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Cited by 180Regulation of Appetite and ObesityNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake

OLSON, BEATRIZ R., DRUTAROSKY, MARCIA D., STRICKER, EDWARD M., VERBALIS, JOSEPH G.·1991·Endocrinology
DOI 10.1210/endo-129-2-785
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Abstract

The inhibition of food intake in rats that results from various anorexigenic treatments is frequently associated with pituitary secretion of oxytocin (OT), but is not caused by circulating OT. We, therefore, evaluated the potential role of brain OT in mediating anorexia induced in rats by systemic administration of cholecystokinin (CCK), hypertonic saline (HS), or lithium chloride (LiCl), treatments that are known to stimulate pituitary OT secretion as well as to inhibit food intake. Food intake was analyzed in 22-h food-deprived rats pretreated with icv injections of either artificial cerebrospinal fluid (aCSF) or 9 nmol of an OT receptor antagonist, [d(CH2)5, Tyr(OMe)2,Orn8]vasotocin (OVT), which was the dose found to be most effective to antagonize the anorexia induced by CCK and HS. Pretreatment with the OT receptor antagonist icv significantly blunted the anorexigenic effect of each agent. After CCK (10 micrograms/kg, ip), food intake increased from 28 +/- 5% of basal intake after a CSF icv to 48 +/- 8% after OVT icv (P less than 0.01); after HS (2 ml 2 M NaCl, ip), food intake increased from 9 +/- 4% of basal intake after aCSF icv to 43 +/- 7% after OVT icv (P less than 0.01); and after LiCl (1.125 mmol/kg, ip), food intake increased from 55 +/- 4% of basal intake after a CSF icv to 80 +/- 9% after OVT icv (P less than 0.01). These data support the hypothesis that pituitary secretion of OT after anorexigenic treatments in rats is associated with coactivation of centrally projecting brain OT pathways, some of which are causally related to the induced inhibition of food intake.

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Metadata

Authors
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G.
Affiliations
University of Pittsburgh (US)
ORCID
VERBALIS, JOSEPH G.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1991-08
Volume
129
Issue
2
Pages
785-791
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo-129-2-785
OpenAlex
W2009849294
Cited by
180
References
32
Citations by year
2026: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 10 · 2014: 12 · 2013: 14 · 2012: 8
FWCI
4.08
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Georgetown University
  • National Institute of Mental Health (MH25140)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, oxytocin receptor antagonist, arginine vasotocin, feeding inhibition, anorexia, cholecystokinin, hypertonic saline, lithium chloride, intracerebroventricular administration
MeSH terms
Animals, Brain, Chlorides, Cholecystokinin, Eating, Lithium, Male, Oxytocin, Pituitary Gland, Rats, Inbred Strains, Saline Solution, Hypertonic, Lithium Chloride, Receptors, Oxytocin, Rats, Angiotensin Receptor Antagonists

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