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Cited by 65

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

Hirsch-Reinshagen, Veronica, Donkin, James, Stukas, Sophie, Chan, Jennifer, Wilkinson, Anna, Fan, Jianjia, Parks, John S., Kuivenhoven, Jan Albert, Lu¨tjohann, Dieter, Pritchard, Haydn, Wellington, Cheryl L.·2009·Journal of Lipid Research
DOI 10.1194/jlr.m800584-jlr200
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  • Maturation of ApoE secreted from astrocytes from discoidal to spherical particles depends on cholesterol esterification by lecithin-cholesterol acyltransferase (LCAT), which is also secreted by astrocytes.

    “Maturation of ApoE secreted from astrocytes from discoidal to spherical particles depends on cholesterol esterification by lecithin–cholesterol acyltransferase (LCAT), which is also secreted by astrocytes (Fig. 1E) [71].”

    From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [71]

    The Abstract says glial cells secrete apoE-containing lipoproteins initially as discs, astrocytes produce LCAT, and that LCAT esterifies cholesterol on those particles. The discussion of particle size (Fig. 5A) shows LCAT-dependent changes consistent with maturation, and the paper describes mature CSF particles as spherical. It does not directly establish that LCAT-dependent esterification causes the specific discoidal-to-spherical shape change asserted in the claim. (LLM, conf=0.84)

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  • LCAT is produced by astrocytes.

    “previous reports reporting that LCAT is produced by astrocytes (93).”

    From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [93]

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Research works printed but not linked: 39

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Metadata

Authors
Hirsch-Reinshagen, V., Donkin, J., Stukas, S., Chan, J., Wilkinson, A., Fan, J., Parks, J. S., Kuivenhoven, J. A., Lu¨tjohann, D., Pritchard, H., & Wellington, C. L.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2009-05
Volume
50
Issue
5
Pages
885-893
ISSN
0022-2275
DOI
10.1194/jlr.m800584-jlr200
Cited by
65
References
4
Language
en
Licence

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