Synaptic and peptidergic connectome of a neurosecretory center in the annelid brain
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Abstract
Abstract Neurosecretory centres in animal brains use peptidergic signalling to influence physiology and behaviour. Understanding neurosecretory centre function requires mapping cell types, synapses, and peptidergic networks. Here we use electron microscopy and gene expression mapping to analyse the synaptic and peptidergic connectome of an entire neurosecretory centre. We mapped 78 neurosecretory neurons in the brain of larval Platynereis dumerilii , a marine annelid. These neurons form an anterior neurosecretory organ expressing many neuropeptides, including hypothalamic peptide orthologues and their receptors. Analysis of peptide-receptor pairs revealed sparsely connected networks linking specific neuronal subsets. We experimentally analysed one peptide-receptor pair and found that a neuropeptide can couple neurosecretory and synaptic brain signalling. Our study uncovered extensive non-synaptic signalling within a neurosecretory centre and its connection to the synaptic brain.
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Four preprohormones of the GnRH superfamily were identified in Platynereis by transcriptomics, bioinformatics, and mass spectrometry.
“Four preprohormones of the gnrh superfamily were identified in Platynereis by a combination of transcriptomics, bioinformatics, and mass spectrometry analyses (refs. 53 and 54 and this study).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [54]
A GnRH-superfamily receptor with clear orthology to the Corazonin Receptor subfamily (CrzR) was identified and shown to interact with both CRZ1 and CRZ2.
“A GnRH-superfamily receptor with clear orthology to the Corazonin Receptor subfamily (CrzR) was identified and shown to interact with both CRZ1 and CRZ2 (54).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [54]
Both CrzRa and CrzRb were activated by CRZ1/GnRHL1 and CRZ2/GnRHL2 and, at higher concentration, also by GnRHL3.
“Both CrzRa and CrzRb were activated by CRZ1/GnRHL1 and CRZ2/GnRHL2 (Fig. 1B and SI Appendix, Fig. S3 C and D; see also ref. 54) and, at higher concentration, also by GnRHL3 (Fig. 1B and SI Appendix, Fig. S3 C and D).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [54]
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- Authors
- Williams, E. A., Verasztó, C., Jasek, S., Conzelmann, M., Shahidi, R., Bauknecht, P., Mirabeau, O., & Jékely, G.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- University of Exeter (GB)
- Inserm (FR)
- Corresponding author
- Jékely, Gáspár
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2017-12-04
- Volume
- 6
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5747525
- OpenAlex
- W2611412176
- Cited by
- 119
- References
- 80
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 34 · 2023: 20 · 2022: 5 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 14 · 2017: 4
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Research Exeter (University of Exeter) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Digital Library (submittedVersion)
- Figshare (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Max-Planck-Gesellschaft
- Deutsche Forschungsgemeinschaft (JE 777/1-1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- peptidergic signaling, synaptic connectivity, connectome, neuropeptides, neuropeptide receptors, hypothalamic neuropeptides, Platynereis dumerilii, larval brain, single-cell transcriptome, neurosecretory cells
- MeSH terms
- Animals, Brain, Neuropeptides, Neurosecretory Systems, Polychaeta, Gene Expression Profiling, Microscopy, Electron, Transmission, Connectome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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