Cited by 308Circadian rhythm and melatoninPlant Molecular Biology ResearchSleep and Work-Related Fatigue

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Transcriptional oscillation of canonical clock genes in mouse peripheral tissues

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Yamamoto, Takuro, Nakahata, Yasukazu, Soma, Haruhiko, Akashi, Makoto, Mamine, Takayoshi, Takumi, Toru·2004·BMC Molecular Biology

DOI 10.1186/1471-2199-5-18PMC PMC535906

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Abstract

BACKGROUND: The circadian rhythm of about 24 hours is a fundamental physiological function observed in almost all organisms from prokaryotes to humans. Identification of clock genes has allowed us to study the molecular bases for circadian behaviors and temporal physiological processes such as hormonal secretion, and has prompted the idea that molecular clocks reside not only in a central pacemaker, the suprachiasmatic nuclei (SCN) of hypothalamus in mammals, but also in peripheral tissues, even in immortalized cells. Furthermore, previous molecular dissection revealed that the mechanism of circadian oscillation at a molecular level is based on transcriptional regulation of clock and clock-controlled genes. RESULTS: We systematically analyzed the mRNA expression of clock and clock-controlled genes in mouse peripheral tissues. Eight genes (mBmal1, mNpas2, mRev-erbalpha, mDbp, mRev-erbbeta, mPer3, mPer1 and mPer2; given in the temporal order of the rhythm peak) showed robust circadian expressions of mRNAs in all tissues except testis, suggesting that these genes are core molecules of the molecular biological clock. The bioinformatics analysis revealed that these genes have one or a combination of 3 transcriptional elements (RORE, DBPE, and E-box), which are conserved among human, mouse, and rat genome sequences, and indicated that these 3 elements may be responsible for the biological timing of expression of canonical clock genes. CONCLUSIONS: The observation of oscillatory profiles of canonical clock genes is not only useful for physiological and pathological examination of the circadian clock in various organs but also important for systematic understanding of transcriptional regulation on a genome-wide basis. Our finding of the oscillatory expression of canonical clock genes with a temporal order provides us an interesting hypothesis, that cyclic timing of all clock and clock-controlled genes may be dependent on several transcriptional elements including 3 known elements, E-box, RORE, and DBPE.

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Authors: Yamamoto, T., Nakahata, Y., Soma, H., Akashi, M., Mamine, T., & Takumi, T.
Affiliations: Osaka City University (JP)
Life Science Institute (JP)
Corresponding author: Takumi, Toru
ORCID: Yamamoto, Takuro
Nakahata, Yasukazu
Akashi, Makoto
Takumi, Toru
Venue: BMC Molecular Biology
Publisher: Springer Science and Business Media LLC
Published: 2004-10-09
Volume: 5
Issue: 1
Pages: 18-18
ISSN: 1471-2199 (ISSN-L)
DOI: 10.1186/1471-2199-5-18
PMC: PMC535906
OpenAlex: W1878038567
Cited by: 308
References: 38
Citations by year: 2026: 7 · 2025: 9 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 13 · 2020: 9 · 2019: 6 · 2018: 13 · 2017: 11 · 2016: 12 · 2015: 12 · 2014: 14 · 2013: 20 · 2012: 23
FWCI: 6.74
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: BMC Molecular Biology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian clock, clock genes, transcriptional oscillations, peripheral circadian rhythms, clock-controlled genes, Bmal1, NPAS2, NR1D1, DBP, REV-ERBβ, Per1, Per2, E-box, mRNA expression, mouse tissues
MeSH terms: Animals, Base Sequence, Cell Line, Circadian Rhythm, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Male, Mice, Inbred BALB C, Molecular Sequence Data, Nerve Tissue Proteins, Nuclear Proteins, Organ Specificity, Transcription Factors, Transcription, Genetic, Receptors, Cytoplasmic and Nuclear, Cell Cycle Proteins, Computational Biology, NIH 3T3 Cells, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, ARNTL Transcription Factors, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1

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Transcriptional oscillation of canonical clock genes in mouse peripheral tissues

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