Cited by 294Probiotics and Fermented FoodsMicrobial Metabolic Engineering and BioproductionBacterial Genetics and Biotechnology

Genomic Diversity and Versatility of Lactobacillus plantarum, a Natural Metabolic Engineer

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Siezen, Roland J, van Hylckama Vlieg, Johan ET·2011·Microbial Cell Factories

Abstract

In the past decade it has become clear that the lactic acid bacterium Lactobacillus plantarum occupies a diverse range of environmental niches and has an enormous diversity in phenotypic properties, metabolic capacity and industrial applications. In this review, we describe how genome sequencing, comparative genome hybridization and comparative genomics has provided insight into the underlying genomic diversity and versatility of L. plantarum. One of the main features appears to be genomic life-style islands consisting of numerous functional gene cassettes, in particular for carbohydrates utilization, which can be acquired, shuffled, substituted or deleted in response to niche requirements. In this sense, L. plantarum can be considered a "natural metabolic engineer".

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  • Whole-genome analysis of EPS clusters has been reported for S. thermophilus, Lpb. plantarum and Lact. lactis; comparative genomic analyses for EPS biosynthesis have been performed for Lb. bulgaricus 2038.

    “Whole-genome analysis of EPS clusters have been already reported for some species, such as S. thermophilus [91], Lpb. plantarum [92] and Lact. lactis; additionally, comparative genomic analyses for EPS biosynthesis have been performed for Lb. bulgaricus 2038 [93].”

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  1. Connelly P Lactobacillus plantarum - A literature review of therapeutic benfefits Journal of the Australian Traditional Medicine Society 2008 14 2 79 82

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Authors
Siezen, R. J., & van Hylckama Vlieg, J. E.
Affiliations
Nederlands Instituut Voor Zuivel Oonderzoek (NL)
Corresponding author
Siezen, Roland J
Venue
Microbial Cell Factories
Published
2011
Volume
10
Issue
Suppl 1
Pages
S3
ISSN
1475-2859 (ISSN-L)
OpenAlex
W2147094340
Cited by
294
References
66
Citations by year
2026: 20 · 2025: 23 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 22 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 24 · 2016: 29 · 2015: 26 · 2014: 9 · 2013: 19 · 2012: 12
Type
conference abstract
Language
en
Open access
Licence
cc-by
Locations
  • Microbial Cell Factories (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Norwegian Biodiversity Information Centre
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
Lactobacillus plantarum, genomic diversity, comparative genomics, genomic islands, gene cassettes, carbohydrate utilization, metabolic versatility, niche adaptation, lactic acid bacteria, industrial applications
MeSH terms
Animals, Humans, Genome, Bacterial, Genomics, Lactobacillus plantarum, Lactiplantibacillus plantarum, Metabolic Engineering

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