Cited by 249Immune Response and InflammationEstrogen and related hormone effectsNF-κB Signaling Pathways

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Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase

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Bhattacharyya, Sandip, Brown, Diane E., Brewer, Judson A., Vogt, Sherri K., Muglia, Louis J.·2007·Blood

DOI 10.1182/blood-2006-10-048215PMC PMC1885507

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Abstract

To explore the role of glucocorticoids in regulation of kinase pathways during innate immune responses, we generated mice with conditional deletion of glucocorticoid receptor (GR) in macrophages (MGRKO). Activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) caused greater mortality and cytokine production in MGRKO mice than in controls. Ex vivo, treatment with dexamethasone (Dex) markedly inhibited LPS-mediated induction of inflammatory genes in control but not GR-deficient macrophages. We show that Dex inhibits p38 MAPK, but not PI3K/Akt, ERK, or JNK, in control macrophages. Associated with p38 inhibition, Dex induced MAP kinase phosphatase-1 (MKP-1) in control, but not MGRKO, macrophages. Consistent with the ex vivo studies, treatment with a p38 MAPK-specific inhibitor resulted in rescue of MGRKO mice from LPS-induced lethality. Taken together, we identify p38 MAPK and its downstream targets as essential for GR-mediated immunosuppression in macrophages.

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Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647
Innate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
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Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A. M., Wilson, C. B., Bassetti, M., & Aderem, A. A. (1999) · Nature · doi:10.1038/44605 · Cited by 1,370
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
Masferrer, J. L., Zweifel, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C., & Seibert, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3228 · Cited by 1,310
The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression
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Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways
McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805
Prostaglandin Endoperoxide H Synthases-1 and -2
Smith, W. L., & DeWitt, D. L. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60430-7 · Cited by 711
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647
How Toll-like receptors signal: what we know and what we don’t know
O'Neill, L. A. J. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.012 · Cited by 614
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Joseph, S. B., Bradley, M. N., Castrillo, A., Bruhn, K. W., Mak, P. A., Pei, L., Hogenesch, J. B., O’Connell, R. M., Cheng, G., Sáez, E., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.032 · Cited by 584
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Chi, H., Barry, S. P., Flach, R. J. R., Wu, J. J., Jones, E. A., Bennett, A. M., & Flavell, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510965103 · Cited by 568
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Kopp, E. B., & Medzhitov, R. M. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00080-3 · Cited by 553
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Yamamoto, M., Yamazaki, S., Uematsu, S., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Kuwata, H., Takeuchi, O., Takeshige, K., et al. (2004) · Nature · doi:10.1038/nature02738 · Cited by 498
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Dean, J. L. E., Brook, M., Clark, A. R., & Saklatvala, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.264 · Cited by 492
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Jackson, J. R., Bolognese, B. J., Hillegass, L. M., Kassis, S., Adams, J. L., Griswold, D. E., & Winkler, J. D. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37283-0 · Cited by 173
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Authors: Bhattacharyya, S., Brown, D. E., Brewer, J. A., Vogt, S. K., & Muglia, L. J.
Affiliations: Departments of Pediatrics
Washington University in St. Louis (US)
ORCID: Muglia, Louis J.
Venue: Blood
Publisher: American Society of Hematology
Published: 2007-01-25
Volume: 109
Issue: 10
Pages: 4313-4319
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2006-10-048215
PMC: PMC1885507
OpenAlex: W2104547539
Cited by: 249
References: 58
Citations by year: 2026: 7 · 2025: 11 · 2024: 9 · 2023: 15 · 2022: 13 · 2021: 11 · 2020: 20 · 2019: 15 · 2018: 10 · 2017: 23 · 2016: 6 · 2015: 15 · 2014: 12 · 2013: 12 · 2012: 11
FWCI: 5.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI50655, R01AI050655, R21AI050655)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: glucocorticoid receptor, macrophages, TLR4, p38 MAPK, dexamethasone, lipopolysaccharide, MKP-1, immunosuppression, innate immunity, inflammatory cytokines, conditional knockout mice, PI3K/Akt, ERK, JNK
MeSH terms: Animals, Dexamethasone, Enzyme Inhibitors, Inflammation, Lipopolysaccharides, Macrophages, Mice, Inbred C57BL, Models, Biological, Phosphoprotein Phosphatases, Receptors, Glucocorticoid, Cytokines, Protein Tyrosine Phosphatases, Immediate-Early Proteins, Mice, Knockout, Cell Cycle Proteins, Inflammation Mediators, p38 Mitogen-Activated Protein Kinases, Toll-Like Receptor 4, Mice, Dual Specificity Phosphatase 1, Protein Phosphatase 1

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Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase

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