Cited by 272Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

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Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity

Ruderman, Neil B., Saha, Asish K., Kraegen, Edward W.·2003·Endocrinology

DOI 10.1210/en.2003-0849

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Abstract

An increasing body of evidence has linked AMP-activated protein kinase (AMPK) and malonyl coenzyme A (CoA) to the regulation of energy balance. Thus, factors that activate AMPK and decrease the concentration of malonyl CoA in peripheral tissues, such as exercise, decrease triglyceride accumulation in the adipocyte and other cells. The data reviewed here suggest that this is related to the fact that these factors concurrently increase fatty acid oxidation, decrease the esterification of fatty acids to form glycerolipids, and, by mechanisms still unknown, increase energy expenditure. Malonyl CoA contributes to these events because it is an allosteric inhibitor of carnitine palmitoyltransferase, the enzyme that controls the transfer of long-chain fatty acyl CoA from the cytosol to the mitochondria, where they are oxidized. AMPK activation in turn increases fatty acid oxidation (by effects on enzymes that govern malonyl CoA synthesis and possibly its degradation) and inhibits triglyceride synthesis. It also increases the expression of uncoupling proteins and the transcriptional regulator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC1alpha), which could possibly increase energy expenditure. Recent studies suggest that the ability of leptin, adiponectin, 5'-aminoimidazole 4-carboxamide riboside (AICAR), adrenergic agonists, and metformin to diminish adiposity may be mediated, at least in part, by AMPK activation in peripheral tissues. In addition, preliminary studies suggest that malonyl CoA and AMPK take part in fuel-sensing and signaling mechanisms in the hypothalamus that could regulate food intake and energy expenditure.

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Authors: Ruderman, N. B., Saha, A. K., & Kraegen, E. W.
Affiliations: Boston University (US)
Garvan Institute of Medical Research (AU)
Corresponding author: Ruderman, Neil B.
ORCID: Ruderman, Neil B.
Saha, Asish K.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2003-12
Volume: 144
Issue: 12
Pages: 5166-5171
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2003-0849
OpenAlex: W2055061083
Cited by: 266
References: 54
Citations by year: 2026: 1 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 12 · 2014: 11 · 2013: 8 · 2012: 26
FWCI: 7.01
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk019514-35)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-19514)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: malonyl-CoA, AMPK, adiposity, energy balance, fatty acid oxidation, carnitine palmitoyltransferase, triglyceride synthesis, uncoupling proteins, PGC-1α, leptin, adiponectin, AICAR, metformin, sympathomimetic drugs, food intake regulation, energy expenditure
MeSH terms: Adipose Tissue, Animals, Humans, Malonyl Coenzyme A, Multienzyme Complexes, Obesity, Protein Serine-Threonine Kinases, AMP-Activated Protein Kinases

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Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity

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