Cited by 714Bone Metabolism and DiseasesTGF-β signaling in diseasesBone health and osteoporosis research

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Transforming Growth Factor-β1 to the Bone

Janssens, Katrien, ten Dijke, Peter, Janssens, Sophie, Van Hul, Wim·2005·Endocrine Reviews

DOI 10.1210/er.2004-0001

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Abstract

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-β1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-β1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-β1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-β1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.

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Authors: Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W.
Affiliations: University of Antwerp (BE)
Department of Molecular Cell Biology (P.t.D.), Leids Universitair Medisch Centrum, 2333 AL Leiden, The Netherlands;
University of Lausanne (CH)
Department of Medical Genetics (K.J., W.V.H.), University of Antwerp, 2610 Antwerp, Belgium;
ORCID: Janssens, Katrien
Janssens, Sophie
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2005-10-01
Volume: 26
Issue: 6
Pages: 743-774
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2004-0001
OpenAlex: W2144206769
Cited by: 710
References: 408
Citations by year: 2026: 12 · 2025: 26 · 2024: 24 · 2023: 35 · 2022: 30 · 2021: 30 · 2020: 27 · 2019: 22 · 2018: 23 · 2017: 34 · 2016: 37 · 2015: 26 · 2014: 46 · 2013: 57 · 2012: 47
FWCI: 2.60
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Fonds Wetenschappelijk Onderzoek
Universiteit Antwerpen
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: TGF-β1, bone metabolism, osteoblasts, osteoclasts, bone remodeling, bone resorption, bone formation, cartilage, skeletal development, cytokine signaling
MeSH terms: Animals, Bone and Bones, Bone Development, Bone Resorption, Cells, Cultured, Humans, Osteoblasts, Osteoclasts, Phenotype, Stem Cells, Signal Transduction, Transforming Growth Factor beta, Protein Isoforms, Transforming Growth Factor beta1

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Transforming Growth Factor-β1 to the Bone

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