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Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Matsumoto, Junichi, Stewart, Tessandra, Sheng, Lifu, Li, Na, Bullock, Kristin, Song, Ning, Shi, Min, Banks, William A, Zhang, Jing·2017·Acta Neuropathologica Communications
DOI 10.1186/s40478-017-0470-4PMC PMC5598000
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  • sEVs can cross the blood-brain barrier and deliver cargo with crucial roles in many neurological disorders.

    “sEVs can cross the blood–brain barrier and deliver cargo with crucial roles in many neurological disorders [17–23].”

    From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [22]

    The Introduction says EVs carry cargo and are considered important in a variety of neurodegenerative diseases. The Results and Discussion show that erythrocyte-derived EV components can cross the blood–brain barrier, particularly under LPS-induced inflammation, but the Discussion says the tested EVs likely included both exosomes and microvesicles and does not establish that intact vesicles crossed. The paper therefore does not establish the claim specifically for sEVs or without that condition. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • RBC-EVs are enriched in the liver, spleen, and kidney.

    “(3) RBC-EVs are enriched in the liver, spleen, and kidney (Matsumoto et al., 2017), and RBC miRNAs are possibly involved in kidney-related diseases (Abraham et al., 2017; Fang et al., 2018).”

    From Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System (2020) · cites this paper as Matsumoto et al., 2017

  • Erythrocyte-derived EVs containing α-synuclein may be another mechanism for the initiation and progression of Parkinson's disease.

    “Investigations have revealed that erythrocyte-derived EVs containing α-synuclein move across the blood–brain barrier through adsorptive-mediated transcytosis, which may be another mechanism for the initiation and progression of Parkinson’s disease (Matsumoto et al., 2017).”

    From Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System (2020) · cites this paper as Matsumoto et al., 2017

  • Erythrocyte-derived EVs containing α-synuclein move across the blood-brain barrier through adsorptive-mediated transcytosis.

    “Investigations have revealed that erythrocyte-derived EVs containing α-synuclein move across the blood–brain barrier through adsorptive-mediated transcytosis, which may be another mechanism for the initiation and progression of Parkinson’s disease (Matsumoto et al., 2017).”

    From Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System (2020) · cites this paper as Matsumoto et al., 2017

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Metadata

Authors
Matsumoto, J., Stewart, T., Sheng, L., Li, N., Bullock, K., Song, N., Shi, M., Banks, W. A., & Zhang, J.
Venue
Acta Neuropathologica Communications
Publisher
Springer Science and Business Media LLC
Published
2017-09-13
Volume
5
Issue
1
ISSN
2051-5960
DOI
10.1186/s40478-017-0470-4
PMC
PMC5598000
Cited by
279
References
10
Language
en
Licence
Funders
National Institutes of Health (R01 ES016873, ES019277, U01 NS091272, U01 NS082137)

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