The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Uterine Peristaltic Activity and the Development of Endometriosis
Abstract
Peristaltic activity of the nonpregnant uterus serves fundamental functions in the early process of reproduction, such as directed transport of spermatozoa into the tube ipsilateral to the dominant follicle, high fundal implantation of the embryo, and, possibly, retrograde menstruation. Hyperperistalsis of the uterus is significantly associated with the development of endometriosis and adenomyosis. In women with hyperperistalsis, fragments of basal endometrium are detached during menstruation and transported into the peritoneal cavity. Fragments of basal endometrium have, because of their equipment with estrogen and progesterone receptors and because of their ability to produce estrogen, an increased potential of implantation and proliferation, resulting in pelvic endometriosis. In addition, hyperperistalsis induces the proliferation of basal endometrium into myometrial dehiscencies. This results in endometriosis-associated adenomyosis with a prevalence of approximately 90%. Adenomyosis results in impaired directed sperm transport and thus constitutes an important cause of sterility in women with endometriosis. Our own date and that from the literature strongly suggest that the principal mechanism of endometriosis/adenomyosis is the paracrine interference of endometrial estrogen with the cyclical endocrine control of archimyometrial peristalsis exerted by the ovary, thus resulting in hyperperistalsis.
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In the citing paper
“Serum oxytocin and uterine peristalsis are elevated in women with endometriosis relative to controls (He et al., 2016; Leyendecker et al., 2004).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Leyendecker et al., 2004
In the citing paper
“Third, uterine hyperperistalsis/dysperistalsis may be a result of archimetral hyperestrogenism [38,47].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [47]
In the citing paper
“On the basis of the data presented above we had suggested that auto-traumatization of the uterus would constitute the critical factor in the development of endometriosis and adenomyosis [3, 4, 33].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [33]
In the citing paper
“It was suggested that this uterine dysfunction in women with endometriosis and adenomyosis is a result of archimetral hyperestrogenism [3, 4, 29, 33].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [33]
In the citing paper
“The basal endometrium in women with endometriosis is twice as thick as in healthy women [21, 33].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [33]
In the citing paper
“As outlined previously, hyperperistalsis causes overt uterine auto-traumatization, detachment of fragments of basal endometrium, and their transtubal dislocation into the peritoneal cavity as well as infiltrative growth of basal endometrium into the underlying myometrium resulting in pelvic endometriosis and uterine adenomyosis, respectively [3, 33].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [33]
Citations
Cites
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
Wilcox, A. J., Weinberg, C. R., & Baird, D. D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512073332301 · Cited by 1,071
(1984) · PubMed · Cited by 997
Leyendecker, G., Kunz, G., Wildt, L., Beil, D., & Deininger, H. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019435 · Cited by 307
Self-citationEndometriosis results from the dislocation of basal endometrium
Leyendecker, G. (2002) · Human Reproduction · doi:10.1093/humrep/17.10.2725 · Cited by 300
Self-citationLyons, E. A., Taylor, P. J., Zheng, X. H., Ballard, G., Levi, C. S., & Kredentser, J. V. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54246-0 · Cited by 272
Treatment of severe postmenopausal endometriosis with an aromatase inhibitor
Takayama, K., Zeitoun, K., Gunby, R. T., Sasano, H., Carr, B. R., & Bulun, S. E. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00022-3 · Cited by 270
Contractions of the inner third of the myometrium
de Vries, K., Lyons, E. A., Ballard, G., Levi, C. S., & Lindsay, D. J. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90983-e · Cited by 243
Noe, M. (1999) · Human Reproduction · doi:10.1093/humrep/14.1.190 · Cited by 216
Self-citationEndometriosis: A dysfunction and disease of the archimetra
Leyendecker, G. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.752 · Cited by 199
Self-citationEndometrial epithelial cells in peritoneal fluid during the early follicular phase
Kruitwagen, R. F. P. M., Poels, L. G., Willemsen, W. N. P., de Ronde, I. J. Y., Jap, P. H. K., & Rolland, R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54119-3 · Cited by 199
Kunz, G., Beil, D., Huppert, P., & Leyendecker, G. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.76 · Cited by 177
Self-citationWildt, L. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.655 · Cited by 149
Self-citationPhysiology: Sperm numbers and distribution within the human Fallopian tube around ovulation
Williams, M., Hill, C. J., Scudamore, I., Dunphy, B., Cooke, I. D., & Barratt, C. L. R. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137975 · Cited by 148
Characteristics of uterine contractility during menses in women with mild to moderate endometriosis
Bulletti, C., De Ziegler, D., Polli, V., Del Ferro, E., Palini, S., & Flamigni, C. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03087-x · Cited by 147
Endometrial tissue in peritoneal fluid
Bartosik, D., Jacobs, S. L., & Kelly, L. J. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49813-4 · Cited by 144
Kunz, G. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.647 · Cited by 136
Self-citationTHE HISTOGENESIS OF ENDOMETRIOSIS
Ridley, J. H. (1968) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-196801000-00001 · Cited by 135
Akande, A. (2003) · Human Reproduction · doi:10.1093/humrep/deh045 · Cited by 117
Crow, J. C., Amso, N. N., Lewin, J. F., & Shaw, R. W. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138428 · Cited by 112
Cyclic changes in the human fallopian tube isthmus and their functional importance
Jansen, R. P. S. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90853-4 · Cited by 111
Salamanca, A., & Beltrán, E. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57680-8 · Cited by 106
Risk factors for endometriosis in the rhesus monkey (Macaca mulatta): a case-control study
Hadfield, R. (1997) · Human Reproduction Update · doi:10.1093/humupd/3.2.109 · Cited by 86
(1989) · PubMed · Cited by 77
Oxytocin and Oxytocin Receptor Gene Expression in the Uterus
Zingg, H. H., Rozen, F., Chu, K., Larcher, A., ARSLAN, A., Richard, S., & Lefebvre, D. L. (1995) · Elsevier eBooks · doi:10.1016/b978-0-12-571150-0.50015-9 · Cited by 75
Untersuchungen über die Entwicklung und Morphologie der menschlichen Uterusmuskulatur
Werth, R., & Grusdew, W. (1898) · Archives of Gynecology and Obstetrics · doi:10.1007/bf01981003 · Cited by 73
Kunz, G. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.667 · Cited by 69
Self-citationZones of the uterus: discrepancy between US and MR images.
Mitchell, D. G., Schönholz, L., Hilpert, P. L., Pennell, R. G., Blum, L., & Rifkin, M. D. (1990) · Radiology · doi:10.1148/radiology.174.3.2406787 · Cited by 67
Sex steroid modulation of neurohypophysial hormone receptors in human nonpregnant myometrium
Maggi, M., Magini, A., Fiscella, A., Giannini, S., Fantoni, G., Toffoletti, F., Massi, G., & Serio, M. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.2.1309835 · Cited by 59
Redefining endometriosis: Endometriosis is an entity with extreme pleiomorphism
Leyendecker, G. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.4 · Cited by 49
Self-citationAmso, N. N., Crow, J. C., Lewin, J. F., & Shaw, R. W. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138429 · Cited by 46
Hysterosalpingo-radionuclide scintigraphy (HERS)
Iturralde, M. P., & Venter, P. F. (1981) · Seminars in Nuclear Medicine · doi:10.1016/s0001-2998(81)80027-x · Cited by 43
Retrograde seeding of endometrial epithelial cells by uterine-tubal flushing
Kruitwagen, R. F. P. M., Poels, L. G., Willemsen, W. N. P., Jap, P. H. K., Thomas, C. M. G., & Rolland, R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54533-6 · Cited by 34
Wetzstein, R. (1965) · J.F. Bergmann-Verlag eBooks · doi:10.1007/978-3-642-53813-1_1 · Cited by 32
Wetzstein, R. (1965) · Archives of Gynecology and Obstetrics · doi:10.1007/bf00672102 · Cited by 32
Friedler, S., Raziel, A., Schachter, M., Strassburger, D., Komarovsky, D., Bern, O., Soffer, Y., Kasterstein, E., & Ron‐El, R. (1999) · Human Reproduction · doi:10.1093/humrep/14.suppl_3.101 · Cited by 26
Uterine contractions in endometriosis: Effects of operative and danazol treatment
Mäkäräinen, L. (1988) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443618809151376 · Cited by 22
Hysterosalpingoscintigraphy: A Simple and Accurate Method of Evaluating Fallopian Tube Patency
Steck, T., Albert, P. J., Börner, W., & Becker, W. (1988) · Nuklearmedizin - NuclearMedicine · doi:10.1055/s-0038-1629459 · Cited by 21
Tsai, M.-L., Webb, R. C., & Loch-Caruso, R. K. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.2.341 · Cited by 20
Steck, T., Würfel, W., Becker, W., & Albert, P. J. (1991) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137510 · Cited by 14
Determination of velocity of tubar transport with dynamic hysterosalpingoscintigraphy
Schmiedehausen, K., KAT, S., ALBERT, N., Platsch, G., Wildt, L., & Kuwert, T. (2003) · Nuclear Medicine Communications · doi:10.1097/01.mnm.0000084577.51410.c4 · Cited by 13
Self-citationLEYENDECKER, G., Kunz, G., Noe, M., Herbertz, M., Beil, D., Huppert, P. E., & Mall, G. (1999) · Reproduktionsmedizin · doi:10.1007/s004440050126 · Cited by 8
Self-citation
Flagged first, then by citations
Research works printed but not linked: 6
- Kunz G., 1996, The dynamics of rapid sperm transport through the female genital tract, Evidence from vaginal sonography of uterine peristalsis (VSUP) and hysterosalpingoscintigraphy (HSSG). Hum. Reprod., 11, 627
- Harper M.J.K. 1994. Gamete and zygote transport.InThe Physiology of Reproduction. E. Knobil & J.D. Neill Eds.: 123‐187. Raven Press. New York.
- Kunz G., 1998, Cervical mucus does not act as a barrier during the luteal phase of the menstrual cycle, Evidence from hysterosalpingoscintigraphy (HSSG). Hum. Reprod., 13, R
- Kunz G., 1998, Sites of implantation in spontaneous conception and in ART cycles, A sonographical study. Hum. Reprod., 13, P
- 10.1210/jc.74.2.385 · DOI
- 10.1093/humrep/15.1.76 · DOI · Paper page
Cited by
Sorted by citations
The pathophysiology of endometriosis and adenomyosis, tissue injury and repair
Leyendecker, G., Wildt, L., & Mall, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1191-0 · Cited by 418
“endometrium into the underlying myometrium resulting in pelvic endometriosis and uterine adenomyosis, respectively [3, 33].”
BackgroundInfluentialSelf-citationTheories on the pathogenesis of endometriosis
Sourial, S., Tempest, N., & Hapangama, D. K. (2014) · International Journal of Reproductive Medicine · doi:10.1155/2014/179515 · Cited by 418
Kunz, G., Beil, D., Huppert, P., Noe, M., Kissler, S., & Leyendecker, G. (2005) · Human Reproduction · doi:10.1093/humrep/dei021 · Cited by 377
Self-citationAdult stem cells in the endometrium
Gargett, C. E., & Masuda, H. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq061 · Cited by 361
Leone, F. P. G., Timmerman, D., Bourne, T., Valentin, L., Epstein, E., Goldstein, S. R., Marret, H., Parsons, A. K., Gull, B., Istre, O., et al. (2009) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7487 · Cited by 343
Metadata
- Authors
- LEYENDECKER, G., KUNZ, G., HERBERTZ, M., BEIL, D., HUPPERT, P., MALL, G., KISSLER, S., NOE, M., & WILDT, L.
- Affiliations
- Klinikum Darmstadt (DE)
- Goethe University Frankfurt (DE)
- University of Vienna (AT)
- Innsbruck Medical University (AT)
- Corresponding author
- LEYENDECKER, GERHARD
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 1034
- Issue
- 1
- Pages
- 338-355
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2021228825
- Cited by
- 162
- References
- 42
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 12 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 16 · 2019: 7 · 2018: 4 · 2017: 11 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 7
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- uterine peristalsis, endometriosis, adenomyosis, retrograde menstruation, sperm transport, female infertility, estrogen, paracrine signaling, endometrial implantation
- MeSH terms
- Endometriosis, Female, Humans, Uterine Contraction, Uterus
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