The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
Abstract
TAM and other myeloid-derived tumor infiltrating cells are reviewed as pivotal players in the tumor microenvironment; implications to anti-cancer therapy are described. The microenvironment of solid tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dysregulated vessels and proteolytic enzymes. TAM, major players in the connection between inflammation and cancer, summarize a number of functions (e.g., promotion of tumor cell proliferation and angiogenesis, incessant matrix turnover, repression of adaptive immunity), which ultimately have an important impact on disease progression. Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors.
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Metadata
- Authors
- Solinas, G., Germano, G., Mantovani, A., & Allavena, P.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-09-09
- Volume
- 86
- Issue
- 5
- Pages
- 1065-1073
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2136166312
- Cited by
- 1,425
- References
- 30
- FWCI
- 21.51
- Type
- journal article
- Language
- en
- Open access
- closed
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