Cited by 155Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and Adiposity

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The role of interleukin-18 in the metabolic syndrome

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Trøseid, Marius, Seljeflot, Ingebjørg, Arnesen, Harald·2010·Cardiovascular Diabetology

DOI 10.1186/1475-2840-9-11PMC PMC2858122

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Abstract

The metabolic syndrome is thought to be associated with a chronic low-grade inflammation, and a growing body of evidence suggests that interleukin-18 (IL-18) might be closely related to the metabolic syndrome and its consequences. Circulating levels of IL-18 have been reported to be elevated in subjects with the metabolic syndrome, to be closely associated with the components of the syndrome, to predict cardiovascular events and mortality in populations with the metabolic syndrome and to precede the development of type 2 diabetes. IL-18 is found in the unstable atherosclerotic plaque, in adipose tissue and in muscle tissue, and is subject to several regulatory steps including cleavage by caspase-1, inactivation by IL-18 binding protein and the influence of other cytokines in modulating its interaction with the IL-18 receptor. The purpose of this review is to outline the role of IL-18 in the metabolic syndrome, with particular emphasis on cardiovascular risk and the potential effect of life style interventions.

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Figure 1 Regulation and biological effects of interleukin-18. The cytokine is expressed as a precursor, pro-IL-18, which is inactive until cleaved by caspase-1. Once secreted, IL-18 is bound and inactivated by IL-18 binding protein (IL-18 BP), and only the free fraction can stimulate a signal transduction via the β-chain of the IL-18 receptor (IL-18R). The biological effect is dependent on the cytokine milieu: IL-18 may stimulate a Th2 response in combination with IL-2, and may act synergistically with IL-12 to stimulate a Th1 response with production of IFN-γ, a central feature of the atherosclerotic lesion.CC BY · PubMed Central

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Authors: Trøseid, M., Seljeflot, I., & Arnesen, H.
Affiliations: Oslo University Hospital (NO)
Corresponding author: Trøseid, Marius
ORCID: Trøseid, Marius
Seljeflot, Ingebjørg
Arnesen, Harald
Venue: Cardiovascular Diabetology
Publisher: Springer Science and Business Media LLC
Published: 2010
Volume: 9
Issue: 1
Pages: 11
ISSN: 1475-2840 (ISSN-L)
DOI: 10.1186/1475-2840-9-11
PMC: PMC2858122
OpenAlex: W2116389925
Cited by: 155
References: 117
Citations by year: 2026: 5 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 4 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 13 · 2016: 10 · 2015: 6 · 2014: 11 · 2013: 18 · 2012: 8
FWCI: 1.52
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Cardiovascular Diabetology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: IL-18, metabolic syndrome, low-grade inflammation, cardiovascular risk, type 2 diabetes, atherosclerotic plaque, adipose tissue, caspase-1, IL-18 binding protein, IL-18 receptor, lifestyle intervention
MeSH terms: Adipose Tissue, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Life Style, Muscles, Risk Factors, Cytokines, Caspase 1, Interleukin-18, Metabolic Syndrome, Intercellular Signaling Peptides and Proteins, Atherosclerosis

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The role of interleukin-18 in the metabolic syndrome

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