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Synergistic Effect of Increased Total Protein Intake and Strength Training on Muscle Strength: A Dose-Response Meta-analysis of Randomized Controlled Trials

Tagawa, Ryoichi, Watanabe, Daiki, Ito, Kyoko, Otsuyama, Takeru, Nakayama, Kyosuke, Sanbongi, Chiaki, Miyachi, Motohiko·2022·Sports Medicine - Open
DOI 10.1186/s40798-022-00508-w
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Abstract

Background: Protein supplementation augments muscle strength gain during resistance training. Although some studies focus on the dose-response relationship of total protein intake to muscle mass or strength, the detailed dose-response relationship between total protein intake and muscle strength increase is yet to be clarified, especially in the absence of resistance training. Objective: We aimed to assess the detailed dose-response relationship between protein supplementation and muscle strength, with and without resistance training. Design: Systematic review with meta-analysis. Data Sources: PubMed and Ichushi-Web (last accessed on March 23, 2022). Eligibility Criteria: Randomized controlled trials investigating the effects of protein intake on muscle strength. Synthesis Methods: A random-effects model and a spline model. Results: A total of 82 articles were obtained for meta-analyses, and data from 69 articles were used to create spline curves. Muscle strength increase was significantly augmented only with resistance training (MD 2.01%, 95% CI 1.09–2.93) and was not augmented if resistance training was absent (MD 0.13%, 95% CI − 1.53 to 1.79). In the dose-response analysis using a spline model, muscle strength increase with resistance training showed a dose-dependent positive association with total protein intake, which is 0.72% (95% CI 0.40–1.04%) increase in muscle strength per 0.1 g/kg body weight [BW]/d increase in total protein intake up to 1.5 g/kg BW/d, but no further gains were observed thereafter. Conclusion: Concurrent use of resistance training is essential for protein supplementation to improve muscle strength. This study indicates that 1.5 g/kg BW/d may be the most appropriate amount of total protein intake for maintaining and augmenting muscle strength along with resistance training.

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Cited by

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Metadata

Authors
Tagawa, R., Watanabe, D., Ito, K., Otsuyama, T., Nakayama, K., Sanbongi, C., & Miyachi, M.
ORCID
Venue
Sports Medicine - Open
Publisher
Springer Science and Business Media LLC
Published
2022-09-04
Volume
8
Issue
1
ISSN
  • 2199-1170
  • 2198-9761
DOI
10.1186/s40798-022-00508-w
Cited by
45
References
20
Language
en
Licence
Funders
Japan Agency for Medical Research and Development (22ek0210166s0801)

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