Cited by 321Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

The DOI matches its Crossref record; 51 of the 55 references it cites were found in a registry or an index.

Association of high-sensitivity C-reactive protein with de novo major depression

Open access

Pasco, Julie A., Nicholson, Geoffrey C., Williams, Lana J., Jacka, Felice N., Henry, Margaret J., Kotowicz, Mark A., Schneider, Hans G., Leonard, Brian E., Berk, Michael·2010·British Journal of Psychiatry

DOI 10.1192/bjp.bp.109.076430

Open this paper in CoChat — free account Open PDF

Abstract

Background: Although there is cross-sectional evidence that changes in the immune system contribute to the pathophysiology of depression, longitudinal data capable of elucidating cause and effect relationships are lacking. Aims: We aimed to determine whether subclinical systemic inflammation, as measured by serum high-sensitivity C-reactive protein (hsCRP) concentration, is associated with an increased risk of de novo major depressive disorder. Method: Major depressive disorder was diagnosed using a clinical interview (SCID–I/NP). This is a retrospective cohort study; from a population-based sample of 1494 randomly selected women recruited at baseline during the period 1994–7, 822 were followed for a decade and provided measures of both exposure and outcome. Of these women, 644 (aged 20–84 years) had no prior history of depression at baseline and were eligible for analysis. Results: During 5827 person-years of follow-up, 48 cases of de novo major depressive disorder were identified. The hazard ratio (HR) for depression increased by 44% for each standard deviation increase in log-transformed hsCRP (ln-hsCRP) (HR = 1.44, 95% CI 1.04–1.99), after adjusting for weight, smoking and use of non-steroidal anti-inflammatory drugs. Further adjustment for other lifestyle factors, medications and comorbidity failed to explain the observed increased risk for depression. Conclusions: Serum hsCRP is an independent risk marker for de novo major depressive disorder in women. This supports an aetiological role for inflammatory activity in the pathophysiology of depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1192/bjp.bp.109.076430

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease
Danesh, J., Wheeler, J. G., Hirschfield, G. M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G. D. O., Pepys, M. B., & Gudnason, V. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032804 · Cited by 2,953
Elevated C-reactive protein levels in overweight and obese adults
Visser, M. (1999) · JAMA · doi:10.1001/jama.282.22.2131 · Cited by 2,494
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein.
Pepys, M., & Baltz, M. (1983) · Advances in Immunology · doi:10.1016/s0065-2776(08)60379-x · Cited by 1,322
Childhood maltreatment predicts adult inflammation in a life-course study
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610362104 · Cited by 1,264 · cited 1×
“Childhood maltreatment predisposes to depression and may play a role in increasing the risk for inflammation in adulthood; 47,48 this has not been entered into the models, as these data were not available.”
Background
Relationships between obesity and DSM-IV major depressive disorder, suicide ideation, and suicide attempts: results from a general population study
Carpenter, K. M., Hasin, D. S., Allison, D. B., & Faith, M. S. (2000) · American Journal of Public Health · doi:10.2105/ajph.90.2.251 · Cited by 1,018
Time-to-Event Analysis of Longitudinal Follow-up of a Survey: Choice of the Time-scale
Korn, E. L., Graubard, B. I., & Midthune, D. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009034 · Cited by 1,011
The macrophage theory of depression
Smith, R. S. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90272-z · Cited by 931
Elevated inflammation levels in depressed adults with a history of childhood maltreatment
Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.409 · Cited by 641 · cited 1×
“Childhood maltreatment predisposes to depression and may play a role in increasing the risk for inflammation in adulthood; 47,48 this has not been entered into the models, as these data were not available.”
Background

Flagged first, then by citations

Show all 55 references

4 of the 55 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

First, 2002, Structured Clinical Interview for DSM–IV–TR Axis I Disorders, Research Version, Non-patient Edition (SCID–I/NP)

Sorted by citations

Items 101–200 of 320

Family caregivers’ sleep disturbance and its associations with multilevel stressors when caring for patients with dementia
Chiu, Y., Lee, Y.-N., Wang, P.-C., Chang, T.-H., Li, C., Hsu, W.-C., & Lee, S. (2013) · Aging & Mental Health · doi:10.1080/13607863.2013.837141 · Cited by 60
C-reactive protein, interleukin-6, soluble tumor necrosis factor α receptor 2 and incident clinical depression
Chocano-Bedoya, P. O., Mirzaei, F., O’Reilly, É. J., Lucas, M., Okereke, O. I., Hu, F. B., Rimm, E. B., & Ascherio, A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.03.023 · Cited by 55
A Comparison of Inflammatory Markers in Depressed and Nondepressed Smokers
Nunes, S. O. V., Vargas, H. O., Brum, J., Prado, E., Vargas, M. M., de Castro, M. R. P., Dodd, S., & Berk, M. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr247 · Cited by 59
Self-citation
Pain and the relationship with mood and anxiety disorders and psychological symptoms
Williams, L. J., Pasco, J. A., Jacka, F. N., Dodd, S., & Berk, M. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.03.001 · Cited by 54
Self-citation
Soluble Urokinase Plasminogen Activator Receptor as a Marker for Use of Antidepressants
Haastrup, E. K., Grau, K., Eugen‐Olsen, J., Thorball, C. W., Kessing, L. V., & Ullum, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110555 · Cited by 54
Depressive symptoms and diet: Their effects on prospective inflammation levels in the elderly
Luciano, M., Mõttus, R., Starr, J. M., McNeill, G., Jia, X., Craig, L. C. A., & Deary, I. J. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.007 · Cited by 53
Inflammatory biomarkers and perinatal depression: A systematic review
Silva‐Fernandes, A., Conde, A., Marques, M., Caparrós-González, R. A., Fransson, E., Mesquita, A. R., Figueiredo, B., & Skalkidou, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0280612 · Cited by 53
A Systematic Review and Meta-Analysis of Depression and Protein–Energy Wasting in Kidney Disease
Gregg, L. P., Carmody, T. J., Le, D., Martins, G., Trivedi, M. H., & Hedayati, S. S. (2019) · Kidney International Reports · doi:10.1016/j.ekir.2019.12.009 · Cited by 55
Depression and Inflammation: Disentangling a Clear Yet Complex and Multifaceted Link
Amodeo, G., Trusso, M. A., & Fagiolini, A. M. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000236 · Cited by 54
Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: a prospective study in UK Biobank
Li, D., Xie, J., Wang, L., Sun, Y., Hu, Y., & Tian, Y. (2023) · BMC Medicine · doi:10.1186/s12916-023-02783-0 · Cited by 49
The association between depressive and anxiety symptoms and bone mineral density in the general population: The HUNT Study
Williams, L. J., Bjerkeset, O. A., Langhammer, A., Berk, M., Pasco, J. A., Henry, M. J., Schei, B., & Forsmo, S. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.11.019 · Cited by 51
Self-citation
Lower Serum Zinc and Higher CRP Strongly Predict Prenatal Depression and Physio-somatic Symptoms, Which All Together Predict Postnatal Depressive Symptoms
Roomruangwong, C., Kanchanatawan, B., Sirivichayakul, S., Mahieu, B., Nowak, G., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9741-5 · Cited by 46
People with schizophrenia and depression have a low omega-3 index
Parletta, N., Zarnowiecki, D. M., Cho, J., Wilson, A. L., Procter, N. G., Gordon, A. L., Bogomolova, S., O’Dea, K., Strachan, J., Ballestrin, M., et al. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.05.007 · Cited by 53
Obesity and the relationship with positive and negative affect
Pasco, J. A., Williams, L. J., Jacka, F. N., Brennan, S. L., & Berk, M. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413483371 · Cited by 48
Self-citation
Cachexia is associated with depression, anxiety and quality of life in cancer patients
Sun, H., Thapa, S., Fu, X., Wen, S., Liu, H., & Yu, S. (2020) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2019-002176 · Cited by 48
Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression
Price, J. B., Bronars, C. A., Erhardt, S., Cullen, K., Schwieler, L., Berk, M., Walder, K. R., McGee, S. L., Frye, M. A., & Tye, S. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.002 · Cited by 47
Self-citation
Associations between dietary patterns and psychological factors: a cross-sectional study among Chinese postmenopausal women
Liu, Z., Ho, S. C., Xie, Y. J., Chen, Y., Chen, Y., Chen, B., Wong, S. Y. S., Chan, D. C.-C., Wong, C. K. M., He, Q., et al. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000701 · Cited by 48
The Importance of Diet and Gut Health to the Treatment and Prevention of Mental Disorders
Dawson, S. L., Dash, S. R., & Jacka, F. N. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.009 · Cited by 49
Self-citation
Risk of Developing Depressive Disorders following Rheumatoid Arthritis: A Nationwide Population-Based Study
Wang, S., Chang, C., Hu, L., Tsai, S., Yang, A. C., & You, Z.-H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107791 · Cited by 45
The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study
Geraets, A. F. J., Köhler, S., Muzambi, R., Schalkwijk, C. G., Oenema, A., Eussen, S. J. P. M., Dagnelie, P. C., Stehouwer, C. D. A., Schaper, N. C., Henry, R. M. A., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05247-9 · Cited by 45
Impact of single nucleotide polymorphisms of base excision repair genes on DNA damage and efficiency of DNA repair in recurrent depression disorder
Czarny, P., Kwiatkowski, D., Toma, M., Kubiak, J., Sliwinska, A., Talarowska, M., Szemraj, J., Maes, M., Galecki, P., & Sliwinski, T. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9971-6 · Cited by 43
Translational Epidemiology in Psychiatry
Weissman, M. M., Brown, A. S., & Talati, A. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.47 · Cited by 43
State‐related alterations of gene expression in bipolar disorder: a systematic review
Munkholm, K., Vinberg, M., Berk, M., & Kessing, L. V. (2012) · Bipolar Disorders · doi:10.1111/bdi.12005 · Cited by 43
Self-citation
Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis
Yan, Z., Jiao, H., Chen, J., Zhang, K., Wang, X., Jiang, Y.-M., Liu, Y., Xue, Z., Ma, Q., Li, X., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.773562 · Cited by 43
How to: Measuring blood cytokines in biological psychiatry using commercially available multiplex immunoassays
Belzeaux-R, R., Lefebvre, M., Lazzari, A., Carpentier, T. L., Consoloni, J.-L., Zendjidjian, X. Y., Abbar, M., Courtet, P., Naudin, J., Boucraut, J., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.010 · Cited by 42
Health Behaviors, Knowledge, Life Satisfaction, and Wellbeing in People with Mental Illness across Four Countries and Comparisons with Normative Sample
Parletta, N., Aljeesh, Y. I., & Baune, B. T. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00145 · Cited by 40
The modified outer membrane protein Amuc_1100 of Akkermansia muciniphila improves chronic stress-induced anxiety and depression-like behavior in mice
Cheng, R., Zhu, H., Yan, S., Hang, T., & Zhang, M. (2022) · Food & Function · doi:10.1039/d2fo01198k · Cited by 42
The relationship between high‐sensitivity C‐reactive protein at admission and post stroke depression: a 6‐month follow‐up study
Yang, R., Lu, B., Li, T., Du, Y., Wang, X., & Jia, Y. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4315 · Cited by 40
Can we vaccinate against depression?
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.018 · Cited by 39
The association between sarcopenia and incident of depressive symptoms: a prospective cohort study
Li, Z., Liu, B., Tong, X., Ma, Y., Bao, T., Yue, J., & Wu, C. (2024) · BMC Geriatrics · doi:10.1186/s12877-023-04653-z · Cited by 40
Body mass index moderates the relationship between C-reactive protein and depressive symptoms: evidence from the China Health and Retirement Longitudinal Study
Qin, T., Liu, W., Yin, M., Shu, C., Yan, M., Zhang, J., & Yin, P. (2017) · Scientific Reports · doi:10.1038/srep39940 · Cited by 40
Understanding depression in type 2 diabetes: a biological approach in observational studies
van Sloten, T. T., & Schram, M. T. (2018) · F1000Research · doi:10.12688/f1000research.13898.1 · Cited by 40
Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder
Czarny, P. L., Wigner, P., Strycharz, J., Świderska, E., Synowiec, E., Szatkowska, M., Śliwińska, A., Talarowska, M. E., Szemraj, J., Su, K., et al. (2019) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1588993 · Cited by 38
Inflammation and remission in older patients with depression treated with electroconvulsive therapy; findings from the MODECT study✰
Carlier, A., Berkhof, J. G., Rozing, M. P., Bouckaert, F., Sienaert, P. A., Eikelenboom, P., Veerhuis, R., Vandenbulcke, M., Berkhof, J. H., Stek, M. L., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.040 · Cited by 39
A Pilot Randomized Treatment-Controlled Trial Comparing Vitamin B6 with Broad-Spectrum Micronutrients for Premenstrual Syndrome
Retallick-Brown, H., Blampied, N. M., & Rucklidge, J. J. (2020) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2019.0305 · Cited by 38
Rapid Regulation of Depression-Associated Genes in a New Mouse Model Mimicking Interferon-α-Related Depression in Hepatitis C Virus Infection
Hoyo-Becerra, C., Liu, Z., Yao, J., Kaltwasser, B., Gerken, G., Hermann, D. M., & Schlaak, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8861-z · Cited by 38
Interactions between pro-inflammatory cytokines and statins on depression in patients with acute coronary syndrome
Kim, S., Kang, H., Bae, K., Shin, I., Hong, Y. J., Ahn, Y., Jeong, M. H., Berk, M., Yoon, J., & Kim, J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.003 · Cited by 37
Self-citation
The promise and limitations of anti-inflammatory agents for the treatment of Major Depressive Disorder
Raison, C. L. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_26 · Cited by 36
Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives
Varghese, S. M., Patel, S., Nandan, A., Jose, A., Ghosh, S., Sah, R. K., Menon, B., Athira, K. V., & Chakravarty, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04205-5 · Cited by 39
Early maternal separation leads to down-regulation of cytokine gene expression
Dimatelis, J. J., Pillay, N., Mutyaba, A. K., Russell, V. A., Daniels, W. M. U., & Stein, D. J. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9304-z · Cited by 36
Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach
Kato, T. A., & Kanba, S. (2013) · Frontiers in Psychology · doi:10.3389/fnhum.2013.00013 · Cited by 39
Preventive strategies in depression: gathering evidence for risk factors and potential interventions
Berk, M., & Jacka, F. N. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.107797 · Cited by 34
Self-citation
Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle
Nunn, A. V. W., Guy, G. W., Brodie, J., & Bell, J. D. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-87 · Cited by 34
The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations
Hiles, S. A., Baker, A., de Malmanche, T., McEvoy, M., Boyle, M., & Attia, J. (2015) · Journal of Behavioral Medicine · doi:10.1007/s10865-015-9637-2 · Cited by 32
Association of inflammatory biomarkers with depressive symptoms and cognitive decline in a community-dwelling healthy older sample: A 3-year follow-up study
Matsushima, J., Kawashima, T., Nabeta, H., Imamura, Y., Watanabe, I., Mizoguchi, Y., Kojima, N., Yamada, S., & Monji, A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.10.030 · Cited by 34
Do Statins Have Antidepressant Effects?
Köhler-Forsberg, O., Gasse, C., Berk, M., & Østergaard, S. D. (2017) · CNS Drugs · doi:10.1007/s40263-017-0422-3 · Cited by 31
Self-citation
Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey
Lee, S., Oh, S. S., Jang, S.-I., & Park, E.-C. (2019) · Scientific Reports · doi:10.1038/s41598-018-36402-3 · Cited by 29
Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort
Osimo, E. F., Stochl, J., Zammit, S., Lewis, G., Jones, P. B., & Khandaker, G. M. (2020) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2019.152143 · Cited by 30
Perivascular spaces as a marker of psychological trauma in depression: A 7‐Tesla MRI study
Ranti, D. L., Warburton, A. J., Rutland, J. W., Dullea, J. T., Markowitz, M., Smith, D., Kligler, S. K., Rutter, S., Langan, M. T., Arrighi‐Allisan, A. E., et al. (2022) · Brain and Behavior · doi:10.1002/brb3.2598 · Cited by 30
Anxiety and depressive disorders among patients with esophageal cancer in Taiwan: a nationwide population-based study
Hu, L.-Y., Ku, F., Wang, Y.-P., Shen, C.-C., Hu, Y.-W., Yeh, C.-M., Chen, P.-M., Chiang, H., Lu, T., Chen, T.-J., et al. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-014-2403-0 · Cited by 27
DNA methylation and the social gradient of osteoporotic fracture: A conceptual model
Brennan-Olsen, S. L., Page, R. S., Berk, M., Riancho, J. A., Leslie, W. D., Wilson, S. G., Saban, K. L., Janusek, L. W., Pasco, J. A., Hodge, J. M., et al. (2015) · Bone · doi:10.1016/j.bone.2015.12.015 · Cited by 32
Self-citation
Inflammation and depressive phenotypes: evidence from medical records from over 12 000 patients and brain morphology
Ironside, M., Admon, R., Maddox, S. A., Mehta, M., Douglas, S., Olson, D. P., & Pizzagalli, D. A. (2019) · Psychological Medicine · doi:10.1017/s0033291719002940 · Cited by 34
Low-grade inflammation and endothelial dysfunction predict four-year risk and course of depressive symptoms: The Maastricht study
Janssen, E. P. C. J., Köhler, S., Geraets, A. F. J., Stehouwer, C. D. A., Schaper, N. C., Sep, S. J. S., Henry, R. M. A., Kallen, C., Schalkwijk, C. G., Koster, A., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.06.013 · Cited by 33
Review of biologic and behavioral risk factors linking depression and peripheral artery disease
Ramirez, J. L., Drudi, L. M., & Grenon, S. M. (2018) · Vascular Medicine · doi:10.1177/1358863x18773161 · Cited by 33
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis
Boles, J. S., Krueger, M. E., Jernigan, J. E., Cole, C. L., Neighbarger, N. K., Huarte, O. U., & Tansey, M. G. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.007 · Cited by 31
Fish-oil supplementation decreases Indoleamine-2,3-Dioxygenase expression and increases hippocampal serotonin levels in the LPS depression model
Carabelli, B., Delattre, A. M., Waltrick, A. P. F., Araújo, G., Suchecki, D., Machado, R. B., de Souza, L. E. R., Zanata, S. M., Zanoveli, J. M., & Ferraz, A. C. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112675 · Cited by 34
A prospective investigation of dietary patterns and internalizing and externalizing mental health problems in adolescents
Trapp, G., Allen, K. L., Black, L. J., Ambrosini, G. L., Jacoby, P., Byrne, S. M., Martin, K., & Oddy, W. H. (2016) · Food Science & Nutrition · doi:10.1002/fsn3.355 · Cited by 31
The role of Neurochemicals, Stress Hormones and Immune System in the Positive Feedback Loops between Diabetes, Obesity and Depression
Wilson, J. B., Epstein, M., Lopez, B., Brown, A. K., Lutfy, K., & Friedman, T. C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1224612 · Cited by 35
Co-morbid cardiovascular disease and depression: sequence of disease onset is linked to mental but not physical self-rated health. Results from a cross-sectional, population-based study
O'Neil, A. E., Williams, E. D., Stevenson, C., Oldenburg, B. F., Berk, M., & Sanderson, K. A. (2011) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-011-0421-5 · Cited by 29
Self-citation
The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders
Karakuła‐Juchnowicz, H., Szachta, P., Opolska, A., Morylowska-Topolska, J., Gałęcka, M., Juchnowicz, D., Krukow, P., & Lasik, Z. (2014) · Nutritional Neuroscience · doi:10.1179/1476830514y.0000000158 · Cited by 31
Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder
Baek, J. H., Kim, H., D, M. F. M., Mischoulon, D., Papakostas, G. I., Nierenberg, A. A., Heo, J.-Y., & Jeon, H. J. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.3.321 · Cited by 33
Associations of number and severity of depressive episodes with C-reactive protein and Interleukin-6
Jeenger, J., Sharma, M. S., Mathur, D. M., & Amandeep, A. (2017) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2017.02.016 · Cited by 28
Partially distinct combinations of psychological, metabolic and inflammatory risk factors are prospectively associated with the onset of the subtypes of Major Depressive Disorder in midlife
Rudaz, D., Vandeleur, C. L., Gebreab, S. Z., Gholam‐Rezaee, M., Strippoli, M. F., Lasserre, A. M., Glaus, J., Castelao, E., Pistis, G., von Känel, R., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.016 · Cited by 32
Dimensions of leisure-time physical activity and risk of depression in the “Seguimiento Universidad de Navarra” (SUN) prospective cohort
Fernández‐Montero, A., Moreno‐Galarraga, L., Sánchez‐Villegas, A., Lahortiga‐Ramos, F., Ruiz‐Canela, M., Martínez‐González, M. Á., & Molero, P. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02502-6 · Cited by 29
Association of serum leptin and ghrelin with depressive symptoms in a Japanese working population: a cross-sectional study
Akter, S., Pham, N. M., Nanri, A., Kurotani, K., Kuwahara, K., Jacka, F. N., Yasuda, K., Sato, M., & Mizoue, T. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-203 · Cited by 28
Self-citation
Association between environmental tobacco smoke and depression among Korean women
Kim, N. H., Kim, H. C., Lee, J. Y., Lee, J., & Suh, I. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-007131 · Cited by 29
Whole-body cryotherapy – promising add-on treatment of depressive disorders
Rymaszewska, J., Lion, K., Szcześniak, D. M., Pawłowski, T., Pieniawska‐Śmiech, K., Kokot, I., Pawlik-Sobecka, L., Płaczkowska, S., Zabłocka, A., & Stańczykiewicz, B. (2018) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/91298 · Cited by 28
Alternate healthy eating index and risk of depression: A meta-analysis and systemematic review
Wu, P.-Y., Lin, M., & Tsai, P. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1477424 · Cited by 28
Towards precision medicine: What are the stratification hypotheses to identify homogeneous inflammatory subgroups
Ioannou, M., Foiselle, M., Mallet, J., Stam, E. L., Godin, O., Dubertret, C., Terro, E., Sommer, I. E., Haarman, B. C. M., Leboyer, M., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.001 · Cited by 28
Systemic low-grade inflammation and subsequent depressive symptoms: Is there a mediating role of physical activity?
Frank, P., Kaushal, A., Poole, L., Lawes, S., Chalder, T., & Cadar, D. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.017 · Cited by 29
Psychosocial Resilience to Inflammation-Associated Depression: A Prospective Study of Breast-Cancer Survivors
Manigault, A. W., Kuhlman, K. R., Irwin, M. R., Cole, S. W., Ganz, P. A., Crespi, C. M., & Bower, J. E. (2022) · Psychological Science · doi:10.1177/09567976221079633 · Cited by 29
Intraoperative Low-Dose S-Ketamine Reduces Depressive Symptoms in Patients with Crohn’s Disease Undergoing Bowel Resection: A Randomized Controlled Trial
Zhang, Z., Yuan, Z., Zhang, W., Yi-bo, W., Cui, L.-Y., Lu, B.-X., Zhang, J., Gong, J.-F., Qing, J., Cheng, H., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12031152 · Cited by 27
Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder
Czarny, P. L., Kwiatkowski, D., Toma, M. M., Gałecki, P., Orzechowska, A., Bobińska, K., Bielecka-Kowalska, A., Szemraj, J., Berk, M., Anderson, G., et al. (2016) · Medical Science Monitor · doi:10.12659/msm.898091 · Cited by 28
Self-citation
Depression with inflammation: longitudinal analysis of a proposed depressive subtype in community dwelling older adults
Gallagher, D., Kiss, A., Lanctôt, K. L., & Herrmann, N. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4645 · Cited by 27
Association between depression and enterovirus infection
Liao, Y., Hsieh, M., Yang, Y., Wang, Y.-C., Tsai, C., Chen, V. C., & Gossop, M. (2017) · Medicine · doi:10.1097/md.0000000000005983 · Cited by 27
Serum phosphatidylinositol as a biomarker for bipolar disorder liability
Knowles, E. E. M., Meikle, P. J., Huynh, K., Göring, H. H. H., Olvera, R. L., Mathias, S. R., Duggirala, R., Almasy, L. A., Blangero, J., Curran, J. E., et al. (2017) · Bipolar Disorders · doi:10.1111/bdi.12468 · Cited by 30
Inflammation associated with coronary heart disease predicts onset of depression in a three-year prospective follow-up: A preliminary study
Sforzini, L., Pariante, C. M., Palacios, J. E., Tylee, A. T., Carvalho, L. A., Viganò, C. A., & Nikkheslat, N. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.023 · Cited by 26
Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective
Kırlıoglu, S. S., & Balcıoğlu, Y. H. (2020) · Psychiatry Investigation · doi:10.30773/pi.2020.0129 · Cited by 28
Elevated Serum Levels of Neopterin at Admission Predicts Depression After Acute Ischemic Stroke: a 6-Month Follow-Up Study
Tang, C., Zhang, Y., Wang, W., Li, W., & Shi, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9220-4 · Cited by 26
Lack of association between depression and C-reactive protein level in the baseline of Longitudinal Study of Adult Health (ELSA-Brasil)
de Menezes, S. T., de Figueiredo, R. C., Goulart, A. C., Nunes, M. A., M. Benseñor, I., Viana, M. C., & Barreto, S. M. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.10.046 · Cited by 25
Association between hs-CRP and depressive symptoms: a cross-sectional study
Ji, Y., Wang, J., Chen, H., Li, J., & Chen, M. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1339208 · Cited by 27
Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder
Gustafsson, A., Ventorp, F., Wisén, A. G. M., Ohlsson, L., Ljunggren, L., & Westrin, Å. (2017) · Biomarker Insights · doi:10.1177/1177271917704193 · Cited by 25
Risk of Depressive Disorder following Non-Alcoholic Cirrhosis: A Nationwide Population-Based Study
Perng, C., Shen, C., Hu, L.-Y., Yeh, C., Chen, M., Tsai, C.-F., Chiang, H., Hung, Y., Su, V. Y., Hu, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088721 · Cited by 25
Clinical Burden of Concomitant Joint Disease in Psoriasis: A US-Linked Claims and Electronic Health Records Database Analysis
Skornicki, M., Prince, P., Suruki, R., Lee, E. S., & Louder, A. M. (2021) · Advances in Therapy · doi:10.1007/s12325-021-01698-7 · Cited by 24
Musculoskeletal deterioration in men accompanies increases in body fat
Pasco, J. A., Gould, H., Brennan-Olsen, S. L., Nicholson, G. C., & Kotowicz, M. A. (2013) · Obesity · doi:10.1002/oby.20496 · Cited by 24
Self-citation
ASPREE-D: Aspirin for the prevention of depression in the elderly
Berk, M., Woods, R. L., Nelson, M. R., Shah, R. C., Reid, C. M., Storey, E., Fitzgerald, S. M., Lockery, J. E., Wolfe, R. S., Mohebbi, M., et al. (2016) · International Psychogeriatrics · doi:10.1017/s104161021600079x · Cited by 26
Self-citation
Secondhand Smoke Exposure and Depressive Symptoms among Korean Adolescents: JS High School Study
Kim, N. H., Park, J. H., Choi, D. P., Lee, J. Y., & Kim, H. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168754 · Cited by 24
Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds
Hadian, Y., Fregoso, D. R., Nguyen, C., Bagood, M. D., Dahle, S. E., Gareau, M. G., & Isseroff, R. R. (2020) · Wound Repair and Regeneration · doi:10.1111/wrr.12800 · Cited by 26
Association between high-sensitivity C-reactive protein levels and depression: Moderation by age, sex, obesity, and aerobic physical activity
Cho, S. H., Lim, J., Lee, J., Lee, J. S., Jeong, H., Lee, M., Ko, Y., Han, C., Ham, B., & Han, K. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.040 · Cited by 24
Interleukin-8 and Depressive Responses to an Inflammatory Challenge: Secondary Analysis of a Randomized Controlled Trial
Kruse, J. L., Boyle, C. C., Olmstead, R., Breen, E. C., Tye, S. J., Eisenberger, N. I., & Irwin, M. R. (2022) · Scientific Reports · doi:10.1038/s41598-022-16364-3 · Cited by 22
Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics
Bajaj, S., & Mahesh, R. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09170-1 · Cited by 25
Omega-3 Fatty Acids as a Treatment for Pediatric Depression. A Phase III, 36 Weeks, Multi-Center, Double-Blind, Placebo-Controlled Randomized Superiority Study
Häberling, I. S., Berger, G. E., Schmeck, K., Held, U., & Walitza, S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00863 · Cited by 25
Prospective associations between hsCRP and GlycA inflammatory biomarkers and depression: The Brazilian longitudinal study of adult health (ELSA-Brasil)
Brunoni, A. R., Salum, G. A., Hoffmann, M. S., Goulart, A. C., Barreto, S. M., Canhada, S., Carvalho, A. F., Koyanagi, A., Cálice-Silva, V., Lotufo, P. A., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.074 · Cited by 22
Vulnerability to inflammation-related depressive symptoms: Moderation by stress in women with breast cancer
Manigault, A. W., Kuhlman, K. R., Irwin, M. R., Cole, S. W., Ganz, P. A., Crespi, C. M., & Bower, J. E. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.004 · Cited by 22
Association between Sleep Duration and Depression among the Elderly Population in China
Zhong, W., Wang, F., Chi, L., Yang, X., Yang, Y., & Wang, Z. (2021) · Experimental Aging Research · doi:10.1080/0361073x.2021.2008755 · Cited by 22
The Relationship between Mental Disorders and the COVID-19 Pandemic—Course, Risk Factors, and Potential Consequences
Markiewicz-Gospodarek, A., Górska, A., Markiewicz, R., Chilimoniuk, Z., Czeczelewski, M., Baj, J., Maciejewski, R., & Masiak, J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159573 · Cited by 23
A practical nutritional guide for the management of sleep disturbances in menopause
Laudisio, D., Barrea, L., Pugliese, G., Aprano, S., Castellucci, B., Savastano, S., Colao, A., & Muscogiuri, G. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1851658 · Cited by 24
Potential biomarkers of major depression diagnosis and chronicity
Galvão, A. C. D. M., de Almeida, R. N., de Sousa, G. M., Leocádio-Miguel, M. A., Palhano-Fontes, F., de Araújo, D. B., Soares, B. L., Maia‐de‐Oliveira, J. P., Nunes, E. A., Hallak, J. E. C., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257251 · Cited by 25
Biomarkers of Postpartum Depression: A Narrative Review
Modzelewski, S., Oracz, A. J., Iłendo, K., Sokół, A., & Waszkiewicz, N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206519 · Cited by 26
Metabolic Syndrome and Elevated C-Reactive Protein Levels in Elderly Patients With Newly Diagnosed Depression
Park, S., Joo, Y. H., McIntyre, R. S., & Kim, B. (2013) · Psychosomatics · doi:10.1016/j.psym.2013.12.010 · Cited by 23

Authors: Pasco, J. A., Nicholson, G. C., Williams, L. J., Jacka, F. N., Henry, M. J., Kotowicz, M. A., Schneider, H. G., Leonard, B. E., & Berk, M.
Affiliations: Barwon Health (AU)
The Alfred Hospital (AU)
Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Pasco, Julie A.
ORCID: Pasco, Julie A.
Nicholson, Geoffrey C.
Williams, Lana J.
Jacka, Felice N.
Kotowicz, Mark A.
Schneider, Hans G.
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2010-11
Volume: 197
Issue: 5
Pages: 372-377
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.109.076430
OpenAlex: W2004252086
Cited by: 321
References: 55
Citations by year: 2026: 5 · 2025: 14 · 2024: 21 · 2023: 21 · 2022: 20 · 2021: 16 · 2020: 31 · 2019: 25 · 2018: 13 · 2017: 22 · 2016: 32 · 2015: 24 · 2014: 22 · 2013: 22 · 2012: 19
FWCI: 6.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 2619 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
Arrow@dit (Dublin Institute of Technology) (submittedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
Deakin Research Online (Deakin University) (submittedVersion)
Figshare (submittedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc)
Research Repository UCD (University College Dublin) (cc-by-nc)
Funders: Medical Research Council
National Health and Medical Research Council
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: high-sensitivity C-reactive protein, major depressive disorder, systemic inflammation, risk factors for depression, women, inflammatory markers, depression pathophysiology, nonsteroidal anti-inflammatory drugs
MeSH terms: Adult, Aged, Aged, 80 and over, Body Weight, C-Reactive Protein, Major Depressive Disorder, Epidemiologic Methods, Female, Humans, Inflammation, Life Style, Middle Aged, Body Mass Index, Age of Onset, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association of high-sensitivity C-reactive protein with de novo major depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks