Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
Open accessAbstract
BACKGROUND: Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability and aggressive behavior based on core symptoms. However, there are still no radical treatments of social impairments in these patients. Oxytocin has been reported to play important roles in multiple social behaviors dependent on social recognition, and has been expected as one of the effective treatments of social impairments of patients with ASDs. CASE PRESENTATION: We present a case of a 16-year-old girl with autistic disorder who treated by long-term administration of oxytocin nasal spray. Her autistic symptoms were successfully treated by two month administration; the girl's social interactions and social communication began to improve without adverse effects. Her irritability and aggressive behavior also improved dramatically with marked decreases in aberrant behavior checklist scores from 69 to 7. CONCLUSION: This case is the first to illustrate long-term administration of oxytocin nasal spray in the targeted treatment of social impairments in a female with autistic disorder. This case suggests that long-term nasal oxytocin spray is promising and well-tolerated for treatment of social impairments of patients with ASDs.
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The open-label study showed that Clinical Global Impression-Improvement score gradually improved over 6 months.
“Our open-label study showed that Clinical Global Impression-Improvement (CGI-I) score gradually improved over 6 months.27”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [27]
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- Authors
- Kosaka, H., Munesue, T., Ishitobi, M., Asano, M., Omori, M., Sato, M., Tomoda, A., & Wada, Y.
- Affiliations
- University of Fukui (JP)
- Kanazawa University (JP)
- Fukui Prefectural University (JP)
- Corresponding author
- Kosaka, Hirotaka
- Venue
- BMC Psychiatry
- Published
- 2012-08-13
- Volume
- 12
- Issue
- 1
- Pages
- 110-110
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC3466125
- OpenAlex
- W2087609223
- Cited by
- 65
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 1
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Research Foundation for Clinical Pharmacology
- Ministry of Education, Culture, Sports, Science and Technology
- SENSHIN Medical Research Foundation
- Japan Society for the Promotion of Science (24300149, 21791120, 24659541)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin, autism spectrum disorder, social dysfunction, nasal spray, irritability, aggression, social communication, treatment tolerability
- MeSH terms
- Autistic Disorder, Communication, Female, Humans, Interpersonal Relations, Oxytocin, Play and Playthings, Social Behavior, Treatment Outcome
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