Lack of association between depression and C-reactive protein level in the baseline of Longitudinal Study of Adult Health (ELSA-Brasil)
Abstract
BACKGROUND: Depression has been linked to increased levels of inflammatory markers in clinical studies, but results from general population samples are inconsistent. We aimed to investigate whether depression was associated with serum CRP levels in a cross-sectional analysis of a large cohort from a middle-income country. METHODS: We analyzed baseline data from 14,821 participants (35-74 years) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Current depression (last 7 days) was assessed by the Clinical Interview Schedule-Revised (CIS-R). Because individuals on antidepressants could be negative on CIS-R due to their therapeutic effect, the explanatory variable had three categories: (1) negative on CIS-R and not using antidepressant (reference); (2) negative on CIS-R but using antidepressant; (3) positive on CIS-R with/without antidepressant use. Associations with CRP were investigated by general linear model (GLM). RESULTS: After adjustments for confounders, neither current depression, nor antidepressant use was statistically associated with elevated CRP levels. Additionally, analyzes stratified by gender, type and severity of depression did not change the results. LIMITATIONS: The reference group in our analysis might include participants with a lifetime history of depression. Additionally, the exclusion of questions on weight fluctuation and appetite from the CIS-R applied in ELSA-Brasil may have slightly underestimated the prevalence of depression, as well as limited our ability to assess the presence of somatic symptoms. CONCLUSION: This study found no association between current depression, use of antidepressants, and serum CRP levels.
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In 14,821 Brazilian participants, no association between serum CRP levels, current depression, and use of antidepressants was found.
“A large cross-sectional study conducted by Menezes et al., 2017, including 14,821 Brazilian participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), investigated the possible association between CRP levels and depression [68]. Current depression was assessed by Clinical Interview Schedule-Revised (CIS-R) and participants were divided into three groups: (a) negative at CIS-R”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [68]
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- Authors
- de Menezes, S. T., de Figueiredo, R. C., Goulart, A. C., Nunes, M. A., M. Benseñor, I., Viana, M. C., & Barreto, S. M.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Barreto, Sandhi Maria
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 208
- Pages
- 448-454
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2544120441
- Cited by
- 25
- References
- 52
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Brazilian Ministry of Health
- Ministry of Science, Technology and Innovation (01 06 0010.00, 01 06 0212.00, 01 06 0300.00, 01 06 0278.00, 01 06 0115.00, 01 06 0071.00)
- National Research Council (300159/99-4)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, C-reactive protein, inflammatory markers, antidepressant use, serum CRP levels, middle-income countries, general population, ELSA-Brasil, somatic symptoms
- MeSH terms
- Adult, Antidepressive Agents, Brazil, C-Reactive Protein, Cross-Sectional Studies, Depression, Female, Health Status, Humans, Interview, Psychological, Longitudinal Studies, Male, Middle Aged, Socioeconomic Factors, Cohort Studies, Biomarkers, Prevalence
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