Cited by 714Bone Metabolism and DiseasesTGF-β signaling in diseasesBone health and osteoporosis research

The DOI matches its Crossref record; 407 of the 408 references it cites were found in a registry or an index.

Transforming Growth Factor-β1 to the Bone

Janssens, Katrien, ten Dijke, Peter, Janssens, Sophie, Van Hul, Wim·2005·Endocrine Reviews

DOI 10.1210/er.2004-0001

Open this paper in CoChat — free account

Abstract

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-β1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-β1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-β1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-β1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.

Integrity signals

Registry

Crossref · 10.1210/er.2004-0001

Cites

407 of 407 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

TGF-β SIGNAL TRANSDUCTION
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 15×
“Runx2 binding sites are found in the promoters of several bone formation markers including collagen 1, ALP, osteopontin, RANKL, and osteocalcin (149).”
BackgroundInfluential
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
The Transforming Growth Factor-Beta Family
Massagué, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,041
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985

Flagged first, then by citations

Show all 408 references

1 of the 408 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

Mumm, 2001, Camurati-Engelmann disease: new mutations in the latency-associated peptide of the transforming growth factor β-1 gene, J Bone Miner Res, 16, S223
Wells, 2001, Polymorphisms in the transforming growth factor-1 and bone mass and bone loss, Bone, 28, S131
Prince, 2002, Effect of the TGF-β T869C and the CYP119 TTTA repeat polymorphisms on bone mineral density and prevalent fracture in elderly women, J Bone Miner Res, 17, S422
Kim, 2000, T/C polymorphism of the TGF-β1 gene is not associated with quantitative ultrasound values of calcaneus in Korean postmenopausal women in Chung-Up district, J Bone Miner Res, 15, S362
Hong, 2003, Lack of association of transforming growth factor β 1 T29→C gene polymorphism with calcaneal quantitative ultrasound parameters and plasma TGF-β1 levels in postmenopausal Korean women., Calcif Tissue Int, 72, S418
Mundy, 1991, The effects of TGF-β on bone., Ciba Found Symp, 157, 137

Sorted by citations

Items 301–400 of 714

Galangin inhibits human osteosarcoma cells growth by inducing transforming growth factor-β1-dependent osteogenic differentiation
Liu, C., Ma, M., Zhang, J., Gui, S., Zhang, X., & Xue, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.030 · Cited by 28
Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease
Meng, X., Wielockx, B., Rauner, M., & Bözec, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.658893 · Cited by 28
“The consequence is enhanced bone resorption and release of other growth factors including TGFα and PDGF, both stimulating tumor growth and eventually also osteolysis (Janssens et al., 2005).”
Background
3D Printed Scaffold Based on Type I Collagen/PLGA_TGF-β1 Nanoparticles Mimicking the Growth Factor Footprint of Human Bone Tissue
Niclot, F. B., Licini, C., Montalbano, G., Fiorilli, S., Mattioli‐Belmonte, M., & Vitale‐Brovarone, C. (2022) · Polymers · doi:10.3390/polym14050857 · Cited by 28
F-Spondin Deficient Mice Have a High Bone Mass Phenotype
Palmer, G. D., Attur, M. G., Yang, Q., Liu, J., Moon, P. M., Beier, F., & Abramson, S. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098388 · Cited by 28
Increased fracture risk and low bone mineral density in patients with loeys–dietz syndrome
Tan, E. W., Offoha, R. U., Oswald, G. L., Skolasky, R. L., Dewan, A. K., Zhen, G., Shapiro, J. R., Dietz, H. C., Cao, X., & Sponseller, P. D. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36029 · Cited by 28
“There are large amounts of TGF-b in bone and cartilage that modulate the activity of osteoblasts and osteoclasts [Centrella et al., 1988; Janssens et al., 2005].”
Background
Aluminum trichloride induces bone impairment through TGF-β1/Smad signaling pathway
Sun, X., Liu, J., Zhuang, C., Yang, X., Han, Y., Shao, B., Song, M., Li, Y., & Zhu, Y. (2016) · Toxicology · doi:10.1016/j.tox.2016.10.002 · Cited by 28
A review of mathematical modeling of bone remodeling from a systems biology perspective
Cook, C. V., Lighty, A. M., Smith, B. J., & Ford Versypt, A. N. (2024) · Frontiers in Systems Biology · doi:10.3389/fsysb.2024.1368555 · Cited by 25
“Its regulatory effects are concentration dependent (Janssens et al., 2005; Wu et al., 2016).”
A Comparison of Human Smooth Muscle and Mesenchymal Stem Cells as Potential Cell Sources for Tissue-Engineered Vascular Patches
Williams, C., Xie, A. W., Emani, S., Yamato, M., Okano, T., Emani, S. M., & Wong, J. Y. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0172 · Cited by 27
Fibrodysplasia Ossificans Progressiva-related Activated Activin-like Kinase Signaling Enhances Osteoclast Formation during Heterotopic Ossification in Muscle Tissues
Yano, M., Kawao, N., Okumoto, K., Tamura, Y., Okada, K., & Kaji, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.526038 · Cited by 27
“Anti-phosphorylated p38 mitogen-activated protein kinase (MAPK), anti-p38 MAPK, anti-phosphorylated Smad1/5/8, anti-phosphorylated Smad2/3, anti-Smad2/3, and anti- -actin antibodies were from Cell Signaling Technology (Danvers, MA).”
BackgroundInfluential
FXIIIA and TGF-β over-expression produces normal musculo-skeletal phenotype in TG2-/- mice
Tarantino, U., Oliva, F., Taurisano, G., Orlandi, A., Pietroni, V., Candi, E., Melino, G., & Maffulli, N. (2008) · Amino Acids · doi:10.1007/s00726-008-0133-7 · Cited by 27
Diabetes mellitus affects the biomechanical function of the callus and the expression of TGF-beta1 and BMP2 in an early stage of fracture healing
Xu, M., Sun, S., Zhang, L., Xu, F., Du, S. L., Zhang, X. D., & Wang, D. W. (2016) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20154736 · Cited by 27
Fam3c modulates osteogenic differentiation by down-regulating Runx2
Bendre, A., Büki, K. G., & Määttä, J. A. (2016) · Differentiation · doi:10.1016/j.diff.2016.11.005 · Cited by 27
Experimental study of the synergistic effect and network regulation mechanisms of an applied combination of BMP‐2, VEGF, and TGF‐β1 on osteogenic differentiation
Wang, Z., Sun, J., Li, Y., Chen, C., Xu, Y., Zang, X., Li, L., & Meng, K. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29462 · Cited by 27
CAR T targets and microenvironmental barriers of osteosarcoma
Zhu, J., Simayi, N., Wan, R., & Huang, W. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2021.12.010 · Cited by 27
The significance of differential expression of genes and proteins in human primary cells caused by microgrooved biomaterial substrata
Lee, M.-H., Kang, J. H., & Lee, S. W. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.034 · Cited by 27
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1
Lee, J., Jeon, S., Kim, B., Takeda, M., Cho, J.-J., Kim, D., Kawabe, H., & Cho, J. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3073 · Cited by 27
Stromal cells promote bone invasion by suppressing bone formation in ameloblastoma
Kazi, G. A. S., Nagatsuka, H., Tamamura, R., Fujii, M., Gündüz, M., Inoue, M., Rivera, R. S., & Nagai, N. (2008) · Histopathology · doi:10.1111/j.1365-2559.2008.03127.x · Cited by 29
Environmental agents affect skeletal growth and development
Holz, J. D., Sheu, T., Drissi, H., Matsuzawa, M., Zuscik, M. J., & Puzas, J. E. (2007) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20087 · Cited by 27
TGFβ Protein Processing and Activity through TCR Triggering of Primary CD8+ T Regulatory Cells
Ménoret, A., Myers, L. M., Lee, S., Mittler, R. S., Rossi, R. J., & Vella, A. T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6091 · Cited by 27
Fracture Healing in Collagen-Related Preclinical Models of Osteogenesis Imperfecta
Zieba, J. T., Munivez, E. M., Castellon, A., Jiang, M., Dawson, B., Ambrose, C. G., & Lee, B. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3979 · Cited by 26
SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells
Elsafadi, M. A., Manikandan, M., Atteya, M., Dawud, R. A., Almalki, S. G., Kaimkhani, Z. A., Aldahmash, A. M., Alajez, N. M., Alfayez, M. A., Kassem, M. S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10983-x · Cited by 26
Transforming Growth Factor-Beta (TGF-β) Signaling in Paravertebral Muscles in Juvenile and Adolescent Idiopathic Scoliosis
Nowak, R., Kwiecien, M., Tkacz, M. A., & Mazurek, U. (2014) · BioMed Research International · doi:10.1155/2014/594287 · Cited by 26
Dynamic Interactions of Chromatin‐Related Mesenchymal Modulator, a Chromodomain Helicase‐DNA‐Binding Protein, with Promoters in Osteoprogenitors
Shur, I., Solomon, R., & Benayahu, D. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0300 · Cited by 26
Transforming Growth Factor-β1 Stimulates Chondrogenic Differentiation of Posterofrontal Suture–Derived Mesenchymal Cells In Vitro
Xu, Y., James, A. W., & Longaker, M. T. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31818cbf44 · Cited by 26
Pioneering bone regeneration: A review of cutting-edge scaffolds in tissue engineering
Alex, Y., Vincent, S., Divakaran, N. C., Uthappa, U. T., Srinivasan, P., Mubarak, S., Al-Harthi, M. A., & Dhamodharan, D. (2024) · Bioprinting · doi:10.1016/j.bprint.2024.e00364 · Cited by 27
Exogenous regucalcin suppresses osteoblastogenesis and stimulates adipogenesis in mouse bone marrow culture
Yamaguchi, M., Weitzmann, M. N., Baile, C. A., & Murata, T. (2012) · Integrative Biology · doi:10.1039/c2ib20118f · Cited by 25
Autonomic nervous regulation of cellular processes during subchondral bone remodeling in osteoarthritis
Rösch, G., Zaucke, F., & Jenei‐Lanzl, Z. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00039.2023 · Cited by 26
Proteomic Analysis of Gingival Tissue and Alveolar Bone during Alveolar Bone Healing
Yang, H., Kwon, J. S., Kook, M.-S., Kang, S. S., Kim, S. E., Sohn, S., Jung, S., Kwon, S., Kim, H.-S., Lee, J. H., et al. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.026740 · Cited by 25
Both cell-surface and secreted CSF-1 expressed by tumor cells metastatic to bone can contribute to osteoclast activation
Yagiz, K., & Rittling, S. R. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.05.002 · Cited by 26
Immunohistochemical localization of connective tissue growth factor, transforming growth factor‐beta1 and phosphorylated‐smad2/3 in the developing periodontium of rats
Li, S., Ge, S., & Yang, P. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12143 · Cited by 24
Enhancement of RANKL‐induced MITF‐E expression and osteoclastogenesis by TGF‐β
Asai, K., Funaba, M., & Murakami, M. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3028 · Cited by 24
LMP1 regulates periodontal ligament progenitor cell proliferation and differentiation
Zhao, L., Navarro, V. P., Kempeinen, K. M., Franco, L. M., Jin, Q., Sugai, J. V., & Giannobile, W. V. (2010) · Bone · doi:10.1016/j.bone.2010.03.013 · Cited by 24
Role of TGF-β1 in Bone Matrix Production in Vascular Smooth Muscle Cells Induced by a High-Phosphate Environment
Wang, N., Wang, X., Changying, X., Sun, B., Yu, X., Hu, J., Liu, J., Zeng, M., Xiong, M., Zhou, S., et al. (2010) · Nephron Experimental Nephrology · doi:10.1159/000313831 · Cited by 24
Reverse engineering development: Crosstalk opportunities between developmental biology and tissue engineering
Marcucio, R., Qin, L., Alsberg, E., & Boerckel, J. D. (2017) · Journal of Orthopaedic Research® · doi:10.1002/jor.23636 · Cited by 24
FAM3C : An Emerging Biomarker and Potential Therapeutic Target for Cancer
Zhu, Y., Pu, Z., Wang, G., Li, Y., Wang, Y., Li, N., & Peng, F. (2021) · Biomarkers in Medicine · doi:10.2217/bmm-2020-0179 · Cited by 27
Effects of Incubator Temperature and Oxygen Concentration During the Plateau Stage of Oxygen Consumption on Turkey Embryo Long Bone Development
Oviedo-Rondon, E. O., Small, J., Wineland, M. J., Christensen, V. L., Grimes, J. L., Funderburk, S. V. L., ., D. T. O., & Mann, K. M. (2008) · Poultry Science · doi:10.3382/ps.2007-00470 · Cited by 24
“Some isoforms of the transforming growth factor β (TGF-β) are the cytokines that regulates production of fibronectins and collagen type II and X in avian growth plates (Schmid and Linsenmayer, 1985; Ling et al., 2000; Janssens et al., 2005).”
Background
A Comprehensive Network and Pathway Analysis of Human Deafness Genes
Stamatiou, G. A., & Stanković, K. M. (2013) · Otology & Neurotology · doi:10.1097/mao.0b013e3182898272 · Cited by 24
Role of Smad3, acting independently of transforming growth factor‐β, in the early induction of Wnt‐β‐catenin signaling by parathyroid hormone in mouse osteoblastic cells
Inoue, Y., Canaff, L., Hendy, G. N., Hisa, I., Sugimoto, T., Chihara, K., & Kaji, H. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22252 · Cited by 24
“Significantly different (P< 0.01) from the value in Smad3-transfected cells. transcriptional activation [Derynck and Zhang, 2003; Janssens et al., 2005].”
BackgroundInfluential
Effect of ionic products of dicalcium silicate coating on osteoblast differentiation and collagen production via TGF-β1 pathway
Li, J., Wei, L., Sun, J., & Guan, G. (2011) · Journal of Biomaterials Applications · doi:10.1177/0885328211416393 · Cited by 23
“conflicting reports about the biphasic effects of TGF-b1 on bone formation.(42,47) In the present study, the transcriptional level of TGF-b RII of MG63 cells cultured in Ca2SiO4DMEM were higher than that in normal DMEM at all time points, the transcriptional level of TGF-b RI of MG63 cell cultured in Ca2SiO4-DMEM sign…”
Background
TGFβ-2 signaling is essential for osteoblast migration and differentiation during fracture healing in medaka fish
Takeyama, K., Chatani, M., Inohaya, K., & Kudō, A. (2016) · Bone · doi:10.1016/j.bone.2016.03.001 · Cited by 23
Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications
Ramli, E. S. M., Sukalingam, K., Kamaruzzaman, M. A., Soelaiman, I. N., Pang, K.-L., & Chin, K. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s291828 · Cited by 28
Distribution of Murine Adipose-Derived Mesenchymal Stem Cells in vivo Following Transplantation in Developing Mice
Liao, X., Li, F., Wang, X., Yanoso, J., & Niyibizi, C. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0086 · Cited by 23
Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis
Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23
The roles of media ingredients in muscle cell culture for cultured meat production—A mini-review
Lee, D.-Y., Yun, S. H., Lee, J., Mariano, E., Choi, Y., Han, D., Park, J., Kim, J. S., Lee, S.-Y., & Hur, S. (2024) · Future Foods · doi:10.1016/j.fufo.2024.100403 · Cited by 25
Cripto favors chondrocyte hypertrophy via TGF ‐β SMAD1 /5 signaling during development of osteoarthritis
de Vinuesa, A. G., Sánchez‐Duffhues, G., Blaney‐Davidson, E., van Caam, A., Lodder, K., Ramos, Y. F., Kloppenburg, M., Meulenbelt, I., van der Kraan, P. M., Goumans, M., et al. (2021) · The Journal of Pathology · doi:10.1002/path.5774 · Cited by 22
Gene expression during induced differentiation of sheep bone marrow mesenchymal stem cells into osteoblasts
Hu, Y., TANG, X.-X., & He, H. (2013) · Genetics and Molecular Research · doi:10.4238/2013.december.11.4 · Cited by 22
“After 1 week of culture, the expression levels of these genes usually increase (Balcerzak et al., 2003; Janssens et al., 2005; Osyczka and Leboy, 2005).”
Background
A novel 17 bp indel in the SMAD3 gene alters transcription level, contributing to phenotypic traits in Chinese cattle
Shi, T., Peng, W., Yan, J.-Y., Cai, H., Lan, X., Lei, C., Bai, Y., & Chen, H. (2016) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-59-151-2016 · Cited by 22
“TGF-β (transforming growth factor beta) regulates bone formation as well as bone resorption depending on its multiple effects on osteoblast and osteoclast migration, proliferation, differentiation and viability (Janssens et al., 2005; Fox and Lovibond, 2005).”
Background
Heme Oxygenase-1 Is a Pivotal Modulator of Bone Turnover and Remodeling: Molecular Implications for Prostate Cancer Bone Metastasis
Anselmino, N., Starbuck, M. W., Labanca, E., Cotignola, J., Navone, N. M., Gueron, G., Zenclussen, A. C., & Vazquez, E. S. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7879 · Cited by 24
Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with corticotomy?
Zaniboni, E., Bagne, L., Camargo, T. F., do Amaral, M. E. C., Felonato, M., de Andrade, T. A. M., dos Santos, G. M. T., Caetano, G. F., Esquisatto, M. A. M., Santamaria, M., et al. (2019) · Clinical Oral Investigations · doi:10.1007/s00784-019-02845-9 · Cited by 22
Chapter 2. Signal Transduction Cascades Controlling Osteoblast Differentiation
Krause, C., de Gorter, D. J. J., Karperien, M., & ten Dijke, P. (2008) · Wiley eBooks · doi:10.1002/9780470623992.ch2 · Cited by 21
Clinical, Diagnostic, and Therapeutic Aspects of the Marfan Syndrome
Cook, J. R., & Ramirez, F. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-7893-1_6 · Cited by 21
Pro-tumorigenic Effects of Transforming Growth Factor Beta 1 in Canine Osteosarcoma
Portela, R. F., Fadl-Alla, B. A., Pondenis, H. C., Byrum, M., Garrett, L. D., Wycislo, K. L., Borst, L. B., & Fan, T. M. (2014) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12348 · Cited by 21
Predicting fracture healing with blood biomarkers: the potential to assess patient risk of fracture nonunion
Chitwood, J. R., Chakraborty, N., Hammamieh, R., Moe, S. M., Chen, N. X., Kacena, M. A., & Natoli, R. M. (2021) · Biomarkers · doi:10.1080/1354750x.2021.1985171 · Cited by 21
TGF-β and BMP Signaling Pathways in Skeletal Dysplasia with Short and Tall Stature
Costantini, A., Guasto, A., & Cormier‐Daire, V. (2023) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-120922-094107 · Cited by 24
Unveiling novel genes upregulated by both rhBMP2 and rhBMP7 during early osteoblastic transdifferentiation of C2C12 cells
Bustos-Valenzuela, J. C., Fujita, A., Halcsik, E., Granjeiro, J. M., & Sogayar, M. C. (2011) · BMC Research Notes · doi:10.1186/1756-0500-4-370 · Cited by 21
Effects of TGF‐β1 on OPG/RANKL Expression of Cementoblasts and Osteoblasts Are Similar without Stress but Different with Mechanical Compressive Stress
Yang, X., Wang, Y., Han, X., Shu, R., Chen, T., Zeng, H., Xu, X., Huang, L., Ren, A., Song, J., et al. (2015) · The Scientific World JOURNAL · doi:10.1155/2015/718180 · Cited by 21
Sympathetic neuron can promote osteoblast differentiation through BMP signaling pathway
Ji-ye, H., Zheng, X., Jiang, S., Chen, X.-D., & Jiang, L. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.02.016 · Cited by 21
Analysis of TGFB1 in European and Japanese Moyamoya disease patients
Liu, C., Roder, C., Schulte, C., Kasuya, H., Akagawa, H., Nishizawa, T., Yoneyama, T., Okada, Y., Khan, N., Tatagiba, M. S., et al. (2012) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2012.05.002 · Cited by 21
Disorders of Mineral Homeostasis in the Newborn, Infant, Child, and Adolescent
Root, A. W., & Diamond, F. (2008) · Elsevier eBooks · doi:10.1016/b978-141604090-3.50022-3 · Cited by 20
Recent Advances in the Discovery of Biomarkers for Canine Osteosarcoma
Luu, A. K., Wood, G. A., & Viloria‐Petit, A. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.734965 · Cited by 20
Adipose-derived stromal/stem cells are verified to be potential seed candidates for bio-root regeneration in three-dimensional culture
Yuan, Y., Zhang, X., Zhan, Y., Tang, S., Deng, P., Wang, Z., & Li, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02907-y · Cited by 22
Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma
Cimmino, A., Fasciglione, G. F., Gioia, M., Marini, S., & Ciaccio, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713344 · Cited by 20
Smad3 Deficiency Leads to Mandibular Condyle Degradation via the Sphingosine 1-Phosphate (S1P)/S1P3 Signaling Axis
Mori, H., Izawa, T., & Tanaka, E. I. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.06.015 · Cited by 20
Secreted Phosphoprotein 24 kD (Spp24) and Spp14 Affect TGF-β Induced Bone Formation Differently
Tian, H., Bi, X., Li, C., Zhao, K.-W., Brochmann, E. J., Montgomery, S. R., Aghdasi, B. G., Chen, D., Daubs, M. D., Wang, J. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072645 · Cited by 20
Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project
Nelson, A. E., Golightly, Y. M., Kraus, V. B., Stäbler, T., Renner, J. B., Helmick, C. G., & Jordan, J. M. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.02.013 · Cited by 20
Bone‐targeted delivery of TGF‐β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati–Engelmann disease
Qin, Y., Tang, S., Zhen, G., Ding, Q., Ding, S., & Cao, X. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13941 · Cited by 20
Regulation of the regenerative activity of dental pulp stem cells from exfoliated deciduous teeth (SHED) of children by TGF-β1 is associated with ALK5/Smad2, TAK1, p38 and MEK/ERK signaling
Chang, H., Chen, I.-L., Wang, Y., Chang, M., Tsai, Y., Lan, W.-C., Wang, T., Yeung, S., & Jeng, J. (2020) · Aging · doi:10.18632/aging.103848 · Cited by 20
Role of vesicular trafficking in skeletal dynamics
Stenbeck, G., & Coxon, F. P. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.01.003 · Cited by 21
Cancer Therapies and Bone Health
Hu, M. I.-N., Lu, H., & Gagel, R. F. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-010-0098-x · Cited by 20
miR‑877‑3p promotes TGF‑β1‑induced osteoblast differentiation of MC3T3‑E1 cells by targeting Smad7
He, G., Chen, J., & Huang, D. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7570 · Cited by 19
Thrombospondins in bone remodeling and metastatic bone disease
Carminati, L., & Taraboletti, G. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00383.2020 · Cited by 20
Inflammation produced by senescent osteocytes mediates age-related bone loss
Wang, Z., Zhang, X., Cheng, X., Ren, T., Xu, W., Li, J., Wang, H., & Zhang, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1114006 · Cited by 19
Effects of different transforming growth factor beta (TGF-β) isomers on wound closure of bone cell monolayers
Sefat, F., Denyer, M. C. T., & Youseffi, M. (2014) · Cytokine · doi:10.1016/j.cyto.2014.05.010 · Cited by 19
A single-point mutation in FGFR2 affects cell cycle and Tgfβ signalling in osteoblasts
Lee, K. M. A., Santos‐Ruiz, L., & Ferretti, P. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.11.006 · Cited by 19
TGF‐β induced PAR‐1 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone
Wang, T., Jiao, J., Zhang, H., Wang, Z., Li, Z., Han, S., Wang, J., Yang, X., Huang, Q., Wu, Z., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30862 · Cited by 19
Divergent Modulation of Adipose-Derived Stromal Cell Differentiation by TGF-β1 Based on Species of Derivation
Lévi, B., James, A. W., Xu, Y., Commons, G. W., & Longaker, M. T. (2010) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3181df64dc · Cited by 19
An update on primary hip osteoarthritis including altered Wnt and TGF- associated gene expression from the bony component of the disease
Kumarasinghe, D. D., Hopwood, B., Kuliwaba, J. S., Atkins, G. J., & Fazzalari, N. L. (2011) · Rheumatology · doi:10.1093/rheumatology/ker291 · Cited by 21
An on‐site preparable, novel bone‐grafting complex consisting of human platelet‐rich fibrin and porous particles made of a recombinant collagen‐like protein
Tsukioka, T., Hiratsuka, T., Nakamura, M., Watanabe, T., Kitamura, Y., Isobe, K., Okudera, T., Okudera, H., Azuma, A., Uematsu, K., et al. (2018) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34234 · Cited by 19
Disorders of mineral homeostasis in children and adolescents
Root, A. W., & Diamond, F. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00027-5 · Cited by 18
Bone biopsy and densitometry findings in a child with Camurati–Engelmann disease
Bondestam, J., Mäyränpää, M. K., Ikegawa, S., Marttinen, E. J., Kröger, H., & Mäkitie, O. (2007) · Clinical Rheumatology · doi:10.1007/s10067-006-0511-z · Cited by 19
Vibration accelerates orthodontic tooth movement by inducing osteoclastogenesis via transforming growth factor-β signalling in osteocytes
Sasaki, K., Takeshita, N., Fukunaga, T., Seiryu, M., Sakamoto, M., Oyanagi, T., Maeda, T., & Takano‐Yamamoto, T. (2022) · European Journal of Orthodontics · doi:10.1093/ejo/cjac036 · Cited by 18
Emerging therapeutic targets for osteoporosis treatment
Chen, M., Qiao, H., Su, Z., Li, H., Ping, Q., & Zong, L. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.912632 · Cited by 18
Mathematical Model of Bone Remodeling Captures the Antiresorptive and Anabolic Actions of Various Therapies
ROSS, D. S., Mehta, K., & Cabal, A. (2016) · Bulletin of Mathematical Biology · doi:10.1007/s11538-016-0229-2 · Cited by 18
The dynamic skeleton
Gonciulea, A. R., & de Beur, S. M. J. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-015-9316-1 · Cited by 18
Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model
Lee, H.-P., Lin, Y., Duh, C., Huang, S., Wang, H., Wu, S.-F., Lin, S., Jean, Y., & Wen, Z. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12331 · Cited by 19
Substitutos Ósseos: conceitos gerais e estado actual
Gutierres, M. A. P., Lopes, M. A., Nandyala, S. H., Cabral, A. T., Almeida, L. E., & Santos, J. D. (2005) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 18
Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics
Guo, W., Yang, Z., Liu, F., Song, J., Yang, W., Li, Y., Hu, W., & Wang, K. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102066 · Cited by 18
“…surface characteristics play a pivotal role in hematoma formation and the subsequent progression, primarily by influencing the rate of hematoma development, its internal composition, and, consequently, the associated inflammatory response, cellular behavior, and bone repair processes [74,75].”
A computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways
Zhou, X., & Liu, J. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-618 · Cited by 17
“What is more, the dysregulated genes IL2RG, IL6R, IL7R and TGFB2 have been reported to be associated with metastasis site or prognosis [31], and CCR6 is associated with both live metastasis in breast cancer [32] and bone metastasis in human neuroblastoma [33].”
Background
Human amniotic epithelial cells regulate osteoblast differentiation through the secretion of TGFβ1 and microRNA-34a-5p
Wang, G., Zhao, F., Yang, D., Wang, J., Qiu, L., & Pang, X. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3261 · Cited by 17
15-Lipoxygenase-1 in osteoblasts promotes TGF-β1 expression via inhibiting autophagy in human osteoarthritis
Wan, Y., Lv, Y., Li, L., & Yin, Z. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109548 · Cited by 17
Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques
Robino, J. J., Pamir, N., Rosário, S., Crawford, L. B., Burwitz, B. J., Roberts, C. T., Kurre, P., & Varlamov, O. (2020) · Bone · doi:10.1016/j.bone.2020.115248 · Cited by 16
Drug Delivery Systems in Bone Regeneration and Implant Dentistry
Anil, S., Al-Sulaimani, A. F., Beeran, A. E., Chalisserry, E. P., R, H. V. P., & Amri, M. D. A. (2015) · InTech eBooks · doi:10.5772/60003 · Cited by 19
Failure of serum transforming growth factor-beta (TGF-β1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project
Nelson, A. E., Fang, F., Shi, X., Kraus, V. B., Stäbler, T., Renner, J. B., Schwartz, T. A., Helmick, C. G., & Jordan, J. M. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.11.010 · Cited by 17
Antisense targeting of TGF-β1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells
Shen, Z.-J., Kim, S. K., Jun, D. Y., Park, W., Kim, Y. H., Malter, J. S., & Moon, B. J. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.01.014 · Cited by 17
Genetics of otosclerosis: finally catching up with other complex traits?
Tavernier, L. J. M., Fransén, E., Valgaeren, H., & Camp, G. V. (2021) · Human Genetics · doi:10.1007/s00439-021-02357-1 · Cited by 16
Actin alpha 2, smooth muscle, a transforming growth factor-β1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway
Fakatava, N., Mitarai, H., Yuda, A., Haraguchi, A., Wada, H., Hasegawa, D., Maeda, H., & Wada, N. (2022) · Journal of Dental Sciences · doi:10.1016/j.jds.2022.08.030 · Cited by 17
Osteogenic Potential of a Polyethylene Glycol Hydrogel Functionalized with Poly-Lysine Dendrigrafts (DGL) for Bone Regeneration
Roumani, S., Jeanneau, C., Giraud, T., Cotten, A., Laucournet, M., Sohier, J., Pithioux, M., & About, I. (2023) · Materials · doi:10.3390/ma16020862 · Cited by 16
The Osteogenic Peptide P-15 for Bone Regeneration: A Narrative Review of the Evidence for a Mechanism of Action
Cheng, C. T., Vyas, P. S., McClain, E. J., Hoelen, T.-C. A., Arts, J. J. C., McLaughlin, C., Altman, D. T., Yu, A. K.-T., & Cheng, B. C. (2024) · Bioengineering · doi:10.3390/bioengineering11060599 · Cited by 16
Re-engineering bone: pathogenesis, diagnosis and emerging therapies for osteoporosis
Dong, X., Liu, H., Yuan, D., Gulati, K., & Liu, Y. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb02628d · Cited by 17
Chronic treatment with angiotensin AT1receptor antagonists reduced serum but not bone TGF-β1levels in ovariectomized rats
Li, Y., Ji, H., Shen, Y., Ding, L.-J., Zhuang, P., Yang, Y., & Huang, Q. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y08-097 · Cited by 16

Authors: Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W.
Affiliations: University of Antwerp (BE)
Department of Molecular Cell Biology (P.t.D.), Leids Universitair Medisch Centrum, 2333 AL Leiden, The Netherlands;
University of Lausanne (CH)
Department of Medical Genetics (K.J., W.V.H.), University of Antwerp, 2610 Antwerp, Belgium;
ORCID: Janssens, Katrien
Janssens, Sophie
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2005-10-01
Volume: 26
Issue: 6
Pages: 743-774
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2004-0001
OpenAlex: W2144206769
Cited by: 710
References: 408
Citations by year: 2026: 12 · 2025: 26 · 2024: 24 · 2023: 35 · 2022: 30 · 2021: 30 · 2020: 27 · 2019: 22 · 2018: 23 · 2017: 34 · 2016: 37 · 2015: 26 · 2014: 46 · 2013: 57 · 2012: 47
FWCI: 2.60
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Fonds Wetenschappelijk Onderzoek
Universiteit Antwerpen
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: TGF-β1, bone metabolism, osteoblasts, osteoclasts, bone remodeling, bone resorption, bone formation, cartilage, skeletal development, cytokine signaling
MeSH terms: Animals, Bone and Bones, Bone Development, Bone Resorption, Cells, Cultured, Humans, Osteoblasts, Osteoclasts, Phenotype, Stem Cells, Signal Transduction, Transforming Growth Factor beta, Protein Isoforms, Transforming Growth Factor beta1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transforming Growth Factor-β1 to the Bone

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks