Genomic Diversity and Versatility of Lactobacillus plantarum, a Natural Metabolic Engineer
Open accessAbstract
In the past decade it has become clear that the lactic acid bacterium Lactobacillus plantarum occupies a diverse range of environmental niches and has an enormous diversity in phenotypic properties, metabolic capacity and industrial applications. In this review, we describe how genome sequencing, comparative genome hybridization and comparative genomics has provided insight into the underlying genomic diversity and versatility of L. plantarum. One of the main features appears to be genomic life-style islands consisting of numerous functional gene cassettes, in particular for carbohydrates utilization, which can be acquired, shuffled, substituted or deleted in response to niche requirements. In this sense, L. plantarum can be considered a "natural metabolic engineer".
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Whole-genome analysis of EPS clusters has been reported for S. thermophilus, Lpb. plantarum and Lact. lactis; comparative genomic analyses for EPS biosynthesis have been performed for Lb. bulgaricus 2038.
“Whole-genome analysis of EPS clusters have been already reported for some species, such as S. thermophilus [91], Lpb. plantarum [92] and Lact. lactis; additionally, comparative genomic analyses for EPS biosynthesis have been performed for Lb. bulgaricus 2038 [93].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [92]
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- Authors
- Siezen, R. J., & van Hylckama Vlieg, J. E.
- Affiliations
- Nederlands Instituut Voor Zuivel Oonderzoek (NL)
- Corresponding author
- Siezen, Roland J
- ORCID
- Siezen, Roland J
- Venue
- Microbial Cell Factories
- Published
- 2011
- Volume
- 10
- Issue
- Suppl 1
- Pages
- S3
- ISSN
- 1475-2859 (ISSN-L)
- PMC
- PMC3271238
- OpenAlex
- W2147094340
- Cited by
- 294
- References
- 66
- Citations by year
- 2026: 20 · 2025: 23 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 22 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 24 · 2016: 29 · 2015: 26 · 2014: 9 · 2013: 19 · 2012: 12
- Type
- conference abstract
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Microbial Cell Factories (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Norwegian Biodiversity Information Centre
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Lactobacillus plantarum, genomic diversity, comparative genomics, genomic islands, gene cassettes, carbohydrate utilization, metabolic versatility, niche adaptation, lactic acid bacteria, industrial applications
- MeSH terms
- Animals, Humans, Genome, Bacterial, Genomics, Lactobacillus plantarum, Lactiplantibacillus plantarum, Metabolic Engineering
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