Does OROS-methylphenidate improve core symptoms and deficits in executive function? Results of an open-label trial in adults with attention deficit hyperactivity disorder

Fallu, Angelo; Richard, Caroline; Prinzo, Rosanna; Binder, Carin

doi:10.1185/030079906x154132

Cited by 42Attention Deficit Hyperactivity DisorderSchizophrenia research and treatmentPharmacology and Obesity Treatment

Does OROS-methylphenidate improve core symptoms and deficits in executive function? Results of an open-label trial in adults with attention deficit hyperactivity disorder

Fallu, Angelo, Richard, Caroline, Prinzo, Rosanna, Binder, Carin·2006·Current Medical Research and Opinion

DOI 10.1185/030079906x154132

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Abstract

Objective This pilot, uncontrolled, open-label study evaluated the safety/tolerability and potential effectiveness of OROS-methylphenidate (OROS-MPH) in adult attention deficit hyperactivity disorder (ADHD). Methods Adults with DSM-IV-defined ADHD were enrolled in this 38-day study. Retrospective childhood diagnosis was made using the Wender Utah Rating Scale. Eligible patients required a baseline Conners Adult ADHD Rating Scale (CAARS) score > or = 24, Clinical Global Impression of Severity (CGI-S) score > or = 4 (at least moderate illness), and Montgomery-Asberg Depression Rating Scale (MADRS) score Results Thirty-two patients formed the safety analysis; however, 30 comprised the effectiveness analysis since two patients did not meet diagnostic inclusion criteria. No serious adverse events were reported and there were no early withdrawals due to adverse events. There were no clinically significant changes in endpoint ECGs, physical examination, or blood pressure. Mean pulse rate increased by 5.9 beats/min (p = 0.003) and mean body weight decreased by 2.2 kg at endpoint (p Conclusions This uncontrolled, open-label trial suggests that OROS-MPH is well tolerated, providing core symptom control with the added benefit of improving executive function. However, future larger, randomized, controlled trials are required.

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The finding that lisdexamfetamine improves executive function in adult ADHD is similar to previous studies in adults with ADHD treated with psychostimulants such as MPH and nonstimulants such as atomoxetine.
“This finding is similar to previous studies in adults with ADHD treated with psychostimulants, such as MPH,35 and nonstimulants, such as atomoxetine.36”
From Exploratory meta-analysis on lisdexamfetamine versus placebo in adult ADHD (2014) · cites this paper as [35]
The effects seen in the current study on weight and cardiovascular parameters were consistent with those previously reported for stimulants, including LDX, in adults.
“The effects seen in the current study on weight and cardiovascular parameters were consistent with those previously reported for stimulants, including LDX, in adults [7-9,18,37].”
From Randomized, double-blind, placebo-controlled, crossover study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder: novel findings using a simulated adult workplace environment design (2010) · cites this paper as [8]

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Open-label (OL) extension trial of the safety and tolerability of OROS® methylphenidate in adults with ADHD – the long-acting methylphenidate in adult ADHD (LAMDA) trial
Philipsen, A., Trott, G.-E., Roesler, M., Gerwe, M., Lee, E., Medori, R., & Schäuble, B. (2007) · Pharmacopsychiatry · doi:10.1055/s-2007-991879
Efficacy and Safety of OROS Methylphenidate in Adults With Attention-Deficit/Hyperactivity Disorder: A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Dose-Escalation Study
Adler, L. A., Zimmerman, B., Starr, H. L., Silber, S., Palumbo, J., Orman, C., & Spencer, T. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181a390ce · Cited by 106 · see citing works

Authors: Fallu, A., Richard, C., Prinzo, R., & Binder, C.
Affiliations: Clinique Woodward, Sherbrooke, Quebec, Canada
Janssen Canada (Canada) (CA)
Corresponding author: Fallu, Angelo
Venue: Current Medical Research and Opinion
Publisher: Informa Healthcare
Published: 2006-11-30
Volume: 22
Issue: 12
Pages: 2557-2566
ISSN: 0300-7995 (ISSN-L)
1473-4877
DOI: 10.1185/030079906x154132
OpenAlex: W2009357282
Cited by: 42
References: 34
Citations by year: 2025: 2 · 2022: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 3
FWCI: 2.97
Type: journal article
Language: en
Open access: closed
Locations: Current Medical Research and Opinion (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords: OROS methylphenidate, attention deficit hyperactivity disorder, adult ADHD, executive function, symptom severity, inattention, hyperactivity/impulsivity, safety and tolerability, pulse rate, weight loss
MeSH terms: Administration, Oral, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Cardiovascular System, Cognition, Cognition Disorders, Delayed-Action Preparations, Disability Evaluation, Female, Humans, Male, Methylphenidate, Middle Aged, Osmosis, Pilot Projects, Psychological Tests, Treatment Outcome, Patient Satisfaction

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Does OROS-methylphenidate improve core symptoms and deficits in executive function? Results of an open-label trial in adults with attention deficit hyperactivity disorder

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