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Cited by 1,134

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Advances in Male Contraception

Open access
Page, Stephanie T., Amory, John K., Bremner, William J.·2008·Endocrine Reviews
DOI 10.1210/er.2007-0041
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Abstract

Despite significant advances in contraceptive options for women over the last 50 yr, world population continues to grow rapidly.Scientists and activists alike point to the devastating environmental impacts that population pressures have caused, including global warming from the developed world and hunger and disease in less developed areas.Moreover, almost half of all pregnancies are still unwanted or unplanned.Clearly, there is a need for expanded, reversible, contraceptive options.Multicultural surveys demonstrate the willingness of men to participate in contraception and their female partners to trust them to do so.Notwithstanding their paucity of options, male methods including vasectomy and condoms account for almost one third of contraceptive use in the United States and other countries.Recent international clinical research efforts have demonstrated high efficacy rates (90 -95%) for hormonally based male contraceptives.Current barriers to expanded use include limited delivery methods and perceived regulatory obstacles, which stymie introduction to the marketplace.However, advances in oral and injectable androgen delivery are cause for optimism that these hurdles may be overcome.Nonhormonal methods, such as compounds that target sperm motility, are attractive in their theoretical promise of specificity for the reproductive tract.Gene and protein array technologies continue to identify potential targets for this approach.Such nonhormonal agents will likely reach clinical trials in the near future.Great strides have been made in understanding male reproductive physiology; the combined efforts of scientists, clinicians, industry and governmental funding agencies could make an effective, reversible, male contraceptive an option for family planning over the next decade.(Endocrine Reviews 29: 465-493, 2008) I. Introduction II.Acceptability of Male Contraception III.Currently Available Male Contraceptive Methods A. Condoms B. Vasectomy IV.Regulation of Testicular Function and Spermatogenesis A. The hypothalamic-pituitary axis: control of gonadotropin secretion B. Testosterone production and androgen action C. Spermatogenesis D. The epididymis V. Male Hormonal Contraception Methods A. Hormonal contraceptive efficacy B. Testosterone alone C. Testosterone-progestin combinations D. Adding GnRH analogs to hormonal contraceptive regimens E. Oral male hormonal contraceptive development F. Reversibility of male hormonal contraception G. Side effects of male hormonal contraceptives H. Selective androgen receptor modulators for male contraception I. Why doesn't hormonal contraception work for all men?VI.Nonhormonal Methods A. Testicular targets B. Epdidymal targets C. Targeting sperm motility or sperm-egg fusion D. Immunological approaches to contraception VII.

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Metadata

Authors
Page, S. T., Amory, J. K., & Bremner, W. J.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2008-04-24
Volume
29
Issue
4
Pages
465-493
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2007-0041
OpenAlex
W2007984040
Cited by
1,134
References
23
FWCI
261.60
Type
journal article
Language
en
Open access
bronze

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