Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis
Open accessAbstract
BACKGROUND: Nonmotor symptoms are common among patients with Parkinson's disease (PD) and some may precede disease diagnosis. METHODS: We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis, using random-effect models. We searched PubMed (1965 through October/November 2012) for the following symptoms: hyposmia, constipation, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, depression, and anxiety. Eligible studies were publications in English with original data on one or more of these symptoms. RESULTS: The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria, mostly (n = 320) on symptoms after PD diagnosis. For all symptoms, the prevalence was substantially higher in PD cases than in controls, each affecting over a third of the patients. Hyposmia was the most prevalent (75.5% in cases vs. 19.1% in controls), followed by constipation (50% vs. 17.7%), anxiety (39.9% vs. 19.1%), rapid eye movement sleep behavior disorder (37.0% vs. 7.0%), depression (36.6% vs. 14.9%), and excessive daytime sleepiness (33.9% vs. 10.5%). We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this. However, the prevalence estimates were fairly robust in several sensitivity analyses. Only 20 studies had data on any symptoms prior to PD diagnosis, but still the analyses revealed higher prevalence in future PD cases than in controls. CONCLUSION: These symptoms are common among PD patients both before and after diagnosis. Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications.
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Non-motor symptoms in Parkinson's disease may precede the classical motor symptoms by several years.
“Some of these symptoms may precede the classical motor symptoms by several years (Abbott et al., 2001;Chen et al., 2015;Gao et al., 2011)”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Chen et al., 2015
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Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
(2000) · Cited by 9,198 · see citing works
Barone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, G., Ceravolo, R., et al. (2009) · Movement Disorders · doi:10.1002/mds.22643 · Cited by 1,445 · see citing works
Prevalence of olfactory impairment in older adults.
Murphy, C., Schubert, C., Cruickshanks, K., Klein, B., Klein, R., & Nondahl, D. (2002) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.288.18.2307 · Cited by 1,083 · see citing works
Suares, N. C., & Ford, A. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.164 · Cited by 906 · see citing works
Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder
Postuma, R. B., Gagnon, J., Vendette, M., Fantini, M. L., Massicotte-Marquez, J., & Montplaisir, J. Y. (2008) · Neurology · doi:10.1212/01.wnl.0000340980.19702.6e · Cited by 779 · see citing works
Meta‐analysis of early nonmotor features and risk factors for Parkinson disease
Noyce, A. J., Bestwick, J. P., Silveira‐Moriyama, L., Hawkes, C. H., Giovannoni, G., Lees, A. J., & Schrag, A. E. (2012) · Annals of Neurology · doi:10.1002/ana.23687 · Cited by 772 · see citing works
Association of olfactory dysfunction with risk for future Parkinson's disease
Ross, G. W., Petrovitch, H., Abbott, R. D., Tanner, C. M., Popper, J. S., Masaki, K., Launer, L. J., & White, L. R. (2007) · Annals of Neurology · doi:10.1002/ana.21291 · Cited by 739 · see citing works
Development of the 12‐Item Cross‐Cultural Smell Identification Test(CC‐SIT)
Doty, R. L., Marcus, A., & Lee, W. W. (1996) · The Laryngoscope · doi:10.1097/00005537-199603000-00021 · Cited by 734 · see citing works
Braak, H., Bohl, J. R., Müller, C. M., Rüb, U., de Vos, R. A. I., & Del Tredici, K. (2006) · Movement Disorders · doi:10.1002/mds.21065 · Cited by 630 · see citing works
Excessive daytime sleepiness and subsequent development of Parkinson disease
Abbott, R. D., Ross, G. W., White, L. R., Tanner, C. M., Masaki, K., Nelson, J. S., Curb, J. D., & Petrovitch, H. (2005) · Neurology · doi:10.1212/01.wnl.0000183056.89590.0d · Cited by 439 · see citing works
Medical records documentation of constipation preceding Parkinson disease
Savica, R., Carlin, J. M., Grossardt, B. R., Bower, J. H., Ahlskog, J. E., Maraganore, D. M., Bharucha, A. E., & Rocca, W. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c34af5 · Cited by 431 · see citing works
Hummel, T. R., Rosenheim, K., Konnerth, C., & Kobal, G. (2001) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348940111001015 · Cited by 394 · see citing works
The prevalence of mental disorders in older people in Western countries – a meta-analysis
Volkert, J., Schulz, H., Härter, M., Wlodarczyk, O., & Andreas, S. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.09.004 · Cited by 390 · see citing works
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century
Claassen, D. O., Josephs, K. A., Ahlskog, J. E., Silber, M. H., Tippmann‐Peikert, M., & Boeve, B. F. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ec7fac · Cited by 389 · see citing works
Determinants of health-related quality of life in Parkinson’s disease: A systematic review
Soh, S., Morris, M. E., & McGinley, J. L. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.08.012 · Cited by 388 · see citing works
Health‐related quality of life in early Parkinson's disease: The impact of nonmotor symptoms
Duncan, G. W., Khoo, T. K., Yarnall, A. J., O'Brien, J. T., Coleman, S. Y., Brooks, D. J., Barker, R. A., & Burn, D. J. (2013) · Movement Disorders · doi:10.1002/mds.25664 · Cited by 383 · see citing works
Parkinson's Disease: The Dual Hit Theory Revisited
Hawkes, C. H., Del Tredici, K., & Braak, H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04365.x · Cited by 303 · see citing works
Bowel movement frequency in late‐life and incidental Lewy bodies
Abbott, R. D., Ross, G. W., Petrovitch, H., Tanner, C. M., Davis, D. G., Masaki, K., Launer, L. J., Curb, J. D., & White, L. R. (2007) · Movement Disorders · doi:10.1002/mds.21560 · Cited by 203 · see citing works
Impaired olfaction and other prodromal features in the Parkinson At‐Risk Syndrome study
Siderowf, A. D., Jennings, D. L., Eberly, S. W., Oakes, D., Hawkins, K. A., Ascherio, A., Stern, M. B., MAREK, K. L., & the PARS Investigators (2012) · Movement Disorders · doi:10.1002/mds.24892 · Cited by 196 · see citing works
Lang, A. E. (2011) · Movement Disorders · doi:10.1002/mds.23609 · Cited by 146 · see citing works
Prospective study of phobic anxiety and risk of Parkinson's disease
Weisskopf, M. G., Chen, H., Schwarzschild, M. A., Kawachi, I. I., & Ascherio, A. (2003) · Movement Disorders · doi:10.1002/mds.10425 · Cited by 145 · see citing works
Self-citationAnxious personality predicts an increased risk of Parkinson's disease
Bower, J. H., Grossardt, B. R., Maraganore, D. M., Ahlskog, J. E., Colligan, R. C., Geda, Y. E., Therneau, T. M., & Rocca, W. A. (2010) · Movement Disorders · doi:10.1002/mds.23230 · Cited by 141 · see citing works
Environmental risk factors for REM sleep behavior disorder
Postuma, R. B., Montplaisir, J. Y., Pelletier, A., Dauvilliers, Y. A., Oertel, W. H., Iranzo, Á., Ferini‐Strambi, L., Arnulf, I., Högl, B., Manni, R., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31825dd383 · Cited by 130 · see citing works
Defining at‐risk populations for Parkinson's disease: Lessons from ongoing studies
Berg, D., MAREK, K. L., Ross, G. W., & Poewe, W. H. (2012) · Movement Disorders · doi:10.1002/mds.24985 · Cited by 128 · see citing works
The PRIPS study: screening battery for subjects at risk for P arkinson's disease
Berg, D., Godau, J., Seppi, K., Behnke, S., Liepelt‐Scarfone, I., Lerche, S., Stockner, H., Gaenslen, A., Mahlknecht, P., Huber, H., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03798.x · Cited by 123 · see citing works
Prodromal features for P arkinson's disease – baseline data from the TREND study
Gaenslen, A., Wurster, I., Brockmann, K., Huber, H., Godau, J., Faust, B., Lerche, S., Eschweiler, G. W., Maetzler, W., & Berg, D. (2014) · European Journal of Neurology · doi:10.1111/ene.12382 · Cited by 117 · see citing works
REM sleep behavior disorder: From dreams to neurodegeneration
Postuma, R. B., Gagnon, J., & Montplaisir, J. Y. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.003 · Cited by 116 · see citing works
A prospective study of bowel movement frequency and risk of Parkinson's disease
Gao, X., Chen, H., Schwarzschild, M. A., & Ascherio, A. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr119 · Cited by 115 · see citing works
Self-citationA longitudinal study of olfactory function in patients with idiopathic Parkinson's disease
Herting, B., Schulze, S., Reichmann, H., Haehner, A., & Hummel, T. R. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0665-5 · Cited by 102 · see citing works
Daytime Napping, Nighttime Sleeping, and Parkinson Disease
Gao, J., Huang, X., Park, Y., Hollenbeck, A. R., Blair, A. E., Schatzkin, A. G., & Chen, H. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwq478 · Cited by 102 · see citing works
Self-citationDepression and the subsequent risk of Parkinson's disease in the NIH‐AARP Diet and Health Study
Fang, F., Xu, Q., Park, Y., Huang, X., Hollenbeck, A. R., Blair, A. E., Schatzkin, A. G., Kamel, F., & Chen, H. (2010) · Movement Disorders · doi:10.1002/mds.23092 · Cited by 96 · see citing works
Self-citationResearch on the Premotor Symptoms of Parkinson’s Disease: Clinical and Etiological Implications
Chen, H., Burton, E. A., Ross, G. W., Huang, X., Savica, R., Abbott, R. D., Ascherio, A., Caviness, J. N., Gao, X., Gray, K. A., et al. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306967 · Cited by 83 · cited 4× · see citing works
“Such assessment in the prodromal stage of PD may further help to better identify populations at risk despite that individual NMS are mostly not specific to PD [15].”
BackgroundInfluentialSelf-citationFatigue in early Parkinson’s disease. Minor inconvenience or major distress?
Herlofson, K., Ongre, S. O., Enger, L. K., Tysnes, O., & Larsen, J. O. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03663.x · Cited by 71 · see citing works
View point: Etiology in Parkinson's disease. Dual hit or spreading intoxication
Reichmann, H. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.04.016 · Cited by 68 · see citing works
Point Estimation of the Parameter of the Binomial Distribution
Chew, V. (1971) · The American Statistician · doi:10.1080/00031305.1971.10477305 · Cited by 33 · see citing works
Psychological functioning in patients with Parkinson's disease
Gupta, A., & Bhatia, S. (2000) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(00)00010-9 · Cited by 22 · see citing works
Individual and joint prevalence of three nonmotor symptoms of PD in the US general population
Chen, H., Huang, X., Guo, X., & Peddada, S. D. (2014) · Movement Disorders · doi:10.1002/mds.25950 · Cited by 17 · see citing works
Self-citationFatigue in early Parkinson’s disease
秦朝晖 (2012) · 中国医学文摘：内科学分册（英文版） · Cited by 4 · see citing works
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Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149 · see citing works
The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
Houser, M. C., & Tansey, M. G. (2017) · npj Parkinson's Disease · doi:10.1038/s41531-016-0002-0 · Cited by 588 · see citing works
Vagotomy and Parkinson disease: A Swedish register–based matched-cohort study
Liu, B., Fang, F., Pedersen, N. L., Tillander, A., Ludvigsson, J. F., Ekbom, A., Svenningsson, P., Chen, H., & Wirdefeldt, K. (2017) · Neurology · doi:10.1212/wnl.0000000000003961 · Cited by 447 · see citing works
Self-citationPeter, I., Dubinsky, M., Bressman, S., Park, A., Lu, C., Chen, N., & Wang, A. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0605 · Cited by 386 · see citing works
The gut microbiota–brain axis in neurological disorder
Ullah, H., Arbab, S., Tian, Y., Liu, C., Chen, Y., Li, Q., Khan, M. I. U., Hassan, I. U., & Li, K. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1225875 · Cited by 279 · see citing works
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Killinger, B. A., Madaj, Z., Sikora, J. W., Rey, N. L., Haas, A. J., Vepa, Y., Lindqvist, D., Chen, H., Thomas, P. M., Brundin, P., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar5280 · Cited by 274 · see citing works
Self-citationWallen, Z. D., Appah, M., Dean, M. N., Sesler, C. L., Factor, S. A., Molho, E., Zabetian, C. P., Standaert, D. G., & Payami, H. (2020) · npj Parkinson s Disease · doi:10.1038/s41531-020-0112-6 · Cited by 252 · see citing works
Constipation preceding Parkinson's disease: a systematic review and meta-analysis
Adams-Carr, K. L., Bestwick, J. P., Shribman, S., Lees, A., Schrag, A., & Noyce, A. J. (2016) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-311680 · Cited by 228 · see citing works
Microbiota Signaling Pathways that Influence Neurologic Disease
Cox, L. M., & Weiner, H. L. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0598-8 · Cited by 208 · see citing works
Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies
Zhang, X., Tang, B., & Guo, J. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00392-8 · Cited by 205 · see citing works
The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies
Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.042 · Cited by 203 · see citing works
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Houser, M. C., Chang, J., Factor, S. A., Molho, E., Zabetian, C. P., Hill‐Burns, E. M., Payami, H., Hertzberg, V., & Tansey, M. G. (2018) · Movement Disorders · doi:10.1002/mds.27326 · Cited by 200 · see citing works
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Araújo, B., Caridade-Silva, R., Soares-Guedes, C., Martins‐Macedo, J., Gomes, E. D., Monteiro, S., & Teixeira, F. G. (2022) · Cells · doi:10.3390/cells11182908 · Cited by 198 · see citing works
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Yang, D., Zhao, D., Ali Shah, S. Z., Wu, W., Lai, M., Zhang, X., Li, J., Guan, Z., Zhao, H., Li, W., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01155 · Cited by 162 · see citing works
Bunker, A., & Róg, T. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.604770 · Cited by 161 · see citing works
Nair, A. T., Ramachandran, V., Joghee, N. M., Shanish Antony, A., & Ramalingam, G. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17105 · Cited by 156 · see citing works
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Weis, S., Schwiertz, A., Unger, M. M., Becker, A., Faßbender, K., Ratering, S., Kohl, M., Schnell, S., Schäfer, K.-H., & Egert, M. (2019) · npj Parkinson s Disease · doi:10.1038/s41531-019-0100-x · Cited by 145 · see citing works
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Svensson, E., Henderson, V. W., Borghammer, P., Horváth–Puhó, E., & Sørensen, H. T. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.05.016 · Cited by 57 · see citing works
A scoping review of neurodegenerative manifestations in explainable digital phenotyping
Alfalahi, H., Dias, S. B., Khandoker, A. H., Chaudhuri, К. R., & Hadjileontiadis, L. J. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00494-0 · Cited by 56 · see citing works
Wang, Y., Du, W., Hu, X., Yu, X., Guo, C., Jin, X., & Wang, W. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.009 · Cited by 56 · see citing works
Singh, S., & Kumar, P. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.10.006 · Cited by 56 · see citing works
Singh, T., Jiao, Y., Ferrando, L. M., Yablonska, S., Li, F., Horoszko, E. C., Lacomis, D., Friedlander, R. M., & Carlisle, D. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-97928-7 · Cited by 55 · see citing works
A Narrative Review of Psychobiotics: Probiotics That Influence the Gut–Brain Axis
Ķimse, L., Reinis, A., Miķelsone-Jansone, L., Gintere, S., & Krūmiņa, A. (2024) · Medicina · doi:10.3390/medicina60040601 · Cited by 53 · see citing works
Hyposmia as a Predictive Marker of Parkinson’s Disease: A Systematic Review and Meta-Analysis
Sui, X., Zhou, C., Li, J., Chen, L., Yang, X., & Li, F. (2019) · BioMed Research International · doi:10.1155/2019/3753786 · Cited by 53 · see citing works
Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson’s Disease
Perez‐Pardo, P., Hartog, M., Garssen, J., & Kraneveld, A. D. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0129-2 · Cited by 52 · see citing works
Gut Microbiota Approach—A New Strategy to Treat Parkinson’s Disease
Liu, J., Xu, F., Nie, Z., & Shao, L. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.570658 · Cited by 51 · see citing works
Accurate Coil Positioning is Important for Single and Paired Pulse TMS on the Subject Level
de Goede, A. A., ter Braack, E. M., & van Putten, M. J. A. M. (2018) · Brain Topography · doi:10.1007/s10548-018-0655-6 · Cited by 50 · see citing works
Malaty, I. A., Martínez‐Martín, P., Chaudhuri, К. R., Odin, P., Škorvánek, M., Shahed, J. J., Soileau, M. J., Lindvall, S., Domingos, J., Jones, S. C., et al. (2022) · BMC Neurology · doi:10.1186/s12883-022-02560-1 · Cited by 49 · see citing works
Neutrophil to lymphocyte ratio in parkinson’s disease: a systematic review and meta-analysis
Hosseini, S., Shafiabadi, N., Khanzadeh, M., Ghaedi, A., Ghorbanzadeh, R., Azarhomayoun, A., Bazrgar, A., Pezeshki, J., Bazrafshan, H., & Khanzadeh, S. (2023) · BMC Neurology · doi:10.1186/s12883-023-03380-7 · Cited by 49 · see citing works
The impact of nonmotor symptoms on quality of life in patients with Parkinson's disease in Taiwan
Liu, W.-M., Wu, R., Lin, C., Tai, C., Yu, R., & Lin, R.-J. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s88968 · Cited by 49 · see citing works
Quantification Analysis of Sleep Based on Smartwatch Sensors for Parkinson’s Disease
Ko, Y.-F., Kuo, P.-H., Wang, C.-F., Chen, Y.-J., Chuang, P.-C., Li, S.-Z., Chen, B., Yang, F.-C., Lo, Y., Yang, Y., et al. (2022) · Biosensors · doi:10.3390/bios12020074 · Cited by 48 · see citing works
Neuropathology of Nonmotor Symptoms of Parkinson's Disease
Jellinger, K. A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.005 · Cited by 47 · see citing works
A literature review of online handwriting analysis to detect Parkinson’s disease at an early stage
Aouraghe, I., Khaissidi, G., & Mrabti, M. (2022) · Multimedia Tools and Applications · doi:10.1007/s11042-022-13759-2 · Cited by 46 · see citing works
Environmental triggers of Parkinson's disease – Implications of the Braak and dual-hit hypotheses
Chen, H., Wang, K., Scheperjans, F., & Killinger, B. A. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105601 · Cited by 44 · see citing works
Self-citationRosch, J. G., Winter, H., DuRoss, A. N., Sahay, G., & Sun, C. (2018) · Colloids and Interface Science Communications · doi:10.1016/j.colcom.2018.12.002 · Cited by 44 · see citing works
Christensen, L. F. B., Jensen, K. F., Nielsen, J., Vad, B. S., Christiansen, G., & Otzen, D. E. (2019) · ACS Omega · doi:10.1021/acsomega.8b03590 · Cited by 44 · see citing works
Prajapati, S. K., Garabadu, D., & Krishnamurthy, S. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9693-6 · Cited by 44 · see citing works
Non motor symptoms in progressive supranuclear palsy: prevalence and severity
Radicati, F. G., Martín, P. M., FOSSATI, C., Chaudhuri, К. R., Torti, M., Rodríguez‐Blázquez, C., Vacca, L., & Stocchi, F. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-017-0037-x · Cited by 43 · see citing works
Therapeutic potential of stem cells for treatment of neurodegenerative diseases
Ahmadian-Moghadam, H., Sadat‐Shirazi, M., & Zarrindast, M. (2020) · Biotechnology Letters · doi:10.1007/s10529-020-02886-1 · Cited by 42 · see citing works
Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease
Perez‐Pardo, P., Broersen, L. M., Kliest, T., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00237 · Cited by 40 · see citing works
Hunn, B. H. M., Vingill, S., Threlfell, S., Alegre-Abarrategui, J., Magdelyns, M., Deltheil, T., Bengoa-Vergniory, N., Oliver, P. L., Cioroch, M., Doig, N. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.029 · Cited by 38 · see citing works
Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms
Rodríguez‐Violante, M., Zerón-Martínez, R., Cervantes‐Arriaga, A., & Corona, T. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.08.005 · Cited by 37 · see citing works
The Challenge and Opportunity to Diagnose Parkinson's Disease in Midlife
Kilzheimer, A., Hentrich, T., Burkhardt, S., & Schulze-Hentrich, J. M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01328 · Cited by 37 · see citing works
Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's disease
Liu, R., Umbach, D. M., Tröster, A. I., Huang, X., & Chen, H. (2020) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2020.02.001 · Cited by 37 · see citing works
Self-citationIrritable bowel syndrome and Parkinson’s disease risk: register-based studies
Liu, B., Sjölander, A., Pedersen, N. L., Ludvigsson, J. F., Chen, H., Fang, F., & Wirdefeldt, K. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-020-00145-8 · Cited by 37 · see citing works
Self-citationThe Gastrointestinal Dysfunction Scale for Parkinson's Disease
Camacho, M., Greenland, J. C., & Williams‐Gray, C. H. (2021) · Movement Disorders · doi:10.1002/mds.28675 · Cited by 37 · see citing works
Deidda, G., & Biazzo, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.753915 · Cited by 36 · see citing works
Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy
Yuan, X.-Y., Chen, Y., & Liu, Z. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i3.225 · Cited by 35 · see citing works
Darweesh, S. K. L., Wolters, F. J., Albert Hofman, D., Stricker, B. H. C., Koudstaal, P. J., & Ikram, M. A. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw122 · Cited by 35 · see citing works
Epidemiological study of elderly constipation in Beijing
Zhang, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i47.13368 · Cited by 32 · see citing works
Wang, K., Zhang, C., Zhang, B., Li, G., Shi, G., Cai, Q., & Huang, M. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114152 · Cited by 30 · see citing works
Elbaz, A. (2016) · Revue Neurologique · doi:10.1016/j.neurol.2016.07.001 · Cited by 30 · see citing works
Nanoparticles of chosen noble metals as reactive oxygen species scavengers
Ivanova, P., Dzięgielewski, K., Drozd, M., Skorupska, S., Grabowska‐Jadach, I., & Pietrzak, M. (2020) · Nanotechnology · doi:10.1088/1361-6528/abc19f · Cited by 30 · see citing works
Polymeric nanoparticles for RNA delivery
Jiang, X., Abedi, K., & Shi, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822425-0.00017-8 · Cited by 30 · see citing works
Variation in Recent Onset Parkinson’s Disease: Implications for Prodromal Detection
Swallow, D. M. A., Lawton, M., Grosset, K. A., Malek, N., Smith, C. R., Bajaj, N. P. S., Barker, R. A., Ben‐Shlomo, Y., Burn, D. J., Foltynie, T., et al. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-150741 · Cited by 29 · see citing works
Gan, J., Wan, Y., Shi, J., Zhou, M., Lou, Z., & Liu, Z. (2018) · BMC Neurology · doi:10.1186/s12883-018-1034-3 · Cited by 29 · see citing works
Yang, H., Shao, Y., Hu, Y., Jin, Q., Wang, P., Tian, L., Ni, Y., Li, S., Al‐Nusaif, M., Liu, C., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70003 · Cited by 28 · see citing works
Li, Y.-J., Leong, I.-I., Fan, J.-Q., Yan, M.-Y., Liu, X., Lu, W.-J., Chen, Y.-Y., Tan, W.-Q., Wang, Y.-T., & Zhuang, L.-X. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1126080 · Cited by 26 · see citing works
The Changing Landscape of Parkinson Epidemiologic Research
Chen, H. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-171238 · Cited by 26 · see citing works
Self-citationConstipation in Parkinson's Disease
Quigley, E. M. M. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771457 · Cited by 25 · see citing works
Phillips, K. A., Ross, C. N., Spross, J., Cheng, C. J. A., Izquierdo, A. M., Biju, K. C., Chen, C., Li, S., & Tardif, S. D. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.010 · Cited by 25 · see citing works
Behl, T., Kaur, G., Sehgal, A., Singh, S., Bhatia, S., Al‐Harrasi, A., Zengin, G., BUNGAU, S. G., Munteanu, M. A., Brisc, M. C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084045 · Cited by 24 · see citing works
Olfactory dysfunction as potential biomarker in neurodegenerative diseases: a narrative review
Cleene, N. D., Schwarzová, K., Labrecque, S., Cerejo, C., Djamshidian, A., Seppi, K., & Heim, B. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1505029 · Cited by 23 · see citing works
Stroke and Coronary Artery Disease Are Associated With Parkinson’s Disease
Li, Q., Wang, C., Tang, H., Chen, S., & Ma, J. (2018) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2018.56 · Cited by 23 · see citing works
Lu, H., Shen, Q., Xie, D., Zhao, Q., & Xu, Y. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01354-9 · Cited by 23 · see citing works
Park, S. J., Kim, K. W., & Lee, E. J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00994 · Cited by 23 · see citing works
REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study
Ma, J., Hou, M.-M., Tang, H.-D., Gao, X., Liang, L., Zhu, L.-F., Zhou, Y., Sheng-yu, Z. H. A., Cui, S.-S., Du, J.-J., et al. (2016) · BMC Neurology · doi:10.1186/s12883-016-0640-1 · Cited by 23 · see citing works
Litteljohn, D., Rudyk, C., Dwyer, Z., Farmer, K., Fortin, T., & Hayley, S. P. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.09.002 · Cited by 23 · see citing works
Hydrogels: potential aid in tissue engineering—a review
Senthilkumar, M. B., Priyanka, G., Rajalakshmi, S., Sankar, R., Sabreen, T., & Ravindran, J. (2021) · Polymer Bulletin · doi:10.1007/s00289-021-03864-x · Cited by 22 · see citing works
Mortality from Parkinson’s disease in China: Findings from a five-year follow up study in Shanghai
Wang, G., Li, X., Hu, Y., Cheng, Q., Wang, C., Xiao, Q., Liu, J., Ma, J., Zhou, H., Pan, J., et al. (2015) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2015.49 · Cited by 22 · see citing works
Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape
Chen, P., & Cabral, H. (2024) · ChemMedChem · doi:10.1002/cmdc.202400274 · Cited by 21 · see citing works
Association between Parkinson’s disease and the faecal eukaryotic microbiota
Weis, S., Meisner, A., Schwiertz, A., Unger, M. M., Becker, A., Fassbender, K. C., Schnell, S., Schäfer, K., & Egert, M. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-021-00244-0 · Cited by 21 · see citing works
A Critical Analysis of Intestinal Enteric Neuron Loss and Constipation in Parkinson’s Disease
O’Day, C., Finkelstein, D. I., Diwakarla, S., & McQuade, R. M. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223262 · Cited by 20 · see citing works
- Authors
- Chen, H., Zhao, E. J., Zhang, W., Lu, Y., Liu, R., Huang, X., Ciesielski-Jones, A. J., Justice, M. A., Cousins, D. S., & Peddada, S.
- Affiliations
- National Institutes of Health (US)
- Social and Scientific Systems (United States) (US)
- Pennsylvania State University (US)
- National Institute of Environmental Health Sciences (US)
- Corresponding author
- Chen, Honglei
- ORCID
- Venue
- Translational Neurodegeneration
- Published
- 2015-01-08
- Volume
- 4
- Issue
- 1
- Pages
- 1-1
- ISSN
- 2047-9158 (ISSN-L)
- PMC
- PMC4322463
- OpenAlex
- W2126909058
- Cited by
- 212
- References
- 40
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 16 · 2023: 21 · 2022: 20 · 2021: 26 · 2020: 20 · 2019: 16 · 2018: 21 · 2017: 28 · 2016: 7 · 2015: 4
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Translational Neurodegeneration (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1z01es101986-03, Z01-ES101986)
- National Institute of Neurological Disorders and Stroke (U01NS082151)
- National Institute of Environmental Health Sciences
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, non-motor symptoms, hyposmia, constipation, REM sleep behavior disorder, excessive daytime sleepiness, depression, anxiety, symptom prevalence, preclinical Parkinson's disease
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