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The LDL modification hypothesis of atherogenesis: an update

Steinberg, Daniel·2009·Journal of Lipid Research

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Research works printed but not linked: 46

  1. Brown, 1983, Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis, Annu. Rev. Biochem., 52, 223, 10.1146/annurev.bi.52.070183.001255 · DOI · Paper page
  2. Kodama, 1988, Purification and characterization of a bovine acetyl low density lipoprotein receptor, Proc. Natl. Acad. Sci. USA., 85, 9238, 10.1073/pnas.85.23.9238 · DOI · Paper page
  3. Henriksen, 1981, Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins, Proc. Natl. Acad. Sci. USA., 78, 6499, 10.1073/pnas.78.10.6499 · DOI · Paper page
  4. Hessler, 1983, Lipoprotein oxidation and lipoprotein-induced cytotoxicity, Arteriosclerosis., 3, 215, 10.1161/01.ATV.3.3.215 · DOI · Paper page
  5. Steinbrecher, 1984, Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids, Proc. Natl. Acad. Sci. USA., 81, 3883, 10.1073/pnas.81.12.3883 · DOI · Paper page
  6. Steinberg, 1989, Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity, N. Engl. J. Med., 320, 915
  7. Chisolm, 2000, The oxidative modification hypothesis of atherogenesis: an overview, Free Radic. Biol. Med., 28, 1815, 10.1016/S0891-5849(00)00344-0 · DOI · Paper page
  8. Navab, 1996, The yin and yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture, Arterioscler. Thromb. Vasc. Biol., 16, 831, 10.1161/01.ATV.16.7.831 · DOI · Paper page
  9. Stocker, 2004, Role of oxidative modifications in atherosclerosis, Physiol. Rev., 84, 1381, 10.1152/physrev.00047.2003 · DOI · Paper page
  10. Glass, 2001, Atherosclerosis. the road ahead, Cell., 104, 503, 10.1016/S0092-8674(01)00238-0 · DOI · Paper page
  11. Boullier, 2001, Scavenger receptors, oxidized LDL, and atherosclerosis, Ann. N. Y. Acad. Sci., 947, 214, 10.1111/j.1749-6632.2001.tb03943.x · DOI · Paper page
  12. Hansson, 2001, Immune mechanisms in atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 21, 1876, 10.1161/hq1201.100220 · DOI · Paper page
  13. Berliner, 1996, The role of oxidized lipoproteins in atherogenesis, Free Radic. Biol. Med., 20, 707, 10.1016/0891-5849(95)02173-6 · DOI · Paper page
  14. Steinberg, 1990, Lipoproteins and atherogenesis. Current concepts, JAMA., 264, 3047, 10.1001/jama.1990.03450230083034 · doi:10.1001/jama.1990.03450230083034
  15. Kruth, 2005, Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein, J. Biol. Chem., 280, 2352, 10.1074/jbc.M407167200 · DOI · Paper page
  16. Zhao, 2006, Constitutive receptor-independent low density lipoprotein uptake and cholesterol accumulation by macrophages differentiated from human monocytes with macrophage-colony-stimulating factor (M-CSF), J. Biol. Chem., 281, 15757, 10.1074/jbc.M510714200 · DOI
  17. Yla¨-Herttuala, 1989, Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man, J. Clin. Invest., 84, 1086, 10.1172/JCI114271 · DOI · Paper page
  18. Leitinger, 2005, Oxidized phospholipids as triggers of inflammation in atherosclerosis, Mol. Nutr. Food Res., 49, 1063, 10.1002/mnfr.200500086 · DOI
  19. Witztum, 1998, Oxidized phospholipids and isoprostanes in atherosclerosis, Curr. Opin. Lipidol., 9, 441, 10.1097/00041433-199810000-00008 · DOI · Paper page
  20. Zhao, 2005, 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway, Prostaglandins Other Lipid Mediat., 78, 185, 10.1016/j.prostaglandins.2005.07.003 · DOI
  21. Cyrus, 2001, Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice, Circulation., 103, 2277, 10.1161/01.CIR.103.18.2277 · DOI · Paper page
  22. George, 2001, 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice, Circulation., 104, 1646, 10.1161/hc3901.095772 · DOI · Paper page
  23. Zhao, 2002, Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia, J. Biol. Chem., 277, 35350, 10.1074/jbc.M205738200 · DOI
  24. Huo, 2004, Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice, Circulation., 110, 2024, 10.1161/01.CIR.0000143628.37680.F6 · DOI · Paper page
  25. Harats, 2000, Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice, Arterioscler. Thromb. Vasc. Biol., 20, 2100, 10.1161/01.ATV.20.9.2100 · DOI · Paper page
  26. Kunjathoor, 2002, Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages, J. Biol. Chem., 277, 49982, 10.1074/jbc.M209649200 · DOI · Paper page
  27. Shih, 2000, Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis, J. Biol. Chem., 275, 17527, 10.1074/jbc.M910376199 · DOI · Paper page
  28. Shen, 1996, Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development, J. Clin. Invest., 98, 2201, 10.1172/JCI119029 · DOI · Paper page
  29. Kuhn, 1997, The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions, Curr. Opin. Lipidol., 8, 111, 10.1097/00041433-199704000-00009 · DOI
  30. Radmark, 2007, 5-lipoxygenase: regulation and possible involvement in atherosclerosis, Prostaglandins Other Lipid Mediat., 83, 162, 10.1016/j.prostaglandins.2007.01.003 · DOI
  31. Aiello, 2002, Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice, Arterioscler. Thromb. Vasc. Biol., 22, 443, 10.1161/hq0302.105593 · DOI · Paper page
  32. Cao, 2009, Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice, Atherosclerosis, 10.1016/j.atherosclerosis.2008.07.045 · DOI
  33. Harrison, 2003, Role of oxidative stress in atherosclerosis, Am. J. Cardiol., 91, 7A, 10.1016/S0002-9149(02)03144-2 · DOI · Paper page
  34. Moore, 2005, Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice, J. Clin. Invest., 115, 2192, 10.1172/JCI24061 · DOI · Paper page
  35. Witztum, 2005, You are right too!, J. Clin. Invest., 115, 2072, 10.1172/JCI26130 · DOI
  36. Kris-Etherton, 2004, Antioxidant vitamin supplements and cardiovascular disease, Circulation., 110, 637, 10.1161/01.CIR.0000137822.39831.F1 · DOI · Paper page
  37. Steinberg, 2002, Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?, Circulation., 105, 2107, 10.1161/01.CIR.0000014762.06201.06 · DOI · Paper page
  38. Sasahara, 1994, Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. I. Is the extent of atherosclerosis related to resistance of LDL to oxidation?, J. Clin. Invest., 94, 155, 10.1172/JCI117301 · DOI · Paper page
  39. Sundell, 2003, AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent, J. Pharmacol. Exp. Ther., 305, 1116, 10.1124/jpet.102.048132 · DOI
  40. Tardif, 2008, Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial, Lancet., 371, 1761, 10.1016/S0140-6736(08)60763-1 · DOI · Paper page
  41. Boaz, 2000, Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial, Lancet., 356, 1213, 10.1016/S0140-6736(00)02783-5 · DOI · Paper page
  42. Tepel, 2003, The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: a randomized, controlled trial, Circulation., 107, 992, 10.1161/01.CIR.0000050628.11305.30 · DOI · Paper page
  43. Ivanovski, 2005, The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice, Kidney Int., 67, 2288, 10.1111/j.1523-1755.2005.00332.x · DOI
  44. Levy, 2006, Application of pharmacogenomics in the prevention of diabetic cardiovascular disease: mechanistic basis and clinical evidence for utilization of the haptoglobin genotype in determining benefit from antioxidant therapy, Pharmacol. Ther., 112, 501, 10.1016/j.pharmthera.2006.05.002 · DOI
  45. Milman, 2008, Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2–2 genotype: a prospective double-blinded clinical trial, Arterioscler. Thromb. Vasc. Biol., 28, 341, 10.1161/ATVBAHA.107.153965 · DOI · Paper page
  46. Blum, 2008, Dual therapy with statins and antioxidants is superior to statins alone in decreasing the risk of cardiovascular disease in a subgroup of middle-aged individuals with both diabetes mellitus and the haptoglobin 2–2 genotype, Arterioscler. Thromb. Vasc. Biol., 28, e18, 10.1161/ATVBAHA.107.159905 · DOI

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Metadata

Authors
Steinberg, D.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2009-04
Volume
50
Pages
S376-S381
ISSN
0022-2275
Cited by
375
References
3
Language
en
Licence

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CoChat. (2026). Citation check: The LDL modification hypothesis of atherogenesis: an update. https://app.cochat.ai/papers/10.1194/jlr.r800087-jlr200
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Steinberg, D. (2009). The LDL modification hypothesis of atherogenesis: an update. Journal of Lipid Research. https://doi.org/10.1194/jlr.r800087-jlr200

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