Cited by 1,752Cancer survivorship and careHealth Education and ValidationHealth Systems, Economic Evaluations, Quality of Life

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument.

Brady, M J, Cella, D F, Mo, F, Bonomi, A E, Tulsky, D S, Lloyd, S R, Deasy, S, Cobleigh, M, Shiomoto, G·1997·Journal of Clinical Oncology

DOI 10.1200/jco.1997.15.3.974

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Abstract

PURPOSE: This is the first published report on the validation of the Functional Assessment of Cancer Therapy-Breast (FACT-B), a 44-item self-report instrument designed to measure multidimensional quality of life (QL) in patients with breast cancer. The FACT-B consists of the FACT-General (FACT-G) plus the Breast Cancer Subscale (BCS), which complements the general scale with items specific to QL in breast cancer. The FACT-B was developed with an emphasis on patients' values and brevity and is available in nine languages. METHODS AND RESULTS: Two validation samples were used for this report. The first (n = 47) was tested twice over a 2-month period to assess sensitivity to change. Significant sensitivity to change in performance status rating (PSR) was demonstrated for the FACT-B total score, the Physical Well-Being (PWB) subscale, the Functional Well-Being (FWB) subscale, and the BCS. Sensitivity to change in QL as measured by the Functional Living Index-Cancer (FLIC) was documented in the FACT-B total score, PWB, FWB, and Emotional Well-Being (EWB). Additional validity and reliability data were obtained from a larger sample (n = 295). The alpha coefficient (internal consistency) for the FACT-B total score was high (alpha = .90), with subscale alpha coefficients ranging from .63 to .86. Evidence supported test-retest reliability, as well as convergent, divergent, and known groups validity. CONCLUSION: The FACT-B is appropriate for use in oncology clinical trials, as well as in clinical practice. It demonstrates ease of administration, brevity, reliability, validity, and sensitivity to change.

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The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., Haes, J. C. J. M. D., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.5.365 · Cited by 16,005
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DeMello, M. M., Pinto, B. M., Mitchell, S., DUNSIGER, S. I., & Stein, K. (2018) · European Journal of Cancer Care · doi:10.1111/ecc.12849 · Cited by 21
“Functional Assessment of Cancer Therapy Scale for Breast Cancer (FACT-B) is a 55-item scale that assesses quality of life and is reliable and valid (Brady et al., 1997).”
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“These observations are consistent with previous research.(34) As recommended,(34) the BCS subscale was retained to include a measure of breast cancer‐specific concerns.”
MethodResult
Mapping function from FACT-B to EQ-5D-5 L using multiple modelling approaches: data from breast cancer patients in China
Yang, Q., Yu, X., Zhang, W., & Li, H. (2019) · Health and Quality of Life Outcomes · doi:10.1186/s12955-019-1224-8 · Cited by 21
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“[8] Brady MJ, Cella DF, Mo F, et al.”
BackgroundMethod
Quality of Life Among Breast Cancer Survivors 2 Years After Diagnosis
Xue, J.-M., Gao, W., & Cao, F. (2015) · Cancer Nursing · doi:10.1097/ncc.0000000000000280 · Cited by 21
The impact of hormonal treatments on quality of life of patients with metastatic breast cancer
Costantino, J. (2002) · Clinical Therapeutics · doi:10.1016/s0149-2918(02)85159-1 · Cited by 21
Maintenance of Fitness and Quality-of-Life Benefits From Supervised Exercise Offered as Supportive Care for Breast Cancer
Kirkham, A. A., Bland, K. A., Wollmann, H., Bonsignore, A., McKenzie, D. C., Patten, C. L. V., Gelmon, K. A., & Campbell, K. L. (2019) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.7276 · Cited by 20
Synergistic Interactions Among Fatigue, Sleep Disturbance, and Depression in Women With Breast Cancer: A Cross-Sectional Study
He, X., Ng, M., Choi, K., Li, L., Zhao, W., Zhang, M., & So, W. (2022) · Oncology nursing forum · doi:10.1188/22.onf.243-254 · Cited by 20
Item Response Theory (IRT): Applications in Quality of Life Measurement, Analysis and Interpretation
Cella, D. F., Chang, C., & Heinemann, A. W. (2002) · Springer eBooks · doi:10.1007/978-1-4757-3625-0_14 · Cited by 19
Self-citation
Work‐related perceptions and quality of life among breast cancer survivors
Keim‐Malpass, J., Levine, B. J., Danhauer, S. C., & Avis, N. E. (2015) · Psycho-Oncology · doi:10.1002/pon.3951 · Cited by 20
“A total FACT-B score is the sum of the five domains.”
MethodInfluential
Mapping and direct valuation: do they give equivalent EQ-5D-5L index scores?
Luo, N., Cheung, Y. B., Ng, R. C. H., & Lee, C. F. (2015) · Health and Quality of Life Outcomes · doi:10.1186/s12955-015-0361-y · Cited by 20
The FACIT-AI, a new tool for assessing symptoms associated with malignant ascites
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Self-citation
Development of a breast reconstruction satisfaction questionnaire (BRECON): Dimensionality and clinical importance of breast symptoms, donor site issues, patient expectations, and relationships
Temple, C. L. F., Cook, E. F., Ross, D. C., Bettger‐Hahn, M., & MacDermid, J. C. (2010) · Journal of Surgical Oncology · doi:10.1002/jso.21477 · Cited by 20
“There were four lumpectomy/mastectomy questionnaires (body image after breast cancer questionnaire—BIBCQ [31], early stage breast cancer questionnaire—ESBC [32], European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Breast-Cancer Specific Module—EORTC-QLQ-BR23 [33], and the functiona…”
Method
Cognitive Effects of Chemotherapy-Induced Menopause in Breast Cancer
Vearncombe, K., Rolfe, M. I., Andrew, B., Pachana, N. A., Wright, M. J., & Beadle, G. F. (2011) · The Clinical Neuropsychologist · doi:10.1080/13854046.2011.631586 · Cited by 20
A social program for adolescent and young adult survivors of pediatric brain tumors: The power of a shared medical experience
Liptak, C. C., Brinkman, T. M., Bronson, A., Delaney, B. L., Chordas, C. A., Brand, S. R., Patenaude, A. F., Muriel, A. C., & Manley, P. E. (2016) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2016.1225146 · Cited by 20
“Higher scores on this measure indicate a better quality of life (Brady et al., 1997).”
Background
Depressive symptoms and positive affect in Chinese and United States breast cancer survivors: a cross-cultural comparison
Milbury, K., Kavanagh, A., Meng, Z., Chen, Z., Chandwani, K. D., Garcia, K., Perkins, G. H., McQuade, J. L., Raghuram, N. V., Nagarathna, R., et al. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-017-3612-0 · Cited by 20
Impact of physical activity in group versus individual physical activity on fatigue in patients with breast cancer: A pilot study
Desbiens, C., Filion, M., Brien, M.-C., Hogue, J., Laflamme, C., & Lemieux, J. (2017) · The Breast · doi:10.1016/j.breast.2017.06.001 · Cited by 21
Endoscopy-assisted breast-conserving surgery for breast cancer patients.
Ozaki, S., & Ohara, M. (2014) · PubMed Central · doi:10.3978/j.issn.2227-684x.2013.12.04 · Cited by 20
“Ideally, these kinds of surveys should also be performed at least three years after radiotherapy with standardized and object ive methods such as a 4-point scoring system for the aesthetic estimation combined with a European Organisation for Research and Treatment of Cancer (EORTC) breast cancer-specific quality of li…”
Method
Immunological Therapies Can Relieve Aromatase Inhibitor-Related Joint Symptoms in Breast Cancer Survivors
Zhang, Q., Tang, D., & Zhao, H. (2010) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e3181cae782 · Cited by 20
“1,(16) and Functional Assessment of Cancer Therapy-General (FACT-G).(17) Serum was obtained at baseline and post-treatment.”
Method
Health-related quality of life in Black breast cancer survivors with and without triple-negative breast cancer (TNBC)
Vadaparampil, S. T., Christie, J., Donovan, K. A., Kim, J., Augusto, B. M., Kasting, M. L., Holt, C. L., Ashing, K. T., Halbert, C. H., & Pal, T. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4173-0 · Cited by 20
Evaluation of Glutathione Metabolic Genes on Outcomes in Advanced Non-small Cell Lung Cancer Patients after Initial Treatment with Platinum-Based Chemotherapy: An NCCTG-97-24-51 Based Study
Yang, P., Mandrekar, S. J., Hillman, S. H., Ziegler, K. L. A., Sun, Z., Wampfler, J. A., Cunningham, J. M., Sloan, J. A., Adjei, A. A., Perez, E. A., et al. (2009) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31819c7a2c · Cited by 20
Quality of Life in Older Adults with HIV Disease
Avis, N. E., & Smith, K. W. (1998) · Research on Aging · doi:10.1177/0164027598206010 · Cited by 20
Evaluation of outcome after immediate breast reconstruction: prospective comparison of four methods.
Gui, G., Kadayaprath, G., Tan, S.-M., Faliakou, E., Choy, C., A'Hern, R., & Ward, A. (2005) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000165081.54107.b9 · Cited by 21
Cross-cultural adaptation of the Disability of Arm, Shoulder, and Hand questionnaire: Spanish for Puerto Rico Version
Portela, A. L. M., Santaella, C. L. C., & Cruz-Gómez, C. (2009) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0b013e32830435b8 · Cited by 20
“Its psychometric properties have been evaluated and it was found to be reliable and valid (Brady et al., 1997).”
A Prospective Pilot Clinical Trial of “The Work” Meditation Technique for Survivors of Breast Cancer
Lev-ari, S., Zilcha-Mano, S., Rivo, L., Geva, R., & Ron, I. (2013) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2013.07.003 · Cited by 19
Interactivity, Presence, and Targeted Patient Care: Mapping e-Health Intervention Effects Over Time for Cancer Patients with Depression
Kim, S. C., Shaw, B. R., Shah, D. V., Hawkins, R. P., Pingree, S., McTavish, F. M., & Gustafson, D. H. (2019) · Health Communication · doi:10.1080/10410236.2017.1399504 · Cited by 19
“The reliability and validity of these measures have been tested in prior research (Baker et al., 2011; Brady et al., 1997; Cella et al., 1993; Gustafson et al., 2005).”
Background
Effect of bright light therapy on cancer-related fatigue and related symptoms: A systematic review and meta-analysis of randomized controlled trials
Lin, L., Tam, K., & Huang, T. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111501 · Cited by 20
Comprehensive Review of Breast Cancer Consequences for the Patients and Their Coping Strategies: A Systematic Review
Kasgri, K. A., Abazari, M., Badeleh, S. M., Badeleh, K. M., & Peyman, N. (2024) · Cancer Control · doi:10.1177/10732748241249355 · Cited by 32
Lymphoedema and health-related quality of life by early treatment in long-term survivors of breast cancer. A comparative retrospective study up to 15 years after diagnosis
Karlsson, K., Wallenius, I., Nilsson-Wikmar, L. B., Lindman, H., & Johansson, B. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2662-4 · Cited by 19
“90) in the English language translation [18].”
Effect of a structured yoga program on fatigue, depression, cardiorespiratory fitness, and quality of life in a postmenopausal breast cancer survivor
Dangi, A. A., Aurangabadkar, S., & Deo, M. (2018) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_61_17 · Cited by 19
“Her quality of life was evaluated using Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer [FACT‐B + 4 (Version 4)].[9] The patient’s total score in all four domains was found to be 77.”
Method
Randomized controlled trial of a breast cancer Survivor Stories intervention for African American women
Thompson, T., Pérez, M., Yan, Y., Kreuter, M. W., Margenthaler, J. A., Colditz, G. A., & Jeffe, D. B. (2020) · Social Science & Medicine · doi:10.1016/j.socscimed.2020.113663 · Cited by 20
Sense of coherence and coping strategies: How they influence quality of life in Iranian women with breast cancer
Zamanian, H., Amini‐Tehrani, M., Adeli, A. M., Daryaafzoon, M., Arsalani, M., Enzevaei, A., & Farjami, M. (2021) · Nursing Open · doi:10.1002/nop2.814 · Cited by 19
“The sum of all five subscales gives us the FACT- B total score, ranging from 0– 144; the higher the total score, the better the HRQoL (Brady et al., 1997).”
Background
A randomized controlled trial of the effect of supervised exercise on functional outcomes in older African American and non‐Hispanic White breast cancer survivors: Are there racial differences in the effects of exercise on functional outcomes?
Owusu, C., Margevicius, S. P., Nock, N. L., Austin, K., Bennet, E., Cerne, S., Hergenroeder, P., Moore, H. C. F., Petkac, J., SCHLUCHTER, M. D., et al. (2022) · Cancer · doi:10.1002/cncr.34184 · Cited by 19
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Parma, D. L., Reynolds, G. L., Muñoz, E., & Ramírez, A. G. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07023-4 · Cited by 19
“These include the 27-item FACT-General (FACT-G), one of the most widely used validated instruments assessing overall response to cancer treatment and survivorship [23, 24]; and the FACT-B, which includes all domains of FACT-G and adds a breast-cancer specific domain [25, 26].”
Method
Effects of Tai Chi Chuan training on the QoL and psychological well-being in female patients with breast cancer: a systematic review of randomized controlled trials
Li, W., You, F., Wang, Q., Shen, Y., Wang, J., & Guo, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1143674 · Cited by 20
Health-Related Quality of Life Among Cancer Survivors Attending Support Groups
Medeiros, E. A., Castañeda, S. F., González, P., Rodríguez, B., Buelna, C., West, D., & Talavera, G. A. (2014) · Journal of Cancer Education · doi:10.1007/s13187-014-0697-8 · Cited by 19
Analysis of patient satisfaction and donor-site morbidity after different types of breast reconstruction
Benditte‐Klepetko, H., Lutgendorff, F., Kästenbauer, T., Deutinger, M., & van der Horst, C. M. A. M. (2014) · Scandinavian Journal of Surgery · doi:10.1177/1457496913512829 · Cited by 19
“This study-specific questionnaire was developed based on questionnaires previously used to assess surgical procedures of the breast, including European organization for Research and Treatment of Cancer Breast Cancer-Specific Quality of Life (EoRTC QLQ BR-23) (12) and Functional Assessment of Cancer Therapy-Breast (FAC…”
Method
Pilot study of yoga for breast cancer survivors with poor quality of life
Levine, A. S., & Balk, J. L. (2012) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2012.06.007 · Cited by 19
Prevalence and Impacts of Upper Limb Morbidity after Treatment for Breast Cancer: A Cross-Sectional Study of Lymphedema and Function
Bulley, C., Coutts, F., Blyth, C., Jack, W. J. L., Chetty, M., Barber, M. D., & Tan, C.-W. (2013) · Cancer and Oncology Research · doi:10.13189/cor.2013.010203 · Cited by 19
“B and FACT B+4 [18].”
Health-related quality of life among women with ductal carcinomain situor early invasive breast cancer: validation of the FACT-B (version 4)
Hahn, E. A., Segawa, E., Kaiser, K., Cella, D. F., & Smith, B. D. (2016) · Expert Review of Quality of Life in Cancer Care · doi:10.1080/23809000.2016.1134259 · Cited by 19
“Originally developed and validated in 1997 [49], the FACT-B has continued to evolve as understanding of HRQL issues in breast cancer patients has continued to advance.”
BackgroundMethodInfluentialSelf-citation
The role of cognitive emotion regulation strategies in health related quality of life of breast cancer patients
Kovac, A., Tovilović, S., Bugarski-Ignjatovic, V., Popovic-Petrovic, S., & Tatic, M. (2020) · Vojnosanitetski Pregled · doi:10.2298/vsp180205178k · Cited by 12
“Breast cancer is often accompanied by patients‘ unpleasant emotional states, which can significantly affect both the undergoing treatment and the quality of life of patients.”
MethodInfluential
Secondary outcomes of a behavioral sleep intervention: A randomized clinical trial.
Palesh, O. G., Scheiber, C., Kesler, S. R., Gevirtz, R., Heckler, C. E., Guido, J. J., Janelsins, M. C., Cases, M. G., Tong, B., Miller, J. M., et al. (2019) · Health Psychology · doi:10.1037/hea0000700 · Cited by 19
Cognitive Functioning and Psychological Well-being in Breast Cancer Patients on Endocrine Therapy
Biró, E. M., Kahán, Z., Kalman, J. L., Rusz, O., Pákáski, M., Irinyi, T., Kelemen, G., Dudás, R., Drótos, G., & Hamvai, C. (2019) · In Vivo · doi:10.21873/invivo.11615 · Cited by 19
Association of Fatigue, Quality of Life and Functional Capacity in Breast Cancer Patients Receiving Adjuvant Chemotherapy
Amarsheda, S., & Bhise, A. R. (2021) · Asian Pacific Journal of Cancer Care · doi:10.31557/apjcc.2021.6.1.59-64 · Cited by 19
Qualidade de vida de mulheres com câncer de mama
Conde, D. M., Pinto-Neto, A. M., Freitas‐Júnior, R., & Aldrighi, J. M. (2006) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1590/s0100-72032006000300010 · Cited by 19
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Muñoz-Mateu, M. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1061-2 · Cited by 19
Quality of life in patients with breast cancer and their rehabilitation needs
Chen, H., Xiao-chun, W., Jiang-bin, W., Jing-bo, Z., & Yao, W. (2013) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.301.3952 · Cited by 19
Novel concepts for the chemoprevention of breast cancer through aromatase inhibition
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“The well-validated Functional Assessment of Cancer Therapy-Breast (FACT-B) and endocrine subscale (ES) (Brady et al. 1997) were used in the ATAC and IES substudies.”
Method
Quality of life in breast cancer: what have we learned and where do we go from here?
Ganz, P. A., & Goodwin, P. J. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545856.005 · Cited by 20
Cisplatin–etoposide alternating with topotecan in patients with extensive stage small cell lung cancer (SCLC)
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Clinical Protocol: A Phase I Trial of Intra Lesional RV-B7.1 Vaccine in the Treatment of Malignant Melanoma. Albert Einstein Center, Bronx, New York.
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Research on the issue of financial toxicity in cancer: A systematic review of the literature
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Cost-Effectiveness of MR-Mammography in Breast Cancer Screening of Women With Extremely Dense Breasts After Two Rounds of Screening
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Impact of Racial/Ethnic Discrimination on Quality of Life Among Breast Cancer Survivors
Shariff‐Marco, S., Sangaramoorthy, M., Ellis, L., Thomsen, C., Roh, J. M., Kroenke, C. H., Valice, E., Kwan, M. L., Ambrosone, C. B., Kushi, L., et al. (2022) · American Journal of Epidemiology · doi:10.1093/aje/kwac208 · Cited by 18
Home-based exercise improves quality of life in breast and prostate cancer survivors: A meta-analysis
Bates‐Fraser, L. C., Riley, S., Stopforth, C. K., Moertl, K. M., Edgar, K. M., Stoner, L. R., & Hanson, E. D. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284427 · Cited by 20
“quantify QoL, including FACT-B [26], FACT-G [27], FACT-P [28], SF-36 [29], IBCSG [30], EORTC [31], PORPUS [32], PFS [33].”
Influential
A Feasibility Randomized Controlled Trial of Prehabilitation During Neoadjuvant Chemotherapy for Women with Breast Cancer: A Mixed Methods Study
Brahmbhatt, P., Hong, N. J. L., Sriskandarajah, A., Alavi, N., Selvadurai, S., Berger‐Richardson, D., Lemon-Wong, S., Mascarenhas, J. C., Gibson, L., Rapier, T., et al. (2024) · Annals of Surgical Oncology · doi:10.1245/s10434-023-14851-z · Cited by 18
Distress and emotional well-being in breast cancer patients prior to radiotherapy: an expectancy-based model
Sohl, S. J., Schnur, J. B., Sucala, M. L., David, D. O., Winkel, G. H., & Montgomery, G. H. (2011) · Psychology and Health · doi:10.1080/08870446.2011.569714 · Cited by 20
“, 2003) that has normative data available for breast cancer patients (Brady et al., 1997).”
Background
The current trend of administering a patient-generated index in the oncological setting: a systematic review
Tang, J. A., Oh, T., Scheer, J. K., & Parsa, A. T. (2014) · Oncology Reviews · doi:10.4081/oncol.2014.245 · Cited by 18
Comparison of the EORTC STO-22 and the FACT-Ga quality of life questionnaires for patients with gastric cancer.
Woo, A. S. J., Fu, T. S., Popovic, M. M., Chow, E., Cella, D. F., Wong, C. S., Lam, H., Pulenzas, N., Lechner, B., Vuong, S., et al. (2016) · PubMed · doi:10.3978/j.issn.2224-5820.2016.01.02 · Cited by 18
“(9) suggested that the low internal consistency of the FACT-G core questionnaire may be an artifact of the sample since previous validation reports have demonstrated higher Cronbach’s alpha values (15,29).”
ResultSelf-citation
Single arm phase II study of oral vitamin B12 for the treatment of musculoskeletal symptoms associated with aromatase inhibitors in women with early stage breast cancer
Campbell, A., Heydarian, R., Ochoa, C., Dwivedi, A. K., & Nahleh, Z. A. (2018) · The Breast Journal · doi:10.1111/tbj.12951 · Cited by 18
“The FACT-ES is a commonly used tool utilized to measure physical, emotional, social and family, and functional well-being as well as endocrine symptoms.(16) The FACT-ES has been tested in women with breast cancer and has shown good internal consistency and stability.”
Method
Predictors of attendance to an oncologist-referred exercise program for women with breast cancer
Bland, K. A., Neil‐Sztramko, S., Kirkham, A. A., Bonsignore, A., Patten, C. L. V., McKenzie, D. C., Gelmon, K. A., & Campbell, K. L. (2018) · Supportive Care in Cancer · doi:10.1007/s00520-018-4180-7 · Cited by 19
Palbociclib‐letrozole as first‐line treatment for advanced breast cancer: Updated results from a Japanese phase 2 study
Takahashi, M., Masuda, N., Nishimura, R., Inoue, K., Ohno, S., Iwata, H., Hashigaki, S., Muramatsu, Y., Umeyama, Y., & Toi, M. (2020) · Cancer Medicine · doi:10.1002/cam4.3091 · Cited by 18
Preliminary Efficacy and Safety of Reishi & Privet Formula on Quality of Life Among Non–Small Cell Lung Cancer Patients Undergoing Chemotherapy: A Randomized Placebo-Controlled Trial
Liu, J., Mao, J. J. J., Li, Q. S., & Lin, H. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420944491 · Cited by 18
Testing subject comprehension of utility questionnaires
Dobrez, D. G., & Calhoun, E. A. (2004) · Quality of Life Research · doi:10.1023/b:qure.0000018475.17665.6e · Cited by 18
“The FACT-G, a health status questionnaire validated for use in cancer and other chronically ill patients [7, 8] provides a general model of health-related quality of life and includes four domains: physical, functional, social/family, and emotional well-being.”
Background
EXercise to prevent AnthrCycline-based Cardio-Toxicity (EXACT) in individuals with breast or hematological cancers: a feasibility study protocol
Keats, M. R., Grandy, S. A., Giacomantonio, N., Macdonald, D. A., Rajda, M., & Younis, T. (2016) · Pilot and Feasibility Studies · doi:10.1186/s40814-016-0084-9 · Cited by 18
“The FACT tools are reliable and valid measures of disease-specific quality of life and fatigue [51–55].”
Method
A Pharmacometric Analysis of Patient-Reported Outcomes in Breast Cancer Patients Through Item Response Theory
Schindler, E., Friberg, L. E., Lum, B. L., Wang, B., Quartino, A. L., Li, C., Girish, S., Jin, J. Y., & Karlsson, M. O. (2018) · Pharmaceutical Research · doi:10.1007/s11095-018-2403-8 · Cited by 18
Body Composition, Serum Biomarkers of Inflammation and Quality of Life in Clinically Stable Women with Estrogen Receptor Positive Metastatic Breast Cancer
Sheean, P., Gomez‐Perez, S. L., Joyce, C., Vasilopoulos, V., Bartolotta, M. B., Robinson, P. A., Lo, S. S., & Lomasney, L. M. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1595053 · Cited by 18
“Women completed the Functional Assessment of Cancer Therapy-Breast (FACT-B) (29) and the”
MethodInfluential
Quality of life issues in relation to the aromatase inhibitor
Fallowfield, L. J. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.05.003 · Cited by 18
Move Onward, Press Forward, and Take a Deep Breath: Can Lifestyle Interventions Improve the Quality of Life of Women With Breast Cancer, and How Can We Be Sure?
Demark‐Wahnefried, W. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.1052 · Cited by 18
Issues in Recruiting and Retaining Asian American Breast Cancer Survivors in a Technology-Based Intervention Study
Im, E., Kim, S., Xu, S., Lee, C., Hamajima, Y., Inohara, A., Chang, K. R., Chee, E., & Chee, W. (2018) · Cancer Nursing · doi:10.1097/ncc.0000000000000657 · Cited by 17
Quality of Life in Early Breast Cancer Patients: A Prospective Observational Study Using the FACT-B Questionnaire
Ursini, L. A., Nuzzo, M., Rosa, C., Guglielmo, F. C. D., Tommaso, M. D., Trignani, M., Borgia, M., ALLAJBEJ, A., Patani, F., CARLO, C. D., et al. (2021) · In Vivo · doi:10.21873/invivo.12443 · Cited by 17
Impact of Effective Intravesical Therapies on Quality of Life in Patients with Non-Muscle Invasive Bladder Cancer: A Systematic Review
Yuen, J. W. M., Wu, R. W. K., Ching, S. S. Y., & Ng, C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710825 · Cited by 17
“• FACT-BI: Contains 39 items to measure 5 domains including physical, social, emotional, functional well-being, and a bladder cancer subscale [65].”
Background
Prediction of Subclinical and Clinical Multiple Organ Failure Dysfunction in Breast Cancer Patients—A Review Using AI Tools
Ionescu, A.-I., Atasiei, D.-I., Ionescu, R. T., Ultimescu, F., Barnonschi, A.-A., Anghel, A.-V., Anghel, C.-A., Antone-Iordache, I.-L., Mitre, R., Bobolocu, A. M., et al. (2024) · Cancers · doi:10.3390/cancers16020381 · Cited by 17
“The easy manner in which to apply the questionnaire, its reliability, and its sensitivity make FACT-B useful in both medical practice and research [90].”
BackgroundInfluential
Attachment-oriented psychological intervention for couples facing breast cancer: protocol of a randomised controlled trial
Nicolaisen, A., Hansen, D. G., Hagedoorn, M., Flyger, H., Rottmann, N., Nielsen, P., Søe, K. L., Pedersen, A., & Johansen, C. (2014) · BMC Psychology · doi:10.1186/2050-7283-2-19 · Cited by 17
“B) for patients (Brady et al. 1997; Northouse et al. 2012) and Functional Assessment of Chronic Illness Therapy–General (FACIT-G)(Brucker et al. 2005) for partners.”
BackgroundMethod
Assessment of the Psychometric Properties of an English Version of the Cancer Dyspnea Scale in People With Advanced Lung Cancer
Uronis, H. E., Shelby, R. A., Currow, D. C., Ahmedzai, S. H., Bosworth, H. B., Sykes, A. D., & Abernethy, A. P. (2012) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2011.10.027 · Cited by 17
Quality of Life in Patients with Metastatic Breast Cancer Treated with Metronomic Chemotherapy
Perroud, H. A., Alasino, C. M., Rico, M. J., Queralt, F., Pezzotto, S. M., Rozados, V. R., & Scharovsky, O. G. (2016) · Future Oncology · doi:10.2217/fon-2016-0075 · Cited by 17
Investigating Associations Between Health-Related Quality of Life and Endocrine Therapy Underuse in Women With Early-Stage Breast Cancer
Pinheiro, L. C., Wheeler, S. B., Reeder-Hayes, K. E., Samuel, C. A., Olshan, A. F., & Reeve, B. B. (2017) · Journal of Oncology Practice · doi:10.1200/jop.2016.018630 · Cited by 17
Quality of Life and Body Image as a Function of Time from Mastectomy
Huang, J., & Chagpar, A. B. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6606-3 · Cited by 17
Can case management improve cancer patients quality of life?
Yin, Y., Wang, Y., Jiang, N.-J., & Long, D.-R. (2020) · Medicine · doi:10.1097/md.0000000000022448 · Cited by 17
Improvement in quality of life and psychological well-being associated with a culturally based psychosocial intervention for Chinese American breast cancer survivors
Lü, Q., Chen, L., Shin, L. J., Wang, C., Dawkins-Moultin, L., Chu, Q., Loh, A., Young, L., & Wang, C. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-020-05942-8 · Cited by 17
Patient-reported outcomes in breast cancer FDA drug labels and review documents
Hong, K., Majercak, K. R., Villalonga-Olives, E., & Perfetto, E. M. (2021) · Journal of Patient-Reported Outcomes · doi:10.1186/s41687-021-00308-y · Cited by 17
“For example, FDA reviewers commented in the Perjeta medical review that, “It is questionable whether the FACT-B questionnaire has content validity.””
MethodInfluential
Implications of a Postoperative Rehabilitation Program on Quality of Life in Women with Primary Breast Cancer Treated with Sentinel Lymph Node Biopsy or Complete Axillary Lymph Node Dissection
Silva, M. P. P. E., Sarian, L. O., Moráis, S. S., do Amaral, M. T. P., de Oliveira, M. M. F., & Derchain, S. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-0161-2 · Cited by 17
Relationship of Psychiatric Diagnosis and Weight Loss Maintenance in Obese Breast Cancer Survivors
Jenkins, I., Djurić, Z., Darga, L. L., DiLaura, N. M., Magnan, M. A., & Hryniuk, W. M. (2003) · Obesity Research · doi:10.1038/oby.2003.185 · Cited by 16
Health Promotion for Cancer Survivors
Meraviglia, M. G., Stuifbergen, A. M., Parsons, D., & Morgan, S. (2013) · Holistic Nursing Practice · doi:10.1097/hnp.0b013e31828a0988 · Cited by 17
Peer mentors delivering a physical activity intervention for cancer survivors: effects among mentors
Pinto, B. M., DUNSIGER, S. I., Stein, K., & Kamson, C. (2017) · Translational Behavioral Medicine · doi:10.1007/s13142-016-0460-2 · Cited by 17
Psychospiritual Well-Being and Symptom Distress in Women With Breast Cancer
Manning-Walsh, J. (2005) · Oncology nursing forum · doi:10.1188/05.onf.e56-e62 · Cited by 19
“Participants in this study had significantly lower psychological and spiritual well-being than has been found in other samples (Brady et al., 1997, 1999).”
MethodResultInfluential
Fatigue assessment in cancer clinical trials
Flechtner, H., & Bottomley, A. (2002) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/14737167.2.1.67 · Cited by 17
A phase II multicenter study of combined topotecan and gemcitabine as first line chemotherapy for advanced non-small cell lung cancer
Joppert, M. (2003) · Lung Cancer · doi:10.1016/s0169-5002(02)00502-0 · Cited by 17
Examining Quality of Life Issues in Relation to Endocrine Therapy for Breast Cancer
Thomas, R. (2003) · American Journal of Clinical Oncology · doi:10.1097/00000421-200308001-00007 · Cited by 17
“The Functional Assessment of Cancer Therapy–Endocrine Subscale (FACT-ES) questionnaire is a QOL assessment tool that includes components specifically designed for women with breast cancer who receive hormonal therapy.(14,15) It combines an 18-item endocrine subscale (ES) with the QOL in breast cancer questionnaire, kn…”
Method
Korean Translation and Validity of FACT-BMT Version 4 and the Quality of Life in Allogeneic Bone Marrow Transplantation Patients
Yoo, H., Lee, K., Lee, J., Eremenco, S. L., Choi, S., Kim, I. H., & Lee, J. (2006) · Quality of Life Research · doi:10.1007/s11136-005-1769-3 · Cited by 16
Quality of life after sentinel lymph node biopsy in early breast cancer
Dubernard, G., Sidéris, L., Delaloge, S., Marsiglia, H. R., Rochard, F., Travagli, J. P., Mathieu, M. C., Lumbroso, J., Spielmann, M., Garbay, J.-R., et al. (2004) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2004.05.006 · Cited by 17
Triathlon training for women breast cancer survivors: feasibility and initial efficacy
Ng, A. V., Cybulski, A. N., Engel, A. A., Papanek, P. E., Sheffer, M. A., Waltke, L. J., & Tjoe, J. A. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-016-3531-5 · Cited by 16
“Breast cancer health-related QOL was obtained using the 37-item Functional Assessment of Cancer Therapy Breast (FACT-B) questionnaire [25].”
Method
Understanding how e‐health interventions meet psychosocial needs of breast cancer patients: The pathways of influence on quality of life and cancer concerns
Kim, S. C., Hawkins, R. P., Shah, D. V., Gustafson, D. H., & Baker, T. B. (2020) · Psycho-Oncology · doi:10.1002/pon.5512 · Cited by 16
“The reliability and validity of these items have been empirically tested and confirmed in the health communication field.(29,30) Individual questions for all key measures, along with scale range and reliability information, are presented in Table S1.”
Background
An experimental study to identify key psychological mechanisms that promote and predict resilience in the aftermath of treatment for breast cancer
Gordon, R., Fawson, S., Moss-Morris, R. E., Armes, J., & Hirsch, C. R. (2021) · Psycho-Oncology · doi:10.1002/pon.5806 · Cited by 15
Effect of myofascial release, stretching, and strengthening on upper torso posture, spinal curvatures, range of motion, strength, shoulder pain and disability, and quality of life in breast cancer survivors
Rao, M. S., & Pattanshetty, R. B. (2022) · Physiotherapy Research International · doi:10.1002/pri.1939 · Cited by 16
Supportive care needs and psychosocial outcomes of rural versus urban women with breast cancer
Eggins, R., Fowler, H., Cameron, J. K., Aitken, J. F., Youl, P., Turrell, G., Chambers, S. K., Dunn, J. C., Pyke, C., Baade, P. D., et al. (2022) · Psycho-Oncology · doi:10.1002/pon.5977 · Cited by 16
“The FACT‐B was used to measure overall mental and physical quality of life.(20) Thirty‐eight items were presented to participants to reflect a range of physical and emotional symptoms and feelings specific to breast cancer treatment such as ‘I have nausea’ and ‘I worry about dying’.”
Method
Evaluating the Effectiveness of Mobile Health in Breast Cancer Care: A Systematic Review
Flaucher, M., Zakreuskaya, A., Nissen, M., Mocker, A., Fasching, P. A., Beckmann, M. W., Eskofier, B. M., & Leutheuser, H. (2023) · The Oncologist · doi:10.1093/oncolo/oyad217 · Cited by 15
“45 Zhu et al 41 used the FACT-B, 46 a questionnaire specifically designed for measuring the health-related QoL in patients with breast cancer.”
Method
Real-world evaluation of an acceptance and commitment therapy–based group programme for breast cancer survivors with fear of cancer recurrence
Sinclair, F., Gillanders, D., Rooney, N., Bonathan, C., Hendry, K., McLoone, P., & Hewitt, C. (2023) · Supportive Care in Cancer · doi:10.1007/s00520-023-08179-3 · Cited by 9
“This tool has been found to have excellent internal consistency ( α = 0.90) [22].”
BackgroundMethodInfluential

Authors: Brady, M. J., Cella, D. F., Mo, F., Bonomi, A. E., Tulsky, D. S., Lloyd, S. R., Deasy, S., Cobleigh, M., & Shiomoto, G.
Affiliations: Rush University Medical Center (US)
Rush University (US)
ORCID: Cella, D F
Bonomi, A E
Tulsky, D S
Lloyd, S R
Cobleigh, M
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 1997-03
Volume: 15
Issue: 3
Pages: 974-986
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.1997.15.3.974
OpenAlex: W1857624176
Cited by: 1,752
References: 39
Citations by year: 2026: 47 · 2025: 76 · 2024: 77 · 2023: 71 · 2022: 97 · 2021: 88 · 2020: 78 · 2019: 87 · 2018: 83 · 2017: 85 · 2016: 83 · 2015: 73 · 2014: 83 · 2013: 70 · 2012: 86
FWCI: 5.28
Type: journal article
Language: en
Open access: closed
Locations: Journal of Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r29ca051926-01a1)
National Cancer Institute (R29CA51926)
Topics: Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Nursing › Research and Theory › Health Education and Validation
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Keywords: FACT-B, breast cancer, quality of life, FACT-G, instrument validation, sensitivity to change, test-retest reliability, internal consistency, known-groups validity, convergent validity, discriminant validity, physical well-being, functional well-being, emotional well-being, Functional Living Index-Cancer, self-report questionnaire
MeSH terms: Adult, Aged, Aged, 80 and over, Breast Neoplasms, Female, Humans, Middle Aged, Quality of Life, Self Concept, Sensitivity and Specificity, Severity of Illness Index, Translations, Reproducibility of Results

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Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument.

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