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ELOVL2: Not just a biomarker of aging

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Advances in Analyzing the Breast Cancer Lipidome and Its Relevance to Disease Progression and Treatment

Ward, A. V., Anderson, S. M., & Sartorius, C. A. (2021) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-021-09505-3 · Cited by 32 · see citing works

Prevalence and clinicoradiological features of spinocerebellar ataxia type 34 in a Japanese ataxia cohort

Ozaki, K., Ansai, A., Nobuhara, K., Araki, T., Kubodera, T., Ishii, T., Higashi, M., Sato, N. J., Soga, K., Mizusawa, H., et al. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.05.019 · Cited by 31 · see citing works

Membrane‐type frizzled‐related protein regulates lipidome and transcription for photoreceptor function

Kautzmann, M.-A. I., Gordon, W. C., Jun, B., Do, K. V., Matherne, B., Fang, Z., & Bazan, N. G. (2019) · The FASEB Journal · doi:10.1096/fj.201902359r · Cited by 30 · see citing works

Inherited disorders of complex lipid metabolism: A clinical review

Xiao, C., Rossignol, F., Vaz, F. M., & Ferreira, C. R. (2021) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12369 · Cited by 31 · see citing works

Effects on vesicular transport pathways at the late endosome in cells with limited very long-chain fatty acids

Obara, K., Kojima, R., & Kihara, A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m034678 · Cited by 31 · see citing works

Serum levels of lipid metabolites in age‐related macular degeneration

Orban, T., Johnson, W. M., Dong, Z., Maeda, T., Maeda, A., Sakai, T., Tsuneoka, H., Mieyal, J. J., & Palczewski, K. (2015) · The FASEB Journal · doi:10.1096/fj.15-275289 · Cited by 29 · see citing works

Isolation and Characterization of the Diatom Phaeodactylum Δ5-Elongase Gene for Transgenic LC-PUFA Production in Pichia pastoris

Jiang, M., Guo, B., Wan, X., Gong, Y., Zhang, Y., & Hu, C. (2014) · Marine Drugs · doi:10.3390/md12031317 · Cited by 29 · see citing works

Cloning and functional characterization of fads2 desaturase and elovl5 elongase from Japanese flounder Paralichthys olivaceus

Kabeya, N., Chiba, M., Haga, Y., Satoh, S., & Yoshizaki, G. (2017) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2017.09.002 · Cited by 29 · see citing works

Human Breast Milk: The Key Role in the Maturation of Immune, Gastrointestinal and Central Nervous Systems: A Narrative Review

Dimitroglou, M., Iliodromiti, Z., Christou, E., Volaki, P., Petropoulou, C., Sokou, R., Boutsikou, Τ., & Iacovidou, N. M. (2022) · Diagnostics · doi:10.3390/diagnostics12092208 · Cited by 28 · see citing works

Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity

Logan, S., Agbaga, M., Chan, M. D., Brush, R. S., & Anderson, R. E. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m045443 · Cited by 28 · see citing works

Overview of how N32 and N34 elovanoids sustain sight by protecting retinal pigment epithelial cells and photoreceptors

Bazan, N. G. (2020) · Journal of Lipid Research · doi:10.1194/jlr.tr120001137 · Cited by 26 · see citing works

Two Modes of Regulation of the Fatty Acid Elongase ELOVL6 by the 3-Ketoacyl-CoA Reductase KAR in the Fatty Acid Elongation Cycle

Naganuma, T., & Kihara, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101823 · Cited by 27 · see citing works

Hetero-oligomeric interactions of an ELOVL4 mutant protein: implications in the molecular mechanism of Stargardt-3 macular dystrophy.

Okuda, A., Naganuma, T., Ohno, Y., Abe, K., Yamagata, M., Igarashi, Y., & Kihara, A. (2010) · PubMed Central · Cited by 26 · see citing works

The ELOVL proteins: Very and ultra long-chain fatty acids at the crossroads between metabolic and neurodegenerative disorders.

Ferrero, E., Vaz, F. M., Cheillan, D., Brusco, A., & Marelli, C. (2025) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2025.109050 · Cited by 24 · see citing works

Factors Differentiating the Antioxidant Activity of Macular Xanthophylls in the Human Eye Retina

Widomska, J., Gruszecki, W. I., & Subczynski, W. K. (2021) · Antioxidants · doi:10.3390/antiox10040601 · Cited by 25 · see citing works

Oral Metformin Inhibits Choroidal Neovascularization by Modulating the Gut-Retina Axis

Zhang, J. Y., Xiao, J. F., Xie, B., Barba, H., Boachie-Mensah, M., Shah, R. N., Nadeem, U., Spedale, M., Dylla, N. P., Lin, H., et al. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.15.21 · Cited by 25 · see citing works

Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision

Rajagopal, R., Zhang, S., Wei, X., Doggett, T. A., Adak, S., Enright, J. M., Shah, V., Ling, G., Chen, S., Yoshino, J., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97076 · Cited by 23 · see citing works

Understanding the Roles of Very-Long-Chain Polyunsaturated Fatty Acids (VLC-PUFAs) in Eye Health

Nwagbo, U., & Bernstein, P. S. (2023) · Nutrients · doi:10.3390/nu15143096 · Cited by 24 · see citing works

Identification of very long-chain (>C24) fatty acid methyl esters using gas chromatography coupled to quadrupole/time-of-flight mass spectrometry with atmospheric pressure chemical ionization source

Garlito, B., Portolés, T., Niessen, W. M. A., Navarro, J. C., Hontoria, F., Monroig, Ó., Varó, I., & Serrano, R. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.11.001 · Cited by 23 · see citing works

Peroxisomal Disorders and Their Mouse Models Point to Essential Roles of Peroxisomes for Retinal Integrity

Das, Y., Swinkels, D., & Baes, M. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084101 · Cited by 24 · see citing works

The catadromous teleost Anguilla japonica has a complete enzymatic repertoire for the biosynthesis of docosahexaenoic acid from α-linolenic acid: Cloning and functional characterization of an Elovl2 elongase

Xu, W., Wang, S., You, C., Zhang, Y., Monroig, Ó., Tocher, D. R., & Li, Y. (2019) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2019.110373 · Cited by 23 · see citing works

Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Marine Gammarids: Molecular Cloning and Functional Characterisation of Three Fatty Acyl Elongases

Ribes‐Navarro, A., Navarro, J. C., Hontoria, F., Kabeya, N., Standal, I. B., Evjemo, J. O., & Monroig, Ó. (2021) · Marine Drugs · doi:10.3390/md19040226 · Cited by 24 · see citing works

Bioavailability and spatial distribution of fatty acids in the rat retina after dietary omega-3 supplementation

Vidal, E., Jun, B., Gordon, W. C., Maire, M., Martine, L., Gregoire, S., Khoury, S., Cabaret, S., Berdeaux, O., Acar, N., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120001057 · Cited by 22 · see citing works

Molecular and Functional Characterization of Elovl4 Genes in Sparus aurata and Solea senegalensis Pointing to a Critical Role in Very Long-Chain (>C24) Fatty Acid Synthesis during Early Neural Development of Fish

Morais, S., Torres-Rodríguez, M., Hontoria, F., Monroig, Ó., Varó, I., Agulleiro, M. J., & Navarro, J. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103514 · Cited by 22 · see citing works

An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice

Olivares‐González, L., Velasco, S., Gallego, I., Esteban‐Medina, M., Puras, G., Loucera, C., Martínez‐Romero, A., Peña-Chilet, M., Pedraz, J. L., & Rodrigo, R. (2022) · Antioxidants · doi:10.3390/antiox12010098 · Cited by 21 · see citing works

The Transcriptional Factor PPARαb Positively Regulates Elovl5 Elongase in Golden Pompano Trachinotus ovatus (Linnaeus 1758)

Zhu, K.-C., Ling, S., Zhao, C.-P., Guo, H., Zhang, N., Guo, L. J., Liu, B.-S., Jiang, S., & Zhang, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01340 · Cited by 21 · see citing works

Analysis of Lipid Peroxidation by UPLC-MS/MS and Retinoprotective Effects of the Natural Polyphenol Pterostilbene

Torres-Cuevas, I., Millán, I., Asensi, M. A., Vento, M., Oger, C., Galano, J., Durand, T., & Ortega, Á. (2021) · Antioxidants · doi:10.3390/antiox10020168 · Cited by 20 · see citing works

Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice

Das, Y., Swinkels, D., Kocherlakota, S., Vinckier, S., Vaz, F. M., Wever, E. J. M., van Kampen, A. H. C., Jun, B., Do, K. V., Moons, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.632930 · Cited by 20 · see citing works

Cardiac dysfunction affects eye development and vision by reducing supply of lipids in fish

Sørhus, E., Meier, S., Donald, C. E., Furmanek, T., Edvardsen, R. B., & Lie, K. K. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.149460 · Cited by 20 · see citing works

Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations

Chen, C. T., Shao, Z., & Fu, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.982564 · Cited by 19 · see citing works

Inducible RPE-specific GPX4 knockout causes oxidative stress and retinal degeneration with features of age-related macular degeneration

Wojciechowski, A. M., Bell, B. A., Song, Y., Anderson, B. D., Conomikes, A., Petruconis, C. R., & Dunaief, J. L. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110028 · Cited by 20 · see citing works

Molecular Species of Phospholipids with Very Long Chain Fatty Acids in Skin Fibroblasts of Zellweger Syndrome

Hama, K., Nagai, T., 西澤, 千., Ikeda, K., Morita, M., Satoh, N., Nakanishi, H., Imanaka, T., Shimozawa, N., Taguchi, R., et al. (2013) · Lipids · doi:10.1007/s11745-013-3848-5 · Cited by 20 · see citing works

Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila

Gordon, H. B., Valdez, L., & Letsou, A. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031286 · Cited by 19 · see citing works

Evaluating Ultra-long-Chain Fatty Acids as Biomarkers of Colorectal Cancer Risk

Perttula, K., Edmands, W. M. B., Grigoryan, H., Cai, X., Iavarone, A. T., Gunter, M. J., Naccarati, A., Polidoro, S., Hubbard, A., Vineis, P., et al. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0204 · Cited by 18 · see citing works

Bioengineered Plants Can Be an Alternative Source of Omega-3 Fatty Acids for Human Health

Lakra, N., Mahmood, S., Marwal, A., M., S. N., & Anwar, K. (2019) · Springer eBooks · doi:10.1007/978-3-030-03344-6_16 · Cited by 18 · see citing works

Expression of genes related to long-chain (C18–22) and very long-chain (>C24) fatty acid biosynthesis in gilthead seabream (Sparus aurata) and Senegalese sole (Solea senegalensis) larvae: investigating early ontogeny and nutritional regulation

Torres-Rodríguez, M., Navarro, J. C., Varó, I., Agulleiro, M. J., Morais, S., Monroig, Ó., & Hontoria, F. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.734949 · Cited by 18 · see citing works

Nutritional regulation of genes responsible for long-chain (C20-24) and very long-chain (>C24) polyunsaturated fatty acid biosynthesis in post-larvae of gilthead seabream (Sparus aurata) and Senegalese sole (Solea senegalensis)

Torres-Rodríguez, M., Navarro, J. C., Varó, I., Monroig, Ó., & Hontoria, F. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735314 · Cited by 18 · see citing works

The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration

Agbaga, M., Stiles, M. A., Brush, R. S., Sullivan, M. T., Machalinski, A. H., Jones, K. L., Anderson, R. E., & Sherry, D. M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02052-8 · Cited by 18 · see citing works

Essential Role of ELOVL4 Protein in Very Long Chain Fatty Acid Synthesis and Retinal Function

Harkewicz, R., Du, H., Tong, Z., Alkuraya, H., Bedell, M., Sun, W., Wang, X., Hsu, Y.-H., Esteve-Rudd, J., Hughes, G., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.256073 · Cited by 93 · see citing works

Current Progress in Deciphering Importance of VLC-PUFA in the Retina

Bennett, L. D., & Anderson, R. E. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-17121-0_20 · Cited by 11 · see citing works

ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3

Yu, M., Benham, A., Logan, S., Brush, R. S., Mandal, M. N. A., Anderson, R. E., & Agbaga, M. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m021386 · Cited by 57 · see citing works

Very long-chain fatty acids support synaptic structure and function in the mammalian retina

Hopiavuori, B. R., Bennett, L. D., Brush, R. S., Hook, M. J. V., Thoreson, W. B., & Anderson, R. E. (2015) · OCL · doi:10.1051/ocl/2015056 · Cited by 9 · see citing works

Very-long-chain polyunsaturated fatty acids in the retina: analysis and clinical relevance in physiological and pathological conditions

Berdeaux, O., & Acar, N. (2011) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2011.0406 · Cited by 4 · see citing works