Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2
Open accessAbstract
BACKGROUND: Inflammasomes have been found to interact with the gut microbiota, and this effect is associated with depression, but the mechanisms underlying this interaction have not been elucidated in detail. RESULTS: The locomotor activity of NLRP3 KO mice was significantly greater than that of their WT littermates, while cohousing and transplantation of the NLRP3 KO gut microbiota avoid the effects of NLRP3 KO on the general locomotor activity at baseline. Meanwhile, transplantation of the NLRP3 KO microbiota alleviated the CUS-induced depressive-like behaviors. The compositions of the gut microbiota in NLRP3 KO mice and WT mice were significantly different in terms of the relative abundance of Firmicutes, Proteobacteria, and Bacteroidetes. Fecal microbiota transplantation (FMT) from NLRP3 KO mice significantly ameliorated the depressive-like behavior induced by chronic unpredictable stress (CUS) in recipient mice. Given the correlation between circular RNA HIPK2 (circHIPK2) and depression and the observation that the level of circHIPK2 expression was significantly increased in CUS-treated mice compared with that in the control group, further experiments were performed. FMT significantly ameliorated astrocyte dysfunction in recipient mice treated with CUS via inhibition of circHIPK2 expression. CONCLUSIONS: Our study illustrates the involvement of the gut microbiota-circHIPK2-astrocyte axis in depression, providing translational evidence that transplantation of the gut microbiota from NLRP3 KO mice may serve as a novel therapeutic strategy for depression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fecal microbiota transplantation significantly alleviated astrocyte dysfunction and depression-like behaviors in recipient depressive mice via inhibition of circHIPK2 expression.
“Fecal microbiota transplantation significantly alleviated astrocyte dysfunction and depression-like behaviors in recipient depressive mice via inhibition of circHIPK2 expression.295”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [295]
The gut microbiota-circHIPK2-astrocyte axis was involved in the development of depression in a stress mouse model.
“the gut microbiota-circHIPK2-astrocyte axis was involved in the development of depression in a stress mouse model.295”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [295]
The role of circRNAs as novel therapeutic targets to ameliorate depression-like symptoms has been demonstrated in various animal models.
“Likewise, the role of circRNAs as novel therapeutic targets to ameliorate depression-like symptoms has been demonstrated in various animal models [21][22][23][24].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
Knockdown of circHIPK2 and overexpression of circSTAG1 have been shown to induce an inhibitory effect on the progression of depression.
“Knockdown of circHIPK2 and overexpression of circSTAG1 have been shown to induce an inhibitory effect on the progression of depression, due to the binding mechanism between circSTAG1 and human AlkB homolog 5 (ALKBH5) and the miR-9 sponge function of circHIPK2.”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
circSTAG1 and circHIPK2 function in astrocyte activation.
“Furthermore, circular STAG1 (circSTAG1) and circular HIPK2 (circHIPK2) were reported to function in astrocyte activation.”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
circSTAG1 and circHIPK2 may be novel therapeutic targets for depression.
“These results suggest that these two circRNAs may be novel therapeutic targets for depression [16,22] (Fig. 3C & D).”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
Transplantation of the gut microbiota from NLRP3 KO mice alleviated astrocyte dysfunction in CUS mice.
“Transplantation of the gut microbiota from pyrin domain containing protein 3 knock out (NLRP3 KO) mice alleviated astrocyte dysfunction in CUS mice.”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
The gut microbiota-circHIPK2-astrocyte axis has a regulatory effect in depression.
“This study revealed a regulatory effect of the gut microbiota-circHIPK2-astrocyte axis in depression, and suggested that transplantation of the gut microbiota may constitute a novel therapeutic strategy for depression [22].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
The expression level of circHIPK2 increased significantly in a CUS mouse model with depression compared with a control group.
“This study found that the expression level of circHIPK2 increased significantly in a CUS mouse model with depression compared with a control group.”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
Transplantation of the gut microbiota may constitute a novel therapeutic strategy for depression.
“This study revealed a regulatory effect of the gut microbiota-circHIPK2-astrocyte axis in depression, and suggested that transplantation of the gut microbiota may constitute a novel therapeutic strategy for depression [22].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
Improved astrocyte function was attributed to the regulation of circHIPK2 expression.
“Improved astrocyte function was attributed to the regulation of circHIPK2 expression.”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
Transplantation of the NLRP3 KO gut microbiota decreases the expression of circHIPK2 and reverses astrocyte dysfunction in the CUS model mouse.
“(C) Transplantation of the NLRP3 KO gut microbiota decreases the expression of circHIPK2 and reverses astrocyte dysfunction in the CUS model mouse.”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
CircHIPK2 (HIPK2) is upregulated in mouse plasma and hippocampus.
“| 19 | CircHIPK2 | HIPK2 | Mouse | √ | | Plasma, Hippocampus | [22] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [22]
FMT from NLPR3 knockout mice resulted in a decrease in anxiety and depressive-like behaviours in recipient mice.
“It was found that FMT from NLPR3 knockout mice resulted in a decrease in anxiety and depressive-like behaviours in the recipient mice [28].”
From Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review (2020) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Vos, T., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32154-2 · Cited by 13,220 · see citing works
Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414 · see citing works
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006 · see citing works
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681 · see citing works
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Cross-national epidemiology of DSM-IV major depressive episode
Bromet, E., Andrade, L. H., Hwang, I., Sampson, N. A., Alonso, J., de Girolamo, G., de Graaf, R., Demyttenaere, K., Hu, C., Iwata, N., et al. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-90 · Cited by 2,221 · see citing works
Grand challenges in global mental health
Collins, P. Y., Patel, V., Joestl, S. S., March, D., Insel, T. R., Daar, A. S., Bordin, I. A., Costello, E. J., Durkin, M., Fairburn, C., et al. (2011) · Nature · doi:10.1038/475027a · Cited by 2,043 · see citing works
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Rothhammer, V., Mascanfroni, I. D., Bunse, L., Takenaka, M. C., Kenison, J. E., Mayo, L., Chao, C.-C., Patel, B., Yan, R., Blain, M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4106 · Cited by 1,559 · see citing works
Astrocyte Control of Synaptic Transmission and Neurovascular Coupling
Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,326 · see citing works
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · see citing works
Psychobiotics and the manipulation of bacteria–gut–brain signals
Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.002 · Cited by 1,068 · see citing works
Correlation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934 · see citing works
Bacterial infection causes stress-induced memory dysfunction in mice
Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., MacQueen, G., & Sherman, P. M. (2011) · Gut · doi:10.1136/gut.2009.202515 · Cited by 909 · see citing works
Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760 · see citing works
The organization of the stress system and its dysregulation in depressive illness
Gold, P. W. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.163 · Cited by 654 · see citing works
Astrocyte-derived ATP modulates depressive-like behaviors
Cao, X., Li, L.-P., Wang, Q., Wu, Q., Hu, H.-H., Zhang, M., Fang, Y.-Y., Zhang, J., Li, S.-J., Xiong, W.-C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3162 · Cited by 615 · see citing works
The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses
Iwata, M., Ota, K. T., & Duman, R. S. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.12.008 · Cited by 580 · see citing works
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works
Möhle, L., Mattei, D., Heimesaat, M. M., Bereswill, S., Fischer, A., Alutis, M., French, T., Hambardzumyan, D., Matzinger, P., Dunay, I. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.074 · Cited by 470 · see citing works
NLRP3 inflammasome in neurological diseases, from functions to therapies
Song, L., Pei, L., Yao, S., Wu, Y., & Shang, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00063 · Cited by 467 · see citing works
Alcocer-Gómez, E., de Miguel, M., Casas-Barquero, N., Núñez-Vasco, J., Sánchez-Alcazar, J. A., Fernández-Rodríguez, A., & Cordero, M. D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.017 · Cited by 443 · see citing works
Pan, Y., Chen, X.-Y., Zhang, Q.-Y., & Kong, L.-D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.04.007 · Cited by 405 · see citing works
Iwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works
Guilloux, J.-P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K., Tseng, G. C., Lewis, D. A., & Sibille, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.113 · Cited by 378 · see citing works
Yue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0865-y · Cited by 334 · see citing works
Self-citationAltered colonic function and microbiota profile in a mouse model of chronic depression
Park, A. J., Collins, J., Blennerhassett, P. A., Ghia, J., Verdu, E. F., Berčík, P., & Collins, S. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12153 · Cited by 291 · see citing works
Manipulating the gut microbiota to maintain health and treat disease
Scott, K. P., Antoine, J., Midtvedt, T., & van Hemert, S. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.25877 · Cited by 284 · see citing works
Huang, R., Zhang, Y., Han, B., Bai, Y., Zhou, R., Gan, G., Chao, J., Hu, G., & Yao, H. (2017) · Autophagy · doi:10.1080/15548627.2017.1356975 · Cited by 278 · see citing works
Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors
Zhang, Y., Liu, L., Peng, Y., Liu, Y., Wu, T., Shen, X., Zhou, J., Sun, D., Huang, A., Wang, X., et al. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12170 · Cited by 200 · see citing works
Gut Microbiota and Brain Function: An Evolving Field in Neuroscience: Table 1.
Foster, J. A., Lyte, M., Meyer, E., & Cryan, J. F. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv114 · Cited by 188 · see citing works
Depression as a Glial-Based Synaptic Dysfunction
Rial, D., Lemos, C., Pinheiro, H., Duarte, J. M., Gonçalves, F. Q., Real, J. I., Prediger, R. D., Gonçalves, N., Gomes, C. A., Canas, P. M., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00521 · Cited by 182 · see citing works
Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome
Alcocer-Gómez, E., Ulecia-Morón, C., Marín-Aguilar, F., Rybkina, T., Casas-Barquero, N., Ruiz-Cabello, J., Ryffel, B., Apetoh, L., Ghiringhelli, F., Bullón, P., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9408-7 · Cited by 172 · see citing works
Epigenetic Signaling in Psychiatric Disorders
Peña, C. J., Bagot, R. C., Labonté, B., & Nestler, E. J. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.03.016 · Cited by 163 · see citing works
Schlösser, R. G. M., Wagner, G., Koch, K., Dahnke, R., Reichenbach, J. R., & Sauer, H. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.08.002 · Cited by 148 · see citing works
Chen, Q., Mo, R., Wu, N., Zou, X., Shi, C., Gong, J., Li, J., Fang, K., Wang, D., De-shen, Y., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00334 · Cited by 91 · see citing works
Qiao, J., Wang, J., Wang, H., Zhang, Y., Zhu, S., Adilijiang, A., Guo, H., Zhang, R., Guo, W., Luo, G., et al. (2015) · Glia · doi:10.1002/glia.22926 · Cited by 80 · see citing works
Barthas, F., Humo, M., Gilsbach, R., Waltisperger, E., Karatas, M., Leman, S., Hein, L., Belzung, C., Boutillier, A., Barrot, M., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.019 · Cited by 80 · see citing works
Niitsu, Y., Hori, O., Yamaguchi, A., Bandô, Y., Ozawa, K., Tamatani, M., Ogawa, S., & Tohyama, M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00245-4 · Cited by 48 · see citing works
Ding, X., Liu, Y., Yan, Z., Li, X., Ma, Q., Jin, Z.-Y., Liu, Y., Li, Y., Liu, Y., Xue, Z., et al. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/1960584 · Cited by 31 · see citing works
Re: Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour
Desbonnet, L., Clarke, G., O’Sullivan, O., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.011 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works
Targeting circular RNAs as a therapeutic approach: current strategies and challenges
He, A. T., Liu, J., Li, F., & Yang, B. B. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00569-5 · Cited by 556 · see citing works
Brain–gut–microbiota axis in depression: A historical overview and future directions
Chang, L., Wei, Y., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.004 · Cited by 395 · see citing works
Kanmani, S., & Koo, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207551 · Cited by 381 · see citing works
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease
Bairamian, D., Sha, S., Rolhion, N., Sokol, H., Dorothée, G., Lemere, C. A., & Krantic, S. M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00522-2 · Cited by 318 · see citing works
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
Han, H., Yi, B., Zhong, R., Wang, M., Zhang, S., Ma, J., Yin, Y., Yin, J., Chen, L., & Zhang, H. (2021) · Microbiome · doi:10.1186/s40168-021-01093-y · Cited by 292 · see citing works
Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review
Chinna Meyyappan, A., Forth, E., Wallace, C. J. K., & Milev, R. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02654-5 · Cited by 254 · see citing works
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“295 Fecal microbiota transplantation signi fi cantly alleviated astrocyte dysfunction and depression-like behaviors in recipient depressive mice via inhibition of circHIPK2 expression.”
BackgroundResultThe NLRP3 inflammasome in depression: Potential mechanisms and therapies
Xia, C., Guo, Y., Lian, W., Yan, Y., Ma, B.-Z., Cheng, Y., Xu, J., He, J., & Zhang, W. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106625 · Cited by 184 · see citing works
Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression
Zheng, P., Yang, J., Li, Y., Wu, J., Liang, W., Yin, B., Tan, X., Huang, Y., Chai, T., Zhang, H., et al. (2020) · Advanced Science · doi:10.1002/advs.201902862 · Cited by 175 · see citing works
Pellegrini, C., Antonioli, L., Calderone, V., Colucci, R., Fornai, M., & Blandizzi, C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101806 · Cited by 174 · see citing works
Li, X., He, C., Li, N., Ding, L., Chen, H., Wan, J., Yang, X., Xia, L., He, W., Xiong, H., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1770042 · Cited by 169 · see citing works
Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours
Yu, X., Bai, Y., Han, B., Ju, M., Tang, T., Shen, L., Li, M., Yang, L., Zhang, Z., Hu, G., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12185 · Cited by 164 · see citing works
Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 182 · see citing works
Gheorghe, C. E., Ritz, N. L., Martin, J. A., Wardill, H. R., Cryan, J. F., & Clarke, G. A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1941711 · Cited by 149 · see citing works
Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease
Wu, S., Liu, X., Jiang, R., Yan, X., & Ling, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650047 · Cited by 146 · see citing works
P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes
Wang, D., Wang, H., Gao, H., Zhang, H., Zhang, H., Wang, Q., & Sun, Z. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00388-1 · Cited by 145 · see citing works
Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
Welcome, M. O., & Mastorakis, N. E. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104769 · Cited by 139 · see citing works
Yang, Z., Li, J., Gui, X., Shi, X., Bao, Z., Han, H., & Li, M. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0729-1 · Cited by 139 · see citing works
Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy
Lin, B., Wang, Y., Zhang, P., Yuan, Y., Zhang, Y., & Chen, G. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01170-x · Cited by 131 · see citing works
The gut microbiome and mental health: advances in research and emerging priorities
Shoubridge, A. P., Choo, J. M., Martin, A. M., Keating, D. J., Wong, M., Licinio, J., & Rogers, G. B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01479-w · Cited by 130 · see citing works
Wu, S., Bekhit, A. E. A., Wu, Q., Chen, M., Liao, X., Wang, J., & Ding, Y. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.12.019 · Cited by 123 · see citing works
Yao, H., Zhang, D., Yu, H., Yuan, H., Shen, H., Lan, X., Liu, H., Chen, X., Meng, F., Wu, X., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01841-y · Cited by 119 · see citing works
He, X., Li, L., Xian, W., Li, M., Zhang, L., Xu, J., Pei, Z., Zheng, H., & Hu, X. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02199-8 · Cited by 116 · see citing works
Zhu, F., Tu, H., & Chen, T. (2022) · Nutrients · doi:10.3390/nu14102081 · Cited by 119 · see citing works
Hu, B., Das, P., Lv, X., Shi, M., Aa, J., Wang, K., Duan, L., Gilbert, J. A., Nie, Y., & Wu, X. (2022) · mSystems · doi:10.1128/msystems.00218-22 · Cited by 107 · see citing works
Zhao, N., Chen, Q.-G., Chen, X., Liu, X.-T., Geng, F., Zhu, M.-M., Yan, F.-L., Zhang, Z.-J., & Ren, Q.-G. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.11.013 · Cited by 105 · see citing works
Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s Disease
Shukla, P. K., Delotterie, D. F., Xiao, J., Pierre, J. F., Rao, R., McDonald, M. P., & Khan, M. M. (2021) · Cells · doi:10.3390/cells10040779 · Cited by 103 · see citing works
Settanni, C. R., Ianiro, G., Bibbò, S., Cammarota, G., & Gasbarrini, A. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110258 · Cited by 104 · see citing works
The gut microbiota–brain axis in neurological disorders
You, M., Chen, N., Yang, Y., Cheng, L., He, H., Cai, Y., Liu, Y., Liu, H., & Hong, G. (2024) · MedComm · doi:10.1002/mco2.656 · Cited by 107 · see citing works
Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain
Xu, H., Huang, H., Zhou, Y., Zhao, H., Xu, J., Shou, D., Liu, Y., Zhou, Y., & Nie, Y. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/6699268 · Cited by 103 · see citing works
Chen, M., Lai, X., Wang, X., Ying, J., Zhang, L., Zhou, B., Liu, X., Zhang, J., Wei, G., & Hua, F. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.745066 · Cited by 96 · see citing works
Zeng, B., Huang, Y., Chen, S., Xu, R., Xu, L., Qiu, J.-H., Shi, F., Liu, S., Zha, Q., Ouyang, D., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00891-0 · Cited by 88 · see citing works
Du, M., Wu, C., Yu, R., Cheng, Y., Tang, Z., Wu, B., Fu, J., Tan, W., Zhou, Q., Zhu, Z., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01711-7 · Cited by 84 · see citing works
Xu, Q., Sun, L., Chen, Q., Jiao, C., Wang, Y., Li, H., Xie, J., Zhu, F., Wang, J., Zhang, W., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.002 · Cited by 84 · see citing works
Tao, W., Ruan, J., Wu, R., Zhao, M., Zhao, T. T., Qi, M., Yau, S., Yao, G., Zhang, H., Hu, Y., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.02.015 · Cited by 84 · see citing works
Alteration of Gut Microbiome and Correlated Lipid Metabolism in Post-Stroke Depression
Jiang, W., Gong, L., Liu, F., Ren, Y., & Mu, J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.663967 · Cited by 83 · see citing works
The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches
Varesi, A., Campagnoli, L. I. M., Chirumbolo, S., Candiano, B., Carrara, A., Ricevuti, G., Esposito, C., & Pascale, A. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106799 · Cited by 85 · see citing works
Cui, Y., Yu, H., Bu, Z., Wen, L., Yan, L.-L., & Feng, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.894298 · Cited by 79 · see citing works
How Oxidative Stress Induces Depression?
Ji, N., Lei, M., Chen, Y., Tian, S., Li, C., & Zhang, B. (2023) · ASN NEURO · doi:10.1177/17590914231181037 · Cited by 82 · see citing works
Agranyoni, O., Meninger-Mordechay, S., Uzan-Yulzari, A., Oren, Z., Salmon‐Divon, M., Rodin, D., Raz, O., Koman, I. E., Koren, O., Pinhasov, A., et al. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00193-9 · Cited by 73 · see citing works
Jang, H., Kim, J.-K., Joo, M.-K., Shin, Y.-J., Lee, C. K., Kim, H. J., & Kim, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-00088-x · Cited by 71 · see citing works
Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice
Wu, L., Lyu, Y., Ramkumar, S., Wu, J., Ojo, B. A., Tang, M., El-Rassi, G. D., Metzinger, K., Smith, B. J., Lucas, E. A., et al. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa222 · Cited by 66 · see citing works
Xiao, L., Zheng, H., Li, J., Zeng, M., He, D., Liang, J., Sun, K., Luo, Y., Li, F., Ping, B., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112797 · Cited by 64 · see citing works
Shi, Y., Song, R., Wang, Z., Zhang, H., Zhu, J., Yue, Y., Zhao, Y., & Zhang, Z. (2021) · eBioMedicine · doi:10.1016/j.ebiom.2021.103337 · Cited by 65 · see citing works
Self-citationInteractions between gut microbes and NLRP3 inflammasome in the gut-brain axis
Ding, Y., Wang, Z., Chen, Y., Guo, Q., & Dong, Y. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.03.017 · Cited by 65 · see citing works
Zhou, Z., Wang, Y., Sun, S., Zhang, K., Wang, L., Zhao, H., & Zhang, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116716 · Cited by 67 · see citing works
Subba, R., Sandhir, R., Singh, S. P., Mallick, B. N., & Mondal, A. C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15136 · Cited by 64 · see citing works
Bi, C., Guo, S., Hu, S., Chen, J., Ye, M., & Liu, Z. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106372 · Cited by 61 · see citing works
Gut Microbiota Regulate Astrocytic Functions in the Brain: Possible Therapeutic Consequences
Zhao, Y.-F., Wei, D., & Tang, Y. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210215123239 · Cited by 60 · see citing works
Remodeling of microbiota gut-brain axis using psychobiotics in depression
Palepu, M. S. K., & Dandekar, M. P. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175171 · Cited by 59 · see citing works
Honda, T. S. B., Ku, J., & Anders, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1214289 · Cited by 60 · see citing works
Noncoding RNAs: Regulatory Molecules of Host–Microbiome Crosstalk
Malmuthuge, N., & Guan, L. L. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2020.12.003 · Cited by 60 · see citing works
Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease
Zhu, F., Li, C., Chu, F., Tian, X., & Zhu, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.544235 · Cited by 58 · see citing works
An interplay between non-coding RNAs and gut microbiota in human health
Fardi, F., Khasraghi, L. B., Shahbakhti, N., Naseriyan, A. S., Najafi, S., Sanaaee, S., Alipourfard, I., Zamany, M., Karamipour, S., Jahani, M., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110739 · Cited by 58 · see citing works
Yan, T., Wang, N., Liu, B., Wu, B., Xiao, F., He, B., & Jia, Y. (2020) · Phytotherapy Research · doi:10.1002/ptr.6799 · Cited by 58 · see citing works
Luo, T., Guo, Z., Liu, D., Guo, Z., Wu, Q., Li, Q., Lin, R., Chen, P., Ou, C., & Chen, M. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2077602 · Cited by 56 · see citing works
Immunotherapy for depression: Recent insights and future targets
Bai, Y., Cai, Y., Chang, D., Li, D., Huo, X., & Zhu, T. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108624 · Cited by 54 · see citing works
Borsom, E. M., Lee, K., & Cope, E. K. (2020) · Brain Sciences · doi:10.3390/brainsci10110814 · Cited by 54 · see citing works
The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis
Cox, L. M., Calcagno, N., Gauthier, C., Madore, C., Butovsky, O., & Weiner, H. L. (2022) · Microbiome · doi:10.1186/s40168-022-01232-z · Cited by 53 · see citing works
NLRP3 Inflammasome: From Pathophysiology to Therapeutic Target in Major Depressive Disorder
Kouba, B. R., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010133 · Cited by 55 · see citing works
Lentinan improves intestinal inflammation and gut dysbiosis in antibiotics-induced mice
Ji, X., Su, L., Zhang, P., Yue, Q., Zhao, C., Sun, X., Li, K., Liu, X., Zhang, S., & Zhao, L. (2022) · Scientific Reports · doi:10.1038/s41598-022-23469-2 · Cited by 48 · see citing works
Liu, P., Chen, J., Ma, S., Zhang, J., & Zhou, J. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa076 · Cited by 45 · see citing works
Huang, L., Ma, Z., Ze, X., Zhao, X., Zhang, M., Lv, X., Zheng, Y., & Liu, H. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1189008 · Cited by 44 · see citing works
Zhang, Y., Sun, Y., Liu, Y., Liu, J., Sun, J., Liu, X., Fan, B., Lü, C., & Wang, F. (2023) · Phytotherapy Research · doi:10.1002/ptr.7813 · Cited by 43 · see citing works
A new perspective on depression and neuroinflammation: Non-coding RNA
Zhou, S., Chen, R., She, Y., Liu, X., Zhao, H., Li, C., & Jia, Y. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.007 · Cited by 42 · see citing works
The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction
Li, Z.-H., Jiang, Y., Long, C., Peng, Q., & Yue, R. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14077 · Cited by 41 · see citing works
Yi, W., Cheng, J., Wei, Q., Pan, R., Song, S., He, Y., Tang, C. K., Liu, X., Zhou, Y., & Su, H. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144568 · Cited by 42 · see citing works
Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential
Gan, H., Lei, Y., Yuan, N., Tang, K., Hao, W., Ma, Q., Wu, M., Zhou, X., Li, X., Huang, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111244 · Cited by 41 · see citing works
NLRP3 Inflammasome From Bench to Bedside: New Perspectives for Triple Negative Breast Cancer
Sonnessa, M., Cioffi, A., Brunetti, O., Silvestris, N., Zito, F. A., Saponaro, C., & Mangia, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01587 · Cited by 38 · see citing works
Liu, D.-C., Tian, Q., Liu, K., Ren, F., Liu, G., Zhou, J., Yuan, L., Fang, Z., Zou, B., & Wang, S. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07766 · Cited by 39 · see citing works
Current landscape of fecal microbiota transplantation in treating depression
Zhang, Q., Bi, Y., Zhang, B., Jiang, Q., Mou, C. K., Lei, L., Deng, Y., Li, Y., Yu, J., Liu, W., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1416961 · Cited by 38 · see citing works
Dual-directional regulation of spinal cord injury and the gut microbiota
Cui, Y., Liu, J., Xiao, L., Liu, S., Chen, H., Wei, Z., Li, H., Yang, Y., Zheng, C., & Li, Z. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.380881 · Cited by 37 · see citing works
León‐Rodríguez, A., Fernández‐Arjona, M. D. M., Grondona, J. M., Pedraza, C., & López-Ávalos, M. D. (2022) · Scientific Reports · doi:10.1038/s41598-022-15617-5 · Cited by 37 · see citing works
Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression
Hu, Y., Zhao, M., Wang, H., Guo, Y., Cheng, X., Zhao, T. T., Wang, H., Zhang, Y., Ma, Y., & Tao, W. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02005-y · Cited by 37 · see citing works
Lin, X., Peng, Y., Guo, Z., He, W., Guo, W., Feng, J., Lin, L., Liu, Q., & Xu, P. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05332-x · Cited by 35 · see citing works
NLRP3 deficiency-induced hippocampal dysfunction and anxiety-like behavior in mice
Komleva, Y. K., Lopatina, O. L., Валерьевна, Г. Я., Shuvaev, А. N., Chernykh, A., Potapenko, I., & Salmina, A. B. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147220 · Cited by 35 · see citing works
Sah, R. K., Nandan, A., Athira, K. V., Prashant, S. K., Sankaran, S., Jose, A., Venkidasamy, B., & Nile, S. H. (2023) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103861 · Cited by 35 · see citing works
Yu, T., Luo, L., Xue, J., Tang, W., Wu, X., & Fan, Y. (2024) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2024.102458 · Cited by 34 · see citing works
Wang, H., Liu, L., Rao, X., Zeng, B., Yu, Y., Zhou, C., Zeng, L., Zheng, P., Pu, J., Xu, S., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01024-9 · Cited by 34 · see citing works
Bai, S., Wang, W., Ting, W., Li, J., Zhang, S., Chen, Z., Qi, X., Chen, J., Cheng, K., & Xie, P. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01130-8 · Cited by 33 · see citing works
Sanchez‐Quintero, M. J., Delgado, J., Vera, D. M., Becerra‐Muñoz, V. M., Queipo‐Ortuño, M. I., Estévez, M., Plaza-Andrades, I. J., Rodríguez‐Capitán, J., Sanchez, P. L., Crespo‐Leiro, M. G., et al. (2022) · Nutrients · doi:10.3390/nu14214650 · Cited by 37 · see citing works
Zhu, Z., Cheng, Y., Liu, X., Xu, X., Ding, W., Ling, Z., Liu, J., & Cai, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1644160 · Cited by 39 · see citing works
Lataliza, A. A. B., de Assis, P. M., Laurindo, L. R., Gonçalves, E. C. D., Raposo, N. R. B., & Dutra, R. C. (2021) · Phytotherapy Research · doi:10.1002/ptr.7318 · Cited by 33 · see citing works
Interplay between Gut Microbiota and NLRP3 Inflammasome in Intracerebral Hemorrhage
Zhang, Y., Yu, W., Flynn, C., Chang, W., Zhang, L., Wang, M., Zheng, W., & Li, P. (2022) · Nutrients · doi:10.3390/nu14245251 · Cited by 33 · see citing works
Interaction mechanisms between major depressive disorder and non-alcoholic fatty liver disease
Shao, Q., Wu, Y., Ji, J., Xu, T., Yu, Q., Ma, C., Liao, X., Cheng, F., & Wang, X. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.711835 · Cited by 32 · see citing works
Gut–Brain Axis: Focus on Neurodegeneration and Mast Cells
Conte, C., Sichetti, M., & Traina, G. (2020) · Applied Sciences · doi:10.3390/app10051828 · Cited by 32 · see citing works
The regulatory role of N6 ‐methyladenosine modification in the interaction between host and microbes
Zhuo, R., Xu, M., Wang, X., Zhou, B., Wu, X., Leone, V., Chang, E. B., & Zhong, X. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1725 · Cited by 32 · see citing works
Chen, L., Qing, W., Yi, Z., Lin, G., Peng, Q., & Zhou, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.701760 · Cited by 31 · see citing works
Pick fecal microbiota transplantation to enhance therapy for major depressive disorder
Meng, Y., Sun, J., & Zhang, G. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110860 · Cited by 31 · see citing works
Host Factors of Favorable Intestinal Microbial Colonization
Pirr, S. M., & Viemann, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584288 · Cited by 29 · see citing works
Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7
Yan, J., Yang, Y., Fan, X., Tang, Y., & Tang, Z. (2021) · Genes · doi:10.3390/genes12050696 · Cited by 30 · see citing works
Gut microbiome at the crossroad of genetic variants and behavior disorders
Cheng, L., Wu, H., Chen, Z., Hao, H., & Zheng, X. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2201156 · Cited by 28 · see citing works
Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU
Cai, Y., Ji, Y., Liu, Y., Zhang, D., Gong, Z., Li, L., Chen, X., Liang, C., Feng, S., Lu, J., et al. (2024) · Theranostics · doi:10.7150/thno.96890 · Cited by 30 · see citing works
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells
Zhao, P., Ning, J., Huang, J., & Huang, X. (2024) · Autoimmunity · doi:10.1080/08916934.2024.2427094 · Cited by 29 · see citing works
Gu, J., Xu, Y.-W., Feng, L.-P., Dong, J., Zhao, L., Liu, C., Wang, H., Zhang, X., Song, C., & Wang, C. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.10.005 · Cited by 29 · see citing works
Targeting the inflammasome in Parkinson’s disease
Su, Q., Ng, W. L., Goh, S. Y., Gulam, M. Y., Wang, L., Tan, E., Ahn, M., & Chao, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.957705 · Cited by 30 · see citing works
Song, Z., Bian, Z., Zhang, Z., Wang, X., Zhu, A., & Zhu, G. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115711 · Cited by 28 · see citing works
Microbial Therapeutics in Neurocognitive and Psychiatric Disorders
Alagiakrishnan, K., & Halverson, T. (2021) · Journal of Clinical Medicine Research · doi:10.14740/jocmr4575 · Cited by 29 · see citing works
Zhang, Y., Zhang, J., Wu, J., Zhu, Q., Chen, C., & Li, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1124454 · Cited by 28 · see citing works
- Authors
- Zhang, Y., Huang, R., Cheng, M., Wang, L., Chao, J., Li, J., Zheng, P., Xie, P., Zhang, Z., & Yao, H.
- Affiliations
- Southeast University (CN)
- China Pharmaceutical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Zhongda Hospital Southeast University (CN)
- Nantong University (CN)
- Corresponding author
- Yao, Honghong
- Venue
- Microbiome
- Published
- 2019-08-22
- Volume
- 7
- Issue
- 1
- Pages
- 116-116
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC6706943
- OpenAlex
- W2969822493
- Cited by
- 263
- References
- 48
- Citations by year
- 2026: 17 · 2025: 36 · 2024: 46 · 2023: 47 · 2022: 55 · 2021: 38 · 2020: 24
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Microbiome (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (2017YFA0104303, 81603090, 81761138048, 81673410)
- Government of Jiangsu Province
- National Key Research and Development Program of China (2017YFA0104303)
- Fundamental Research Funds for the Central Universities (2242019, 2017YFA0104303)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, NLRP3 inflammasome, depression, depression-like behavior, astrocyte dysfunction, circular RNA, fecal microbiota transplantation, chronic unpredictable mild stress, locomotor activity, depression treatment
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Astrocytes, Behavior, Animal, Depression, Male, Mice, Inbred C57BL, Protein Serine-Threonine Kinases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
