The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging: The Diet of the World's Longest‐Lived People and Its Potential Impact on Morbidity and Life Span
Open accessAbstract
Long-term caloric restriction (CR) is a robust means of reducing age-related diseases and extending life span in multiple species, but the effects in humans are unknown. The low caloric intake, long life expectancy, and the high prevalence of centenarians in Okinawa have been used as an argument to support the CR hypothesis in humans. However, no long-term, epidemiologic analysis has been conducted on traditional dietary patterns, energy balance, and potential CR phenotypes for the specific cohort of Okinawans who are purported to have had a calorically restricted diet. Nor has this cohort's subsequent mortality experience been rigorously studied. Therefore, we investigated six decades of archived population data on the elderly cohort of Okinawans (aged 65-plus) for evidence of CR. Analyses included traditional diet composition, energy intake, energy expenditure, anthropometry, plasma DHEA, mortality from age-related diseases, and current survival patterns. Findings include low caloric intake and negative energy balance at younger ages, little weight gain with age, life-long low BMI, relatively high plasma DHEA levels at older ages, low risk for mortality from age-related diseases, and survival patterns consistent with extended mean and maximum life span. This study lends epidemiologic support for phenotypic benefits of CR in humans and is consistent with the well-known literature on animals with regard to CR phenotypes and healthy aging.
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“The Okinawans’ diet, characterized by a substantial consumption of vegetables, legumes, and sweet potatoes, is inherently plant-based and low in calories [7,156,157,158,159,160,161].”
From The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento (2025) · cites this paper as [157]
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“Japanese diets have been of considerable interest, particularly from Okinawa, which until recently experienced among the lowest rates of CHD in the world.111”
From Components of a Cardioprotective Diet: New Insights (2011) · cites this paper as [111]
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“Appropriate energy balance and little age-related weight gain are also important features of the Okinawan diet pattern.111”
From Components of a Cardioprotective Diet: New Insights (2011) · cites this paper as [111]
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Citations
Cites
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Cited by
Sorted by citations
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216
“Such observational analyses could partly overestimate benefits, because never drinkers could include those who have avoided alcohol because of unmeasured factors that relate to later poor health.(290) Yet, magnitudes and consistency of observed lower risks of CHD and diabetes across diverse populations, together with…”
A review on the extraction methods use in medicinal plants, principle, strength and limitation
(2015) · Medicinal & Aromatic Plants · doi:10.4172/2167-0412.1000196 · Cited by 1,325
Molecular mechanisms of dietary restriction promoting health and longevity
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Caloric restriction improves memory in elderly humans
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Components of a Cardioprotective Diet: New Insights
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Metadata
- Authors
- WILLCOX, B. J., WILLCOX, D. C., TODORIKI, H., FUJIYOSHI, A., YANO, K., HE, Q., CURB, J. D., & SUZUKI, M.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Okinawa Prefectural College of Nursing (JP)
- University of the Ryukyus (JP)
- Pacific Health Research and Education Institute (US)
- Corresponding author
- WILLCOX, BRADLEY J.
- WILLCOX, D. CRAIG
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2007-10
- Volume
- 1114
- Issue
- 1
- Pages
- 434-455
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2165781101
- Cited by
- 370
- References
- 61
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 23 · 2023: 22 · 2022: 24 · 2021: 24 · 2020: 20 · 2019: 23 · 2018: 19 · 2017: 15 · 2016: 20 · 2015: 12 · 2014: 25 · 2013: 26 · 2012: 17
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r03ag021293-01)
- National Institute on Aging (K08AG022788, R03AG021293-01, K08 AG22788-02, R01AG027060)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- caloric restriction, Okinawan diet, healthy aging, centenarians, energy balance, lifespan extension, energy intake, energy expenditure, body mass index, survival patterns
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Haplorhini, Diet, Female, Humans, Japan, Life Expectancy, Male, Middle Aged, Morbidity, United States, Caloric Restriction
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