Dietary Phytoestrogens

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889

Cloning of a novel receptor expressed in rat prostate and ovary.

Kuiper, G. G. J. M., Enmark, E., Pelto‐Huikko, M., Nilsson, S., & Gustafsson, J.-Α. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,802

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

Kuiper, G. G. J. M., Carlsson, B., Grandien, K., Enmark, E., Häggblad, J., Nilsson, S., & Gustafsson, J.-A. (1997) · Endocrinology · doi:10.1210/endo.138.3.4979 · Cited by 4,442

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203

Molecular basis of agonism and antagonism in the oestrogen receptor

Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature · doi:10.1038/39645 · Cited by 3,355

Evidence for decreasing quality of semen during past 50 years.

Carlsen, E., Giwercman, A., Keiding, N., & Skakkebæk, N. E. (1992) · BMJ · doi:10.1136/bmj.305.6854.609 · Cited by 2,768

ERβ: Identification and characterization of a novel human estrogen receptor

Mosselman, S., Polman, J., & Dijkema, R. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00782-x · Cited by 2,269

Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices

Armstrong, B. K., & Doll, R. (1975) · International Journal of Cancer · doi:10.1002/ijc.2910150411 · Cited by 2,161

Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids

Anderson, J. W., Johnstone, B. M., & Cook-Newell, M. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508033330502 · Cited by 2,048

Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?

Sharpe, R. M., & Skakkebæk, N. E. (1993) · The Lancet · doi:10.1016/0140-6736(93)90953-e · Cited by 1,849

Generation and reproductive phenotypes of mice lacking estrogen receptor β

Krege, J. H., Hodgin, J. B., Couse, J. F., Enmark, E., Warner, M. N., Mahler, J. F., Sar, M., Korach, K. S., Gustafsson, J.-Α., & Smithies, O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15677 · Cited by 1,717

Soy intake and cancer risk: A review of the in vitro and in vivo data

Messina, M. J., Persky, V., Setchell, K. D. R., & Barnes, S. (1994) · Nutrition and Cancer · doi:10.1080/01635589409514310 · Cited by 1,315

Phyto-oestrogens and Western Diseases

Adlercreutz, H., & Mazur, W. (1997) · Annals of Medicine · doi:10.3109/07853899709113696 · Cited by 1,282

The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones

Setchell, K. D. R., Brown, N. M., & Lydeking-Olsen, E. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.12.3577 · Cited by 1,209

Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

Pike, A. C. W., Brzozowski, A. M., Hubbard, R. E., Bonn, T., Thorsell, A., Engström, O., Ljunggren, J., Gustafsson, J., & Carlquist, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4608 · Cited by 990

Bioavailability of Pure Isoflavones in Healthy Humans and Analysis of Commercial Soy Isoflavone Supplements

Setchell, K. D. R., Brown, N. M., Desai, P. B., Zimmer-Nechemias, L., Wolfe, B., Brashear, W. T., Kirschner, A. S., Cassidy, A., & Heubi, J. E. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1362s · Cited by 974

Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County

Shimizu, H., Ross, R., Bernstein, L., Yatani, R., Henderson, B. E., & Mack, T. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.210 · Cited by 890

DIETARY PHYTOESTROGENS

Kurzer, M. S., & Xu, X. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.353 · Cited by 840

Cadherin-catenin complex: Protein interactions and their implications for cadherin function

Aberle, H., Schwartz, H. T., & Kemler, R. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19960616)61:4 · Cited by 806

Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

Barkhem, T., Carlsson, B., Nilsson, Y., Enmark, E., Gustafsson, J.-Α., & Nilsson, S. V. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.105 · Cited by 770

Dietary effects on breast-cancer risk in Singapore

Lee, H. P., Lee, J. W. N., Gourley, L., Duffy, S. W., Day, N., & Estève, J. (1991) · The Lancet · doi:10.1016/0140-6736(91)92867-2 · Cited by 765

Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators

Cavalieri, E. L., Stack, D. E., Devanesan, P. D., Todorović, R., Dwivedy, I., Higginbotham, S. M., Johansson, S. L., Patil, K. D., Gross, M. L., Gooden, J. K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10937 · Cited by 728

Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women

Cassidy, A., Bingham, S. A., & Setchell, K. D. R. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.3.333 · Cited by 727

Case-control study of phyto-oestrogens and breast cancer

Ingram, D., Sanders, K., Kolybaba, M. L., & Lopez, D. G. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01339-1 · Cited by 722

Exposure of infants to phyto-oestrogens from soy-based infant formula

Setchell, K. D. R., Zimmer-Nechemias, L., Cai, J., & Heubi, J. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09480-9 · Cited by 704

A SPECIFIC BREEDING PROBLEM OF SHEEP ON SUBTERRANEAN CLOVER PASTURES IN WESTERN AUSTRALIA

Bennetts, H. W., Uuderwood, E. J., & Shier, F. L. (1946) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.1946.tb15473.x · Cited by 671

Mammalian lignan production from various foods

Thompson, L. U., Robb, P. A., SERRAINO, M. R., & Cheung, F. (1991) · Nutrition and Cancer · doi:10.1080/01635589109514139 · Cited by 633

Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease

Setchell, K. D. R., Borriello, S. P., Hulme, P., KIRK, D. N., & Axelson, M. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.3.569 · Cited by 619

Menopausal Hormone Replacement Therapy and Risk of Ovarian Cancer

Lacey, J. V. (2002) · JAMA · doi:10.1001/jama.288.3.334 · Cited by 617

Soybean Phytoestrogen Intake and Cancer Risk

Herman, C., Adlercreutz, T., Goldin, B. R., Gorbach, S. L., Höckerstedt, K., Watanabe, S., Hämäläinen, E. K., Markkanen, M. H., Mäkelä, T., Wähäla, K., et al. (1995) · Journal of Nutrition · doi:10.1093/jn/125.3_suppl.757s · Cited by 594

International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption

Rose, D., Boyar, A. P., & Wynder, E. L. (1986) · Cancer · doi:10.1002/1097-0142(19861201)58:11 · Cited by 593

Interindividual Variation in Metabolism of Soy Isoflavones and Lignans: Influence of Habitual Diet on Equol Production by the Gut Microflora

Rowland, I. R., Wiseman, H., Sanders, T. A. B., Adlercreutz, H., & Bowey, E. A. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc3601_5 · Cited by 583

Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors

Feng, W., Ribeiro, R. C. J., Wagner, R. L., Nguyen, H. T., Apriletti, J. W., Fletterick, R. J., Baxter, J. D., Kushner, P. J., & West, B. L. (1998) · Science · doi:10.1126/science.280.5370.1747 · Cited by 579

Phytoestrogens: epidemiology and a possible role in cancer protection.

Adlercreutz, H. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103s7103 · Cited by 558

Complementary and Alternative Medicine for Menopausal Symptoms: A Review of Randomized, Controlled Trials

Kronenberg, F., & Fugh-Berman, A. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-10-200211190-00009 · Cited by 555

Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes

Hung, L. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00102-4 · Cited by 549

Soybean Isoflavones Improve Cardiovascular Risk Factors without Affecting the Reproductive System of Peripubertal Rhesus Monkeys

Anthony, M. S., Clarkson, T. B., Hughes, C. L., Morgan, T. M., & Burke, G. L. (1996) · Journal of Nutrition · doi:10.1093/jn/126.1.43 · Cited by 534

Phytoestrogen content of foods—a compendium of literature values

Reinli, K., & Block, G. (1996) · Nutrition and Cancer · doi:10.1080/01635589609514470 · Cited by 503

Antioxidant and Antipromotional Effects of the Soybean Isoflavone Genistein

Wei, H., Bowen, R., Cai, Q., Barnes, S., & Wang, Y. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-208-43844 · Cited by 502

Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro.

Zava, D., & Duwe, G. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514498 · Cited by 491

Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

Iafrati, M. D., Karas, R. H., Aronovitz, M. A., Kim, S., Sullivan, T. R., Lubahn, D. B., O’Donnell, T. F. X., Korach, K. S., & Mendelsohn, M. E. (1997) · Nature Medicine · doi:10.1038/nm0597-545 · Cited by 486

Intake of Fruits and Vegetables and Risk of Breast Cancer

Smith‐Warner, S. A., Spiegelman, D. L., Yaun, S., Adami, H., Beeson, W. L., van den Brandt, P. A., Folsom, A. R., Fraser, G. E., Freudenheim, J. L., Goldbohm, R. A., et al. (2001) · JAMA · doi:10.1001/jama.285.6.769 · Cited by 458

A Randomized Trial Comparing the Effect of Casein With That of Soy Protein Containing Varying Amounts of Isoflavones on Plasma Concentrations of Lipids and Lipoproteins

Crouse, J. R., Morgan, T. M., Terry, J. G., Ellis, J., Vitolins, M. Z., & Burke, G. L. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.17.2070 · Cited by 447

Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cells

Okura, A., Arakawa, H., Oka, H., Yoshinari, T., & Monden, Y. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80030-5 · Cited by 438

Long-term Intake of Dietary Fiber and Decreased Risk of Coronary Heart Disease Among Women

Wolk, A. (1999) · JAMA · doi:10.1001/jama.281.21.1998 · Cited by 432

Dietary phytoestrogens and cancer: in vitro and in vivo studies

Adlercreutz, H., Mousavi, Y., Clark, J., Höckerstedt, K., Hämäläinen, E. K., Wähälä, K., Mäkelä, T., & Hase, T. A. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90359-q · Cited by 431

Soy Isoflavones Improve Systemic Arterial Compliance but Not Plasma Lipids in Menopausal and Perimenopausal Women

Nestel, P. J., Yamashita, T., Sasahara, T., Pomeroy, S., Dart, A. M., Komesaroff, P. A., Owen, A. J., & Abbey, M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3392 · Cited by 430

Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat

Murkies, A. L., Lombard, C., Strauss, B. J., Wilcox, G., Burger, H., & Morton, M. S. (1995) · Maturitas · doi:10.1016/0378-5122(95)00899-v · Cited by 414

Survival of reproductive behaviors in estrogen receptor β gene-deficient (βERKO) male and female mice

Ogawa, S., Chan, J. S. W., Chester, A. E., Gustafsson, J.-Α., Korach, K. S., & Pfaff, D. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12887 · Cited by 399

Origin of lignans in mammals and identification of a precursor from plants

Axelson, M., Sjövall, J., Gustafsson, B. E., & Setchell, K. D. R. (1982) · Nature · doi:10.1038/298659a0 · Cited by 398

Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance

Tikkanen, M. J., Wähälä, K., Ojala, S., Vihma, V., & Adlercreutz, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3106 · Cited by 398

Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats

Bowey, E. A., Adlercreutz, H., & Rowland, I. R. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00324-1 · Cited by 391

Production and metabolism of lignans by the human faecal flora

Borriello, S. P., Setchell, K. D. R., Axelson, M., & Lawson, A. M. (1985) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1985.tb01427.x · Cited by 380

Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans

Wiseman, H., O’Reilly, J. D., Adlercreutz, H., Mallet, A. I., Bowey, E. A., Rowland, I. R., & Sanders, T. A. B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.395 · Cited by 377

Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies

Setchell, K. D. R., & Lydeking-Olsen, E. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.593s · Cited by 369

Pituitary-Gonadal Relations in Infancy: 2. Patterns of Serum Gonadal Steroid Concentrations in Man from Birth to Two Years of Age

Winter, J. S. D., Hughes, I. A., Reyes, F. I., & Faiman, C. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-4-679 · Cited by 364

Effect of Genistein on In Vitro and In Vivo Models of Cancer

Barnes, S. H. (1995) · Journal of Nutrition · doi:10.1093/jn/125.3_suppl.777s · Cited by 364

Detection of the effects of phytoestrogens on sheep and cattle

Adams, N. R. (1995) · Journal of Animal Science · doi:10.2527/1995.7351509x · Cited by 358

Dietary estrogens—A probable cause of infertility and liver disease in captive cheetahs

Setchell, K. D. R., Gosselin, S. J., Welsh, M. B., Johnston, J. O., Balistreri, W. F., Kramer, L., Dresser, B. L., & Tarr, M. J. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)91006-7 · Cited by 353

Evaluation of a Recombinant Yeast Cell Estrogen Screening Assay

Coldham, N. G., Dave, M., Sivapathasundaram, S., McDonnell, D. P., Connor, C., & Sauer, M. J. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105734 · Cited by 352

Intake of Dietary Fiber and Risk of Coronary Heart Disease in a Cohort of Finnish Men

Pietinen, P., Rimm, E. B., Korhonen, P. A., Hartman, A. M., Willett, W. C., Albanes, D., & Virtamo, J. R. K. (1996) · Circulation · doi:10.1161/01.cir.94.11.2720 · Cited by 346

Genistein suppresses mammary cancer in rats

Lamartiniere, C. A., Moore, J. B., Brown, N. M., Thompson, R., Hardin, M. J., & Barnes, S. (1995) · Carcinogenesis · doi:10.1093/carcin/16.11.2833 · Cited by 338

In vitro bioassays of non-steroidal phytoestrogens

Markiewicz, L., Garey, J. D., Adlercreutz, H., & Gurpide, E. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90009-l · Cited by 335

Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin.

Snedeker, S. M. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s135 · Cited by 324

Phytoestrogens and breast cancer

Adlercreutz, H. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00273-x · Cited by 323

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION: Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats

Murrill, W. B., Brown, N. M., Zhang, J.-X., Manzolillo, P. A., Barnes, S., & Lamartiniere, C. A. (1996) · Carcinogenesis · doi:10.1093/carcin/17.7.1451 · Cited by 322

Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes

Wang, C., Mäkelä, T., Hase, T. A., Adlercreutz, H., & Kurzer, M. S. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90030-2 · Cited by 321

Exposure to Soy-Based Formula in Infancy and Endocrinological and Reproductive Outcomes in Young Adulthood

Strom, B. L. (2001) · JAMA · doi:10.1001/jama.286.7.807 · Cited by 319

Comparison of Isoflavones Among Dietary Intake, Plasma Concentration and Urinary Excretion for Accurate Estimation of Phytoestrogen Intake

Arai, Y., Uehara, M., Sato, Y., Kimira, M., Eboshida, A., Adlercreutz, H., & Watanabe, S. (2000) · Journal of Epidemiology · doi:10.2188/jea.10.127 · Cited by 314

Soya–a dietary source of the non-steroidal oestrogen equol in man and animals

Axelson, M., Sjövall, J., Gustafsson, B. E., & Setchell, K. D. R. (1984) · Journal of Endocrinology · doi:10.1677/joe.0.1020049 · Cited by 307

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells

Arts, J., Kuiper, G. G. J. M., Janssen, J. M. M. F., Gustafsson, J.-Α., Löwik, C. W. G. M., Pols, H. A. P., & van Leeuwen, J. P. T. M. (1997) · Endocrinology · doi:10.1210/endo.138.11.5652 · Cited by 305

Rapid HPLC Analysis of Dietary Phytoestrogens from Legumes and from Human Urine

Franke, A. A., Custer, L. J., Cerna, C. M., & Narala, K. K. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-208-43826 · Cited by 304

Bioavailability, Disposition, and Dose-Response Effects of Soy Isoflavones When Consumed by Healthy Women at Physiologically Typical Dietary Intakes

Setchell, K. D. R., Brown, N. M., Desai, P. B., Zimmer-Nechemias, L., Wolfe, B., Jakate, A. S., Creutzinger, V., & Heubi, J. E. (2003) · Journal of Nutrition · doi:10.1093/jn/133.4.1027 · Cited by 302

Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques

Honoré, E. K., Williams, J. K., Anthony, M. S., & Clarkson, T. B. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81872-9 · Cited by 298

The Incidence of Hip Fracture in Four Asian Countries: The Asian Osteoporosis Study (AOS)

Lau, E. M. C., Lee, J. K., Suriwongpaisal, P., Saw, S., De, S. D., Khir, A., & Sambrook, P. N. (2001) · Osteoporosis International · doi:10.1007/s001980170135 · Cited by 296

A large-scale, hospital-based case-control study of risk factors of breast cancer according to menopausal status

Hirose, K., Tajima, K., Hamajima, N., Inoue, M., Takezaki, T., Kuroishi, T., Yoshida, M., & Tokudome, S. (1995) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1995.tb03032.x · Cited by 287

The distribution of estrogen receptor-β mRNA in the rat hypothalamus

Shughrue, P. J., Komm, B. S., & Merchenthaler, I. J. (1996) · Steroids · doi:10.1016/s0039-128x(96)00222-x · Cited by 285

A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids

Joannou, G. E., KELLY, G. E., Reeder, A. Y., Waring, M. A., & Nelson, C. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00131-i · Cited by 282

Soy, Soy Phytoestrogens and Cardiovascular Disease

Clarkson, T. B. (2002) · Journal of Nutrition · doi:10.1093/jn/132.3.566s · Cited by 270

Phytoestrogen Concentrations in Serum from Japanese Men and Women over Forty Years of Age

Morton, M. S., Arisaka, O., Miyake, N., Morgan, L. D., & Evans, B. A. J. (2002) · Journal of Nutrition · doi:10.1093/jn/131.10.3168 · Cited by 270

Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products

Cassidy, A., Bingham, S. A., & Setchell, K. D. R. (1995) · British Journal Of Nutrition · doi:10.1079/bjn19950160 · Cited by 269

Phytoestrogen Supplements for the Treatment of Hot Flashes: The Isoflavone Clover Extract (ICE) Study

Tice, J. A., Ettinger, B. B., Ensrud, K. E., Wallace, R. B., BLACKWELL, T. L., & Cummings, S. R. (2003) · JAMA · doi:10.1001/jama.290.2.207 · Cited by 268

Quantitative Determination of Lignans and Isoflavonoids in Plasma of Omnivorous and Vegetarian Women by Isotope Dilution Gas Chromatographγ-Mass Spectrometry

Adlercreutz, H., Fotsis, T., Lampe, J. W., Wähälä, K., Mäkelä, T., Brunow, G., & Hase, T. A. (1993) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519309090693 · Cited by 265

The Variable Metabolic Response to Dietary Isoflavones in Humans

KELLY, G. E., Joannou, G. E., Reeder, A. Y., Nelson, C., & Waring, M. A. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-208-43829 · Cited by 264

Soy Protein Versus Soy Phytoestrogens in the Prevention of Diet-Induced Coronary Artery Atherosclerosis of Male Cynomolgus Monkeys

Anthony, M. S., Clarkson, T. B., Bullock, B. C., & Wagner, J. D. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2524 · Cited by 262

Oestrogen receptor knockout mice: roles for oestrogen receptors α and β in reproductive tissues

Hewitt, S. C., & Korach, K. S. (2003) · Reproduction · doi:10.1530/rep.0.1250143 · Cited by 261

Induction by Estrogen Metabolite 16 ;-Hydroxyestrone of Genotoxic Damage and Aberrant Proliferation in Mouse Mammary Epithelial Cells

TELANG, N. T., Suto, A., Wong, G. Y., Osborne, M. P., & Bradlow, H. L. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.8.634 · Cited by 261

Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells

Wang, C., & Kurzer, M. S. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514582 · Cited by 253

Whole‐grain consumption and chronic disease: Protective mechanisms

Slavin, J. L., Jacobs, D. R., & Marquart, L. F. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514495 · Cited by 241

Urinary isoflavonoid phytoestrogen and lignan Excretion After Consumption of Fermented and Unfermented Soy Products

Hutchins, A. M., Slavin, J. L., & Lampe, J. W. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00149-2 · Cited by 238

Lignan and isoflavonoid conjugates in human urine

Adlercreutz, H., van der Wildt, J., Kinzel, J., Attalla, H., Wähäla, K., Mäkelä, T., Hase, T. A., & Fotsis, T. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)00146-d · Cited by 234

Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women

Merz-Demlow, B. E., Duncan, A. M., Wangen, K. E., Xu, X., Carr, T. P., Phipps, W. R., & Kurzer, M. S. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1462 · Cited by 231

Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women

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