Cited by 714Bone Metabolism and DiseasesTGF-β signaling in diseasesBone health and osteoporosis research

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Transforming Growth Factor-β1 to the Bone

Janssens, Katrien, ten Dijke, Peter, Janssens, Sophie, Van Hul, Wim·2005·Endocrine Reviews

DOI 10.1210/er.2004-0001

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Abstract

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-β1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-β1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-β1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-β1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.

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TGF-β SIGNAL TRANSDUCTION
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 15×
“Runx2 binding sites are found in the promoters of several bone formation markers including collagen 1, ALP, osteopontin, RANKL, and osteocalcin (149).”
BackgroundInfluential
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
The Transforming Growth Factor-Beta Family
Massagué, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,041
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985

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Research works printed but not linked: 6

Mumm, 2001, Camurati-Engelmann disease: new mutations in the latency-associated peptide of the transforming growth factor β-1 gene, J Bone Miner Res, 16, S223
Wells, 2001, Polymorphisms in the transforming growth factor-1 and bone mass and bone loss, Bone, 28, S131
Prince, 2002, Effect of the TGF-β T869C and the CYP119 TTTA repeat polymorphisms on bone mineral density and prevalent fracture in elderly women, J Bone Miner Res, 17, S422
Kim, 2000, T/C polymorphism of the TGF-β1 gene is not associated with quantitative ultrasound values of calcaneus in Korean postmenopausal women in Chung-Up district, J Bone Miner Res, 15, S362
Hong, 2003, Lack of association of transforming growth factor β 1 T29→C gene polymorphism with calcaneal quantitative ultrasound parameters and plasma TGF-β1 levels in postmenopausal Korean women., Calcif Tissue Int, 72, S418
Mundy, 1991, The effects of TGF-β on bone., Ciba Found Symp, 157, 137

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“…factor for study as it plays a pivotal role in both dentine and bone repair, complementing and influencing the activity of other growth factors such as BMPs and IGFs also present in the mineralised matrix (Bostrom and Asnis, 1998; Barnes et al., 1999; Janssens et al., 2005; Dimitriou et al., 2005).”
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“TGF-β is vital in bone tissue development and maintenance, significantly affecting chondrocyte and osteoblast metabolism [103].”
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Giovanini, A. F., Passoni, G. N. D. S., Göhringer, I., Deliberador, T. M., Zielak, J. C., Storrer, C. L. M., Casagrande, T. A. C., & Scariot, R. (2017) · Clinical Oral Investigations · doi:10.1007/s00784-017-2292-y · Cited by 7
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“TGF-β 1 is one of the earliest signs of prechon-drogenic cell migration and condensation (Goldring et al., 2006) and its importance for the latter process was demonstrated by severely under-mined collagen maturation and matrix deposition in TGF-β 1 KO mice (Janssens et al., 2005).”
Background
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Kim, J., Li, H. M., Kim, Y., Lee, Y., Shim, J.-H., Lim, S. S., & Kang, Y. (2012) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x12500954 · Cited by 7
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“Extensive literature on the effects of TGF-b 1 on skeletal homeostasis presents diverse and occasionally con ﬂ icting conclusions [reviewed in (24, 25)].”
Background
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“In the bone formation process, TGF-β 1 recruits MSCs, and enhances their proliferation and early osteogenic differentiation by promoting extracellular matrix (ECM) protein production, thus facilitating bone formation [61].”
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Šalma, I., Pilmane, M., Skaģers, A., Vētra, J., Šalms, Ģ., Bērziņa-Cimdiņa, L., & Seržāne, R. (2009) · PubMed · Cited by 6
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Background
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Background
Fluorides in caries prevention. Dental practitioner handbook No. 20
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Background
Loading- and Unloading-Driven Regulation of Phosphorylation of eIF2^|^alpha;
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Background
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“Growth factors, such as TGFB, are involved in wound healing, angiogenesis and bone regeneration [60].”
Background
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“The results of several studies suggest that TGFβ induces initial pre-osteoblast proliferation and differentiation, while inhibiting terminal differentiation into a more mature osteoblast phenotype [1,6,24].”
BackgroundResult
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Yeni, Y. N., Dong, X., Zhang, B., GIBSON, G. J., & Fyhrie, D. P. (2009) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-009-0896-5 · Cited by 5
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Background
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BackgroundInfluential
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Background
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Background
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Scheiner, S., Pivonka, P., Hellmich, C., & Smith, D. W. (2012) · arXiv (Cornell University) · doi:10.48550/arxiv.1201.2488 · Cited by 4
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de Queiroz, A. C., Pelissari, C., Paris, A. F. C., Rodrigues, M. F. S. D., & Martins, M. T. (2023) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2023.105636 · Cited by 3
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Lu, Y., Xu, H., Ji, X., Zhou, Y., Hu, Z., Amevor, F. K., Du, R., Zhao, X., Liu, Y., & Wang, Y. (2025) · Animal Bioscience · doi:10.5713/ab.25.0413 · Cited by 3
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Bocharov, E. V., Pavlov, K. V., Blommers, M. J. J., Arvinte, T., & Arseniev, A. S. (2008) · Topics in current chemistry · doi:10.1007/128_2007_17 · Cited by 3
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BackgroundInfluential
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Jiajue, R., Wu, B., Jiang, Y., Wang, O., Li, M., Xing, X., & Xia, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5548 · Cited by 3
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Ott, S. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802792-9.00002-1 · Cited by 3
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Sun, Y., Tan, J. S., Yin, X., Wu, B., & Feng, B. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00492 · Cited by 3
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Ge, D. H., Yu, S. W., Ziegler, J. D., & Schwarzkopf, R. M. (2018) · JBJS Case Connector · doi:10.2106/jbjs.cc.17.00286 · Cited by 3
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Oranger, A., Colaianni, G., & Grano, M. (2013) · Springer eBooks · doi:10.1007/978-88-470-5483-7_1 · Cited by 3
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Iranparvar, A., Nozariasbmarz, A., DeGrave, S., & Tayebi, L. (2019) · Springer eBooks · doi:10.1007/978-3-030-21583-5_14 · Cited by 3
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Zumsande, M. (2011) · Qucosa (Saxon State and University Library Dresden) · Cited by 3
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Background
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Fernandes, C. J. D. C. (2024) · Extracellular Vesicle · doi:10.1016/j.vesic.2024.100042 · Cited by 2
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Stanwick, M., Fenesha, F., Hamid, A., Kang, K., Kanniard, D., Kim, I. K., Mandarano, N., Schumacher, F. L., & Peters, S. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136847 · Cited by 2
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Toejing, P., Myint, O., Leelahavanichkul, A., Sridurongrit, S., Greenblatt, M. B., & Lotinun, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062704 · Cited by 2
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Togawa, M., Nakajima, A., Fukumashi, N., & Kawato, T. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01783-6 · Cited by 2
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Yang, T., Feng, X., Wang, N., Zhang, T., Zheng, Z., & Wang, G. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-06153-9 · Cited by 3
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Edwards, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00005-4 · Cited by 2
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Wei, G., Hu, Y. Y., Zheng, L., Huo, J., Tang, T., & Deng, F. (2013) · Journal of Applied Oral Science · doi:10.1590/1679-775720130160 · Cited by 2
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Pennline, J. A., & Mulugeta, L. (2014) · NASA STI Repository (National Aeronautics and Space Administration) · Cited by 2
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Hannink, G., Piek, E., Hendriks, J. M. A., van der Kraan, P. M., Schreurs, B. W., & Buma, P. (2008) · International Orthopaedics · doi:10.1007/s00264-007-0513-8 · Cited by 2
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Moon, S.-H. (2007) · Journal of Korean society of spine surgery · doi:10.4184/jkss.2007.14.2.120 · Cited by 2
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Yamashita, H., Ochiai, H., Saito, A. M., Shintani, S., & Azuma, T. (2014) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.23.9 · Cited by 2
Tumor–bone interactions: there is no place like bone
Fournier, P. G. J., Juárez, P., & Guise, T. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00002-9 · Cited by 2

Authors: Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W.
Affiliations: University of Antwerp (BE)
Department of Molecular Cell Biology (P.t.D.), Leids Universitair Medisch Centrum, 2333 AL Leiden, The Netherlands;
University of Lausanne (CH)
Department of Medical Genetics (K.J., W.V.H.), University of Antwerp, 2610 Antwerp, Belgium;
ORCID: Janssens, Katrien
Janssens, Sophie
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2005-10-01
Volume: 26
Issue: 6
Pages: 743-774
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2004-0001
OpenAlex: W2144206769
Cited by: 710
References: 408
Citations by year: 2026: 12 · 2025: 26 · 2024: 24 · 2023: 35 · 2022: 30 · 2021: 30 · 2020: 27 · 2019: 22 · 2018: 23 · 2017: 34 · 2016: 37 · 2015: 26 · 2014: 46 · 2013: 57 · 2012: 47
FWCI: 2.60
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Fonds Wetenschappelijk Onderzoek
Universiteit Antwerpen
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: TGF-β1, bone metabolism, osteoblasts, osteoclasts, bone remodeling, bone resorption, bone formation, cartilage, skeletal development, cytokine signaling
MeSH terms: Animals, Bone and Bones, Bone Development, Bone Resorption, Cells, Cultured, Humans, Osteoblasts, Osteoclasts, Phenotype, Stem Cells, Signal Transduction, Transforming Growth Factor beta, Protein Isoforms, Transforming Growth Factor beta1

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Transforming Growth Factor-β1 to the Bone

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