Oxytocin and Autism Spectrum Disorders
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose core symptoms include deficits in social interaction and communication besides restricted and repetitive behaviors. Although ASD is highly prevalent, affecting 1/100 in the general population, no medication for the core symptoms has been established. Therefore, the disorder is considered a huge unmet medical need and a heavy burden on individuals with ASD, their families, and entire society. Oxytocin is expected to be a potential therapeutic resource for the social core symptoms of ASD, since this neuropeptide can modulate human social behavior and cognition. This review article provides an overview of both experimental and clinical studies on effects of oxytocin administration on behavior, neural underpinnings, and symptomatology of ASD. Although the number of studies is increasing, several issues remain for further development of clinical application of the neuropeptide. The issues include optimization of administration route, doses, treatment duration, interval of administrations, and timing of starting treatment. Additional issues involve investigating neurobiological mechanisms of treatment and developing a reliable tool to accurately and objectively assess longitudinal changes in the core symptoms of ASD. Some of these issues are discussed in this review.
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There remains a lack of conclusive evidence for the long-term beneficial effects of OXT in addressing the core symptoms of autism.
“Of pertinence, there remains a lack of conclusive evidence for the long-term beneficial effects of OXT in addressing the core symptoms of autism [89].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [89]
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Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling
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- Authors
- Yamasue, H., & Domes, G.
- Affiliations
- Hamamatsu University (JP)
- Universität Trier (DE)
- Corresponding author
- Yamasue, Hidenori
- Domes, Gregor
- Venue
- Current Topics in Behavioral Neurosciences
- Publisher
- Springer International Publishing
- Published
- 2017
- Volume
- 35
- Pages
- 449-465
- ISSN
- 1866-3370 (ISSN-L)
- 1866-3389
- OpenAlex
- W2740286558
- Semantic Scholar
- d308573876a609682c000623f8194c6e359193b0
- Cited by
- 109
- References
- 57
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 15 · 2023: 18 · 2022: 15 · 2021: 13 · 2020: 16 · 2019: 7 · 2018: 6 · 2017: 1
- FWCI
- 31.57
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Current topics in behavioral neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin, autism spectrum disorder, social behavior, social communication deficits, neuropeptide therapy, treatment optimization, neurobiological mechanisms, treatment outcome assessment, unmet medical needs
- MeSH terms
- Autism Spectrum Disorder, Child, Humans, Interpersonal Relations, Oxytocin, Social Behavior
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