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Isolated Growth Hormone Deficiency (GHD) in Childhood and Adolescence: Recent Advances
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“Besides holding for retesting purposes, it is recommended to continue GH therapy in patients with confirmed GHD during the transition period, even if adult height has been achieved, as treatment is associated with improved body composition, bone health, cognitive function, QOL, and lipid metabolism in adulthood.73,76,92,98,120”
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“Thus, while diagnostic thresholds have been well defined for adult GHD, appropriate thresholds for the diagnosis of GHD in childhood and adolescence are currently debated.92”
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“Previous consensus guidelines suggest that a peak stimulated GH concentration <10 μg/L indicates the presence of GHD in children. However, this threshold value does not take into account sex, age, BMI, or the specific stimulation test used.9,81,92”
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200 of 458 shown
Cited by
Wexler, T. L., Reifschneider, K., Backeljauw, P., Cárdenas, J. F., Hoffman, A. R., Miller, B. S., & Yuen, K. C. J. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0384 · Cited by 19
Assessment of anterior-posterior spinal curvatures in children suffering from hypopituitarism
Kobylińska, M., Malak, R., Majewska, K., Kędzia, A., & Samborski, W. (2019) · BMC Endocrine Disorders · doi:10.1186/s12902-019-0462-4 · Cited by 5
Metadata
- Authors
- Alatzoglou, K. S., Webb, E. A., Le Tissier, P., & Dattani, M. T.
- Affiliations
- Developmental Endocrinology Research Group (K.S.A., E.A.W., M.T.D.), Clinical and Molecular Genetics Unit, and Birth Defects Research Centre (P.L.T.), UCL Institute of Child Health, London WC1N 1EH, United Kingdom;
- Faculty of Life Sciences (P.L.T.), University of Manchester, Manchester M13 9PT, United Kingdom
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2014-01-22
- Volume
- 35
- Issue
- 3
- Pages
- 376-432
- ISSN
- 0163-769X
- 1945-7189
- Cited by
- 134
- References
- 35
- Language
- en
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