Cited by 321Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

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Association of high-sensitivity C-reactive protein with de novo major depression

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Pasco, Julie A., Nicholson, Geoffrey C., Williams, Lana J., Jacka, Felice N., Henry, Margaret J., Kotowicz, Mark A., Schneider, Hans G., Leonard, Brian E., Berk, Michael·2010·British Journal of Psychiatry

DOI 10.1192/bjp.bp.109.076430

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Abstract

Background: Although there is cross-sectional evidence that changes in the immune system contribute to the pathophysiology of depression, longitudinal data capable of elucidating cause and effect relationships are lacking. Aims: We aimed to determine whether subclinical systemic inflammation, as measured by serum high-sensitivity C-reactive protein (hsCRP) concentration, is associated with an increased risk of de novo major depressive disorder. Method: Major depressive disorder was diagnosed using a clinical interview (SCID–I/NP). This is a retrospective cohort study; from a population-based sample of 1494 randomly selected women recruited at baseline during the period 1994–7, 822 were followed for a decade and provided measures of both exposure and outcome. Of these women, 644 (aged 20–84 years) had no prior history of depression at baseline and were eligible for analysis. Results: During 5827 person-years of follow-up, 48 cases of de novo major depressive disorder were identified. The hazard ratio (HR) for depression increased by 44% for each standard deviation increase in log-transformed hsCRP (ln-hsCRP) (HR = 1.44, 95% CI 1.04–1.99), after adjusting for weight, smoking and use of non-steroidal anti-inflammatory drugs. Further adjustment for other lifestyle factors, medications and comorbidity failed to explain the observed increased risk for depression. Conclusions: Serum hsCRP is an independent risk marker for de novo major depressive disorder in women. This supports an aetiological role for inflammatory activity in the pathophysiology of depression.

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Authors: Pasco, J. A., Nicholson, G. C., Williams, L. J., Jacka, F. N., Henry, M. J., Kotowicz, M. A., Schneider, H. G., Leonard, B. E., & Berk, M.
Affiliations: Barwon Health (AU)
The Alfred Hospital (AU)
Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Pasco, Julie A.
ORCID: Pasco, Julie A.
Nicholson, Geoffrey C.
Williams, Lana J.
Jacka, Felice N.
Kotowicz, Mark A.
Schneider, Hans G.
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2010-11
Volume: 197
Issue: 5
Pages: 372-377
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.109.076430
OpenAlex: W2004252086
Cited by: 321
References: 55
Citations by year: 2026: 5 · 2025: 14 · 2024: 21 · 2023: 21 · 2022: 20 · 2021: 16 · 2020: 31 · 2019: 25 · 2018: 13 · 2017: 22 · 2016: 32 · 2015: 24 · 2014: 22 · 2013: 22 · 2012: 19
FWCI: 6.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 2619 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
Arrow@dit (Dublin Institute of Technology) (submittedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
Deakin Research Online (Deakin University) (submittedVersion)
Figshare (submittedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc)
Research Repository UCD (University College Dublin) (cc-by-nc)
Funders: Medical Research Council
National Health and Medical Research Council
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: high-sensitivity C-reactive protein, major depressive disorder, systemic inflammation, risk factors for depression, women, inflammatory markers, depression pathophysiology, nonsteroidal anti-inflammatory drugs
MeSH terms: Adult, Aged, Aged, 80 and over, Body Weight, C-Reactive Protein, Major Depressive Disorder, Epidemiologic Methods, Female, Humans, Inflammation, Life Style, Middle Aged, Body Mass Index, Age of Onset, Young Adult

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Association of high-sensitivity C-reactive protein with de novo major depression

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