Seroreactivity to Dirofilariaantigens in people from different areas of Serbia
Open accessAbstract
BACKGROUND: The Northern part of Serbia is hyperendemic-endemic for canine dirofilarioses. Considering this fact, many human dirofilarial infections could be expected, however only about 30 cases in Serbia have been described until today. Aims of this survey were to assess the people reactivity to the antigens of D. repens and D. immitis and to identify risk factors for the contact exposure. METHODS: Investigation included sera taken from 297 people (179 women and 118 men) living in different areas of Serbia (Pančevo, Novi Sad, Zaječar, Leskovac, Vranje, Niš, Pirot). Sera were analysed by means of two indirect enzyme-linked immunosorbent (ELISA) home-designed that use as antigens adult somatic/metabolic polyproteins of D. repens (DR) and D. immitis (DI), respectively. The results were elaborated using the statistical method of descriptive and quantitative analysis. RESULTS: Significant differences by area in the reactivity of human sera to dirofilarial antigens were not observed (p = 0.056). A high seroreactivity was demonstrated in people from the towns of northern Serbia (Pančevo = 27,1%; Novi Sad = 16,3%), as well as in people from Zaječar (eastern Serbia = 15,8%) and Vranje (southern Serbia = 15,1%). No differences were evidenced between people reactivity to polyproteins of the two dirofilarial species, nor differences related to the gender of examinees. Factor risks evidenced were: i) place of residence; ii) spending work time outdoors during the mosquito season; iii) spending time outdoors and nearby rivers, lakes, swamps or canals; unespectedly, iv) cat owning. CONCLUSION: The findings emerging from this investigation indicate that clinicians and public health authorities should pay greater attention to this zoonosis. Continuing education and training of physicians will greatly contribute to the knowledge of the actual impact of filarial worms on animal and public health, and allow for the planning of suitable measures to prevent the infections.
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The same study points out that the highest seroreactivity is recorded in the northeastern part of Serbia (Pančevo, 27.1%) close to sites where D. repens was found in wild animals in this study.
“The same study points out that the highest seroreactivity is recorded in the northeastern part of the country (Pančevo, 27.1%) close to sites where D. repens was found in wild animals in this study.”
From First records of Dirofilaria repens in wild canids from the region of Central Balkan (2014) · cites this paper as Tasić-Otašević et al., 2014
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- Authors
- Tasić-Otašević, S. A., Gabrielli, S. V., Tasić, A. V., MiladinovićTasić, N. L., Kostić, J. T., Ignjatović, A. M., Popović Dragonjić, L. D., Milošević, Z. G., Arsić-Arsenijević, V. S., & Cancrini, G. A.
- Affiliations
- Sapienza University of Rome (IT)
- University of Nis (RS)
- University of Belgrade (RS)
- Venue
- BMC Infectious Diseases
- Published
- 2014-02-08
- Volume
- 14
- Issue
- 1
- Pages
- 68-68
- ISSN
- 1471-2334 (ISSN-L)
- PMC
- PMC3922270
- OpenAlex
- W2018955689
- Cited by
- 24
- References
- 27
- Citations by year
- 2026: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Infectious Diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Keywords
- Dirofilaria repens, Dirofilaria immitis, seroprevalence, zoonoses, risk factors, outdoor exposure, cat ownership, northern Serbia, canine dirofilariasis
- MeSH terms
- Adolescent, Adult, Animals, Antibodies, Helminth, Antigens, Helminth, Cats, Child, Dirofilaria immitis, Dirofilariasis, Dogs, Female, Humans, Male, Middle Aged, Zoonoses, Serbia, Young Adult, Dirofilaria repens
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