Cited by 572Stress Responses and CortisolHeart Rate Variability and Autonomic ControlSalivary Gland Disorders and Functions

Salivary α‐Amylase in Biobehavioral Research: Recent Developments and Applications

GRANGER, DOUGLAS A., KIVLIGHAN, KATIE T., El‐SHEIKH, MONA, GORDIS, ELANA B., STROUD, LAURA R.·2007·Annals of the New York Academy of Sciences

Abstract

Abstract: In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the noninvasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. This widespread enthusiasm has led to somewhat of a renaissance in behavioral science. At the cutting edge, the focus is on testing innovative theoretical models of individual differences in behavior as a function of multilevel biosocial processes in the context of everyday life. Several new studies have generated renewed interest in salivary α‐amylase (sAA) as a surrogate marker of the autonomic/sympathetic nervous system component of the psychobiology of stress. This article reviews sAA's properties and functions; presents illustrative findings relating sAA to stress and the physiology of stress, behavior, cognitive function, and health; and provides practical information regarding specimen collection and assay. The overarching intent is to accelerate the learning curve such that investigators avoid potential pitfalls associated with integrating this unique salivary analyte into the next generation of biobehavioral research.

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Crossref · 10.1196/annals.1384.008

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Authors
GRANGER, D. A., KIVLIGHAN, K. T., El‐SHEIKH, M., GORDIS, E. B., & STROUD, L. R.
Affiliations
  • Pennsylvania State University (US)
  • Johns Hopkins University (US)
  • Auburn University (US)
  • University at Albany, State University of New York (US)
  • Brown University (US)
Corresponding author
GRANGER, DOUGLAS A.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2007-03
Volume
1098
Issue
1
Pages
122-144
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2118909914
Cited by
572
References
50
Citations by year
2026: 17 · 2025: 14 · 2024: 28 · 2023: 30 · 2022: 22 · 2021: 17 · 2020: 28 · 2019: 35 · 2018: 34 · 2017: 43 · 2016: 50 · 2015: 35 · 2014: 45 · 2013: 30 · 2012: 36
FWCI
9.26
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pennsylvania State University
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD041428, P01 HD 39667-01A1, P01HD039667)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
Keywords
salivary amylase, stress physiology, autonomic nervous system, sympathetic nervous system, non-invasive biomarkers, individual differences in behavior, cognitive function, sample collection
MeSH terms
alpha-Amylases, Behavior, Humans, Saliva, Salivary Proteins and Peptides, Biomarkers

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