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The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration

Rosenberger, Karen, Derkow, Katja, Dembny, Paul, Krüger, Christina, Schott, Eckart, Lehnardt, Seija·2014·Journal of Neuroinflammation
DOI 10.1186/s12974-014-0166-7PMC PMC4182775
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  1. Kawai T, Akira S: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010, 11: 373-384. 10.1038/ni.1863. · DOI · Paper page
  2. Broz P, Monack DM: Newly described pattern recognition receptors team up against intracellular pathogens. Nat Rev Immunol. 2013, 13: 551-565. 10.1038/nri3479. · DOI
  3. Owens T: Toll-like receptors in neurodegeneration. Curr Top Microbiol Immunol. 2009, 336: 105-120.
  4. Bsibsi M, Ravid R, Gveric D, van Noort JM: Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol. 2002, 61: 1013-1021. · DOI
  5. Lehmann SM, Rosenberger K, Kruger C, Habbel P, Derkow K, Kaul D, Rybak A, Brandt C, Schott E, Wulczyn FG, Lehnardt S: Extracellularly delivered single-stranded viral RNA causes neurodegeneration dependent on TLR7. J Immunol. 2012, 189: 1448-1458. 10.4049/jimmunol.1201078. · DOI · Paper page
  6. Tang SC, Arumugam TV, Xu X, Cheng A, Mughal MR, Jo DG, Lathia JD, Siler DA, Chigurupati S, Ouyang X, Magnus T, Camandola S, Mattson MP: Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A. 2007, 104: 13798-13803. 10.1073/pnas.0702553104. · DOI · Paper page
  7. Kim Y, Zhou P, Qian L, Chuang JZ, Lee J, Li C, Iadecola C, Nathan C, Ding A: MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. J Exp Med. 2007, 204: 2063-2074. 10.1084/jem.20070868. · DOI · Paper page
  8. Ziegler G, Harhausen D, Schepers C, Hoffmann O, Rohr C, Prinz V, Konig J, Lehrach H, Nietfeld W, Trendelenburg G: TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem Biophys Res Commun. 2007, 359: 574-579. 10.1016/j.bbrc.2007.05.157. · DOI
  9. Mishra BB, Gundra UM, Teale JM: Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis. J Neuroinflammation. 2008, 5: 53-10.1186/1742-2094-5-53. · DOI
  10. Hanke ML, Kielian T: Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci (Lond). 2011, 121: 367-387. 10.1042/CS20110164. · DOI
  11. Tahara K, Kim HD, Jin JJ, Maxwell JA, Li L, Fukuchi K: Role of toll-like receptor signalling in Abeta uptake and clearance. Brain. 2006, 129: 3006-3019. 10.1093/brain/awl249. · DOI · Paper page
  12. Weber JR, Tuomanen EI: Cellular damage in bacterial meningitis: an interplay of bacterial and host driven toxicity. J Neuroimmunol. 2007, 184: 45-52. 10.1016/j.jneuroim.2006.11.016. · DOI
  13. Lehmann SM, Kruger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kälin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci. 2012, 15: 827-835. 10.1038/nn.3113. · DOI · Paper page
  14. Boje KM, Arora PK: Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 1992, 587: 250-256. 10.1016/0006-8993(92)91004-X. · DOI · Paper page
  15. Lehnardt S, Schott E, Trimbuch T, Laubisch D, Krueger C, Wulczyn G, Nitsch R, Weber JR: A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. J Neurosci. 2008, 28: 2320-2331. 10.1523/JNEUROSCI.4760-07.2008. · DOI
  16. Hoffmann O, Braun JS, Becker D, Halle A, Freyer D, Dagand E, Lehnardt S, Weber JR: TLR2 mediates neuroinflammation and neuronal damage. J Immunol. 2007, 178: 6476-6481. 10.4049/jimmunol.178.10.6476. · DOI
  17. Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA, Volpe JJ, Vartanian T: Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A. 2003, 100: 8514-8519. 10.1073/pnas.1432609100. · DOI · Paper page
  18. Rieu I, Powers SJ: Real-time quantitative RT-PCR: design, calculations, and statistics. Plant Cell. 2009, 21: 1031-1033. 10.1105/tpc.109.066001. · DOI · Paper page
  19. Olson JK, Miller SD: Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol. 2004, 173: 3916-3924. 10.4049/jimmunol.173.6.3916. · DOI · Paper page
  20. Ebert S, Gerber J, Bader S, Muhlhauser F, Brechtel K, Mitchell TJ, Nau R: Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination. J Neuroimmunol. 2005, 159: 87-96. 10.1016/j.jneuroim.2004.10.005. · DOI
  21. Bessler WG, Johnson RB, Wiesmuller K, Jung G: B-lymphocyte mitogenicity in vitro of a synthetic lipopeptide fragment derived from bacterial lipoprotein. Hoppe Seylers Z Physiol Chem. 1982, 363: 767-770. 10.1515/bchm2.1982.363.2.767. · DOI
  22. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S: Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002, 169: 10-14. 10.4049/jimmunol.169.1.10. · DOI
  23. Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S: Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol. 2002, 169: 6668-6672. 10.4049/jimmunol.169.12.6668. · DOI
  24. Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S: Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 2002, 420: 324-329. 10.1038/nature01182. · DOI
  25. Lehnardt S, Henneke P, Lien E, Kasper DL, Volpe JJ, Bechmann I, Nitsch R, Weber JR, Golenbock DT, Vartanian T: A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol. 2006, 177: 583-592. 10.4049/jimmunol.177.1.583. · DOI
  26. Lehnardt S, Wennekamp J, Freyer D, Liedtke C, Krueger C, Nitsch R, Bechmann I, Weber JR, Henneke P: TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. J Immunol. 2007, 179: 6134-6143. 10.4049/jimmunol.179.9.6134. · DOI
  27. Bottcher T, von Mering M, Ebert S, Meyding-Lamade U, Kuhnt U, Gerber J, Nau R: Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Neurosci Lett. 2003, 344: 17-20. 10.1016/S0304-3940(03)00404-X. · DOI
  28. Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT: Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002, 169: 3970-3977. 10.4049/jimmunol.169.7.3970. · DOI · Paper page
  29. Nicolle D, Fremond C, Pichon X, Bouchot A, Maillet I, Ryffel B, Quesniaux VJ: Long-term control of Mycobacterium bovis BCG infection in the absence of Toll-like receptors (TLRs): investigation of TLR2-, TLR6-, or TLR2-TLR4-deficient mice. Infect Immun. 2004, 72: 6994-7004. 10.1128/IAI.72.12.6994-7004.2004. · DOI
  30. Kono H, Rock KL: How dying cells alert the immune system to danger. Nat Rev Immunol. 2008, 8: 279-289. 10.1038/nri2215. · DOI · Paper page
  31. Lehnardt S, Lehmann S, Kaul D, Tschimmel K, Hoffmann O, Cho S, Krueger C, Nitsch R, Meisel A, Weber JR: Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J Neuroimmunol. 2007, 190: 28-33. 10.1016/j.jneuroim.2007.07.023. · DOI
  32. Koedel U, Angele B, Rupprecht T, Wagner H, Roggenkamp A, Pfister HW, Kirschning CJ: Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol. 2003, 170: 438-444. 10.4049/jimmunol.170.1.438. · DOI
  33. Sato S, Nomura F, Kawai T, Takeuchi O, Muhlradt PF, Takeda K, Akira S: Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol. 2000, 165: 7096-7101. 10.4049/jimmunol.165.12.7096. · DOI
  34. Beutler E, Gelbart T, West C: Synergy between TLR2 and TLR4: a safety mechanism. Blood Cells Mol Dis. 2001, 27: 728-730. 10.1006/bcmd.2001.0441. · DOI
  35. Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, Hellman J: MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol. 2007, 178: 1164-1171. 10.4049/jimmunol.178.2.1164. · DOI
  36. Gao JJ, Xue Q, Papasian CJ, Morrison DC: Bacterial DNA and lipopolysaccharide induce synergistic production of TNF-alpha through a post-transcriptional mechanism. J Immunol. 2001, 166: 6855-6860. 10.4049/jimmunol.166.11.6855. · DOI
  37. Gao JJ, Zuvanich EG, Xue Q, Horn DL, Silverstein R, Morrison DC: Cutting edge: bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages. J Immunol. 1999, 163: 4095-4099. · DOI
  38. Blanco P, Palucka AK, Pascual V, Banchereau J: Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev. 2008, 19: 41-52. 10.1016/j.cytogfr.2007.10.004. · DOI
  39. Wang J, Shao Y, Bennett TA, Shankar RA, Wightman PD, Reddy LG: The functional effects of physical interactions among Toll-like receptors 7, 8, and 9. J Biol Chem. 2006, 281: 37427-37434. 10.1074/jbc.M605311200. · DOI
  40. Berghofer B, Haley G, Frommer T, Bein G, Hackstein H: Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-alpha production. J Immunol. 2007, 178: 4072-4079. 10.4049/jimmunol.178.7.4072. · DOI
  41. Marshall JD, Heeke DS, Gesner ML, Livingston B, Van Nest G: Negative regulation of TLR9-mediated IFN-alpha induction by a small-molecule, synthetic TLR7 ligand. J Leukoc Biol. 2007, 82: 497-508. 10.1189/jlb.0906575. · DOI
  42. Hailer NP, Jarhult JD, Nitsch R: Resting microglial cells in vitro: analysis of morphology and adhesion molecule expression in organotypic hippocampal slice cultures. Glia. 1996, 18: 319-331. 10.1002/(SICI)1098-1136(199612)18:4<319::AID-GLIA6>3.0.CO;2-S. · DOI
  43. Tauber SC, Ebert S, Weishaupt JH, Reich A, Nau R, Gerber J: Stimulation of Toll-like receptor 9 by chronic intraventricular unmethylated cytosine-guanine DNA infusion causes neuroinflammation and impaired spatial memory. J Neuropathol Exp Neurol. 2009, 68: 1116-1124. 10.1097/NEN.0b013e3181b7fde5. · DOI
  44. Yang QW, Lu FL, Zhou Y, Wang L, Zhong Q, Lin S, Xiang J, Li JC, Fang CQ, Wang JZ: HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling. J Cereb Blood Flow Metab. 2011, 31: 593-605. 10.1038/jcbfm.2010.129. · DOI
  45. Dalpke AH, Lehner MD, Hartung T, Heeg K: Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance. Immunology. 2005, 116: 203-212. 10.1111/j.1365-2567.2005.02211.x. · DOI
  46. Mallard C: Innate immune regulation by toll-like receptors in the brain. ISRN Neurol. 2012, 2012: 701950-10.5402/2012/701950. · DOI
  47. Rosenzweig HL, Minami M, Lessov NS, Coste SC, Stevens SL, Henshall DC, Meller R, Simon RP, Stenzel-Poore MP: Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance. J Cereb Blood Flow Metab. 2007, 27: 1663-1674. 10.1038/sj.jcbfm.9600464. · DOI
  48. Stevens SL, Ciesielski TM, Marsh BJ, Yang T, Homen DS, Boule JL, Lessov NS, Simon RP, Stenzel-Poore MP: Toll-like receptor 9: a new target of ischemic preconditioning in the brain. J Cereb Blood Flow Metab. 2008, 28: 1040-1047. 10.1038/sj.jcbfm.9600606. · DOI
  49. Hua F, Ma J, Ha T, Kelley J, Williams DL, Kao RL, Kalbfleisch JH, Browder IW, Li C: Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury. J Neuroimmunol. 2008, 199: 75-82. 10.1016/j.jneuroim.2008.05.009. · DOI
  50. Pradillo JM, Fernandez-Lopez D, Garcia-Yebenes I, Sobrado M, Hurtado O, Moro MA, Lizasoain I: Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning. J Neurochem. 2009, 109: 287-294. 10.1111/j.1471-4159.2009.05972.x. · DOI
  51. Fan H, Cook JA: Molecular mechanisms of endotoxin tolerance. J Endotoxin Res. 2004, 10: 71-84. 10.1179/096805104225003997. · DOI
  52. Kreutzberg GW: Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19: 312-318. 10.1016/0166-2236(96)10049-7. · DOI · Paper page
  53. Henderson B, Calderwood SK, Coates AR, Cohen I, van Eden W, Lehner T, Pockley AG: Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants. Cell Stress Chaperones. 2010, 15: 123-141. 10.1007/s12192-009-0137-6. · DOI

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Metadata

Authors
Rosenberger, K., Derkow, K., Dembny, P., Krüger, C., Schott, E., & Lehnardt, S.
Venue
Journal of Neuroinflammation
Publisher
Springer Science and Business Media LLC
Published
2014-09-20
Volume
11
Issue
1
ISSN
1742-2094
DOI
10.1186/s12974-014-0166-7
PMC
PMC4182775
Cited by
84
References
6
Language
en
Licence
creativecommons.org/licenses/by/4.0 (unspecified)

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