Internet-based grief therapy for bereaved individuals after loss due to haematological cancer: study protocol of a randomized controlled trial
Open accessAbstract
BACKGROUND: Approximately 10% of the individuals experiencing the death of a loved one develop prolonged grief disorder (PGD) after bereavement. Family members of haematological cancer patients might be particularly burdened since their loss experience is preceded by a very strenuous time of disease and aggressive treatment. However, support needs of relatives of cancer patients often remain unmet, also after the death of the patient. Therapeutic possibilities are enhanced by providing easily available and accessible Internet-based therapies. This study will adapt and evaluate an Internet-based grief therapy for bereaved individuals after the loss of a significant other due to haematological cancer. METHODS: The efficacy of the Internet-based grief therapy is evaluated in a randomized controlled trial with a wait-list control group. Inclusion criteria are bereavement due to hematological cancer and meeting the diagnostic criteria for PGD. Exclusion criteria are severe depression, suicidality, dissociative tendency, psychosis, posttraumatic stress disorder, substance use disorder, and current psychotherapeutic or psychopharmacological treatment. The main outcome is PGD severity. Secondary outcomes are depression, anxiety, somatization, posttraumatic stress, quality of life, sleep quality, and posttraumatic growth. Data is collected pre- and posttreatment. Follow-up assessments will be conducted 3, 6, and 12 months after completion of the intervention. The Internet-based grief therapy is assumed to have at least moderate effects regarding PGD and other bereavement-related mental health outcomes. Predictors and moderators of the treatment outcome and PGD will be determined. DISCUSSION: Individuals bereaved due to haematological cancer are at high risk for psychological distress. Tailored treatment for this particularly burdened target group is missing. Our study results will contribute to a closing of this healthcare gap. TRIAL REGISTRATION: German Clinical Trial Register UTN: U1111-1186-6255 . Registered 1 December 2016.
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Online interventions have advantages including greater flexibility and anonymity, and have demonstrated positive effects comparable to face-to-face therapy.
“During the last decades, an increase in the implementation of online interventions has been observed due to the advantages that this entails, such as having greater flexibility and anonymity, in addition to having demonstrated positive effects comparable to face-to-face therapy (Wagner et al., 2014; Hoffmann et al., 2018).”
From A Self-Applied Multi-Component Psychological Online Intervention Based on UX, for the Prevention of Complicated Grief Disorder in the Mexican Population During the COVID-19 Outbreak: Protocol of a Randomized Clinical Trial (2021) · cites this paper as Hoffmann et al., 2018
The online modality is chosen based on advantages such as greater flexibility and anonymity compared to face-to-face therapy.
“The online modality is chosen based on the advantages that some authors have found, such as greater flexibility and anonymity compared to face-to-face therapy (Wagner et al., 2014; Hoffmann et al., 2018).”
From A Self-Applied Multi-Component Psychological Online Intervention Based on UX, for the Prevention of Complicated Grief Disorder in the Mexican Population During the COVID-19 Outbreak: Protocol of a Randomized Clinical Trial (2021) · cites this paper as Hoffmann et al., 2018
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Erfassung religiöser und spiritueller Einstellungen
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Relationship Between Physical and Psychological Status of Cancer Patients and Caregivers
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Internetbasierte Psychotherapie “Interapy„
Wagner, B., & Lange, A. (2008) · Springer eBooks · doi:10.1007/978-3-540-75736-8_9 · Cited by 12 · see citing works
Tanimukai, H., Hirai, K., Adachi, H., & Kishi, A. (2014) · Annals of Hematology · doi:10.1007/s00277-014-2139-4 · Cited by 11 · see citing works
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1 of the 100 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [13]Stewart BW Wild CP World cancer report 2014 2014 Lyon, France International Agency for Research on Cancer 39432694
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Kaiser, J., Nagl, M., Hoffmann, R., Linde, K., & Kersting, A. (2022) · JMIR Mental Health · doi:10.2196/27642 · Cited by 39 · see citing works
Investigation of a Web-Based Explainable AI Screening for Prolonged Grief Disorder
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“The online modality is chosen based on the advantages that some authors have found, such as greater flexibility and anonymity compared to face-to-face therapy (Wagner et al., 2014; Hoffmann et al., 2018).”
BackgroundInfluentialZhang, P., Yang, H., Zhu, K., Chang, C., Lv, W., Li, R., Li, X., Ye, T., & Cao, D. (2023) · Biomedicines · doi:10.3390/biomedicines11112884 · Cited by 18 · see citing works
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Bereavement in Hematologic Malignancies and Serious Blood Disorders
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Tur, C., Campos, D., Díaz-Sanahuja, L., Fernández-Buendía, S., Grimaldos, J., la Coba-Cañizares, L. D., Kazlauskas, E., & Quero, S. (2025) · Behavioral Sciences · doi:10.3390/bs15101312
- Authors
- Hoffmann, R., Große, J., Nagl, M., Niederwieser, D., Mehnert, A., & Kersting, A.
- Affiliations
- Leipzig University (DE)
- University Hospital Leipzig (DE)
- Corresponding author
- Hoffmann, Rahel
- Venue
- BMC Psychiatry
- Published
- 2018-02-27
- Volume
- 18
- Issue
- 1
- Pages
- 52-52
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC5827988
- OpenAlex
- W2794758680
- Cited by
- 18
- References
- 100
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 1
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- José Carreras Leukämie-Stiftung (DJCLS R15/22)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Grief, Bereavement, and Mental Health
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
- Keywords
- prolonged grief disorder, bereavement, hematologic cancer, online therapy, grief therapy, family caregivers, relatives of cancer patients, depression, anxiety, post-traumatic stress, posttraumatic growth, quality of life, sleep quality, somatization
- MeSH terms
- Adult, Anxiety, Bereavement, Depression, Family, Female, Follow-Up Studies, Grief, Humans, Male, Middle Aged, Psychotherapy, Quality of Life, Stress Disorders, Post-Traumatic, Therapy, Computer-Assisted, Cognitive Behavioral Therapy, Treatment Outcome, Hematologic Neoplasms, Internet
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