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Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease
Open accessAbstract
BACKGROUND: Alterations in blood-brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson's disease progression. However, few studies have addressed this issue in patients at different stages of disease. METHODS: Albumin was measured in cerebrospinal fluid and serum samples obtained from 73 non-demented subjects with idiopathic Parkinson's disease and 47 age-matched control subjects. The albumin ratio (AR) was calculated to assess blood-cerebrospinal fluid and blood-brain barrier function. The group of patients with Parkinson's disease included 46 subjects with Hoehn-Yahr staging between 1 and 2 and 27, with a score ranging from 2.5 to 4. RESULTS: Statistically significant differences in albumin ratio were found between patients with advanced disease, and both early-stage and unaffected groups. Conversely, early-phase patients did not differ from healthy subjects. Additionally, dopaminergic treatment seems to exert a possible effect on AR values. CONCLUSIONS: Our study demonstrates that possible dysfunction of the blood-cerebrospinal fluid barrier, blood-brain barrier, or both, characterize Parkinson's disease progression. The associations between clinical scores, treatments and biochemical findings suggest a progressive impairment of barrier integrity during the course of the disease.
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“These biomarkers are further altered as patients progress into more advanced PD stages with dementia (288, 474).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [474]
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Metadata
- Authors
- Pisani, V., Stefani, A., Pierantozzi, M., Natoli, S., Stanzione, P., Franciotta, D., & Pisani, A.
- Affiliations
- University of Rome Tor Vergata (IT)
- Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IT)
- Corresponding author
- Pisani, Antonio
- ORCID
- Venue
- Journal of Neuroinflammation
- Published
- 2012-08-08
- Volume
- 9
- Issue
- 1
- Pages
- 188-188
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC3441323
- OpenAlex
- W2155862034
- Cited by
- 158
- References
- 21
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 15 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 18 · 2019: 9 · 2018: 17 · 2017: 9 · 2016: 10 · 2015: 12 · 2014: 6 · 2013: 7 · 2012: 1
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Keywords
- Parkinson's disease, blood-brain barrier permeability, blood-CSF barrier, albumin ratio, cerebrospinal fluid albumin, disease progression, Hoehn-Yahr staging, dopaminergic therapy, barrier dysfunction
- MeSH terms
- Adult, Aged, Aged, 80 and over, Albumins, Blood-Brain Barrier, Female, Humans, Male, Middle Aged, Parkinson Disease, Severity of Illness Index, Cohort Studies, Biomarkers
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