Cited by 1,752Cancer survivorship and careHealth Education and ValidationHealth Systems, Economic Evaluations, Quality of Life

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument.

Brady, M J, Cella, D F, Mo, F, Bonomi, A E, Tulsky, D S, Lloyd, S R, Deasy, S, Cobleigh, M, Shiomoto, G·1997·Journal of Clinical Oncology

DOI 10.1200/jco.1997.15.3.974

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Abstract

PURPOSE: This is the first published report on the validation of the Functional Assessment of Cancer Therapy-Breast (FACT-B), a 44-item self-report instrument designed to measure multidimensional quality of life (QL) in patients with breast cancer. The FACT-B consists of the FACT-General (FACT-G) plus the Breast Cancer Subscale (BCS), which complements the general scale with items specific to QL in breast cancer. The FACT-B was developed with an emphasis on patients' values and brevity and is available in nine languages. METHODS AND RESULTS: Two validation samples were used for this report. The first (n = 47) was tested twice over a 2-month period to assess sensitivity to change. Significant sensitivity to change in performance status rating (PSR) was demonstrated for the FACT-B total score, the Physical Well-Being (PWB) subscale, the Functional Well-Being (FWB) subscale, and the BCS. Sensitivity to change in QL as measured by the Functional Living Index-Cancer (FLIC) was documented in the FACT-B total score, PWB, FWB, and Emotional Well-Being (EWB). Additional validity and reliability data were obtained from a larger sample (n = 295). The alpha coefficient (internal consistency) for the FACT-B total score was high (alpha = .90), with subscale alpha coefficients ranging from .63 to .86. Evidence supported test-retest reliability, as well as convergent, divergent, and known groups validity. CONCLUSION: The FACT-B is appropriate for use in oncology clinical trials, as well as in clinical practice. It demonstrates ease of administration, brevity, reliability, validity, and sensitivity to change.

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The functional assessment of cancer therapy scale: development and validation of the general measure
Cella, D. F., Tulsky, D. S., Gray, G., Sarafian, B., Linn, E., Bonomi, A., Silberman, M., Yellen, S. B., Winicour, P., & Brannon, J. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.3.570 · Cited by 6,020
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Effectiveness of Baduanjin Exercise on Quality of Life and Psychological Health in Postoperative Patients With Breast Cancer: A Systematic Review and Meta-analysis
Ye, X., Ren, Z., Vafaei, S., Zhang, J.-M., Song, Y., Wang, Y., & Song, P. (2022) · Integrative Cancer Therapies · doi:10.1177/15347354221104092 · Cited by 56
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Harder, H., Ballinger, R., Langridge, C., Ring, A. E., & Fallowfield, L. J. (2013) · Psycho-Oncology · doi:10.1002/pon.3338 · Cited by 50
“These scales have good psychometric characteristics and have been used in older cancer populations [22,24].”
Method
Lymphedema and quality of life in Chinese women after treatment for breast cancer
Mak, S. S. S., Mo, F. K. F., Suen, J. J. S., Chan, S. L., Ma, W. L., & Yeo, W. (2009) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2009.01.005 · Cited by 50
“QOL was assessed using the Functional Assessment of Cancer Therapy–Breast Cancer subscale (FACT-Bþ 4) questionnaire (Coster et al., 2001).”
MethodResultSelf-citation
Comparison of Breast Cancer-Related Lymphedema (Upper Limb Swelling) Prevalence Estimated Using Objective and Subjective Criteria and Relationship with Quality of Life
Bulley, C., Gaal, S., Coutts, F., Blyth, C., Jack, W. J. L., Chetty, U., Barber, M. D., & Tan, C.-W. (2013) · BioMed Research International · doi:10.1155/2013/807569 · Cited by 50
The Validity and Utility of the M. D. Anderson Symptom Inventory in Patients With Breast Cancer: Evidence From the Symptom Outcomes and Practice Patterns Data From the Eastern Cooperative Oncology Group
Mendoza, T. R., Zhao, F., Cleeland, C. S., Wagner, L. I., Patrick‐Miller, L. J., & Fisch, M. J. (2013) · Clinical Breast Cancer · doi:10.1016/j.clbc.2013.02.014 · Cited by 50
Long-term assessment of quality of life in the Intergroup Exemestane Study: 5 years post-randomisation
Fallowfield, L. J., Kilburn, L., Langridge, C., Snowdon, C. F., Bliss, J. M., & Coombes, R. C. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.43 · Cited by 50
Patient-Reported Outcomes and Survivorship in Radiation Oncology: Overcoming the Cons
Siddiqui, F., Liu, A. K., Bruner, D. W., & Movsas, B. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.0707 · Cited by 50
Evaluating Minimal Important Differences for the FACT-Melanoma Quality of Life Questionnaire
Askew, R. L., Xing, Y., Palmer, J. L., Cella, D. F., Moyé, L. A., & Cormier, J. N. (2009) · Value in Health · doi:10.1111/j.1524-4733.2009.00570.x · Cited by 52
Self-citation
Psychological effects and mediators of a group multi-component program for breast cancer survivors
Sherman, K. A., Heard, G., & Cavanagh, K. (2010) · Journal of Behavioral Medicine · doi:10.1007/s10865-010-9265-9 · Cited by 52
“…functional and breast cancer-specific components of the FACT-B scale, which is particularly appropriate for use with exercise interventions (Brady et al. 1997), and has proven sensitivity in detecting quality of life-related changes in breast cancer populations (Coster et al. 2001), and in…”
BackgroundResult
Patient-reported outcomes in cancer survivorship
Gordon, B.-B. E., & Chen, R. C. (2017) · Acta Oncologica · doi:10.1080/0284186x.2016.1268265 · Cited by 50
“FACT-B [14] Includes FACT-G (see Table 1) plus 10-item breast cancer subscale 44 Higher scores reflect better quality of life English, Chinese, Korean, Malayalam, Spanish”
Method
Remote, proactive, telephone based management of toxicity in outpatients during adjuvant or neoadjuvant chemotherapy for early stage breast cancer: pragmatic, cluster randomised trial
Krzyzanowska, M. K., Julian, J. A., Gu, C., Powis, M., Li, Q., Enright, K. A., Howell, D., Earle, C. C., Gandhi, S., Rask, S., et al. (2021) · BMJ · doi:10.1136/bmj-2021-066588 · Cited by 49
Effects of auricular acupressure on chemotherapy-induced nausea and vomiting in breast cancer patients: a preliminary randomized controlled trial
Tan, J.-Y. B., Molassiotis, A., Suen, L. K. P., Liu, J., Wang, T., & Huang, H. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03543-y · Cited by 49
“QoL The FACT-B is a BC-specific QoL assessment that consists of four general subscales (physical, social/family, emotional, and functional well-being) and one BC-specific subscale [40, 41].”
Method
Fertility and parenthood issues in young female cancer patients—a systematic review
Sobota, A., & Özakinci, G. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-014-0388-9 · Cited by 50
“Finally, Reh et al. [52] showed that among young cancer patients with various diagnoses referred to a fertility clinic, social domain of QoL as measured by FACT [56] improved over time in those who had undergone FP procedures, with other QoL scores remaining stable over time.”
Method
To measure or not to measure? Reviewing the assessment of spirituality and religion in health-related quality of life
O’Connell, K. A., & Skevington, S. M. (2007) · Chronic Illness · doi:10.1177/1742395307079195 · Cited by 54
Quality of life in lung cancer: does disclosure of the diagnosis have an impact?
Lheureux, M. (2003) · Lung Cancer · doi:10.1016/j.lungcan.2003.08.018 · Cited by 49
Shoulder Mobility, Muscular Strength, and Quality of Life in Breast Cancer Survivors with and without Tai Chi Qigong Training
Fong, S. S. M., Ng, S. S. M., Luk, W. S., Chung, J. W. Y., Chung, L. M. Y., Tsang, W. W. N., & Chow, L. P. Y. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/787169 · Cited by 50
Complementary medicine for fatigue and cortisol variability in breast cancer survivors
Jain, S., Pavlik, D., Distefan, J. M., Bruyere, R. R. L., Acer, J., Garcia, R. R., Coulter, I. D., Ives, J. A., Roesch, S. C., Jonas, W. B., et al. (2011) · Cancer · doi:10.1002/cncr.26345 · Cited by 50
“Time since surgery, mo 27 (2-78) 22 (2-77) 33 (2-108) .”
Influential
A Morbidity Screening Tool for identifying fatigue, pain, upper limb dysfunction and lymphedema after breast cancer treatment: A validity study
Bulley, C., Coutts, F., Blyth, C., Jack, W. J. L., Chetty, U., Barber, M. D., & Tan, C.-W. (2013) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2013.10.006 · Cited by 49
“An additional breast cancer subscale can be added to the FACT G, making it the FACT B, with further possible questions about arm morbidity, making it the FACT B þ 4 (Brady et al., 1997).”
BackgroundResult
Unraveling Uses and Effects of an Interactive Health Communication System
Han, J. Y., Hawkins, R. P., Shaw, B. R., Pingree, S., Mctavish, F. M., & Gustafson, D. H. (2009) · Journal of Broadcasting & Electronic Media · doi:10.1080/08838150802643787 · Cited by 49
“These outcomes have been widely tested and demonstrated in terms of reliability, validity, and responsiveness to clinical change (Brady et al., 1997; Gustafson et al., 2001, 2002, 2005).”
Background
Validation of the Mexican-Spanish version of the EORTC QLQ-C30 and BR23 questionnaires to assess health-related quality of life in Mexican women with breast cancer
Cerezo, O., Oñate-Ocaña, L. F., Arrieta-Joffe, P., González‐Lara, F., García-Pasquel, M. J., Bargalló‐Rocha, E., & Vilar‐Compte, D. (2012) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2012.01336.x · Cited by 49
“HRQL has been evaluated in several studies with Functional Assessment of Cancer Therapy-General and its subscale, the Functional Assessment of Cancer Therapy-Sub-scale questionnaires (Brady et al. 1997; Lee et al. 2004).”
BackgroundMethod
Quality of Life, Mood, and Prognostic Understanding in Patients with Metastatic Breast Cancer
Shin, J. A., El-Jawahri, A. R., Parkes, A. M., Schleicher, S. M., Knight, H. P., & Temel, J. S. (2016) · Journal of Palliative Medicine · doi:10.1089/jpm.2016.0027 · Cited by 49
Quality of life and symptom burden in patients with metastatic breast cancer
Ecclestone, C., Chow, R., Pulenzas, N., Zhang, L., Leahey, A., Hamer, J., DeAngelis, C., Bedard, G., McDonald, R. E., Bhatia, A., et al. (2016) · Supportive Care in Cancer · doi:10.1007/s00520-016-3217-z · Cited by 49
“The FACT-B has been found to have good internal consistency, test-retest reliability and high divergent, convergent and known group validity [11].”
Background
Immediate expander/implant breast reconstruction followed by post-mastectomy radiotherapy for breast cancer: Aesthetic, surgical, satisfaction and quality of life outcomes in women with high-risk breast cancer
Brennan, M. E., Flitcroft, K. L., Warrier, S. K., Snook, K., & Spillane, A. J. (2016) · The Breast · doi:10.1016/j.breast.2016.08.008 · Cited by 49
Patient-Reported Self-Efficacy, Anxiety, and Health-Related Quality of Life During Chemotherapy: Results From a Longitudinal Study
Papadopoulou, C., Kotronoulas, G., Schneider, A., Miller, M., McBride, J., Polly, Z., Bettles, S., Whitehouse, A., McCann, L., Kearney, N., et al. (2017) · Oncology nursing forum · doi:10.1188/17.onf.127-136 · Cited by 49
RESILIENCE: Phase III Randomized, Double-Blind Trial Comparing Sorafenib With Capecitabine Versus Placebo With Capecitabine in Locally Advanced or Metastatic HER2-Negative Breast Cancer
Baselga, J. M., Zamagni, C., Gómez, P., Bermejo, B., Nagai, S. E., Melichar, B., Chan, A., Mangel, L., Bergh, J. C. S., Costa, F. P., et al. (2017) · Clinical Breast Cancer · doi:10.1016/j.clbc.2017.05.006 · Cited by 49
Factors Associated with Health-related Quality-of-life in Breast Cancer Survivors: Influence of the Type of Surgery
Ohsumi, S., Shimozuma, K., Morita, S., Hara, F., Takabatake, D., Takashima, S., Taira, N., Aogi, K., & Takashima, S. (2009) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyp060 · Cited by 51
“) regularly were asked to complete the patient-administered questionnaires between July 2004 and March 2005 to assess QOL [Functional Assessment of Cancer Therapy scale-Breast: FACT-B (11)] and psychological distress [Hospital Anxiety and Depression Scale: HADS (12)].”
Method
Psychological Aspects of Breast Cancer
Penberthy, J. K., Stewart, A. L., Centeno, C. F., & Penberthy, D. R. (2023) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2023.04.010 · Cited by 48
Social constraints and quality of life among chinese-speaking breast cancer survivors: a mediation model
You, J., & Lü, Q. (2014) · Quality of Life Research · doi:10.1007/s11136-014-0698-4 · Cited by 50
“The reliabilities for all the questionnaires were satisfactory in the current study and were comparable to those in the original English version of questionnaires [42– 44, 46].”
Result
Dragon boat racing and health-related quality of life of breast cancer survivors: a mixed methods evaluation
Ray, H. A., & Verhoef, M. J. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-205 · Cited by 46
“The baseline quantitative survey included demographic data, disease characteristics and the Functional Assessment of Cancer Therapy-Breast (FACT-B) [55], Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp12) [56], and the Functional Assessment of Cancer Therapy-Fatigue Scale (FACITFa…”
BackgroundMethodInfluential
Emotional Coping Differences Among Breast Cancer Patients From an Online Support Group: A Cross-Sectional Study
Batenburg, A., & Das, E. H. H. J. (2014) · Journal of Medical Internet Research · doi:10.2196/jmir.2831 · Cited by 48
“Emotional well-being was measured according to 6 items from the Functional Assessment of Chronic Illness Therapy questionnaire (FACIT-B) [45] (Cronbach alpha=.81).”
MethodInfluential
Quality of life after breast cancer surgery: What have we learned and where should we go next?
Pockaj, B. A., Degnim, A. C., Boughey, J. C., Gray, R. J., McLaughlin, S. A., Dueck, A. C., Perez, E. A., Halyard, M. Y., Frost, M. H., Cheville, A. L., et al. (2009) · Journal of Surgical Oncology · doi:10.1002/jso.21151 · Cited by 50
Does a Patient-Held Quality-of-Life Diary Benefit Patients With Inoperable Lung Cancer?
Mills, M. E., Murray, L., Johnston, B. T., Cardwell, C. R., & Donnelly, M. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.5687 · Cited by 48
Barriers to Recruitment and Adherence in a Randomized Controlled Diet and Exercise Weight Loss Intervention Among Minority Breast Cancer Survivors
Aycinena, A. C., Valdovinos, C., Crew, K. D., Tsai, W. Y., Mata, J. M., Sandoval, R., Hershman, D. L., & Greenlee, H. (2016) · Journal of Immigrant and Minority Health · doi:10.1007/s10903-015-0310-1 · Cited by 53
“At baseline and 6-months, quality of life was assessed using the more detailed Functional Assessment of Cancer Therapy-Breast Quality-of-Life Instrument (FACT-B), a 44-item self-report survey for patients with BC [23].”
Method
Ongoing unmet needs in treating estrogen receptor-positive/HER2-negative metastatic breast cancer
Başaran, G., Twelves, C. J., Dieras, V. C., Cortés, J., & Awada, A. H. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.12.002 · Cited by 49
LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases
Swearingen, A. E. D. V., Siegel, M. B., Deal, A. M., Sambade, M. J., Hoyle, A. P., Hayes, D. N., Jo, H., Little, P., Dees, E. C., Muss, H. B., et al. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4852-5 · Cited by 47
Brief culturally informed smartphone interventions decrease breast cancer symptom burden among Latina breast cancer survivors
Yanez, B. R., Oswald, L. B., Baik, S. H., Buitrago, D., Iacobelli, F., Perez-Tamayo, A. M., Guitelman, J., Penedo, F. J., & Buscemi, J. (2019) · Psycho-Oncology · doi:10.1002/pon.5281 · Cited by 49
“The 36‐item Functional Assessment of Cancer Therapy–Breast (FACT‐ B) assessed five domains in the context of breast cancer over the past week: breast cancer well‐being (eg, “I am bothered by hair loss” [reverse]), physical well‐being (eg, “I have nausea” [reverse]), social/family well‐being (eg, “I feel close to my fr…”
Background
Doctor–Patient Communication about Advance Directives in Metastatic Breast Cancer
Ozanne, E. M., Partridge, A. H., Moy, B., Ellis, K. J., & Sepucha, K. (2009) · Journal of Palliative Medicine · doi:10.1089/jpm.2008.0254 · Cited by 48
Use of a Depression Screening Tool and a Fluoxetine-Based Algorithm to Improve the Recognition and Treatment of Depression in Cancer Patients
Passik, S. D., Kirsh, K. L., Theobald, D., Donaghy, K. B., Holtsclaw, E., Edgerton, S., & Dugan, W. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00493-1 · Cited by 48
The relevance of experiential avoidance in breast cancer distress: insights from a psychological group intervention.
Aguirre‐Camacho, A., Pelletier, G., González‐Márquez, A., Blanco‐Donoso, L. M., García‐Borreguero, P., & Moreno‐Jiménez, B. (2017) · Psycho-Oncology · doi:10.1002/pon.4162 · Cited by 47
“For this study, the Spanish adaptation of the FACT-B was used [26].”
BackgroundInfluential
Hypofractionated vs Conventionally Fractionated Postmastectomy Radiation After Implant-Based Reconstruction
Wong, J. S., Uno, H., Tramontano, A. C., Fisher, L., Pellegrini, C., Abel, G. A., Burstein, H. J., Chun, Y. S., King, T. A., Schrag, D., et al. (2024) · JAMA Oncology · doi:10.1001/jamaoncol.2024.2652 · Cited by 47
Emotional Approach Coping and the Effects of Online Peer-Led Support Group Participation Among Patients With Breast Cancer: A Longitudinal Study
Batenburg, A., & Das, E. H. H. J. (2014) · Journal of Medical Internet Research · doi:10.2196/jmir.3517 · Cited by 47
“Specifically, we assessed patients’ intensity of online support group participation, emotional approach coping [25], and 3 measures of well-being that are generally associated with breast cancer diagnosis at 2 points in time: emotional well-being [29], depression [30], and breast cancer-related concerns [31].”
Influential
Validación de la versión española del Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer (FACT-B+4)
Belmonte, R., Garín, O., Badía, M. S., Latiesas, J. S., Marco, E., & Ferrer, M. (2011) · Medicina Clínica · doi:10.1016/j.medcli.2010.11.028 · Cited by 47
Interactivity and presence of three eHealth interventions
Hawkins, R. P., Han, J. Y., Pingree, S., Shaw, B. R., Baker, T. B., & Roberts, L. J. (2010) · Computers in Human Behavior · doi:10.1016/j.chb.2010.03.011 · Cited by 47
“79) assessed the impact of breast cancer and treatment on quality of life; this scale was used and validated extensively in other studies (Brady et al., 1997; Cella, Tulsky, Gray, Sarafian, Linn, Bonomi et al., 1993).”
MethodInfluential
Tumor response and health-related quality of life in clinically selected patients from Asia with advanced non-small-cell lung cancer treated with first-line gefitinib: Post hoc analyses from the IPASS study
Wu, Y.-L. L. C., Fukuoka, M., Mok, T. S. K., Saijo, N., Thongprasert, S., Yang, J. C., Chu, D.-T., Yang, J., & Rukazenkov, Y. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2013.03.004 · Cited by 47
Therapy choices and quality of life in young breast cancer survivors: a short-term follow-up
Lee, M. C., Bhati, R. S., von Rottenthaler, E. E., Reagan, A., Karver, S. B., Reich, R. R., & Quinn, G. P. (2013) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2013.08.003 · Cited by 47
Quality of Life in 650 Lung Cancer Survivors 6 Months to 4 Years After Diagnosis
Svobodník, A., Yang, P., Novotny, P. J., Bass, E. B., Garces, Y. I., Jett, J. R., Bonner, J. A., & Sloan, J. A. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.8.1024 · Cited by 47
Effects of a Mindfulness-Based Stress Reduction Program on the Physical and Psychological Status and Quality of Life in Patients With Metastatic Breast Cancer
Lee, C. E., Kim, S., Kim, S., Joo, H. M., & Lee, S. H. (2017) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000220 · Cited by 47
Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in real-world practice in six European countries
von Moos, R., Body, J., Rider, A., de Courcy, J. J., Bhowmik, D., Gatta, F., Hechmati, G., & Qian, Y. (2017) · Journal of bone oncology · doi:10.1016/j.jbo.2017.11.004 · Cited by 47
“The PSCFs incorporated three instruments to facilitate the collection of PRO data on pain and QoL from patients with BMs and from those with metastases located at sites other than the bone (non-BMs), which included the BPI [24], the 5-dimension 3-level EuroQol questionnaire (EQ-5D), the EuroQol visual analog scale (EQ…”
Method
Understanding racial/ethnic differences in breast cancer-related physical well-being: the role of patient–provider interactions
Check, D., Chawla, N., Kwan, M. L., Pinheiro, L. C., Roh, J. M., Ergas, I. J., Stewart, A. L., Kolevska, T., Ambrosone, C. B., & Kushi, L. H. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4776-0 · Cited by 47
“The FACT-B is a validated, breast cancerspecific quality of life instrument that has been extensively used to measure quality of life in breast cancer patients and survivors across the care continuum.”
Influential
Development and Validation of the BREAST-Q Breast-Conserving Therapy Module
Klassen, A. F., Dominici, L. S., Fuzesi, S., Cano, S., Atisha, D. M., Locklear, T., Gregorowitsch, M. L., Tsangaris, E., Morrow, M., King, T. A., et al. (2020) · Annals of Surgical Oncology · doi:10.1245/s10434-019-08195-w · Cited by 49
Health-related quality of life assessment after breast reconstruction
Potter, S., Thomson, H. J., Greenwood, R., Hopwood, P., & Winters, Z. (2009) · British journal of surgery · doi:10.1002/bjs.6605 · Cited by 47
A Randomized Controlled Trial of Relaxation Training to Reduce Hot Flashes in Women with Primary Breast Cancer
Fenlon, D., Corner, J. L., & Haviland, J. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2007.05.014 · Cited by 47
“3) Marital status No current partner 18 (24) 19 (26) Married/partner 54 (72) 50 (67) Missing data 4 (5) 0 (0) Ethnic origin Caucasian 71 (93) 72 (97) Other (including mixed race) 5 (6) 2 (2) Time since diagnosis Less than 2 years 20 (26) 33 (45) 2e5 years 26 (34) 20 (27) Over 5 years 30 (39) 21 (28) Time since last me…”
An Exploratory Analysis of Fear of Recurrence among African-American Breast Cancer Survivors
Taylor, T. R., Huntley, E. D., Sween, J., Makambi, K. H., Mellman, T. A., Williams, C. D., Carter-Nolan, P. L., & Frederick, W. (2011) · International Journal of Behavioral Medicine · doi:10.1007/s12529-011-9183-4 · Cited by 47
“The FACT-B has been widely used in breast cancer studies and has been found to be reliable, valid, and easy to administer [32].”
Method
The effect of an evidence-based Tai chi intervention on the fatigue-sleep disturbance-depression symptom cluster in breast cancer patients: A preliminary randomised controlled trial
Yao, L.-Q., Kwok, S. W. H., Tan, J.-Y. B., Wang, T., Liu, X., Bressington, D. T., Chen, S.-L., & Huang, H. (2022) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2022.102202 · Cited by 49
The Role of the Mediterranean Diet in Breast Cancer Survivorship: A Systematic Review and Meta-Analysis of Observational Studies and Randomised Controlled Trials
Chen, G., Leary, S. D., Niu, J., Perry, R. E., & Papadaki, A. (2023) · Nutrients · doi:10.3390/nu15092099 · Cited by 47
“The higher the score, the better the QoL [53].”
Background
The Hand-Foot Skin Reaction and Quality of Life Questionnaire: An Assessment Tool for Oncology
Anderson, R. T., Keating, K. N., Doll, H., & CAMACHO, F. T. (2015) · The Oncologist · doi:10.1634/theoncologist.2014-0219 · Cited by 47
Associations of physical activity with quality of life and functional ability in breast cancer patients during active adjuvant treatment: the Pathways Study
Mandelblatt, J. S., Luta, G., Kwan, M. L., Makgoeng, S. B., Ergas, I. J., Roh, J. M., Sternfeld, B., Adams-Campbell, L. L., & Kushi, L. H. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1483-5 · Cited by 45
“We used the Functional Assessment of Cancer TherapyBreast Cancer (FACT-B) Version 4 to assess health-related QOL from the baseline interview as our primary outcome measure [9].”
Method
A pilot study on disseminating physical activity promotion among cancer survivors: a brief report
Pinto, B. M., Rabin, C., Abdow, S., & Papandonatos, G. D. (2007) · Psycho-Oncology · doi:10.1002/pon.1268 · Cited by 46
“Significant positive effects were found in participants’ self-reported PA, QOL, fatigue, and vigor at 12 and 24 weeks.”
BackgroundInfluential
The English and Chinese versions of the five-level EuroQoL Group's five-dimension questionnaire (EQ-5D) were valid and reliable and provided comparable scores in Asian breast cancer patients
Lee, C. F., Ng, R. C. H., Luo, N., Wong, N. S., Yap, Y. S., Lo, S. K., Chia, W. K., Yee, A., Krishna, L. K. R., Wong, C., et al. (2012) · Supportive Care in Cancer · doi:10.1007/s00520-012-1512-x · Cited by 46
“The validity and reliability of, and the comparability between the English and Chinese versions of the FACT-B have been previously demonstrated [11, 12, 20].”
BackgroundMethod
Final results of the TANIA randomised phase III trial of bevacizumab after progression on first-line bevacizumab therapy for HER2-negative locally recurrent/metastatic breast cancer
Vrdoljak, E., Marschner, N. W., Zielinski, C. C., Gligorov, J., Cortés, J., Puglisi, F., Aapro, M., Fallowfield, L. J., Fontana, A., Inbar, M., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw316 · Cited by 47
Economic and Humanistic Burden of Triple-Negative Breast Cancer: A Systematic Literature Review
Huang, M., Haiderali, A., Fox, G. E., Frederickson, A. M., Cortés, J., Fasching, P. A., & O’Shaughnessy, J. (2022) · PharmacoEconomics · doi:10.1007/s40273-021-01121-7 · Cited by 45
“FACT-B FACT-B is an instrument that assesses five domains of HRQoL in BC patients (physical well-being, social well-being, emotional well-being, functional wellbeing, and BC subscale) [68].”
Method
Design and implementation of the Exercise for Health trial — A pragmatic exercise intervention for women with breast cancer
Hayes, S. C., Rye, S., Battistutta, D., Yates, P. M., Pyke, C., Bashford, J., & Eakin, E. (2011) · Contemporary Clinical Trials · doi:10.1016/j.cct.2011.03.015 · Cited by 45
Long-Term Effect of an Interdisciplinary Supportive Care Intervention for Lung Cancer Survivors After Surgical Procedures
Raz, D. J., Sun, V. C.-Y., Kim, J. Y., Williams, A. C., Koczywas, M., Cristea, M. C., Reckamp, K. L., Hayter, J., Tiep, B. L., & FERRELL, B. R. (2015) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2015.07.031 · Cited by 45
Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer
Jones, L. W., Douglas, P. S., Eves, N. D., Marcom, P. K., Kraus, W. E., Herndon, J. E., Inman, B. A., Allen, J. D., & Peppercorn, J. M. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-531 · Cited by 46
“QOL will be assessed using the Functional Assessment of Cancer Therapy Breast (FACT-B) scale developed for the assessment of patient symptoms and QOL in breast cancer patients [36].”
Effects of global meaning and illness-specific meaning on health outcomes among breast cancer patients
Sherman, A. C., Simonton, S., Latif, U., & Bracy, L. (2010) · Journal of Behavioral Medicine · doi:10.1007/s10865-010-9267-7 · Cited by 47
Menopausal symptoms, sexual function, depression, and quality of life in Korean patients with breast cancer receiving chemotherapy
Park, H., & Yoon, H. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1815-6 · Cited by 45
“QOL was measured with the Korean version of Functional Assessment of Cancer Therapy—Breast Cancer Version 4 (FACT-B), and it has been shown to have satisfactory validity [28].”
Method
Review of treatment assessment using DCE-MRI in breast cancer radiation therapy
Wang, C. (2014) · World Journal of Methodology · doi:10.5662/wjm.v4.i2.46 · Cited by 45
Online Support Groups for Women with Metastatic Breast Cancer: A Feasibility Pilot Study
Vilhauer, R. P., McClintock, M. K., & Matthews, A. K. (2010) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2010.504504 · Cited by 45
“…measuring physical well-being, social/family well-being, emotional well-being, functional well-being, and coping with breast cancer-related distress (Brady et al., 1997); the Multidimensional Scale of Perceived Social Support (MSPSS), a 12-item, 7-point, questionnaire with subscales that measure…”
Method
Do Patient-reported Outcome Measures Agree with Clinical and Photographic Assessments of Normal Tissue Effects after Breast Radiotherapy? The Experience of the Standardisation of Breast Radiotherapy (START) Trials in Early Breast Cancer
Haviland, J., Hopwood, P., Mills, J., Sydenham, M. A., Bliss, J. M., & Yarnold, J. R. (2016) · Clinical Oncology · doi:10.1016/j.clon.2016.01.011 · Cited by 44
Illness perception and sense of well-being in breast cancer patients
Lee, Y., Baek, J. M., Jeon, Y. W., & Im, E. (2019) · Patient Preference and Adherence · doi:10.2147/ppa.s225561 · Cited by 46
“The Functional Assessment of Cancer Therapy for Breast Cancer (FACT-B) was used to assess participants’ sense of well-being on five domains: physical well-being, social/family well-being, emotional well-being, functional well-being, and breast-cancer-specific well-being.(28,29) It is a 36-item questionnaire rated on a…”
Method
Perceived social support and coping style as mediators between resilience and health-related quality of life in women newly diagnosed with breast cancer: a cross-sectional study
Zhou, K., Ning, F., Wang, X., Wang, W., Han, D., & Li, X. (2022) · BMC Women s Health · doi:10.1186/s12905-022-01783-1 · Cited by 45
“0 total score (ranging from 0 to 144) is the sum of the ve subscales scores, with a higher score indicating better HRQoL [24].”
Background
Facilitating lifestyle changes to manage menopausal symptoms in women with breast cancer: a randomized controlled pilot trial of The Pink Women's Wellness Program
Anderson, D. J., Seib, C., McCarthy, A. L., Yates, P., Porter-Steele, J., McGuire, A., & Young, L. (2015) · Menopause · doi:10.1097/gme.0000000000000421 · Cited by 45
Cognitive Behavioral Therapy for Insomnia, Mindfulness, and Yoga in Patients With Breast Cancer with Sleep Disturbance: A Literature Review
Zeichner, S. B., Zeichner, R. L., Gogineni, K., Shatil, S., & Ioachimescu, O. (2017) · Breast Cancer Basic and Clinical Research · doi:10.1177/1178223417745564 · Cited by 43
“17–21 As they can have a tremendous influence on a patient’s sleep pattern, clinicians should assess for and address the following confounding factors during their initial patient assessment: (1) disease-related (ie, laboratory and radiographic studies and where patients are in their cancer diagnosis/treatment timelin…”
Mapping clinical outcomes to generic preference-based outcome measures: development and comparison of methods.
Alava, M. H., Wailoo, A., Pudney, S., Gray, L., & Manca, A. (2020) · Health Technology Assessment · doi:10.3310/hta24340 · Cited by 38
Effect of a 4-Week Internet-Delivered Mindfulness-Based Cancer Recovery Intervention on the Symptom Burden and Quality of Life of Patients With Breast Cancer: Randomized Controlled Trial
Wang, L., Chen, X., Peng, Y., Zhang, K., Ma, J., Xu, L., Liu, Z., Liu, L., Luo, Y., & Gu, C. (2022) · Journal of Medical Internet Research · doi:10.2196/40059 · Cited by 44
“Missing data (<20%) were handled with the participants’ average response on the remaining scale items, and the missing data in the FACT-B questionnaire were treated by the proportion method per the manual instructions [33].”
Method
Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial
Scott, J. M., Lee, J., Herndon, J. E., Michalski, M., Lee, C. P., O’Brien, K. A., SASSO, J. P., Yu, A. F., Rowed, K., Bromberg, J., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad085 · Cited by 44
The association of chemotherapy versus hormonal therapy and health outcomes among patients with hormone receptor-positive, HER2−negative metastatic breast cancer: experience from the patient perspective
Gupta, S., Zhang, J., & Jérusalem, G. (2014) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/14737167.2014.949243 · Cited by 44
“Functional assessment of cancer therapy-breast The functional assessment of cancer therapy-breast (FACT-B) was used to measure HRQoL [33,34], consisting of the FACT-General (FACT-G) plus the Breast Cancer Subscale (BCS).”
Method
Randomized Controlled Trial of Patient Navigation for Newly Diagnosed Cancer Patients: Effects on Quality of Life
Hendren, S. K., Griggs, J. J., Epstein, R. M., Humiston, S. G., Jean‐Pierre, P., Winters, P., Sanders, M., Loader, S., & Fiscella, K. A. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0537 · Cited by 47
“Furthermore, QOL was measured using wellvalidated instruments with demonstrated sensitivity to change (18, 21).”
Contemplative self healing in women breast cancer survivors: a pilot study in underserved minority women shows improvement in quality of life and reduced stress
Charlson, M. E., Loizzo, J. J., Moadel, A. B., Neale, M., Newman, C., Olivo, E. L., Wolf, E. J., & Peterson, J. C. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-349 · Cited by 44
Effect of empowerment on the quality of life of the survivors of breast cancer: The moderating effect of self‐help group participation
Shin, S. H., & Park, H. (2017) · Japan Journal of Nursing Science · doi:10.1111/jjns.12161 · Cited by 44
Cancer-Relevant Self-Efficacy Is Related to Better Health-Related Quality of Life and Lower Cancer-Specific Distress and Symptom Burden Among Latina Breast Cancer Survivors
Baik, S. H., Oswald, L. B., Buitrago, D., Buscemi, J., Iacobelli, F., Perez-Tamayo, A. M., Guitelman, J., Diaz, A., Penedo, F. J., & Yanez, B. R. (2020) · International Journal of Behavioral Medicine · doi:10.1007/s12529-020-09890-9 · Cited by 47
“55) [44] as well as other samples of Latina BCS (M = 105; SD = 19.”
BackgroundMethod
Reliability and validity of the Functional Assessment of Cancer Therapy General (FACT-G) in French cancer patients
Costet, N., Lapierre, V., Benhamou, E., & Galès, C. L. (2005) · Quality of Life Research · doi:10.1007/s11136-004-5531-z · Cited by 44
“Comparison of results from this study with findings from other studies [6, 7, 20, 21] is not strictly valid since previous studies involved prior versions of the questionnaire.”
Result
Quality of life assessment in advanced non-small-cell lung cancer patients undergoing an accelerated radiotherapy regimen: report of ECOG study 4593
Auchter, R. M., Scholtens, D. M., Adak, S., Wagner, H., Cella, D. F., & Mehta, M. P. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(01)01604-2 · Cited by 44
Self-citation
The role of depression in the relationship between cognitive decline and quality of life among breast cancer patients
Park, J.-H., Jung, Y. S., Jung, Y.-M., & Bae, S. H. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-018-4546-x · Cited by 43
Measuring Quality of Life Using Patient-Reported Outcomes in Real-World Metastatic Breast Cancer Patients: The Need for a Standardized Approach
Clarijs, M. E., Thurell, J., Kühn, F., Groot, C. A. U., Hedayati, E., Karsten, M. M., Jager, A., & Koppert, L. B. (2021) · Cancers · doi:10.3390/cancers13102308 · Cited by 45
“ESAS, FACT-B Meisel, J.L. et al., 2012 [40] To evaluate psychological adjustment of women living long-term with metastatic disease Cross-sectional study 28 eligible US women, of which 18 completed the questionnaires.”
Influential
Effectiveness of three exercise programs and intensive follow-up in improving quality of life, pain, and lymphedema among breast cancer survivors: a randomized, controlled 6-month trial
Lin, Y., Wu, C., He, C., Yan, J., Chen, Y., Gao, L., Liu, R., & Cao, B. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07494-5 · Cited by 47
Quality of life among a population-based cohort of older patients with breast cancer
Neuner, J. M., Zokoe, N., McGinley, E. L., Pezzin, L. E., Yen, T. W. F., Schapira, M. M., & Nattinger, A. B. (2014) · The Breast · doi:10.1016/j.breast.2014.06.002 · Cited by 43
“The FACT-B BCS includes nine items regarding bother or worry about cancer and symptoms over the previous seven days, and has had extensive reliability and validity testing [43].”
Method
Expressive Writing in Women With Advanced Breast Cancer
Laccetti, M. (2007) · Oncology nursing forum · doi:10.1188/07.onf.1019-1024 · Cited by 43
“Despite that fact that item analysis was used extensively in developing the FACT-B to reduce item content redundancy (Brady et al., 1997), some overlap may still exist.”
How does adjuvant chemotherapy affect menopausal symptoms, sexual function, and quality of life after breast cancer?
Marino, J. L., Saunders, C. M., Emery, L. I., Green, H., Doherty, D. A., & Hickey, M. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000664 · Cited by 43
Trajectories of quality of life following breast cancer diagnosis
Goyal, N. G., Levine, B. J., Zee, K. J. V., Naftalis, E. Z., & Avis, N. E. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4677-2 · Cited by 44
“The Functional Assessment of Cancer Therapy-Breast (FACT-B [13]), a breast cancer-specific measure, is considered to be more sensitive to disease-related changes * Nancy E. Avis navis@wakehealth.edu 1 Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, N…”
BackgroundMethodInfluential
Association of Transforming Growth Factor β Polymorphism C−509T With Radiation-Induced Fibrosis Among Patients With Early-Stage Breast Cancer
Grossberg, A. J., Lei, X. J., Xu, T., Shaitelman, S. F., Hoffman, K. E., Bloom, E. S., Stauder, M. C., Tereffe, W., Schlembach, P. J., Woodward, W. A., et al. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.2583 · Cited by 43
“Breast Cancer (FACT-B) module trial outcome index.(30) Each”
Background
Priority Symptoms in Advanced Breast Cancer: Development and Initial Validation of the National Comprehensive Cancer Network-Functional Assessment of Cancer Therapy-Breast Cancer Symptom Index (NFBSI-16)
Garcia, S. F., Rosenbloom, S. K., Beaumont, J. L., Merkel, D. E., Roenn, J. H. V., Rao, D., & Cella, D. F. (2011) · Value in Health · doi:10.1016/j.jval.2011.08.1739 · Cited by 44
Self-citation
Exercise therapy in women who have had breast cancer: design of the Sheffield women's exercise and well-being project
Daley, A. (2004) · Health Education Research · doi:10.1093/her/cyg094 · Cited by 43
“This change represents a shift from being fully ambulatory with symptoms to being fully ambulatory without symptoms (Brady et al., 1997).”
Background
Development and initial evaluation of a telephone-delivered, behavioral activation, and problem-solving treatment program to address functional goals of breast cancer survivors
Lyons, K. D., Hull, J. G., Kaufman, P. A., Li, Z., Seville, J. L., Ahles, T. A., Kornblith, A. B., & Hegel, M. T. (2015) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2014.1002659 · Cited by 42
“The Functional Assessment of Cancer Therapy-Breast Cancer + Arm Morbidity (FACT-B+4) is a 41-item self-report measure of health-related quality of life specifically designed for breast cancer patients (Brady et al., 1997; Coster, Poole, & Fallowfield, 2001).”
Background
Indications of Clinical and Genetic Predictors for Aromatase Inhibitors Related Musculoskeletal Adverse Events in Chinese Han Women with Breast Cancer
Wang, J., Lu, K., Song, Y., Xie, L., Zhao, S., Wang, Y., Sun, W., Liu, L., Zhao, H., Tang, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068798 · Cited by 41
“Repaired the scales (WOMAC, M-SACRAH, BPI-SF and FACT-G) and told the patients how to write: WS HZ DT WM.”
MethodInfluential
Longitudinal Reciprocal Relationships Between Quality of Life and Coping Strategies Among Women with Breast Cancer
Paek, M.-S., Ip, E. H., Levine, B. J., & Avis, N. E. (2016) · Annals of Behavioral Medicine · doi:10.1007/s12160-016-9803-y · Cited by 42
“Mean FACT-B domain scores by survey time points Ann Behav Med.”
MethodInfluential
Return to work after breast cancer diagnosis: An observational prospective study in Brazil
Landeiro, L. C. G., Gagliato, D. D. M., Fêde, Â., Fraile, N. M. P., López, R. V. M., da Fonseca, L. G., Petry, V., Testa, L., Hoff, P. M., & Mano, M. S. (2018) · Cancer · doi:10.1002/cncr.31735 · Cited by 44
“QOL was assessed at 6, 12, and 24 months after diagnosis using the FACT-B questionnaire.(16) Clinical variables included cancer stage, immunohistochemistry, cancer-directed treatment (chemotherapy, radiotherapy, endocrine therapy, and antihuman epidermal growth factor receptor 2 [anti-HER2] therapy), comorbidity, and…”
Method
Effects of Progressive Upper Limb Exercises and Muscle Relaxation Training on Upper Limb Function and Health-Related Quality of Life Following Surgery in Women with Breast Cancer: A Clinical Randomized Controlled Trial
Zhou, K., Wang, W., An, J., Li, M., Li, J., & Li, X. (2019) · Annals of Surgical Oncology · doi:10.1245/s10434-019-07305-y · Cited by 42
Expressive writing as a therapeutic intervention for people with advanced disease: a systematic review
Kupeli, N., Chatzitheodorou, G., Troop, N., McInnerney, D., Stone, P. C., & Candy, B. (2019) · BMC Palliative Care · doi:10.1186/s12904-019-0449-y · Cited by 52
Value Lies in the Eye of the Patients: The Why, What, and How of Patient-reported Outcomes Measures
Ciani, O., & Federici, C. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.11.016 · Cited by 42

Authors: Brady, M. J., Cella, D. F., Mo, F., Bonomi, A. E., Tulsky, D. S., Lloyd, S. R., Deasy, S., Cobleigh, M., & Shiomoto, G.
Affiliations: Rush University Medical Center (US)
Rush University (US)
ORCID: Cella, D F
Bonomi, A E
Tulsky, D S
Lloyd, S R
Cobleigh, M
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 1997-03
Volume: 15
Issue: 3
Pages: 974-986
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.1997.15.3.974
OpenAlex: W1857624176
Cited by: 1,752
References: 39
Citations by year: 2026: 47 · 2025: 76 · 2024: 77 · 2023: 71 · 2022: 97 · 2021: 88 · 2020: 78 · 2019: 87 · 2018: 83 · 2017: 85 · 2016: 83 · 2015: 73 · 2014: 83 · 2013: 70 · 2012: 86
FWCI: 5.28
Type: journal article
Language: en
Open access: closed
Locations: Journal of Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r29ca051926-01a1)
National Cancer Institute (R29CA51926)
Topics: Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Nursing › Research and Theory › Health Education and Validation
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Keywords: FACT-B, breast cancer, quality of life, FACT-G, instrument validation, sensitivity to change, test-retest reliability, internal consistency, known-groups validity, convergent validity, discriminant validity, physical well-being, functional well-being, emotional well-being, Functional Living Index-Cancer, self-report questionnaire
MeSH terms: Adult, Aged, Aged, 80 and over, Breast Neoplasms, Female, Humans, Middle Aged, Quality of Life, Self Concept, Sensitivity and Specificity, Severity of Illness Index, Translations, Reproducibility of Results

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Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument.

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