Influence of oxytocin on feeding behavior in the rat
Abstract
Oxytocin, whether administered intraperitoneally (IP) (375-6,000 micrograms/kg) or intracerebroventricularly (ICV) (1-10 micrograms/rat), dose-dependently reduced food consumption and time spent eating and increased the latency to the first meal in rats fasted for 21 hr. Pretreatment with the oxytocin antagonist d(CH2)5Tyr(Me)-[Orn8]vasotocin (ICV 10 micrograms/rat) completely prevented the feeding inhibitory effect of an equal dose of ICV oxytocin, and per se increased food intake. Our data further support the hypothesis that oxytocin plays the role of neurotransmitter or neuromodulator in the CNS, and suggest that its involvement in a number of homeostatic systems may include appetite control.
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In rodent studies, oxytocin affects energy expenditure.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [6]
Preclinical studies indicate that oxytocin is anorexigenic and has beneficial metabolic effects.
“Preclinical studies indicate that oxytocin is anorexigenic and has beneficial metabolic effects.”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [4]
In animal models, administration of oxytocin to rats reduces caloric intake, and this effect is reversed by first giving an oxytocin antagonist.
“Administration of oxytocin to rats reduces caloric intake, and this effect is reversed by first giving an oxytocin antagonist(4, 5).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [4]
In rodent studies, oxytocin acts as a strong inhibitor of food intake.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [6]
In rodent studies, oxytocin affects glucose homeostasis.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [6]
Oxytocin inhibits feeding after intracerebroventricular injection in rodents.
“Oxytocin has been shown in a number of experiments in rodents to inhibit feeding after intracerebroventricular injection (6,8).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [6]
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- Authors
- Arletti, R., Benelli, A., & Bertolini, A.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 10
- Issue
- 1
- Pages
- 89-93
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2094704091
- Cited by
- 328
- References
- 34
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 10 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 17 · 2019: 12 · 2018: 16 · 2017: 16 · 2016: 16 · 2015: 16 · 2014: 20 · 2013: 13 · 2012: 11
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, feeding behavior, dietary intake, appetite regulation, intracerebroventricular administration, intraperitoneal administration, fasting
- MeSH terms
- Animals, Cerebral Ventricles, Feeding Behavior, Grooming, Injections, Intraperitoneal, Injections, Intraventricular, Male, Oxytocin, Rats, Inbred Strains, Reference Values, Rats
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