Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation

Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539 · see citing works

Mechanisms and Functions of Inflammasomes

Lamkanfi, M., & Dixit, V. M. (2014) · Cell · doi:10.1016/j.cell.2014.04.007 · Cited by 2,521 · see citing works

The gut microbiota–brain axis in behaviour and brain disorders

Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149 · see citing works

Sleep disturbance, sleep duration, and inflammation: A systematic review and meta-analysis of cohort studies and experimental sleep deprivation

Irwin, M. R., Olmstead, R., & Carroll, J. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.014 · Cited by 2,085 · see citing works

Short- and long-term health consequences of sleep disruption

Medic, G., Wille, M., & Hemels, M. (2017) · Nature and Science of Sleep · doi:10.2147/nss.s134864 · Cited by 1,776 · see citing works

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works

The gut microbiome in neurological disorders

Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336 · see citing works

The sleep-deprived human brain

Krause, A. J., Simon, E. B., Mander, B. A., Greer, S. M., Saletin, J. M., Goldstein-Piekarski, A. N., & Walker, M. P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.55 · Cited by 1,200 · see citing works

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Wang, X., Sun, G., Feng, T., Zhang, J., Huang, X., Wang, T., Xie, Z., Chu, X., Yang, J., Wang, H., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0216-x · Cited by 1,144 · see citing works

Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis

Shi, L., Chen, S.-J., Ma, M.-Y., Bao, Y.-P., Han, Y., Wang, Y.-M., Shi, J., Vitiello, M. V., & Lu, L. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.06.010 · Cited by 1,009 · see citing works

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

Zhuang, Z.-Q., Shen, L.-L., Li, W.-W., Fu, X., Zeng, F., Gui, L., Lü, Y., Cai, M., Zhu, C., Tan, Y.-L., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180176 · Cited by 885 · see citing works

Sleep Deprivation and Activation of Morning Levels of Cellular and Genomic Markers of Inflammation

Irwin, M. R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1756 · Cited by 850 · see citing works

The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

Holth, J. K., Fritschi, S. K., Wang, C., Pedersen, N. P., Cirrito, J. R., Mahan, T. E., Finn, M. B., Manis, M., Geerling, J. C., Fuller, P. M., et al. (2019) · Science · doi:10.1126/science.aav2546 · Cited by 813 · see citing works

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Kim, M.-S., Kim, Y., Choi, H., Kim, W., Park, S., Lee, D., Kim, D. K., Kim, H. J., Choi, H., Hyun, D.-W., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317431 · Cited by 614 · see citing works

Chronic sleep disruption alters gut microbiota, induces systemic and adipose tissue inflammation and insulin resistance in mice

Poroyko, V. A., Carreras, A., Khalyfa, A., Khalyfa, A. A., Leone, V., Peris, E., Almendros, I., Gileles-Hillel, A., Qiao, Z., Hubert, N., et al. (2016) · Scientific Reports · doi:10.1038/srep35405 · Cited by 480 · see citing works

Sleep Loss Activates Cellular Inflammatory Signaling

Irwin, M. R., Wang, M., Ribeiro, D., Cho, H. J., Olmstead, R., Breen, E. C., Martinez-Maza, O., & Cole, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.004 · Cited by 467 · see citing works

Microbiota and the social brain

Sherwin, E., Bordenstein, S. R., Quinn, J. L., Dinan, T. G., & Cryan, J. F. (2019) · Science · doi:10.1126/science.aar2016 · Cited by 462 · see citing works

Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449 · see citing works

Sleep function: Toward elucidating an enigma

Krueger, J. M., Frank, M. G., Wisor, J. P., & Roy, S. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.08.005 · Cited by 440 · see citing works

Short sleep duration and cardiometabolic risk: from pathophysiology to clinical evidence

Tobaldini, E., Fiorelli, E. M., Solbiati, M., Costantino, G., Nobili, L., & Montano, N. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0109-6 · Cited by 357 · see citing works

NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis

Sendler, M., van den Brandt, C., Glaubitz, J., Wilden, A., Golchert, J., Weiß, F. U., Homuth, G., Chama, L. L. D. F., Mishra, N., Mahajan, U. M., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.09.040 · Cited by 352 · see citing works

Microbiota regulate social behaviour via stress response neurons in the brain

Wu, W., Adame, M. D., Liou, C.-W., Barlow, J. T., Lai, T.-T., Sharon, G., Schretter, C. E., Needham, B. D., Wang, M., Tang, W., et al. (2021) · Nature · doi:10.1038/s41586-021-03669-y · Cited by 344 · see citing works

Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals

Benedict, C., Vogel, H., Jonas, W., Woting, A., Blaut, M., Schürmann, A., & Cedernaes, J. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.003 · Cited by 324 · see citing works

Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function

Kreutzmann, J. C., Havekes, R., Abel, T., & Meerlo, P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.053 · Cited by 309 · see citing works

Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn

Xu, K., Gao, X., Xia, G., Chen, M., Zeng, N., Wang, S., You, C., Tian, X., Di, H., Tang, W., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323263 · Cited by 308 · see citing works

Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Wang, Z., Chen, W.-H., Li, S.-X., He, Z.-M., Zhu, W.-L., Ji, Y.-B., Wang, Z., Zhu, X.-M., Yuan, K., Bao, Y.-P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01113-1 · Cited by 307 · see citing works

Roles and applications of probiotic Lactobacillus strains

Zhang, Z., Lv, J., Pan, L., & Zhang, Y. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9217-9 · Cited by 296 · see citing works

Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2

Zhang, Y., Huang, R., Cheng, M., Wang, L., Chao, J., Li, J., Zheng, P., Xie, P., Zhang, Z., & Yao, H. (2019) · Microbiome · doi:10.1186/s40168-019-0733-3 · Cited by 263 · see citing works

The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease

Hanslik, K. L., & Ulland, T. K. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.570711 · Cited by 236 · see citing works

Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence

Mancuso, C., & Santangelo, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.009 · Cited by 232 · see citing works

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

Sutinen, E. M., Pirttilä, T., Anderson, G., Salminen, A., & Ojala, J. O. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-199 · Cited by 228 · see citing works

New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

Shen, H., Guan, Q., Zhang, X., Yuan, C., Tan, Z., Zhai, L., Hao, Y., Gu, Y., & Han, C. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109884 · Cited by 204 · see citing works

In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

Li, J. J., Wang, B., Kodali, M. C., Chen, C., Kim, E., Patters, B. J., Lan, L.-B., Kumar, S., Wang, X., Yue, J., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1038-8 · Cited by 202 · see citing works

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

Liao, L., Schneider, K. M., Gálvez, E. J. C., Frissen, M., Marschall, H., Su, H., Hatting, M., Wahlstrom, A. M., Haybaeck, J., Puchas, P., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316670 · Cited by 175 · see citing works

Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans

Irwin, M. R., Witarama, T., Caudill, M. M., Olmstead, R., & Breen, E. C. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.017 · Cited by 163 · see citing works

Human and rat gut microbiome composition is maintained following sleep restriction

Zhang, S. L., Bai, L., Goel, N., Bailey, A., Jang, C. J., Bushman, F. D., Meerlo, P., Dinges, D. F., & Sehgal, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620673114 · Cited by 139 · see citing works

Inflammasomes and intestinal inflammation

Zmora, N., Levy, M., Pevsner-Fishcer, M., & Elinav, E. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.19 · Cited by 125 · see citing works

Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases

Pellegrini, C., Fornai, M., Antonioli, L., Blandizzi, C., & Calderone, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122876 · Cited by 110 · see citing works

Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States

Robbins, R., Quan, S. F., Weaver, M. D., Bormes, G., Barger, L. K., & Czeisler, C. A. (2021) · Aging · doi:10.18632/aging.202591 · Cited by 102 · see citing works

Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome

Bowers, S. J., Vargas, F., González, A., He, S., Jiang, P., Dorrestein, P. C., Knight, R. D., Wright, K. P., Lowry, C. A., Fleshner, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229001 · Cited by 99 · see citing works

Acute Sleep-Wake Cycle Shift Results in Community Alteration of Human Gut Microbiome

Liu, Z., Wei, Z.-Y., Chen, J., Chen, K., Mao, X., Liu, Q., Sun, Y., Zhang, Z., Zhang, Y., Zhou, D., et al. (2020) · mSphere · doi:10.1128/msphere.00914-19 · Cited by 96 · see citing works

Adolescent sleep restriction effects on cognition and mood

Short, M. A., & Chee, M. W. L. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.02.008 · Cited by 85 · see citing works

Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase‐ and mitochondria‐dependent ROS production

Wang, K., Yao, Y., Zhu, X., Zhang, K., Zhou, F., & Zhu, L. (2016) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21887 · Cited by 73 · see citing works

Beneficial Effects of Lactobacillus plantarum Strains on Non-Alcoholic Fatty Liver Disease in High Fat/High Fructose Diet-Fed Rats

Park, E., Lee, Y., Kim, S. M., Park, G.-S., Lee, Y. H., Jeong, D. Y., Kang, J., & Lee, H. (2020) · Nutrients · doi:10.3390/nu12020542 · Cited by 70 · see citing works

Assessment of mouse cognitive and anxiety-like behaviors and hippocampal inflammation following a repeated and intermittent paradoxical sleep deprivation procedure

Yin, M., Chen, Y., Zheng, H., Pu, T., Marshall, C., Wu, T., & Xiao, M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.12.034 · Cited by 67 · see citing works

Sleep deprivation accelerates the progression of alzheimer’s disease by influencing Aβ-related metabolism

Chen, L., Huang, J., Yang, L., Zeng, X., Zhang, Y. P., Wang, X., Chen, M., Li, X., Zhang, Y., & Zhang, M. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.047 · Cited by 51 · see citing works

A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota

Aidy, S. E., Bolsius, Y. G., Raven, F., & Havekes, R. (2019) · Journal of Sleep Research · doi:10.1111/jsr.12920 · Cited by 50 · see citing works

Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway

Jia, L., Chen, H., Yang, J., Fang, X., Niu, W., Zhang, M., Li, J., Pan, X., Ren, Z., Sun, J., et al. (2019) · Innate Immunity · doi:10.1177/1753425919881502 · Cited by 35 · see citing works

Gut Microbiota and Disorders of the Central Nervous System

Vuotto, C., Battistini, L., Caltagirone, C., & Borsellino, G. (2020) · The Neuroscientist · doi:10.1177/1073858420918826 · Cited by 34 · see citing works

Lactobacillus plantarum ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation

Park, M., Park, E., Kim, S.-H., & Lee, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094444 · Cited by 18 · see citing works

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease

Heneka, M. T., McManus, R. M., & Latz, E. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0137-1 · Cited by 17 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

Gut microbiota‐derived short‐chain fatty acids and depression: deep insight into biological mechanisms and potential applications

Cheng, J., Hu, H., Ju, Y., Liu, J., Wang, M., Liu, B., & Zhang, Y. (2024) · General Psychiatry · doi:10.1136/gpsych-2023-101374 · Cited by 216 · see citing works

The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review

Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 182 · see citing works

Gut microbiota dysbiosis in hyperuricaemia promotes renal injury through the activation of NLRP3 inflammasome

Zhou, X., Ji, S., Chen, L., Liu, X., Deng, Y., You, Y., Wang, M., He, Q., Peng, B., Yang, Y., et al. (2024) · Microbiome · doi:10.1186/s40168-024-01826-9 · Cited by 92 · see citing works

Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration

Sun, J. F., Zeng, Q., Wu, Z., Huang, L., Sun, T., Liu, C., Zhang, B., Chen, C., & Wang, H. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00347 · Cited by 70 · see citing works

Current landscape of fecal microbiota transplantation in treating depression

Zhang, Q., Bi, Y., Zhang, B., Jiang, Q., Mou, C. K., Lei, L., Deng, Y., Li, Y., Yu, J., Liu, W., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1416961 · Cited by 38 · see citing works

Ganoderma lucidum polysaccharide alleviates cognitive dysfunction by inhibiting neuroinflammation via NLRP3/NF-κB signaling pathway

Jiang, Y., Wang, Z., Wang, W., Liu, Y., Meng, Y., Wang, Y., Fan, M., & Cai, C. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119065 · Cited by 30 · see citing works

Sleep deprivation-induced cognitive impairment: Unraveling the role of neuroinflammation

Yuan, X., & Wang, C. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115419 · Cited by 37 · see citing works

Fecal microbiota from patients with Parkinson's disease intensifies inflammation and neurodegeneration in A53T mice

Yang, H., Shao, Y., Hu, Y., Jin, Q., Wang, P., Tian, L., Ni, Y., Li, S., Al‐Nusaif, M., Liu, C., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70003 · Cited by 28 · see citing works

Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling

Luca, R. D., Arrè, V., Nardone, S., Incerpi, S., Giannelli, G., Trivedi, P., Anastasiadou, E., & Negro, R. (2025) · Gut · doi:10.1136/gutjnl-2025-334938 · Cited by 31 · see citing works

Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation

Zhu, W., Zhang, H., Niu, T., Liu, K., Farooqui, H. F. M., Sun, R., Chen, X., Yuan, Y., & Wang, S. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.051 · Cited by 26 · see citing works

NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

Zhao, N., 东南大学医学院神经内科, 江. 南. 2., Xiu, C., Chen, Q.-G., Liu, X.-T., Geng, F., Zhu, M., Yan, F., Zhang, Z., Ren, Q., et al. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2024.085 · Cited by 25 · see citing works

Gut-brain relationship in dementia and Alzheimer's disease: Impact on stress and immunity

Mukherjee, U., & Reddy, P. H. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102843 · Cited by 24 · see citing works

Ozone rectal insufflation mitigates chronic rapid eye movement sleep deprivation-induced cognitive impairment through inflammation alleviation and gut microbiota regulation in mice

Cheng, J., Williams, J. P., Zhou, L., Wang, P., Sun, L.-N., Li, R., & An, J. (2024) · Medical Gas Research · doi:10.4103/mgr.medgasres-d-23-00036 · Cited by 22 · see citing works

Circadian rhythm, microglia-mediated neuroinflammation, and Alzheimer’s disease

Geng, F., Zhao, N., & Ren, Q. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106044 · Cited by 22 · see citing works

Washed microbiota transplantation targeting both gastrointestinal and extraintestinal symptoms in patients with irritable bowel syndrome

Zhang, Z., Li, Q., Zhang, S., Liu, Y., Lu, G., Wen, Q., Cui, B., Zhang, F., & Zhang, F. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110839 · Cited by 23 · see citing works

Alzheimer's disease-like pathology induced by Porphyromonas gingivalis in middle-aged mice is mediated by NLRP3 inflammasome via the microbiota-gut-brain axis

Zhang, P., Liu, Y., Jin, X., Hu, Z., Yang, J., Lu, H. X., Hang, T., & Song, M. O. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241302498 · Cited by 20 · see citing works

Urolithin A Ameliorates Athletic Ability and Intestinal Microbiota in Sleep Deprivation from the Perspective of the Gut‐Muscle Axis

Zhu, H., Zhao, H., Qian, H., & Liu, C. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300599 · Cited by 20 · see citing works

Sunset Yellow dye effects on gut microbiota, intestinal integrity, and the induction of inflammasomopathy with pyroptotic signaling in male Wistar rats

Zahran, S. A., Mansour, S. M., Ali, A. E., Kamal, S. M., Römling, U., El-Abhar, H. S., & Ali‐Tammam, M. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114585 · Cited by 19 · see citing works

Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice

Chen, J., Ma, W., Yue, S., Li, D., Chen, L., Zhang, C., Guan, Y., Li, C., Jiang, C., Liao, G., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01554-5 · Cited by 19 · see citing works

Targeting microbiota to alleviate the harm caused by sleep deprivation

Chen, H., Wang, C., Bai, J., Song, J., Bu, L., Ming, L., & Suo, H. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127467 · Cited by 15 · see citing works

The influence of sleep disorders on perioperative neurocognitive disorders among the elderly: A narrative review

Chen, C., Zhai, R., Lan, X., Yang, S., Tang, S., Xiong, X., He, Y., Lin, J., Feng, J., Chen, D., et al. (2024) · Ibrain · doi:10.1002/ibra.12167 · Cited by 15 · see citing works

Microbiota-gut-brain axis pathogenesis and targeted therapeutics in sleep disorders

Pan, D., Li, J., Chen, S., Gu, S., Jiang, M., & Xu, Q. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1721606 · Cited by 15 · see citing works

Wendan Decoction exerts therapeutic effects on insomnia by regulating gut microbiota and tryptophan metabolism

Tian, Y., Meng, J., Zhang, D., Zhai, B., Cheng, J., Zou, J., Shi, Y., & Guo, D. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157028 · Cited by 14 · see citing works

Aflatoxin B 1 exposure causes splenic pyroptosis by disturbing the gut microbiota-immune axis

Chen, H., Ye, L., Wang, Y., Chen, J., Wang, J., Li, X., Lei, H., & Liu, Y. (2024) · Food & Function · doi:10.1039/d3fo04717b · Cited by 14 · see citing works

Emerging Insights into Postoperative Neurocognitive Disorders: The Role of Signaling Across the Gut-Brain Axis

Yu, W., Zhu, Z., & Tang, F. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04228-y · Cited by 14 · see citing works

The association between gut microbiota and insomnia: A systematic review and meta-analysis

Chen, S., Li, H., Ning, M., Yu, B. Y. M., Wu, S., Cheng, W.-Y., Li, Y., & Yeung, W.-F. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102236 · Cited by 13 · see citing works

The interactions along the microbiota—gut—brain axis in the regulation of circadian rhythms, sleep mechanisms and disorders

Shirolapov, I. V., Витальевна, Г. О., Kovalev, A. M., Shafigullina, L. R., Ulivanova, V. A., Kozlov, A. V., Еreshchenko, A. A., Lyamin, A. V., & Zakharov, A. V. (2024) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202412405279 · Cited by 13 · see citing works

SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats

Jia, J., Tao, W., Chen, T., Zhong, Q., Sun, J., Xu, Y., Sui, X., Chen, C., & Zhang, Z. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03585-4 · Cited by 13 · see citing works

Galectin-9 activates the TLR4-NLRP3 inflammasome pathway and promotes tau pathology in Alzheimer’s disease

Guo, X., Zhang, G., Peng, Q., Liu, H., Ye, K., Xiao, T., Liu, C., Zhang, X., Li, S., Wang, H., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106158 · Cited by 11 · see citing works

Treatment of preterm brain injury via gut‐microbiota–metabolite–brain axis

Li, L., Liu, T., & Shi, Y. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14556 · Cited by 10 · see citing works

Akkermansia muciniphila Modulates Central Nervous System Autoimmune Response and Cognitive Impairment by Inhibiting Hippocampal NLRP3 ‐Mediated Neuroinflammation

Li, X., Lin, D., Hu, X., Shi, X., Huang, W., Ouyang, Y., Chen, X., Xiong, Y., Wu, X., Hong, D., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70320 · Cited by 10 · see citing works

Omega-3 polyunsaturated fatty acids attenuate cognitive impairment via the gut-brain axis in diabetes-associated cognitive dysfunction rats

Huang, H., Zhao, T., & Ma, W. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.03.015 · Cited by 9 · see citing works

Integrative fMRI and multiomics reveal neuroprotective mechanisms of Astragalus membranaceus in sleep deprivation-induced depression

Jiao, Y., Xiao, D., Li, X., Jiang, M., & Li, H. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156959 · Cited by 9 · see citing works

Therapeutic potential of atorvastatin in ischemic stroke: an investigation into its anti-inflammatory effect by targeting the gut-brain axis

Chen, L., Zhuo, L., Zheng, J., Sun, X., Sun, J., & Liu, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06803-w · Cited by 9 · see citing works

Unraveling the gut microbiota-brain axis: Mechanisms, pathophysiology, and therapeutic opportunities

Jiang, C., Nageeb, W. M., Batool, S., Hashish, A., Alkhawagah, S. M., Ibrahim, H. A. A., Zhu, W., Che, C., Li, X., Jin, M., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116224 · Cited by 12 · see citing works

Dynamic human gut microbiome and immune shifts during an immersive psychosocial intervention program

Zhou, X., Ganz, A. B., Rayner, A., Cheng, T. Y., Oba, H., Rolnik, B. M., Lancaster, S. M., Lu, X., Li, Y., Johnson, J. S., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.12.027 · Cited by 11 · see citing works

Advances in Autophagy–Lysosomal Pathway and Neurodegeneration via Brain–Gut Axis

Yao, P., & Han, H. (2025) · Biomedicines · doi:10.3390/biomedicines13061390 · Cited by 9 · see citing works

A new perspective on cognitive impairment in major depressive disorder: Changes in gut microbiota and their inflammatory regulatory mechanisms

Song, X., Zhong, Q., Zhang, R., Lai, S., Wu, Y., Yin, J., Liu, Y., Sun, J., Zhang, J., Lü, X., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119648 · Cited by 9 · see citing works

Research Progress on the Pathogenesis of Post-Stroke Depression

Chen, J., Li, W., Por, J., Liu, H., Shen, Y., & Cai, L. (2025) · ACS Omega · doi:10.1021/acsomega.5c05338 · Cited by 8 · see citing works

Nuclear receptor Nr1d1 links sleep deprivation to intestinal homeostasis via microbiota-derived taurine

Wang, Z., Zhou, L., Zheng, Y., Zhong, X., Huang, R., Sun, W., Wang, S., & Li, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07089-8 · Cited by 8 · see citing works

WuYou decoction effectively reduces neuronal damage, synaptic dysfunction, and Aβ production in rats exposed to chronic sleep deprivation by modulating the Aβ-related enzymes and SIRT1/Nrf2/NF-κB pathway

Wang, Z., Wu, D., Hu, X., Hu, X., Zhu, Q., Lai, B., Zeng, C., & Long, Q. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118939 · Cited by 7 · see citing works

The Role of Interactions along the Brain–Gut–Microbiome Axis in the Regulation of Circadian Rhythms, Sleep Mechanisms, and Their Disorders

Shirolapov, I. V., Витальевна, Г. О., Kovalev, A. M., Shafigullina, L. R., Ulivanova, V. A., Kozlov, A. V., Еreshchenko, A. A., Lyamin, A. V., & Zakharov, A. V. (2024) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-024-01712-9 · Cited by 6 · see citing works

AnMei decoction ameliorates cognitive impairment in rats with chronic sleep deprivation by mitigating hippocampal neuroinflammation and restoring synaptic architecture

Xu, Z., Zhang, J.-L., Li, F., Xu, B., Xia, J., Wang, P., & Xie, G. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119101 · Cited by 6 · see citing works

Allantoin ameliorates dopaminergic neuronal damage in MPTP-induced Parkinson's disease mice via regulating oxidative damage, inflammation, and gut microbiota disorder

Yang, S., Sun, X., Liu, D., Zhang, Y., Gao, X., He, J., Cui, M., Fu, S., & He, D. (2024) · Food & Function · doi:10.1039/d4fo02167c · Cited by 6 · see citing works

Overexpression of colonic VIP ameliorates cognitive function and barrier system damage caused by sevoflurane anesthesia and surgery in aged rats with fragile brain functions

Liao, H., Wang, X., Yang, C., Wang, Z., Liu, X., Liu, H., Zhang, J., Shen, H., & Wang, H. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115328 · Cited by 5 · see citing works

The multifaceted impact of a high-salt environment on the immune system and its contribution to salt-sensitive hypertension

Wang, L., Hu, J., & Ren, K. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102244 · Cited by 6 · see citing works

Exercise as a modulator of gut microbiota for improvement of sleep quality: a narrative review

Zhao, B., Sun, J., Xiang, L., & Su, Z. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1639099 · Cited by 5 · see citing works

Gut microbiota–neuroinflammation axis: A new mechanism and therapeutic target for comorbid depression in epilepsy

wang, X., Liu, M., Cao, L., Huang, H., Yang, J., Zhang, H., pan, C., & Xu, Z. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101150 · Cited by 5 · see citing works

Sex-dependent and long-lasting effects of adolescent sleep deprivation on social behaviors in adult mice

Xue, J., Li, B., Huang, B., Feng, H., Li, X., Liang, S., Yuan, F., Wang, S., Shi, H., Shao, J., et al. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173657 · Cited by 5 · see citing works

Umbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota

Jiang, Y., Ni, Z., Dai, H., Luo, X., Xing, J., Wang, R., & Zhang, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c07117 · Cited by 4 · see citing works

From alpha diversity to zeitgebers: Functional implications and potential mechanisms linking the gut microbiome to sleep and circadian disruption (Part II)

Maki, K. A., Barb, J. J., Xu, S., Papneja, S., Alkhatib, J., Butera, G., & Wallen, G. R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106609 · Cited by 4 · see citing works

From alpha diversity to zeitgebers: Bacterial gut microbiome associations with sleep and circadian disruption (Part I)

Maki, K. A., Barb, J. J., Alkhatib, J., Butera, G., & Wallen, G. R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106578 · Cited by 4 · see citing works

Shuangxia Decoction attenuates sleep disruption in 5×FAD mice through neuroinflammation inhibition: An integrative analysis of transcriptomic and molecular biology investigations

Wang, J., Pan, H., Tang, H., Zhang, J., Li, T., Liu, Y., Huang, Y., Fei, Z., & Wang, Y. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119642 · Cited by 4 · see citing works

Metagenomics Reveals Sex-Based Differences in Murine Fecal Microbiota Profiles Induced by Chronic Alcohol Consumption

Domínguez-Pino, M., Mellado, S., Cuesta, C. M., Grillo-Risco, R., Garcia‐García, F., & Pascual, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312534 · Cited by 4 · see citing works

Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic ProgramPreprint

Zhou, X., Ganz, A. B., Rayner, A., Cheng, T. Y., Oba, H., Rolnik, B. M., Lancaster, S. M., Lu, X., Li, Y., Johnson, J. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.26.600881 · Cited by 4 · see citing works

Gut microbiota: a new target for the prevention and treatment of insomnia using Chinese herbal medicines and their active components

Wu, C., Dou, J., Song, X., Yang, F., Liu, X., Song, W., & Zhang, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1572007 · Cited by 3 · see citing works

Traditional Chinese Medicine Improves the Development of Vascular Thrombotic Inflammation: The Key Role of Gut Microbiota and Its Derived Metabolites

Xu, J., Zhang, Y., Liao, J., Le, W., Wu, G., & Zhang, W. (2025) · Phytotherapy Research · doi:10.1002/ptr.70012 · Cited by 3 · see citing works

Ophiopogon polysaccharide can improve memory impairment induced by sleep deprivation in aged rats by regulating gut microbiota and inhibiting TLR4/NF-κB pathway in hippocampus

Zhou, M., Yang, Y., Wang, S., & Zhang, J. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115601 · Cited by 4 · see citing works

Exercise training mitigates age-related cognitive decline by attenuating TMAO-induced inflammation

Zhang, R., Li, L., Xi, X., Zhu, Z., Dai, T., & Gong, W. (2026) · Scientific Reports · doi:10.1038/s41598-026-36354-z · Cited by 2 · see citing works

Role of oral-gut microbiota dysbiosis in regulating systemic impairment during age-related obesity: an animal study

Tian, Y., Min, Y., Bai, J., Chen, Y., Cong, X., & Gao, X. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1781222 · Cited by 2 · see citing works

Bound polyphenols from seabuckthorn pomace alleviate sleep deprivation-induced cognitive impairment via gut microbiota-driven homovanillic acid-mediated neuroprotection

Peng, J., Qin, X., Yan, H., Amanbayeva, A., Han, X., Li, X., Yang, Y., Liu, X., & Lan, Y. (2026) · Food Research International · doi:10.1016/j.foodres.2026.119440 · Cited by 2 · see citing works

Gut Microbiome–Sleep Crosstalk: Mechanistic Pathways, Dysbiosis Signatures, and Microbiome‐Based Interventions

Oriquat, G., Al-Hasnaawei, S., Mousa, H. M., Malathi, H., Singla, S., Sahoo, S., Arora, V., Chauhan, A. S., & Nourizadeh, M. (2026) · Brain and Behavior · doi:10.1002/brb3.71525 · Cited by 3 · see citing works

Akkermansia muciniphila alleviates diabetic cognitive impairment by inhibiting NLRP3 inflammasome activation and ameliorating hippocampal synaptic defects

Du, Y., An, Y., Cao, Z., Xu, G., Chu, M., & Lu, Y. (2026) · Food & Function · doi:10.1039/d5fo03902a · Cited by 2 · see citing works

Modified life’s essential 8 mediate the correlation between dietary index for gut microbiota and sleep disorders

Fang, J., Wang, Z., Yu, J., Ye, Y., Du, A., & Ferrari, M. W. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1611714 · Cited by 1 · see citing works

Coffee mitigated cognitive impairments in sleep-deprived mice by regulating circadian rhythm, inflammation, oxidative stress, and intestinal ecology

Jiang, H.-B., Wei, F.-F., Li, W., Lin, Z., Zhu, C., Wu, Y., Wang, Y., & Song, L. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107317 · Cited by 1 · see citing works

Flavonoids from Ficus pandurate var. angustifolia W.C. Cheng Restore Cognitive Impairment and Regulate the Gut Microbiota in Sleep-Deprived Mice

Dai, H., Luo, S., & Zhang, X. (2025) · Foods · doi:10.3390/foods14162888 · Cited by 1 · see citing works

Gut microbiota and its metabolites promote painful diabetic peripheral neuropathy complicated with cognitive dysfunction in mice

Yang, J., Lv, X., Xu, Y., Huang, F., Yang, X., Shi, X., Zhao, L., Liang, C., Wang, D., Fang, Y., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1599954 · Cited by 1 · see citing works

Sleep deprivation disrupts vestibular compensation by activating TLR4/NF-κB/NLRP3 signalling in the deafferented vestibular nuclei

Li, Z., Lai, J., Li, Y., Dong, L., Li, J., Zhou, T., Shen, H., Zhu, H., Yu, D., Wang, P., et al. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111550 · Cited by 1 · see citing works

Oolong tea polyphenols alleviate cognitive impairment in sleep-deprived mice through the microbiota–gut–brain axis

Hu, N., Dai, H., Tong, M., Sun, S., Zhao, M., & Zhang, X. (2025) · Food & Function · doi:10.1039/d5fo03736k · Cited by 1 · see citing works

Investigations on the effects of SH2B2 on Parkinson’s disease based on its in vivo and in vitro neurotoxic model

Zhao, L., Han, K., & Sun, L. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.12.069 · Cited by 1 · see citing works

Cry2 deficiency leads to cognitive impairment through the microbiota-gut-brain axis mediated S1P/NLRP3/IL-1β pathway in mice

Geng, F., Zhao, N., Zhou, L., Liu, X.-T., Chen, X., Wang, Z.-T., Zhang, Z.-J., & Ren, Q.-G. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03706-5 · Cited by 1 · see citing works

Sleep Disorders in Neurodegenerative Diseases: Pathological Correlations and Underlying Mechanisms

Wang, Z., He, F., Li, L., Wang, W., Zhang, L., Tang, J., & Le, W. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01609-2 · Cited by 1 · see citing works

Meningeal lymphatic dysfunction mediates postoperative sleep deprivation-induced cognitive decline via impaired neuroinflammatory clearance

Huang, B., Tu, W., Zhou, H., Mo, L., Yang, Q., Sheng, Y., Sun, D., Meng, B., Chi, Z., Lv, Y., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03784-5 · Cited by 1 · see citing works

Sodium Houttuyfonate improves cognitive impairment in mice after chronic sleep deprivation by inhibiting microglial inflammation and ferroptosis

Li, R., Zhu, Y., Wei, H., Yu, M., & Xu, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116688 · Cited by 1 · see citing works

Vitamin E and melatonin synergistically attenuate sleep deprivation-induced Nrf2 dysregulation and hippocampal ferroptosis in Alzheimer's disease mouse models

Gao, Q., Sun, J., Hei, B., Zhou, J., Wang, B., Wang, D., Hu, S., Liu, J., Wang, D., & Fan, J. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115781 · Cited by 1 · see citing works

The NLRP3–α-Synuclein Circuit: A Core Driver and Therapeutic Target in Parkinson’s Disease

Liu, K., he, Z., Zhang, L., Wu, Y.-M., & Xiao, L. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s597280 · Cited by 1 · see citing works

Peripheral to central: Exploring the neural, endocrine, and immune pathways of the gut-brain axis in postoperative neurocognitive dysfunction

Cao, R., Shi, Z., Ou, W., & Liu, Z. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111975 · Cited by 1 · see citing works

From Gut to Genome: Systems‐Level Microbiome Signaling in Inter‐Organ Communication in Health and Disease

Li, L., Han, Y., Yu, M., Yang, H., Tareen, A. M., Arain, M. A., Wang, Y., & Yin, S. (2026) · Comprehensive physiology · doi:10.1002/cph4.70233 · Cited by 1 · see citing works

Research hotspots and trends in the interaction mechanisms of neuroinflammation and sleep disorders: A bibliometric analysis based on WOS

Zhao, N., Zhu, Z., Gong, Q., & Jiang, R. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.08.011 · Cited by 1 · see citing works

Gut microbiota dysbiosis in hyperuricemia promotes renal injury through the activation of NLRP3 inflammasomePreprint

Zhou, X., Ji, S., Chen, L., Liu, X., Deng, Y., You, Y., Wang, M., He, Q., Peng, B., Yang, Y., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3469191/v1

High fat and high cholesterol diet induced cognitive impairment in GSDMD knockout mice via the compensatory activation of apoptosis pathway

Liu, R., Wang, G., Gu, K., Ma, T., He, Z., Qin, L., & Wan, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.119978

Global hotspots and research trends of gut microbiota in sleep disorders: a bibliometric analysis (2011-2024)Preprint

Guo, L., Xie, C., Wang, X., Xu, Y., & Cheng, G. (2025) · medRxiv · doi:10.1101/2025.08.07.25333265

Additional file 1 of Gut microbiota dysbiosis in hyperuricaemia promotes renal injury through the activation of NLRP3 inflammasome

Zhou, X., Ji, S., Chen, L., Liu, X., Deng, Y., You, Y., Wang, M., He, Q., Peng, B., Yang, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26082635

Additional file 1 of Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice

Chen, J., Ma, W., Yue, S., Li, D., Chen, L., Zhang, C., Guan, Y., Li, C., Jiang, C., Liao, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25422338

Additional file 2 of Gut microbiota dysbiosis in hyperuricaemia promotes renal injury through the activation of NLRP3 inflammasome

Zhou, X., Ji, S., Chen, L., Liu, X., Deng, Y., You, Y., Wang, M., He, Q., Peng, B., Yang, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26082689

Akkermansia muciniphila Ameliorates Chronic Sleep Deprivation-Induced Glucose Intolerance and Inflammatory Cytokine Activation

Wang, Z., Ma, Y., Li, M., Jiang, X., Pan, Q., Deng, M., & Guo, L. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl45680

Dietary EPA shows superior efficacy over DHA in chronic sleep deprivation-induced cognitive decline by disrupting the crosstalk between intestinal ferroptosis and gut-derived Aβ production

Chen, L., Wang, X., Yang, Y., Shi, H., Zhang, N., Wang, Z., Han, J., & Wen, M. (2026) · Food & Function · doi:10.1039/d5fo03915k

SLC22A3 deficiency leads to cognitive impairment through the cardio-neuroinflammatory axis mediated HA/H1R/NLRP3 pathway in heart failure mice

Wang, Z., Zhou, L., Zhao, N., Li, T., Geng, F., Kong, J., Zhang, Y., Zhang, Z., & Ren, Q.-G. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104127

Pathological Remuneration of Oxidative Stress in Limiting Gut-Brain Axis

Kumar, R., Kashyap, A., & Naqvi, S. (2026) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-032-19837-2_5

Joint trajectories of sleep duration and depressive symptoms and risk of incident multimorbidity: a longitudinal analysis with machine learning prediction

Jiang, J., Li, Z., Zhang, Z., Ji, S., Zhang, Z., Wu, Y., Li, Y., Yu, M., Qiao, P., Xu, J. H., et al. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07694-2

Dendrobium huoshanense Ameliorates Sleep Deprivation-Induced Ileal Mucus Barrier Dysfunction by Regulating Steroid Hormone Biosynthesis and the HPA Axis in Rats

Luo, X., Jin, S., Fang, Y., Zhao, Q., Xie, H., & Han, L. (2026) · Metabolites · doi:10.3390/metabo16060376

Sleep disorders and blood-brain barrier dysfunction: mechanisms, biomarkers, and therapeutic implications for neurocognitive decline

Li, M.-Y., Lin, Y.-N., Chen, X.-X., Huang, K., Lin, J., Hua, Z., Ran, X., Shen, Y., Ban, C.-L., Xia, K.-X., et al. (2026) · LabMed discovery. · doi:10.1016/j.lmd.2026.100131

Enterochromaffin Cells Drive Anxiety-Like Behaviors in Sleep-Deprived Mice

Zhai, Y., Ma, L., Zhuo, L., Wang, F., Zhang, L., Han, J., Qin, Y., Luo, P., Wang, X., Zhou, G., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.06.014

Mechanisms of Limosilactobacillus fermentum DACN8320 in Alleviating Sleep Deprivation-Related Cognitive Dysfunction: A Microbial-Intestinal-Brain Axis Study

Zhou, X., Chen, H., Wang, C., Li, Y., Lin, D., Song, J., & Suo, H. (2026) · Journal of Future Foods · doi:10.1016/j.jfutfo.2026.06.017

Magnolin and Lanosterol in WenYangTongbi pill-mediated Foxs1-Nlrp3 axis suppression alleviates chronic sleep deprivation-induced cognitive impairment

Yu-jing, C., Yun, F.-B., Yang, X., Li, Q., Li, Q., Chen, W., Yang, S.-Y., Li, M.-J., Zhang, C., & Hu, P. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158629

Fermented red quinoa alleviates sleep deprivation-induced anxiety-like behavior and inflammation associated with gut microbiota modulation

Ma, J., Jiang, H., Wei, F., Zhu, C., Wu, Y., & Song, L. (2026) · Food Research International · doi:10.1016/j.foodres.2026.120213

Polygonatum cyrtonema Polysaccharides Alleviate Sleep Deprivation-Induced Behavioral Disorders via Gut Microbiota-Dependent Regulation of the Butyrate-HDAC3 Signaling Axis

Chen, Y., Gong, X., Chen, Y., Cheng, K., & Zhang, X. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c06317

Do microbiota rhythms influence cognitive performance? - A narrative review

Kapela, M., Barszcz, E., Michno, K., Zielińska, D., Strzelecki, D., & Gawlik-Kotelnicka, O. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1903770

Artemisinin ameliorates experimental autoimmune prostatitis by suppressing NLRP3 inflammasome-induced pyroptosis via the Nrf2/HO-1 axis

Feng, R., Zhang, A., Li, Y., Wang, P., Guo, H., Hu, Y., Tan, M., & Xu, D. (2026) · Molecular Immunology · doi:10.1016/j.molimm.2026.06.013

Weizmannia coagulans BC99 Improve Cognitive Impairment Induced by Chronic Sleep Deprivation via Inhibiting the Brain and Intestine’s NLRP3 Inflammasome

Sun, Q., Fan, J., Zhao, L., Qu, Z., Dong, Y., Wu, Y., & Gu, S. (2025) · Foods · doi:10.3390/foods14060989 · Cited by 10 · see citing works

NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

Zhao, N., 东南大学医学院神经内科, 江. 南. 2., Xiu, C., Chen, Q.-G., Liu, X.-T., Geng, F., Zhu, M., Yan, F., Zhang, Z., Ren, Q., et al. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2024.085 · Cited by 25 · see citing works

Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Wang, Z., Chen, W.-H., Li, S.-X., He, Z.-M., Zhu, W.-L., Ji, Y.-B., Wang, Z., Zhu, X.-M., Yuan, K., Bao, Y.-P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01113-1 · Cited by 307 · see citing works

<i>Akkermansia muciniphila</i> supplementation prevents cognitive impairment in sleep-deprived mice by modulating microglial engulfment of synapses

Li, N., Tan, S., Wang, Y., Deng, J., Wang, N., Zhu, S., Tian, W., Xu, J., & Wang, Q. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2252764 · Cited by 117 · see citing works

Lactobacillus acidophilus CICC 22162 alleviates sleep deprivation-induced cognitive impairment by remodeling gut microbiota and enhancing S-adenosylmethionine-mediated neuroimmune regulation

Jiang, Z., Zhang, Z., Shi, M., Li, X., Zhang, X., Liu, C., Wang, Y., Zhu, J., Gu, C., & Yang, Z. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1889475