, L., & Ugolini, S. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00526-2 · Cited by 174
Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity
Cole, S. W. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.02.006 · Cited by 156
New Insights in Glucocorticoid Receptor Signaling—More Than Just a Ligand-Binding Receptor
Scheschowitsch, K., Leite, J. A., & Assreuy, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00016 · Cited by 164
Vettorazzi, S., Bode, C., Dejager, L., Frappart, L., Shelest, E., Klaßen, C., Tasdogan, A., Reichardt, H. M., Libert, C., Schneider, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms8796 · Cited by 158
Quatrini, L., Wieduwild, É., Escalière, B., Filtjens, J., Chasson, L., Laprie, C., Vivier, É., & Ugolini, S. (2018) · Nature Immunology · doi:10.1038/s41590-018-0185-0 · Cited by 155
Kleiman, A., Hübner, S., Parkitna, J. M. R., Neumann, A., Hofer, S., Weigand, M. A., Bauer, M., Schmid, W., Schütz, G., Libert, C., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-192112 · Cited by 152
Glucocorticoid Signaling: An Update from a Genomic Perspective
Sacta, M. A., Chinenov, Y. V., & Rogatsky, I. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105323 · Cited by 155
Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor
Escoter-Torres, L., Caratti, G., Mechtidou, A., Tuckermann, J. P., Uhlenhaut, N. H., & Vettorazzi, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01859 · Cited by 156
Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action
Oh, K., Patel, H., Gottschalk, R. A., Lee, W. S., Baek, S., Fraser, I. D. C., Hager, G. L., & Sung, M. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.012 · Cited by 148
Negative regulatory approaches to the attenuation of Toll-like receptor signaling
Anwar, M. A., Basith, S., & Choi, S. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.28 · Cited by 144
Immune Effects of Corticosteroids in Sepsis
Heming, N., Sivanandamoorthy, S., Meng, P., Bounab, R., & Annane, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01736 · Cited by 148
The multiple facets of glucocorticoid action in rheumatoid arthritis
Baschant, U., Lane, N. E., & Tuckermann, J. P. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.166 · Cited by 140
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease
Wancket, L. M., Frazier, W. J., & Liu, Y. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.11.017 · Cited by 137
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
Vandevyver, S., Dejager, L., Bogaert, T. V., Kleyman, A., Liu, Y., Tuckermann, J. P., & Libert, C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60006 · Cited by 133
Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice
Whirledge, S., & DeFranco, D. B. (2017) · Endocrinology · doi:10.1210/en.2017-00728 · Cited by 123
Glucocorticoids in Sepsis: To Be or Not to Be
Vandewalle, J., & Libert, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01318 · Cited by 125
Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
Shimba, A., & Ikuta, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02143 · Cited by 121
Shipp, L. E., Lee, J. V., Yu, C.-Y., Pufall, M. A., Zhang, P., Scott, D. K., & Wang, J.-C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013754 · Cited by 123
Chapman, K. E., Coutinho, A. E., Zhang, Z., Kipari, T. M. J., Savill, J., & Seckl, J. R. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.002 · Cited by 125
Moyes, K. M., Drackley, J. K., Morin, D. E., Bionaz, M., Rodriguez‐Zas, S. L., Everts, R. E., Lewin, H. A., & Loor, J. J. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-542 · Cited by 119
p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-κB pathway
Liu, S., Feng, G., Wang, G., & Liu, G. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.009 · Cited by 115
Endothelial Response to Glucocorticoids in Inflammatory Diseases
Zielińska, K. A., Moortel, L. V., Opdenakker, G., Bosscher, K. D., & den Steen, P. E. V. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00592 · Cited by 120
Xie, Y., Tolmeijer, S. H., Oskam, J. M., Tonkens, T., Meijer, A. H., & Schaaf, M. J. M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.037887 · Cited by 114
Stress and innate immunity in carp: Corticosteroid receptors and pro-inflammatory cytokines
Stolte, E. H., Nabuurs, S. B., Bury, N. R., Sturm, A., Flik, G., Savelkoul, H. F. J., & Kemenade, B. M. L. V.-V. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.07.022 · Cited by 120
Sokołowska, M., Chen, L. Y., Eberlein, M. H., Martínez‐Antón, A., Liu, Y., Alsaaty, S., Qi, H.-Y., Logun, C., Horton, M. R., & Shelhamer, J. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.515106 · Cited by 111
Baschant, U., Frappart, L., Rauchhaus, U., Bruns, L., Reichardt, H. M., Kamradt, T., Bräuer, R., & Tuckermann, J. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105857108 · Cited by 106
Martinez, G. J., Appleton, M., Kipp, Z. A., Loria, A. S., Min, B., & Hinds, T. D. (2023) · Physiological Reviews · doi:10.1152/physrev.00021.2023 · Cited by 115
Defining the role of glucocorticoids in inflammation
Ronchetti, S., Migliorati, G., Bruscoli, S., & Riccardi, C. (2018) · Clinical Science · doi:10.1042/cs20171505 · Cited by 104
Glucocorticoid receptor signaling in bone cells
Moutsatsou, P., Kassi, E. N., & Papavassiliou, A. G. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.04.005 · Cited by 98
Li, C. C., Munitić, I., Mittelstadt, P. R., Castro, E., & Ashwell, J. D. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002269 · Cited by 99
Protein tyrosine phosphatases: dual‐specificity phosphatases in health and disease
Pulido, R., & van Huijsduijnen, R. H. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06250.x · Cited by 97
Role of Dual Specificity Phosphatases in Biological Responses to Glucocorticoids
Clark, A. R., Martins, J. R. S., & Tchen, C. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700053200 · Cited by 95
Bhattacharyya, S., Zhao, Y., Kay, T. W. H., & Muglia, L. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017296108 · Cited by 93
Pinsino, A., Russo, R., Bonaventura, R., Brunelli, A., Marcomini, A., & Matranga, V. (2015) · Scientific Reports · doi:10.1038/srep14492 · Cited by 99
Zheng, Y., Xiong, S., Jiang, P., Liu, R., Liu, X., Qian, J., Zheng, X., & Chu, Y. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.031 · Cited by 95
Zhang, Y., Bai, X.-T., Zhu, K.-Y., Jin, Y., Deng, M., Le, H., Fu, Y., Chen, Y., Zhu, J., Look, A. T., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.2155 · Cited by 90
Clark, A. R., & Dean, J. L. E. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160166 · Cited by 91
Host immune responses during Taenia solium Neurocysticercosis infection and treatment
Prodjinotho, U. F., Lema, J., Lacorcia, M., Schmidt, V., Vejzagić, N., Sikasunge, C. S., Ngowi, B. J., Winkler, A. S., & da Costa, C. P. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008005 · Cited by 86
The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in the inflammatory response
Chapman, K. E., Coutinho, A. E., Gray, M., Gilmour, J. S., Savill, J., & Seckl, J. R. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.09.031 · Cited by 85
The Temporal and Spatial Distribution of Macrophage Subpopulations During Arteriogenesis
Troidl, C., Jung, G., Troidl, K., Hoffmann, J., Möllmann, H., NEF, H. M., Schaper, W. K. A., Hamm, C. W., & Schmitz-Rixen, T. (2012) · Current Vascular Pharmacology · doi:10.2174/1570161111309010005 · Cited by 86
Familial interstitial disease with I73T mutation: A mid‐ and long‐term study
Taam, R. A., Jaubert, F., Emond, S., Bourgeois, M. L., Epaud, R., Karila, C., Feldmann, D., Scheinmann, P., & Jacques de, B. L. I. C. (2009) · Pediatric Pulmonology · doi:10.1002/ppul.20970 · Cited by 78
Yang, C., Ko, S., Cho, B.-G., Shin, D. M., Yuk, J., Li, S., Kim, J., Evans, R. M., Jung, J., Song, D., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00181.x · Cited by 78
A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis
Loft, A., Schmidt, S. F., Caratti, G., Stifel, U., Havelund, J., Sekar, R., Kwon, Y., Sulaj, A., Chow, K. K., Alfaro, A. J., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.004 · Cited by 76
Li, B., Zhang, R., Li, J., Zhang, L., Ding, G., Luo, P., He, S., Dong, Y., Jiang, W., Lu, Y., et al. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2007.10.024 · Cited by 75
Glucocorticoid Regulation of Mouse and Human Dual Specificity Phosphatase 1 (DUSP1) Genes
Tchen, C. R., Martins, J. R. S., Paktiawal, N., Perelli, R., Saklatvala, J., & Clark, A. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.037309 · Cited by 75
Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration
van Dijk, G., van Heijningen, S., Reijne, A. C., Nyakas, C., van der Zee, E. A., & Eisel, U. L. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00173 · Cited by 75
Wijagkanalan, W., Higuchi, Y., Kawakami, S., Teshima, M., Sasaki, H., & Hashida, M. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.050153 · Cited by 74
The role of scaffold proteins in JNK signalling
Engström, W., Ward, A., & Moorwood, K. (2009) · Cell Proliferation · doi:10.1111/j.1365-2184.2009.00654.x · Cited by 73
Mitogen‐Activated Protein Kinase Phosphatase 1 as an Inflammatory Factor and Drug Target
Korhonen, R., & Moilanen, E. (2013) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12141 · Cited by 73
Crosstalk between p38 MAPK and GR Signaling
Zeyen, L., Seternes, O. M., & Mikkola, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063322 · Cited by 70
Corticosteroid use in neurocysticercosis
Nash, T. E., Mahanty, S., García, H. H., & The Cysticercosis Group in Peru (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.86 · Cited by 69
Mogensen, T. H., Berg, R. S., Paludan, S. R., & Østergaard, L. J. (2007) · Infection and Immunity · doi:10.1128/iai.00856-07 · Cited by 69
Zhang, J., Wang, Q., Zhu, N., Yu, M., Shen, B., Xiang, J., & Lin, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.87 · Cited by 65
Arthritis and the role of endogenous glucocorticoids
Macfarlane, E., Seibel, M. J., & Zhou, H. (2020) · Bone Research · doi:10.1038/s41413-020-00112-2 · Cited by 64
Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress
Shimba, A., Ejima, A., & Ikuta, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.706951 · Cited by 64
Wang, X., Nelin, L. D., Kuhlman, J. R., Meng, X., Welty, S. E., & Liu, Y. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.09.003 · Cited by 61
Adjunctive Oral Methylprednisolone in Pediatric Acute Pyelonephritis Alleviates Renal Scarring
Huang, Y.-Y., Chen, M.-J., Chiu, N.-T., Chou, H., Lin, K.-Y., & Chiou, Y. (2011) · PEDIATRICS · doi:10.1542/peds.2010-0297 · Cited by 61
Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2
Young, M. J., Clyne, C. D., & Chapman, K. E. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0260 · Cited by 64
The Role of Glucocorticoids in the Management of COVID-19
Alexaki, V. I., & Henneicke, H. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1300-2550 · Cited by 61
The neuroendocrine control of the innate immune system in health and brain diseases
Bellavance, M., & Rivest, S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01129.x · Cited by 61
Quatrini, L., Wieduwild, É., Guia, S., Bernat, C., Glaichenhaus, N., Vivier, É., & Ugolini, S. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171048 · Cited by 62
Neuroendocrine regulation of innate lymphoid cells
Quatrini, L., Vivier, É., & Ugolini, S. (2018) · Immunological Reviews · doi:10.1111/imr.12707 · Cited by 58
Control of immunity and allergy by steroid hormones
Ikuta, K., Ejima, A., Abe, S., & Shimba, A. (2022) · Allergology International · doi:10.1016/j.alit.2022.07.006 · Cited by 62
Koenen, M., Culemann, S., Vettorazzi, S., Caratti, G., Frappart, L., Baum, W., Krönke, G., Baschant, U., & Tuckermann, J. P. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-212762 · Cited by 59
Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice
Kwon, H., Won, Y.-S., Park, O., Feng, D., & Gao, B. (2013) · Hepatology · doi:10.1002/hep.26748 · Cited by 57
Wang, J., Wang, R., Wang, H., Yang, X., Yang, J., Xiong, W., Wen, Q., & Ma, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-01174-9 · Cited by 57
The glucocorticoid receptor in inflammatory processes: transrepression is not enough
Hübner, S., Dejager, L., Libert, C., & Tuckermann, J. P. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0106 · Cited by 57
Liao, J., Wang, X., Bi, Y., Shen, B., Shao, K., Yang, H., Lu, Y., Zhang, Z., Chen, X., Liu, H., et al. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.2hi1113-611rr · Cited by 56
Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation
Busada, J. T., Ramamoorthy, S., Cain, D. W., Xu, X., Cook, D. N., & Cidlowski, J. A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123233 · Cited by 53
Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma
Klaßen, C., Karabinskaya, A., Dejager, L., Vettorazzi, S., Moorleghem, J. V., Lühder, F., Meijsing, S. H., Tuckermann, J. P., Bohnenberger, H., Libert, C., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601691 · Cited by 54
Kamiyama, K., Matsuda, N., Yamamoto, S., Takano, K.-I., Takano, Y., Yamazaki, H., Kageyama, S.-I., Yokoo, H., Nagata, T., Hatakeyama, N., et al. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00459.2007 · Cited by 53
Bhattacharyya, S., Ratajczak, C. K., Vogt, S. K., Kelley, C., Colonna, M., Schreiber, R. D., & Muglia, L. J. (2010) · Blood · doi:10.1182/blood-2009-06-224782 · Cited by 53
Burris, T. P., de Vera, I. M. S., Côté, I., Flaveny, C. A., Wanninayake, U. S., Chatterjee, A., Walker, J. K., Steinauer, N., Zhang, J., Coons, L. A., et al. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000436 · Cited by 54
Yang, J., Ding, J., Ding, J., Chen, L.-H., Wang, Y.-L., Li, S., & Wu, H. (2008) · Inflammation · doi:10.1007/s10753-008-9079-x · Cited by 50
The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue
Lucas, K., Morris, G., Anderson, G., & Maes, M. H. J. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150317224645 · Cited by 50
Ince, L. M., Zhang, Z., Beesley, S., Vonslow, R. M., Saer, B., Matthews, L. C., Begley, N., Gibbs, J. E., Ray, D. W., & Loudon, A. S. I. (2018) · The FASEB Journal · doi:10.1096/fj.201800026rr · Cited by 50
Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation
Sorrells, S. F., Caso, J. R., Munhoz, C. D., Hu, C. K., Tran, K. V., Miguel, Z. D., Chien, B. Y., & Sapolsky, R. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4705-12.2013 · Cited by 46
Metadata
- Authors
- Bhattacharyya, S., Brown, D. E., Brewer, J. A., Vogt, S. K., & Muglia, L. J.
- Affiliations
- Departments of Pediatrics
- Washington University in St. Louis (US)
- ORCID
- Muglia, Louis J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2007-01-25
- Volume
- 109
- Issue
- 10
- Pages
- 4313-4319
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC1885507
- OpenAlex
- W2104547539
- Cited by
- 249
- References
- 58
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 9 · 2023: 15 · 2022: 13 · 2021: 11 · 2020: 20 · 2019: 15 · 2018: 10 · 2017: 23 · 2016: 6 · 2015: 15 · 2014: 12 · 2013: 12 · 2012: 11
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI50655, R01AI050655, R21AI050655)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- glucocorticoid receptor, macrophages, TLR4, p38 MAPK, dexamethasone, lipopolysaccharide, MKP-1, immunosuppression, innate immunity, inflammatory cytokines, conditional knockout mice, PI3K/Akt, ERK, JNK
- MeSH terms
- Animals, Dexamethasone, Enzyme Inhibitors, Inflammation, Lipopolysaccharides, Macrophages, Mice, Inbred C57BL, Models, Biological, Phosphoprotein Phosphatases, Receptors, Glucocorticoid, Cytokines, Protein Tyrosine Phosphatases, Immediate-Early Proteins, Mice, Knockout, Cell Cycle Proteins, Inflammation Mediators, p38 Mitogen-Activated Protein Kinases, Toll-Like Receptor 4, Mice, Dual Specificity Phosphatase 1, Protein Phosphatase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review