Cited by 236Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsInflammasome and immune disorders

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Danger-associated molecular patterns in Alzheimer’s disease

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Venegas, Carmen, Heneka, Michael T·2017·Journal of Leukocyte Biology

DOI 10.1189/jlb.3mr0416-204r

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Abstract

Pathogen-associated molecular patterns (PAMPs) and endogenous “danger” signals, known as danger-associated molecular patterns (DAMPs), released from cells alert the innate immune system and activate several signal transduction pathways through interactions with the highly conserved pattern recognition receptors (PRRs). Both PAMPs and DAMPs directly induce proinflammatory cascades and trigger the formation of the inflammasome, mediating the release of cytokines. Here, we highlight the role of DAMPs, including amyloid β (Aβ), high-mobility group box 1 (HMGB1), the S100 family proteins, chromogranin A, and nucleic acids, in the innate-immune activation during the course of Alzheimer disease (AD), the most frequent neurodegenerative disorder.

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Authors: Venegas, C., & Heneka, M. T.
Affiliations: University of Bonn (DE)
Corresponding author: Heneka, Michael T
ORCID: Venegas, Carmen
Heneka, Michael T
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2016-10-21
Volume: 101
Issue: 1
Pages: 87-98
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.3mr0416-204r
OpenAlex: W2534771646
Cited by: 236
References: 156
Citations by year: 2026: 24 · 2025: 26 · 2024: 29 · 2023: 25 · 2022: 29 · 2021: 30 · 2020: 30 · 2019: 15 · 2018: 15 · 2017: 11
FWCI: 1.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
DZNE Pub (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: damage-associated molecular patterns, Alzheimer's disease, innate immunity, pattern recognition receptors, pathogen-associated molecular patterns, inflammasome, amyloid-beta, HMGB1, S-100 protein, chromogranin A, nucleic acids, neuroinflammation, cytokine production
MeSH terms: Alarmins, Alzheimer Disease, Animals, Humans, Inflammation, Models, Biological, Receptors, Pattern Recognition, Molecular Targeted Therapy

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Danger-associated molecular patterns in Alzheimer’s disease

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