Inhaled oxytocin increases positive social behaviors in newborn macaques
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Significance: Oxytocin promotes positive social behaviors in several species and therefore may be a therapeutic tool for neurodevelopmental disorders. It remains untested, however, whether oxytocin may affect infants, and whether effects may vary depending on infants’ social skills or interest. To test these predictions, we administered nebulized oxytocin to rhesus macaque newborns. Macaques, like humans, engage in complex face-to-face mother–infant interactions. Oxytocin increased infants’ affiliative communicative gestures and decreased salivary cortisol, and higher oxytocin levels were associated with greater social interest. Infants with stronger imitative skills were most positively influenced by oxytocin, suggesting that oxytocin sensitivity may underlie early social motivation. These results suggest that oxytocin may be a promising early intervention for infants at risk for abnormal social functions.
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IN-OXT treatment increases gaze following, increases socially oriented gaze, and alters social attention in a wide variety of contexts in macaques.
“This work provides anatomical support for other findings in macaques, which indicate that IN-OXT treatment increases gaze following67, increases socially oriented gaze68, and alters social attention in a wide variety of contexts69–74.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [73]
When administered intranasally, OT increases communicative gesturing in rhesus infants.
“When administered intranasally, OT increases the time that rhesus monkeys spend viewing the eyes of conspecifics in static images (Dal Monte et al., 2014a; Ebitz et al., 2013) and communicative gesturing in rhesus infants (Simpson et al., 2014).”
From Oxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys (2016) · cites this paper as Simpson et al., 2014
Inhaled oxytocin increases affiliative behaviors such as lip smacking and visual attention and close proximity to the caregiver in newborn macaques.
“This is in line with recent studies in newborn macaques showing that inhaled oxytocin increases affiliative behaviors such as lip smacking and visual attention and close proximity to the caregiver (Simpson et al. 2014).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Simpson et al. 2014
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Parr, L. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00278 · Cited by 23 · see citing works
Effects of chronic oxytocin on attention to dynamic facial expressions in infant macaques
Parr, L. A., Brooks, J. M., Jonesteller, T., Moss, S., Jordano, J. O., & Heitz, T. R. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.028 · Cited by 23 · see citing works
- Authors
- Simpson, E. A., Sclafani, V., Paukner, A., Hamel, A. F., Novak, M. A., Meyer, J. S., Suomi, S. J., & Ferrari, P. F.
- Affiliations
- University of Parma (IT)
- National Institutes of Health (US)
- University of Massachusetts Amherst (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-04-28
- Volume
- 111
- Issue
- 19
- Pages
- 6922-6927
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4024859
- OpenAlex
- W2059625922
- Cited by
- 82
- References
- 84
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 13 · 2015: 10 · 2014: 5
- FWCI
- 19.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lincoln Repository (University of Lincoln) (acceptedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (Z99HD999999, R24OD011180)
- National Center for Research Resources (#RR11122, R24RR011122)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD064653)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- oxytocin, caregiver-infant interaction, imitation, salivary cortisol, anxiolytic effects, social skills, infant development, neurodevelopmental disorders
- MeSH terms
- Administration, Inhalation, Animals, Animal Communication, Animals, Newborn, Behavior, Animal, Female, Hydrocortisone, Imitative Behavior, Macaca mulatta, Male, Oxytocics, Oxytocin, Saliva, Social Behavior, Recognition, Psychology, Models, Animal
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