Cited by 1,042Bone Metabolism and DiseasesBone health and osteoporosis researchParathyroid Disorders and Treatments

The DOI matches its Crossref record; 332 of the 332 references it cites were found in a registry or an index.

The Osteocyte: An Endocrine Cell … and More

Open access

Dallas, Sarah L., Prideaux, Matthew, Bonewald, Lynda F.·2013·Endocrine Reviews

DOI 10.1210/er.2012-1026PMC PMC3785641

Open this paper in CoChat — free account Open PDF

Abstract

Few investigators think of bone as an endocrine gland, even after the discovery that osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and potentially other organs.In fact, until the last few years, osteocytes were perceived by many as passive, metabolically inactive cells.However, exciting recent discoveries have shown that osteocytes encased within mineralized bone matrix are actually multifunctional cells with many key regulatory roles in bone and mineral homeostasis.In addition to serving as endocrine cells and regulators of phosphate homeostasis, these cells control bone remodeling through regulation of both osteoclasts and osteoblasts, are mechanosensory cells that coordinate adaptive responses of the skeleton to mechanical loading, and also serve as a manager of the bone's reservoir of calcium.Osteocytes must survive for decades within the bone matrix, making them one of the longest lived cells in the body.Viability and survival are therefore extremely important to ensure optimal function of the osteocyte network.As we continue to search for new therapeutics, in addition to the osteoclast and the osteoblast, the osteocyte should be considered in new strategies to prevent and treat bone disease.(Endocrine Reviews 34: 658 -690, 2013) I. Introduction II.Osteocyte Differentiation and Embedding III.Morphology of Osteocytes, Their Dendrites, and Lacunocanalicular System IV. Osteocyte Selective Genes/Proteins and Their Potential Functions V. Tools for Studying Osteocytes VI.Osteocyte Mechanosensation and Transduction A. How osteocytes sense loading B. How loading affects osteocyte signaling VII.Osteocytes as Orchestrators of Bone Formation and Resorption VIII.Osteocyte Life, Death, and in Between IX.Osteocytic Perilacunar Remodeling: An Old Concept Rediscovered X.The Osteocyte as an Endocrine Cell XI.Crosstalk Between Osteocytes and Muscle Cells XII.Role of Osteocytes in Disease XIII.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/er.2012-1026

Cites

332 of 332 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639
The amazing osteocyte
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287
Self-citation
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235
Das Gesetz der Transformation der Knochen
Wolff, J. (1893) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0028-1144106 · Cited by 2,037
FGF23 induces left ventricular hypertrophy
Faul, C., Amaral, A. P., Oskouei, B., Hu, M.-C., Sloan, A., Isakova, T., Gutiérrez, O. M., Aguillon-Prada, R., Lincoln, J., Hare, J. M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46122 · Cited by 2,027
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778
Self-citation
Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.
Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.
Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
White, K., Evans, W. E., O'Riordan, J., Speer, M., Econs, M., Lorenz-Depiereux, B., Grabowski, M., Meitinger, T., & Strom, T. (2000) · Nature Genetics · doi:10.1038/81664 · Cited by 1,467

Flagged first, then by citations

Show all 330 references

Research works printed but not linked: 11

Holtrop, 1990, Light and electron microscopical structure of bone forming cells, 1
Guo, 2006, Identification of proteins involved in cytoskeletal rearrangement, anti-hypoxia and membrane channels in osteocytes over osteoblasts, J Bone Miner Res, 21, S168
Dallas, 2007, Dynamic imaging of fluorescently tagged osteoblast and osteocyte populations integrates mineralization dynamics with osteoblast to osteocyte transition, J Bone Miner Res, 22, S13
Veno, 2010, A membrane targeted GFP selectively expressed in osteocytes reveals cell and membrane dynamics in living osteocytes, J Bone Miner Res, 25, S56
Veno, 2007, Dynamic imaging in living calvaria reveals the motile properties of osteoblasts and osteocytes and suggests heterogeneity of osteoblasts in bone, J Bone Miner Res, 22, S13
Sprague, 1996, Phenotypic changes following over-expression of sense or antisense E11 cDNA in ROS 17/2.8 cells, J Bone Miner Res, 11, S132
Wang, The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading [published online ahead of print January 29, 2013], J Bone Miner Res
Javaheri, 2011, b-Catenin haploinsufficiency in osteocytes abolishes the osteogenic effect of mechanical loading in vivo, J Bone Miner Res, 26, S24
Zhao, 2011, Osteocyte autophagy declines with age in mice and suppression of autophagy decreases bone mass, J Bone Miner Res, 27, S13
Liu, 2006, Elevated levels of FGF23 in dentin matrix protein 1 (DMP1) null mice potentially explain phenotypic similarities to Hyp mice, J Bone Miner Res, 21, S51
Lara, 2011, A muscle derived soluble factor activates PI3K/β-catenin signaling in osteocytes, J Bone Miner Res, 26, S242

Sorted by citations

Items 401–500 of 999

Oscillating Fluid Flow Activated Osteocyte Lysate‐Based Hydrogel for Regulating Osteoblast/Osteoclast Homeostasis to Enhance Bone Repair
Zheng, L., Zhou, D., Ju, F., Liu, Z., Yan, C., Dong, Z., Chen, S., Deng, L., Chan, S., Deng, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202204592 · Cited by 25
Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue
Nottmeier, C., Lavický, J., González‐López, M., Knauth, S., Kahl‐Nieke, B., Amling, M., Schinke, T., Helms, J. A., Křivánek, J., Koehne, T., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-36699-9 · Cited by 25
Autonomic nervous regulation of cellular processes during subchondral bone remodeling in osteoarthritis
Rösch, G., Zaucke, F., & Jenei‐Lanzl, Z. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00039.2023 · Cited by 26
Regulation of Sclerostin Production in Human Male Osteocytes by Androgens: Experimental and Clinical Evidence
Nisio, A. D., Toni, L. D., Speltra, E., Rocca, M. S., Taglialavoro, G., Ferlin, A., & Foresta, C. (2015) · Endocrinology · doi:10.1210/en.2015-1244 · Cited by 25
Aging of the Bone
Wei, Y., & Sun, Y. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_12 · Cited by 25
Rethinking Fragility Fractures in Type 2 Diabetes: The Link between Hyperinsulinaemia and Osteofragilitas
Cooper, I. D., Brookler, K. H., & Crofts, C. A. P. (2021) · Biomedicines · doi:10.3390/biomedicines9091165 · Cited by 29
Role of sclerostin in the pathogenesis of chronic kidney disease-mineral bone disorder
Asamiya, Y., Tsuchiya, K., & Nitta, K. (2016) · Renal Replacement Therapy · doi:10.1186/s41100-016-0024-4 · Cited by 24
Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene
Lhaneche, L., Hald, J. D., Domingues, A., Hannouche, D., Délepine, M., Zélénika, D., Boland, A., Ostertag, A., Cohen-Solal, M. E., Langdahl, B. L., et al. (2016) · Bone · doi:10.1016/j.bone.2016.08.004 · Cited by 24
High Glucose Downregulates Connexin 43 Expression and Its Gap Junction and Hemichannel Function in Osteocyte-like MLO-Y4 Cells Through Activation of the p38MAPK/ERK Signal Pathway
Yang, L., Zhou, G., Li, M., Li, Y., Yang, L., Fu, Q., & Tian, Y. E. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s239892 · Cited by 24
Assessment of Osteocytes: Techniques for Studying Morphological and Molecular Changes Associated with Perilacunar/Canalicular Remodeling of the Bone Matrix
Dole, N. S., Yee, C. S., Schurman, C. A., Dallas, S. L., & Alliston, T. N. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1028-2_17 · Cited by 24
Self-citation
Positive and Negative Regulators of Sclerostin Expression
Iwamoto, R., Koide, M., Udagawa, N., & Kobayashi, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094895 · Cited by 27
Mechanistic and therapeutic insights gained from studying rare skeletal diseases
Tosi, L. L., & Warman, M. L. (2015) · Bone · doi:10.1016/j.bone.2015.03.016 · Cited by 24
Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells
Choi, H., Srikanth, S., Atti, E., Pirih, F. Q. M., Nervina, J. M., Gwack, Y., & Tetradis, S. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.03.007 · Cited by 24
Immunomodulatory nanomedicine for osteoporosis: Current practices and emerging prospects
Luo, Y., Liu, H., Chen, M., Zhang, Y., Zheng, W., Wu, L., Liu, Y., Liu, Y., Luo, E., & Liu, X. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.03.011 · Cited by 24
Apheresis Platelet Rich-Plasma for Regenerative Medicine: An In Vitro Study on Osteogenic Potential
Pulcini, S., Merolle, L., Marraccini, C., Quartieri, E., Mori, D., Schiroli, D., Berni, P., Iotti, B., Bartolomeo, E. D., Baricchi, R., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168764 · Cited by 23
Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders
Alioli, C., Demesmay, L., Peyruchaud, O., & Machuca‐Gayet, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073427 · Cited by 23
Glucocorticoids cause mandibular bone fragility and suppress osteocyte perilacunar-canalicular remodeling
Alemi, A. S., Mazur, C. M., Fowler, T. W., Woo, J. J., Knott, P. D., & Alliston, T. N. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.09.004 · Cited by 23
Fibroblast-secreted trophic factors contribute with ECM remodeling stimulus and upmodulate osteocyte gene markers in osteoblasts
Fernandes, C. J. D. C., & Zambuzzi, W. F. (2019) · Biochimie · doi:10.1016/j.biochi.2019.10.013 · Cited by 23
Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification
Alioli, C., Demesmay, L., Laurencin‐Dalicieux, S., Beton, N., Farlay, D., Follet, H., Amri, S., Duboeuf, F., Chun, J. J. M., Rivera, R. R., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158715 · Cited by 26
A comparison of alendronate to varying magnitude PEMF in mitigating bone loss and altering bone remodeling in skeletally mature osteoporotic rats
Androjna, C., Yee, C. S., White, C. R., Waldorff, E. I., Ryaby, J. T., Zborowski, M., Alliston, T. N., & Midura, R. J. (2020) · Bone · doi:10.1016/j.bone.2020.115761 · Cited by 22
FGF7-induced E11 facilitates cell-cell communication through connexin43
Liu, X., Bai, M., Sun, Y., Hu, X., Wang, C., Xie, J., & Ye, L. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.65240 · Cited by 22
Pathways Controlling Formation and Maintenance of the Osteocyte Dendrite Network
Wang, J. S., & Wein, M. N. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00753-8 · Cited by 26
Dexamethasone Induced Osteocyte Apoptosis in Steroid‐Induced Femoral Head Osteonecrosis through ROS ‐Mediated Oxidative Stress
Zhang, X., Yang, Z., Xu, Q., Xu, C., Shi, W., Pang, R., Zhang, K., Liang, X., Li, H., Li, Z., et al. (2024) · Orthopaedic Surgery · doi:10.1111/os.14010 · Cited by 22
Nitric Oxide as a Mediator of Estrogen Effects in Osteocytes
Joshua, J., Kalyanaraman, H., Marathe, N., & Pilz, R. B. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00010-6 · Cited by 22
Creating High-Resolution Multiscale Maps of Human Tissue Using Multi-beam SEM
Pereira, A. F., Hageman, D. J., Garbowski, T., Riedesel, C., Knothe, U. R., Zeidler, D., & Tate, M. L. K. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005217 · Cited by 22
Sclerostin levels predict cardiovascular mortality in long-term hemodialysis patients: A prospective observational cohort study
Kalousová, M., Sulková, S., Kuběna, A. A., Zakiyanov, O., Tesař, V., & Zima, T. (2019) · Physiological Research · doi:10.33549/physiolres.934034 · Cited by 22
Effects of ionizing radiation on woven bone: influence on the osteocyte lacunar network, collagen maturation, and microarchitecture
Mendes, E. M., Iriê, M. S., Rabelo, G. D., Borges, J. S., Dechichi, P., Diniz, R. S., & Soares, P. B. F. (2019) · Clinical Oral Investigations · doi:10.1007/s00784-019-03138-x · Cited by 22
Activation of HIFa Pathway in Mature Osteoblasts Disrupts the Integrity of the Osteocyte/Canalicular Network
Zuo, G., Zhang, L., Jin, Q., Kang, H., Jia, P., Chen, H., Shen, X., Guo, L., Zhou, H., Wang, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121266 · Cited by 22
Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research
Mohammadkhah, M., Slavković, V., & Klinge, S. (2025) · Bioengineering · doi:10.3390/bioengineering12060579 · Cited by 21
Role of cortical bone in hip fracture
REEVE, J. (2017) · BoneKEy Reports · doi:10.1038/bonekey.2016.82 · Cited by 21
Alterations of bone material properties in growing Ifitm5/BRIL p.S42 knock-in mice, a new model for atypical type VI osteogenesis imperfecta
Hedjazi, G., Ram, G. G., Blouin, S., Schemenz, V., Wagermaier, W., Fratzl, P., Hartmann, M. A., Zwerina, J., Fratzl‐Zelman, N., & Marini, J. C. (2022) · Bone · doi:10.1016/j.bone.2022.116451 · Cited by 21
Roles of osteocytes in phosphate metabolism
Michigami, T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.967774 · Cited by 22
Hypoxia‐Inducible Factor‐2α Signaling in the Skeletal System
Mendoza, S. V., Genetos, D. C., & Yellowley, C. E. (2023) · JBMR Plus · doi:10.1002/jbm4.10733 · Cited by 25
Macrophage-to-osteocyte communication: Impact in a 3D in vitro implant-associated infection model
Giraldo-Osorno, P. M., Wirsig, K., Asa’ad, F., Omar, O., Trobos, M., Bernhardt, A., & Palmquist, A. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.08.005 · Cited by 25
Activation of AMP-activated protein kinase decreases receptor activator of NF-κB ligand expression and increases sclerostin expression by inhibiting the mevalonate pathway in osteocytic MLO-Y4 cells
Yokomoto‐Umakoshi, M., Kanazawa, I., Takeno, A., Tanaka, K., Notsu, M., & Sugimoto, T. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.072 · Cited by 21
Role of the Wnt/β-Catenin Pathway in Renal Osteodystrophy
Bisson, S.-K., Ung, R., & Mac‐Way, F. (2018) · International Journal of Endocrinology · doi:10.1155/2018/5893514 · Cited by 21
Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
Hua, R., Gu, S., & Jiang, J. X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.892229 · Cited by 21
Osteoporosis Update: Proceedings of the 2013 Santa Fe Bone Symposium
Lewiecki, E. M., Bilezikian, J. P., Bonewald, L. F., Compston, J. E., Heaney, R. P., Kiel, D. P., Miller, P. D., & Schousboe, J. T. (2014) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2013.11.006 · Cited by 21
Self-citation
Isolation of Osteocytes from Mature and Aged Murine Bone
Stern, A. R., & Bonewald, L. F. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1619-1_1 · Cited by 22
Self-citation
TNF-α promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis
Cui, H., Li, J., Li, X., Su, T., Wen, P., Wang, C., Deng, X., Fu, Y., Zhao, W., Li, C., et al. (2024) · Bone · doi:10.1016/j.bone.2024.117050 · Cited by 19
Sclerostin
Honasoge, M., Rao, A. D., & Rao, S. D. (2014) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000114 · Cited by 19
Glucose uptake inhibition decreases expressions of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteocalcin in osteocytic MLO-Y4-A2 cells
Takeno, A., Kanazawa, I., Notsu, M., Tanaka, K., & Sugimoto, T. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00159.2017 · Cited by 20
The Role of Dickkopf-1 in Thyroid Hormone–Induced Changes of Bone Remodeling in Male Mice
Tsourdi, E. A., Colditz, J., Lademann, F., Rijntjes, E., Köhrle, J., Niehrs, C., Hofbauer, L. C., & Rauner, M. (2019) · Endocrinology · doi:10.1210/en.2018-00998 · Cited by 20
Relationships between the Bone Expression of Alzheimer’s Disease-Related Genes, Bone Remodelling Genes and Cortical Bone Structure in Neck of Femur Fracture
Stapledon, C. J. M., Stamenkov, R. B., Cappai, R., Clark, J., Bourke, A., Solomon, L. B., & Atkins, G. J. (2021) · Calcified Tissue International · doi:10.1007/s00223-020-00796-y · Cited by 22
Osteocytic Connexin43 Channels Regulate Bone–Muscle Crosstalk
Li, G., Zhang, L., Ning, K., Yang, B., Acosta, F. M., Shang, P., Jiang, J. X., & Xu, H. (2021) · Cells · doi:10.3390/cells10020237 · Cited by 20
Effects of Active Vitamin D or FGF23 Antibody on Hyp Mice Dentoalveolar Tissues
dos Santos, E. J. L., Chavez, M. B., Tan, M. H., Mohamed, F. F., Kolli, T. N., Foster, B. L., & Liu, E. S. (2021) · Journal of Dental Research · doi:10.1177/00220345211011041 · Cited by 20
Impact of Intrinsic Muscle Weakness on Muscle–Bone Crosstalk in Osteogenesis Imperfecta
Gremminger, V. L., & Phillips, C. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094963 · Cited by 21
Aesculetin Accelerates Osteoblast Differentiation and Matrix-Vesicle-Mediated Mineralization
Na, W., Kang, M., Park, S., Kim, D. Y., Oh, S. Y., Oh, M.-S., Park, S., Kang, I., & Kang, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212391 · Cited by 22
Perilacunar bone tissue exhibits sub-micrometer modulus gradation which depends on the recency of osteocyte bone formation in both young adult and early-old-age female C57Bl/6 mice
Rux, C. J., Vahidi, G., Darabi, A., Cox, L. M., & Heveran, C. M. (2022) · Bone · doi:10.1016/j.bone.2022.116327 · Cited by 20
Advances in understanding of phosphate homeostasis and related disorders
Michigami, T. (2022) · Endocrine Journal · doi:10.1507/endocrj.ej22-0239 · Cited by 23
Single-cell RNA sequencing identifies Fgf23-expressing osteocytes in response to 1,25-dihydroxyvitamin D3 treatment
Hanai, A., Kawabata, A., Nakajima, K., Masuda, K., Urakawa, I., Abe, M., Yamazaki, Y., & Fukumoto, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1102751 · Cited by 20
Bone on-a-chip: a 3D dendritic network in a screening platform for osteocyte-targeted drugs
Lipreri, M. V., Pompo, G. D., Boanini, E., Graziani, G., Sassoni, E., Baldini, N., & Avnet, S. (2023) · Biofabrication · doi:10.1088/1758-5090/acee23 · Cited by 22
Human bone chips release of sclerostin and FGF ‐23 into the culture medium: an in vitro pilot study
Brolese, E. K., Buser, D., Kuchler, U., Schaller, B., & Gruber, R. (2014) · Clinical Oral Implants Research · doi:10.1111/clr.12432 · Cited by 20
Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia
Chan, W. C. W., Tsang, K. Y., Cheng, Y., Ng, V. C. W., Chik, H., Tan, Z., Boot-Handford, R., BOYDE, A., Cheung, K., Cheah, K. S. E., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx339 · Cited by 20
Loss of Gsα in osteocytes leads to osteopenia due to sclerostin induced suppression of osteoblast activity
Fulzele, K. S., Dedic, C., Lai, F., Bouxsein, M., Lotinun, S., Baron, R., & Pajevic, P. D. (2018) · Bone · doi:10.1016/j.bone.2018.09.021 · Cited by 20
FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction
Liu, X., Li, X., Bai, M., Chen, X., Wang, C., Xie, J., & Ye, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-33247-8 · Cited by 20
Osteoporosis: From osteoscience to neuroscience and beyond
Kwan, P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.02.001 · Cited by 20
Revolutionizing diabetic wound healing: Targeted therapeutic strategies based on growth factors
Yadav, J. P., Patel, D. K., Verma, A., & Pathak, P. (2024) · Obesity Medicine · doi:10.1016/j.obmed.2024.100535 · Cited by 19
The effect of burn on serum concentrations of sclerostin and FGF23
Klein, G. L., Herndon, D. N., Le, P. T., Andersen, C. R., Benjamin, D. A., & Rosen, C. J. (2015) · Burns · doi:10.1016/j.burns.2015.04.001 · Cited by 19
Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading
Maurel, D. B., Duan, P., Farr, J. N., Cheng, A.-L., Johnson, M. L., & Bonewald, L. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158381 · Cited by 19
Self-citation
Bergenin increases osteogenic differentiation and prevents methylglyoxal-induced cytotoxicity in MC3T3-E1 osteoblasts
Suh, K. S., Chon, S., & Choi, E. M. (2017) · Cytotechnology · doi:10.1007/s10616-017-0135-y · Cited by 19
Impact of Genetic and Pharmacologic Inhibition of Myostatin in a Murine Model of Osteogenesis Imperfecta
Omosule, C. L., Gremminger, V. L., AGUILLARD, A., Jeong, Y., Harrelson, E. N., Miloscio, L., Mastaitis, J. W., Rafique, A., Kleiner, S., Pfeiffer, F. M., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4223 · Cited by 21
Cementocyte alterations associated with experimentally induced cellular cementum apposition in Hyp mice
dos Santos, E. J. L., Salmon, C. R., Chavez, M. B., de Almeida, A. B., Tan, M. H., Chu, E. Y., Sallum, E. A., Casati, M. Z., Ruiz, K. G. S., Kantovitz, K. R., et al. (2021) · Journal of Periodontology · doi:10.1002/jper.21-0119 · Cited by 18
Mechanisms of sphingosine-1-phosphate (S1P) signaling on excessive stress-induced root resorption during orthodontic molar intrusion
Wang, H., Li, T., Wang, X., Guan, Y., Jiang, Y., Chen, S., Zou, S., & Duan, P. (2021) · Clinical Oral Investigations · doi:10.1007/s00784-021-04084-3 · Cited by 18
Osteocytes and Cancer
Pin, F., Prideaux, M., Bonewald, L. F., & Bonetto, A. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00712-9 · Cited by 20
Self-citation
Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator
de Souza, P. C., Henning, P., & Lerner, U. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063287 · Cited by 17
Vibration accelerates orthodontic tooth movement by inducing osteoclastogenesis via transforming growth factor-β signalling in osteocytes
Sasaki, K., Takeshita, N., Fukunaga, T., Seiryu, M., Sakamoto, M., Oyanagi, T., Maeda, T., & Takano‐Yamamoto, T. (2022) · European Journal of Orthodontics · doi:10.1093/ejo/cjac036 · Cited by 18
Osteocyte Remodeling of the Lacunar-Canalicular System: What’s in a Name?
Heveran, C. M., & Boerckel, J. D. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00766-3 · Cited by 18
Expression of nucleobindin 1 (NUCB1) in pancreatic islets and other endocrine tissues
Williams, P., Tulke, S., Ilegems, E., Berggren, P., & Broberger, C. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1948-z · Cited by 20
Involvement of Bone in Systemic Endocrine Regulation
Zofkova, I. (2018) · Physiological Research · doi:10.33549/physiolres.933843 · Cited by 18
A new perspective on mechanisms governing skeletal complications in type 1 diabetes
Şeref-Ferlengez, Z., Suadicani, S. O., & Thi, M. M. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13202 · Cited by 17
Osteocyte-lacuna shape and canaliculi architecture dictate fluid flow around osteocyte, and strain of cell and bone matrix: implications for cell mechanobiology and bone fragility
Muñoz, A., Paolis, A. D., Cardoso, L., & Carriero, A. (2025) · Bone · doi:10.1016/j.bone.2025.117613 · Cited by 19
Pharmacological Regulation of Primary Cilium Formation Affects the Mechanosensitivity of Osteocytes
Ding, D., Yang, X. Y., Luan, H., Wu, X., He, C., Sun, L., & Fan, Y. (2020) · Calcified Tissue International · doi:10.1007/s00223-020-00756-6 · Cited by 17
Focus on Osteosclerotic Progression in Primary Myelofibrosis
Spampinato, M., Giallongo, C., Romano, A., Longhitano, L., Spina, E. L., Avola, R., Scandura, G., Dulcamare, I., Bramanti, V., Rosa, M. D., et al. (2021) · Biomolecules · doi:10.3390/biom11010122 · Cited by 17
Effects of Extracellular Osteoanabolic Agents on the Endogenous Response of Osteoblastic Cells
Alloisio, G., Ciaccio, C., Fasciglione, G. F., Tarantino, U., Marini, S., Coletta, M., & Gioia, M. (2021) · Cells · doi:10.3390/cells10092383 · Cited by 20
Impact of degradable magnesium implants on osteocytes in single and triple cultures
Bernhardt, A., Helmholz, H., Kilian, D., Willumeit‐Römer, R., & Gelinsky, M. (2022) · Biomaterials Advances · doi:10.1016/j.msec.2022.112692 · Cited by 17
Cadmium accelerates autophagy of osteocytes by inhibiting the PI3K / AKT / mTOR signaling pathway
Song, R., He, S., Cao, Y., Lu, Y., Peng, Y., Zou, H., Tong, X., Ran, D., Ma, Y., & Liu, Z. (2023) · Environmental Toxicology · doi:10.1002/tox.23823 · Cited by 17
Sclerostin: clinical insights in muscle–bone crosstalk
Moretti, A., & Iolascon, G. (2023) · Journal of International Medical Research · doi:10.1177/03000605231193293 · Cited by 18
Microdroplets Encapsulated with NFATc1-siRNA and Exosomes-Derived from MSCs Onto 3D Porous PLA Scaffold for Regulating Osteoclastogenesis and Promoting Osteogenesis
Luo, P. F., Zhang, Y., Huang, M., Luo, G., Ma, Y., & Wang, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s443413 · Cited by 17
Bone cells, sclerostin, and FGF23: what’s bred in the bone will come out in the flesh
Ott, S. M. (2015) · Kidney International · doi:10.1038/ki.2014.360 · Cited by 17
Skeletal muscle Ca2+ mishandling: Another effect of bone-to-muscle signaling
Regan, J. N., Waning, D. L., & Guise, T. A. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.11.007 · Cited by 16
Organ‐to‐Cell‐Scale Health Assessment Using Geographical Information System Approaches with Multibeam Scanning Electron Microscopy
Tate, M. L. K., Zeidler, D., Pereira, A. F., Hageman, D. J., Garbowski, T., Mishra, S. K., Gardner, L., & Knothe, U. R. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600026 · Cited by 17
G-CSF Inhibits Growths of Osteoblasts and Osteocytes by Upregulating Nitric Oxide Production in Neutrophils
Zhao, J., Zhao, Q., Ning, P., Shang, K., Liu, C., Ni, M., Li, C., Zhang, K., & Gao, C. (2019) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000005769 · Cited by 17
The Role of Epigenetic Functionalization of Implants and Biomaterials in Osseointegration and Bone Regeneration—A Review
Asa’ad, F., Pelanyte, G., Philip, J., Dahlin, C., & Larsson, L. (2020) · Molecules · doi:10.3390/molecules25245879 · Cited by 17
Primary Disorders of Phosphate Metabolism
Carpenter, T. O. (2014) · Cited by 17
Histomorphology
Stout, S. D., Cole, M. E., & Agnew, A. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-809738-0.00006-5 · Cited by 21
Multiscale bone quality analysis in osteoarthritic knee joints reveal a role of the mechanosensory osteocyte network in osteophytes
Rabelo, G. D., Scheidt, A. V., Klebig, F., Hemmatian, H., Çıtak, M., Amling, M., Busse, B., & Jähn, K. (2020) · Scientific Reports · doi:10.1038/s41598-019-57303-z · Cited by 18
Transformation of Mature Osteoblasts into Bone Lining Cells and RNA Sequencing-Based Transcriptome Profiling of Mouse Bone during Mechanical Unloading
Hong, A. R., Kim, K., Lee, J. Y., Yang, J., Kim, J. H., Shin, C. S., & Kim, S. W. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.35.2.456 · Cited by 19
Osteocalcin and GPR158: linking bone and brain function
Li, J., Lou, S., & Bian, X. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1564751 · Cited by 20
Embedding cells within nanoscale, rapidly mineralizing hydrogels: A new paradigm to engineer cell-laden bone-like tissue
Mansoorifar, A., Subbiah, R., Balbinot, G. D. S., Parthiban, S. P., & Bertassoni, L. E. (2020) · Journal of Structural Biology · doi:10.1016/j.jsb.2020.107636 · Cited by 16
Novel in vitro microfluidic platform for osteocyte mechanotransduction studies
Xu, L., Song, X., Carroll, G., & You, L. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa025 · Cited by 16
Advanced oxidation protein products aggravate age‑related bone loss by increasing sclerostin expression in osteocytes via ROS‑dependent downregulation of Sirt1
Zeng, J., Xiao, Q. F., Li, X., & Chen, J. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4941 · Cited by 16
Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
Sabol, H. M., Amorim, T., Ashby, C., Halladay, D., Anderson, J. L., Cregor, M. D., Sweet, M. L., Nookaew, I., Kurihara, N., Roodman, G. D., et al. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100785 · Cited by 16
Duchenne Muscular Dystrophy Gene Therapy
Saad, F. A., Saad, J. F., Siciliano, G., Merlini, L., & Angelini, C. I. (2022) · Current Gene Therapy · doi:10.2174/1566523223666221118160932 · Cited by 17
Deconstructing cellular senescence in bone and beyond
Hofbauer, L. C., Lademann, F., & Rauner, M. (2023) · Journal of Clinical Investigation · doi:10.1172/jci169069 · Cited by 17
Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice
Fu, Y.-F., Guo, Y.-X., Xia, S., Zhou, T., Zhao, Y., Jia, Z., & Zhang, Y. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112408 · Cited by 16
The past 10 years—new hormones, new functions, new endocrine organs
Bouillon, R., Drucker, D. J., Ferrannini, E., Grinspoon, S. K., Rosen, C. J., & Zimmet, P. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.142 · Cited by 16
Effects of Rosiglitazone on the Outcome of Experimental Periapical Lesions in Mice
de Oliveira, K. M. H., Garlet, G. P., ROSSI, A. D., Barreiros, D., de Queiroz, A. M., da Silva, L. A. B., Nelson‐Filho, P., & da Silva, R. A. B. (2017) · Journal of Endodontics · doi:10.1016/j.joen.2017.06.026 · Cited by 16
Analysis of Physiological Responses to Thyroid Hormones and Their Receptors in Bone
Bassett, J. H. D., & Williams, G. R. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7902-8_12 · Cited by 17
Lithium-Doped Biological-Derived Hydroxyapatite Coatings Sustain In Vitro Differentiation of Human Primary Mesenchymal Stem Cells to Osteoblasts
Florian, P. E., Duta, L., Grumezescu, V., Popescu‐Pelin, G., Popescu, A. C., Oktar, F. N., Evans, R. W., & Constantinescu, A. R. (2019) · Coatings · doi:10.3390/coatings9120781 · Cited by 16

Authors: Dallas, S. L., Prideaux, M., & Bonewald, L. F.
Affiliations: University of Missouri–Kansas City (US)
ORCID: Dallas, Sarah L.
Prideaux, Matthew
Bonewald, Lynda F.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2013-04-26
Volume: 34
Issue: 5
Pages: 658-690
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2012-1026
PMC: PMC3785641
OpenAlex: W2142302926
Cited by: 1,042
References: 330
Citations by year: 2026: 60 · 2025: 83 · 2024: 60 · 2023: 88 · 2022: 85 · 2021: 113 · 2020: 106 · 2019: 108 · 2018: 89 · 2017: 73 · 2016: 70 · 2015: 69 · 2014: 32 · 2013: 5
FWCI: 5.40
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrine Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Missouri
University of Missouri-Kansas City
National Institutes of Health (AR46798, PO1AG039355, AG039355)
National Institute on Aging (P01AG039355)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR051517, R56AR051517, P01AR046798, R21AR054449)
National Center for Research Resources (S10RR027668)
Army Research Office
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Keywords: osteocytes, fibroblast growth factor 23, bone mineral homeostasis, phosphate homeostasis, bone remodeling, osteoclast regulation, mechanosensing, mechanotransduction, osteocyte differentiation, osteocyte survival, bone disease
MeSH terms: Bone Resorption, Cell Communication, Cell Differentiation, Humans, Osteocytes, Osteogenesis, Cell Death, Muscle Cells, Mechanotransduction, Cellular, Endocrine Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Osteocyte: An Endocrine Cell … and More

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks