Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults

Deutz, Nicolaas E.P.; Pereira, Suzette L.; Hays, Nicholas P.; Oliver, Jeffery S.; Edens, Neile K.; Evans, Chris M.; Wolfe, Robert R.

doi:10.1016/j.clnu.2013.02.011

Cited by 288Muscle metabolism and nutritionNutrition and Health in AgingSpaceflight effects on biology

Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults

Deutz, Nicolaas E.P., Pereira, Suzette L., Hays, Nicholas P., Oliver, Jeffery S., Edens, Neile K., Evans, Chris M., Wolfe, Robert R.·2013·Clinical Nutrition

DOI 10.1016/j.clnu.2013.02.011

Open this paper in CoChat — free account

Abstract

Background Loss of muscle mass due to prolonged bed rest decreases functional capacity and increases hospital morbidity and mortality in older adults. Objective To determine if HMB, a leucine metabolite, is capable of attenuating muscle decline in healthy older adults during complete bed rest. Design A randomized, controlled, double-blinded, parallel-group design study was carried out in 24 healthy (SPPB ≥ 9) older adult subjects (20 women, 4 men), confined to complete bed rest for ten days, followed by resistance training rehabilitation for eight weeks. Subjects in the experimental group were treated with HMB (calcium salt, 1.5 g twice daily - total 3 g/day). Control subjects were treated with an inactive placebo powder. Treatments were provided starting 5 days prior to bed rest till the end rehabilitation phase. DXA was used to measure body composition. Results Nineteen eligible older adults (BMI: 21-33; age: 60-76 year) were evaluable at the end of the bed rest period (Control n = 8; Ca-HMB n = 11). Bed rest caused a significant decrease in total lean body mass (LBM) (2.05 ± 0.66 kg; p = 0.02, paired t-test) in the Control group. With the exclusion of one subject, treatment with HMB prevented the decline in LBM over bed rest -0.17 ± 0.19 kg; p = 0.23, paired t-test). There was a statistically significant difference between treatment groups for change in LBM over bed rest (p = 0.02, ANOVA). Sub-analysis on female subjects (Control = 7, HMB = 8) also revealed a significant difference in change in LBM over bed rest between treatment groups (p = 0.04, ANOVA). However, differences in function parameters could not be observed, probably due to the sample size of the study. Conclusions In healthy older adults, HMB supplementation preserves muscle mass during 10 days of bed rest. These results need to be confirmed in a larger trial.

Integrity signals

Registry

Crossref · 10.1016/j.clnu.2013.02.011

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

b-HMB supplementation preserved muscle mass during 10 days of bed rest in healthy older adults (age range 60 to 75 years).
“Although the number of b-HMB studies in older people remains limited, results of a recent study demonstrated that b-HMB supplementation preserved muscle mass during 10 days of bed rest in healthy older adults (age range 60 to 75 years).204”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [204]

A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission
Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792 · see citing works
The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · see citing works
Balance in elderly patients: the "get-up and go" test.
Mathias, S., Nayak, U. S., & Isaacs, B. (1986) · PubMed · Cited by 1,539 · see citing works
Hazards of Hospitalization of the Elderly
Creditor, M. C. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-3-199302010-00011 · Cited by 1,409 · see citing works
Effect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults
Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R., & Evans, W. J. (2007) · JAMA · doi:10.1001/jama.297.16.1772-b · Cited by 933 · see citing works
Self-citation
Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial
Fearon, K. C. H. (2003) · Gut · doi:10.1136/gut.52.10.1479 · Cited by 603 · see citing works
Functional Outcomes of Acute Medical Illness and Hospitalization in Older Persons
Sager, M. A. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060067008 · Cited by 578 · see citing works
Functional Impact of 10 Days of Bed Rest in Healthy Older Adults
Kortebein, P., Symons, T. B., Ferrando, A., Paddon-Jones, D., Ronsen, O., Protas, E., Conger, S., Lombeida, J., Wolfe, R., & Evans, W. J. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.10.1076 · Cited by 550 · see citing works
Self-citation
Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
Ferrando, A. A., Sheffield-Moore, M., Yeckel, C. W., Gilkison, C., Jiang, J., Achacosa, A., Lieberman, S. A., Tipton, K., Wolfe, R. R., & Urban, R. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2001 · Cited by 522 · see citing works
Self-citation
Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study
Newman, A. B., Haggerty, C. L., Goodpaster, B., Harris, T., Kritchevsky, S., Nevitt, M., Miles, T. P., Visser, M., & The Health, A. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51105.x · Cited by 505 · see citing works
Prolonged bed rest decreases skeletal muscle and whole body protein synthesis
Ferrando, A. A., Lane, H. W., Stuart, C. A., Davis-Street, J. E., & Wolfe, R. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e627 · Cited by 498 · see citing works
Self-citation
The Natural History of Functional Morbidity in Hospitalized Older Patients
Hirsch, C. H., Sommers, L., Olsen, A., Mullen, L., & Winograd, C. H. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb03451.x · Cited by 485 · see citing works
Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2–Driven VHL −/− Renal Cancer
Smith, K., Gunaratnam, L., Morley, M., Franovic, A., Mekhail, K., & Lee, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0169 · Cited by 456 · see citing works
Essential Amino Acid and Carbohydrate Supplementation Ameliorates Muscle Protein Loss in Humans during 28 Days Bedrest
Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Sanford, A. P., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032159 · Cited by 338 · see citing works
Self-citation
Reversal of cancer-related wasting using oral supplementation with a combination of β-hydroxy-β-methylbutyrate, arginine, and glutamine
May, P. E., Barber, A. E., D'Olimpio, J. T., Hourihane, A., & Abumrad, N. N. (2002) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)00823-1 · Cited by 318 · see citing works
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review
Wilson, G. J., Wilson, J. M., & Manninen, A. H. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-1 · Cited by 306 · see citing works
Effect of β-hydroxy-β-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
Flakoll, P. J., Sharp, R. L., Baier, S. M., Levenhagen, D. K., Carr, C., & Nissen, S. (2004) · Nutrition · doi:10.1016/j.nut.2004.01.009 · Cited by 262 · see citing works
Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress
Paddon-Jones, D., Sheffield-Moore, M., Cree, M. G., Hewlings, S. J., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0651 · Cited by 254 · see citing works
Self-citation
Lower extremity muscle mass predicts functional performance in mobility-limited elders
Reid, K. F., Naumova, E. N., Carabello, R. J., Phillips, E. M., & Fielding, R. A. (2008) · The journal of nutrition health & aging · doi:10.1007/bf02982711 · Cited by 243 · see citing works
EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.03.009 · Cited by 237 · see citing works
Self-citation
Get up and go
Lawton, G. (2006) · The New Scientist · Cited by 233 · see citing works
Nutritional Treatment for Acquired Immunodeficiency Virus‐Associated Wasting Using β‐Hydroxy β‐Methylbutyrate, Glutamine, and Arginine: A Randomized, Double‐Blind, Placebo‐Controlled Study
Clark, R. E., Feleke, G., Din, M., Yasmin, T., Singh, G., Khan, F. A., & Rathmacher, J. A. (2000) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607100024003133 · Cited by 230 · see citing works
Body Composition in 70-Year-Old Adults Responds to Dietary β-Hydroxy-β-Methylbutyrate Similarly to That of Young Adults
Vukovich, M. D., Stubbs, N. B., & Bohlken, R. M. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.7.2049 · Cited by 222 · see citing works
Resistance exercise maintains skeletal muscle protein synthesis during bed rest
Ferrando, A. A., Tipton, K. D., Bamman, M. M., & Wolfe, R. R. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.3.807 · Cited by 221 · see citing works
Self-citation
Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food
Deutz, N. E. P., Safar, A., Schutzler, S. E., Memelink, R., Ferrando, A., Spencer, H., van Helvoort, A., & Wolfe, R. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.05.008 · Cited by 204 · see citing works
Self-citation
Attenuation of Proteasome-Induced Proteolysis in Skeletal Muscle by β-Hydroxy-β-Methylbutyrate in Cancer-Induced Muscle Loss
Smith, H. J., Mukerji, P., & Tisdale, M. J. (2005) · Cancer Research · doi:10.1158/0008-5472.277.65.1 · Cited by 170 · see citing works
β-Hydroxy-β-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats
Hao, Y., Jackson, J. R., Wang, Y., Edens, N., Pereira, S. L., & Alway, S. E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00840.2010 · Cited by 124 · see citing works
Self-citation
Screening for Falls in Community-Dwelling Elderly
Murphy, M. A., Olson, S. L., Protas, E. J., & Overby, A. R. (2003) · Journal of Aging and Physical Activity · doi:10.1123/japa.11.1.66 · Cited by 115 · see citing works
The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation
Fitts, R. H., Romatowski, J. G., Peters, J., Paddon‐Jones, D., Wolfe, R. R., & Ferrando, A. A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00573.2006 · Cited by 113 · see citing works
Self-citation
Resistance Training and Timed Essential Amino Acids Protect against the Loss of Muscle Mass and Strength During 28 Days of Bed Rest and Energy Deficit
Brooks, N., Cloutier, G. J., Cadena, S. M., Layne, J. E., Nelsen, C. A., Freed, A. M., Roubenoff, R., & Castaneda-Sceppa, C. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01346.2007 · Cited by 102 · see citing works
Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by β-hydroxy-β-methylbutyrate
Eley, H. L., Russell, S. T., & Tisdale, M. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90530.2008 · Cited by 100 · see citing works
Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats
Kovařík, M., Muthný, T., Šišpera, L., & Holeček, M. (2010) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-010-0037-3 · Cited by 93 · see citing works
Nutritional status after short-term dietary supplementation in hospitalized malnourished geriatric patients
Bos, C., Benamouzig, R., Bruhat, A., Roux, C., Valensi, P. E., Ferrière, F., & Tomé, D. (2001) · Clinical Nutrition · doi:10.1054/clnu.2000.0387 · Cited by 59 · see citing works
Attenuation of the protein wasting associated with bed rest by branched-chain amino acids
Stein, T. P., Schluter, M. D., Leskiw, M. J., & Boden, G. H. (1999) · Nutrition · doi:10.1016/s0899-9007(99)00120-3 · Cited by 59 · see citing works
Vitamin D Status Affects Strength Gains in Older Adults Supplemented With a Combination of β‐Hydroxy‐β‐Methylbutyrate, Arginine, and Lysine
Fuller, J. C., Baier, S. M., Flakoll, P. J., Nissen, S., Abumrad, N. N., & Rathmacher, J. A. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111413903 · Cited by 59 · see citing works
Effects of resistance exercise combined with essential amino acid supplementation and energy deficit on markers of skeletal muscle atrophy and regeneration during bed rest and active recovery
Brooks, N. E., Cadena, S. M., Vannier, E. G., Cloutier, G. J., Carámbula, S. F., Myburgh, K. H., Roubenoff, R., & Castaneda‐Sceppa, C. (2010) · Muscle & Nerve · doi:10.1002/mus.21780 · Cited by 56 · see citing works
Branched-chain amino acid supplementation during bed rest: effect on recovery
Stein, T. P., Donaldson, M. R., Leskiw, M. J., Schluter, M. D., Baggett, D. W., & Boden, G. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00481.2002 · Cited by 53 · see citing works
The Catabolic Effects of Prolonged Inactivity and Acute Hypercortisolemia Are Offset by Dietary Supplementation
Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1702 · Cited by 52 · see citing works
Self-citation
Analysis of β-hydroxy-β-methyl butyrate in plasma by gas chromatography and mass spectrometry
Nissen, S., Koevering, M. V., & Webb, D. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90522-b · Cited by 49 · see citing works
Postoperative Deterioration in Muscular Function
Edwards, H. (1982) · Archives of Surgery · doi:10.1001/archsurg.1982.01380310021005 · Cited by 42 · see citing works
Maintaining Muscle Function in Patients on Bed Rest
Brower, P., & Hicks, D. J. (1972) · AJN American Journal of Nursing · doi:10.1097/00000446-197207000-00032 · Cited by 3 · see citing works
β‐hydroxy‐β‐methyl butyrate (HMB) stimulates mammalian target of rapamycin complex 1 (mTORc1) signaling via a phosphatidylinositol‐3‐kinase (PI3K)‐dependent pathway
Hill, D. S., Szewczyk, N. J., Smith, K., Brookfield, R., Loughna, P. T., Rathmacher, J. A., Rennie, M. J., & Atherton, P. J. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.1059.10 · Cited by 1 · see citing works

Flagged first, then by citations

1 of the 43 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Zachwieja, 1999, Effect of the leucine metabolite ß-hydroxy-ß-methylbutyrate on muscle protein synthesis during prolonged bedrest, FASEB J, 13, A1025

Sorted by citations

Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · see citing works
Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)
Cruz-Jentoft, A. J., Landi, F., Schneider, S. M., Zuniga, C., Arai, H., Boirie, Y., Chen, L.-K., Fielding, R. A., Martin, F. C., Michel, J.-P., et al. (2014) · Age and Ageing · doi:10.1093/ageing/afu115 · Cited by 1,963 · see citing works
Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group
Deutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738 · see citing works
Self-citation
IOC Consensus Statement: Dietary Supplements and the High-performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099027 · Cited by 1,004 · see citing works
Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.
the IOF-ESCEO Sarcopenia Working Group, Beaudart, C., Dawson, A., Shaw, S. C., Harvey, N. C., Kanis, J. A., Binkley, N., Reginster, J. Y., Chapurlat, R., Chan, D. C., et al. (2017) · Osteoporosis International · doi:10.1007/s00198-017-3980-9 · Cited by 602 · see citing works
“The study duration varied: 24 weeks [13], 12 weeks [37], and 8 weeks [16].”
BackgroundMethodInfluential
Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease
Argilés, J. M., Campos, N., Lopez-Pedrosa, J. M., Rueda, R., & Rodriguez-Mañas, L. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.04.019 · Cited by 581 · see citing works
Sarcopenia: A Contemporary Health Problem among Older Adult Populations
Papadopoulou, S. Κ. (2020) · Nutrients · doi:10.3390/nu12051293 · Cited by 592 · see citing works
IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0020 · Cited by 540 · see citing works
“Potential use for HMB during extreme inactivity/disuse or recovery from injury, but these effects have only been described in older adults following 10 days of bed rest (Deutz et al., 2013).”
Background
Does nutrition play a role in the prevention and management of sarcopenia?
Robinson, S. M., Reginster, J. Y., Rizzoli, R., Shaw, S. C., Kanis, J. A., Bautmans, I., Bischoff-Ferrari, H., Bruyère, O., Cesari, M., Dawson-Hughes, B., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.016 · Cited by 491 · see citing works
Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial
Deutz, N. E., Matheson, E. M., Matarese, L. E., Luo, M., Baggs, G. E., Nelson, J. L., Hegazi, R. A., Tappenden, K. A., & Ziegler, T. R. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2015.12.010 · Cited by 472 · see citing works
Self-citation
Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia
Wall, B. T., Dirks, M. L., & van Loon, L. J. C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.07.003 · Cited by 400 · see citing works
Skeletal muscle atrophy: From mechanisms to treatments
Yin, L., Li, N., Jia, W., Wang, N., Liang, M., Yang, X., & Du, G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105807 · Cited by 408 · see citing works
Interventions for Treating Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies
Yoshimura, Y., Wakabayashi, H., Yamada, M., Kim, H., Harada, A., & Arai, H. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.03.019 · Cited by 365 · see citing works
UEFA expert group statement on nutrition in elite football. Current evidence to inform practical recommendations and guide future research
Collins, J., Maughan, R. J., Gleeson, M., Bilsborough, J., Jeukendrup, A., Morton, J. P., Phillips, S. M., Armstrong, L., Burke, L. M., Close, G. L., et al. (2021) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-101961 · Cited by 303 · see citing works
Perioperative nutrition: Recommendations from the ESPEN expert group
Lobo, D. N., Gianotti, L. V., Adiamah, A., Barazzoni, R., Deutz, N. E. P., Dhatariya, K., Greenhaff, P. L., Hiesmayr, M., Jakobsen, D. H., Kłęk, S., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.03.038 · Cited by 299 · see citing works
“However, when beta-hydroxybeta-methylbutyrate (HMB) supplementation was used in a randomized placebo-controlled trial [46] in healthy volunteers undergoing a period of 10 days bedrest, this resulted in a significant reduction in the amount of muscle loss associated with the bedrest as well as an increase in muscle mas…”
BackgroundMethodSelf-citation
Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions
Holeček, M. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12208 · Cited by 287 · see citing works
Advances in muscle health and nutrition: A toolkit for healthcare professionals
Prado, C. M., Landi, F., Chew, S. T. H., Atherton, P. J., Molinger, J., Ruck, T., & Gonzalez, M. C. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.07.041 · Cited by 237 · see citing works
Muscle loss: The new malnutrition challenge in clinical practice
Landi, F., Camprubi-Robles, M., Bear, D. E., Cederholm, T., Malafarina, V., Welch, A. A., & Cruz-Jentoft, A. J. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.021 · Cited by 235 · see citing works
Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation
Tanner, R. E., Brunker, L. B., Agergaard, J., Barrows, K. M., Briggs, R. A., Kwon, O. S., Young, L. M., Hopkins, P. N., Volpi, E., Marcus, R. L., et al. (2015) · The Journal of Physiology · doi:10.1113/jp270699 · Cited by 223 · see citing works
“Recently, we (Drummond et al. 2012) and others (Kortebein et al. 2007; Breen et al. 2013; Deutz et al. 2013) have shown that reduced physical activity or 7–10 days bed rest in older adults decreased lean tissue and compromised the anabolic potency to feeding/essential amino acids, e.g. blunted…”
Background
Acute Sarcopenia Secondary to Hospitalisation - An Emerging Condition Affecting Older Adults
Welch, C., Hassan-Smith, Z. K., Greig, C. A., Lord, J. M., & Jackson, T. (2018) · Aging and Disease · doi:10.14336/ad.2017.0315 · Cited by 223 · see citing works
Dietary protein and muscle in older persons
Paddon‐Jones, D., & Leidy, H. J. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000011 · Cited by 203 · see citing works
Dietary Supplements for Health, Adaptation, and Recovery in Athletes
Rawson, E. S., Miles, M. P., & Larson-Meyer, D. E. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0340 · Cited by 201 · see citing works
Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise
Brook, M. S., Wilkinson, D. J., Phillips, B. E., Pérez‐Schindler, J., Philp, A., Smith, K., & Atherton, P. J. (2015) · Acta Physiologica · doi:10.1111/apha.12532 · Cited by 193 · see citing works
“…known to have potent affects on both MPS and MPB (Wilkinson et al. 2013), have potential to prevent or slow the decline in bed rest-related muscle loss (Deutz et al. 2013), indicating the importance of nutritional strategies for assisting in combating the accelerated mass loss (Magne et al. 2013).”
Background
Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies
Nunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00425.2021 · Cited by 183 · see citing works
β-Hydroxy-β-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: a systematic review and meta-analysis
Bear, D. E., Langan, A., Dimidi, E., Wandrag, L., Harridge, S. D. R., Hart, N., Connolly, B. A., & Whelan, K. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy373 · Cited by 167 · see citing works
Leucine partially protects muscle mass and function during bed rest in middle-aged adults
English, K. L., Mettler, J. A., Ellison, J. B., Mamerow, M. M., Arentson-Lantz, E., Pattarini, J. M., Ploutz-Snyder, R., Sheffield-Moore, M., & Paddon-Jones, D. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.112359 · Cited by 162 · see citing works
Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis
Wu, H., Xia, Y., Jiang, J., Du, H., Guo, X., Liu, X., Li, C., Huang, G., & Niu, K. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.06.020 · Cited by 157 · see citing works
“Six studies were found to fit the criteria (Baier et al., 2009; Deutz et al., 2013; Flakoll et al., 2004; May, Barber, D’Olimpio, Hourihane, & Abumrad, 2002; Stout et al., 2013; Vukovich, Stubbs, & Bohlken, 2001).”
Background
Greater loss in muscle mass and function but smaller metabolic alterations in older compared with younger men following 2 wk of bed rest and recovery
Pišot, R., Marusic, U., Biolo, G., Mazzucco, S., Lazzer, S., Grassi, B., Reggiani, C., Toniolo, L., di Prampero, P. E., Passaro, A., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00858.2015 · Cited by 150 · see citing works
Nutritional support in chronic obstructive pulmonary disease (COPD): an evidence update
Collins, P. F., Yang, I. A., Chang, Y.-C., & Vaughan, A. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.10.41 · Cited by 148 · see citing works
Nutritional Supplements in Support of Resistance Exercise to Counter Age-Related Sarcopenia
Phillips, S. M. (2015) · Advances in Nutrition · doi:10.3945/an.115.008367 · Cited by 144 · see citing works
Diet for the prevention and management of sarcopenia
Calvani, R., Picca, A., Coelho‐Júnior, H. J., Tosato, M., Marzetti, E., & Landi, F. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155637 · Cited by 153 · see citing works
The Impact of Step Reduction on Muscle Health in Aging: Protein and Exercise as Countermeasures
Oikawa, S. Y., Holloway, T. M., & Phillips, S. M. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00075 · Cited by 141 · see citing works
Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome
Lochlainn, M. N., Bowyer, R. C. E., & Steves, C. J. (2018) · Nutrients · doi:10.3390/nu10070929 · Cited by 138 · see citing works
“Urinary [31,131] and blood urea concentration [131], and urinary HMB levels [157] have also been used with the aim of objectively verifying compliance.”
Method
Sarcopenia: Current treatments and new regenerative therapeutic approaches
Lo, J. C. Y., Kin Pong, U., Yiu, T. L., Ong, M. T., & Lee, W. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.04.002 · Cited by 133 · see citing works
Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
Brioche, T., Pagano, A. F., Py, G., & Chopard, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.006 · Cited by 129 · see citing works
“Deutz et al. (2013) did not report any effect of HMB on muscle strength after 10 days of bed rest in the elderly (men and women) but showed a clear tendency to limit the decrease observed; the latter result did not reach statistical significance probably due to the small sample size.”
BackgroundInfluential
Aging impairs the recovery in mechanical muscle function following 4days of disuse
Hvid, L. G., Suetta, C., Nielsen, J., Jensen, M. M., Frandsen, U., Ørtenblad, N., Kjær, M., & Aagaard, P. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.012 · Cited by 122 · see citing works
“…appear to occur very fast within the initial phase (days) of disuse followed by an attenuated rate of decline as time progresses (Deschenes et al., 2008; Deutz et al., 2013; Hvid et al., 2010, 2013; Kortebein et al., 2008; LeBlanc et al., 1992; Narici and de Boer, 2011; Suetta et al., 2009, 2012).”
Strategies to maintain skeletal muscle mass in the injured athlete: Nutritional considerations and exercise mimetics
Wall, B. T., Morton, J. P., & van Loon, L. J. C. (2014) · European Journal of Sport Science · doi:10.1080/17461391.2014.936326 · Cited by 122 · see citing works
“Moreover, initial studies suggest that prolonged HMB supplementation (1.5 g twice daily) may also offer protective effects on muscle mass during a period of bedrest in older individuals (Deutz et al., 2013).”
BackgroundInfluential
Rehabilitation Nutrition for Injury Recovery of Athletes: The Role of Macronutrient Intake
Papadopoulou, S. Κ. (2020) · Nutrients · doi:10.3390/nu12082449 · Cited by 118 · see citing works
“, 2013 [64] HMB Randomized, controlled, double-blinded, parallel-group design study was carried out in 24 healthy (SPPB ≥ 9) older adult subjects (20 women, 4 men), confined to complete bed rest for ten days, followed by resistance training rehabilitation for eight weeks.”
BackgroundInfluential
Nutritional Considerations and Strategies to Facilitate Injury Recovery and Rehabilitation
Smith‐Ryan, A. E., Hirsch, K. R., Cabre, H. E., Gould, L. M., & Blue, M. N. M. (2020) · Journal of Athletic Training · doi:10.4085/1062-6050-550-19 · Cited by 120 · see citing works
Beta-hydroxy beta-methylbutyrate/arginine/glutamine (HMB/Arg/Gln) supplementation to improve the management of cachexia in patients with advanced lung cancer: an open-label, multicentre, randomised, controlled phase II trial (NOURISH)
Pascoe, J. S., Jackson, A. E., Gaskell, C., Gaunt, C. H., Thompson, J., Billingham, L. J., & Steven, N. M. (2021) · BMC Cancer · doi:10.1186/s12885-021-08519-8 · Cited by 99 · see citing works
Bed rest and accelerated aging in relation to the musculoskeletal and cardiovascular systems and frailty biomarkers: A review
Kehler, D. S., Theou, O., & Rockwood, K. J. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110643 · Cited by 88 · see citing works
The Effect of β-Hydroxy-β-Methylbutyrate (HMB) on Sarcopenia and Functional Frailty in Older Persons: A Systematic Review
Oktaviana, J., Zanker, J., Vogrin, S., & Duque, G. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-1153-y · Cited by 84 · see citing works
The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis
Girolamo, F. G. D., Fiotti, N., Milanović, Z., Situlin, R., Mearelli, F., Vinci, P., Šimunič, B., Pišot, R., Narici, M. V., & Biolo, G. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.633987 · Cited by 82 · see citing works
A simple remote nutritional screening tool and practical guidance for nutritional care in primary practice during the COVID-19 pandemic
Krznarić, Ž., Bender, D. V., Laviano, A., Cuerda, C., Landi, F., Monteiro, R., Pirlich, M., & Barazzoni, R. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.05.006 · Cited by 79 · see citing works
An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly
McCarty, M. F., & DiNicolantonio, J. J. (2015) · AGE · doi:10.1007/s11357-015-9823-8 · Cited by 79 · see citing works
Neuromuscular Electrical Stimulation Combined with Protein Ingestion Preserves Thigh Muscle Mass But Not Muscle Function in Healthy Older Adults During 5 Days of Bed Rest
Reidy, P. T., McKenzie, A. I., Brunker, P., Nelson, D. S., Barrows, K. M., Supiano, M. A., LaStayo, P. C., & Drummond, M. J. (2017) · Rejuvenation Research · doi:10.1089/rej.2017.1942 · Cited by 79 · see citing works
The Effect of a 12-Week Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation on Highly-Trained Combat Sports Athletes: A Randomised, Double-Blind, Placebo-Controlled Crossover Study
Durkalec-Michalski, K., Jeszka, J., & Podgórski, T. (2017) · Nutrients · doi:10.3390/nu9070753 · Cited by 78 · see citing works
“Some favorable changes caused by HMB supplementation were also registered in the elderly [17,40].”
Background
Supplements with purported effects on muscle mass and strength
Valenzuela, P. L., Morales, J. S., Emanuele, E., Pareja-Galeano, H., & Lucia, A. (2019) · European Journal of Nutrition · doi:10.1007/s00394-018-1882-z · Cited by 78 · see citing works
Computed tomography measured psoas density predicts outcomes in trauma
Yoo, T., Lo, W. D., & Evans, D. C. (2017) · Surgery · doi:10.1016/j.surg.2017.03.014 · Cited by 78 · see citing works
South Asian Working Action Group on SARCOpenia (SWAG-SARCO) – A consensus document
Dhar, M., Kapoor, N., Suastika, K., Khamseh, M. E., Selim, S., Kumar, V., Raza, S. A., Azmat, U., Pathania, M., Mahadeb, Y., et al. (2022) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2022.04.001 · Cited by 79 · see citing works
One Week of Hospitalization Following Elective Hip Surgery Induces Substantial Muscle Atrophy in Older Patients
Kouw, I. W. K., Groen, B. B. L., Smeets, J. S. J., Kramer, I. F., van Kranenburg, J. M. X., Nilwik, R., Geurts, J. A. P., ten Broeke, R. H. M., Poeze, M., van Loon, L. J. C., et al. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.06.018 · Cited by 75 · see citing works
Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults
Standley, R. A., Distéfano, G., Trevino, M. B., Chen, E., Narain, N. R., Greenwood, B. P., Kondakci, G., Tolstikov, V., Kiebish, M. A., Yu, G., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa001 · Cited by 75 · see citing works
Muscle Atrophy: Present and Future
Cao, R. Y., Li, J., Dai, Q., Li, Q. X., & Yang, J. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1435-3_29 · Cited by 75 · see citing works
Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy
Trevino, M. B., Zhang, X., Standley, R. A., Wang, M., Han, X., Reis, F. C. G., Periasamy, M., Yu, G., Kelly, D. P., Goodpaster, B. H., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00161.2019 · Cited by 74 · see citing works
“To identify pathways involved in disuse muscle atrophy, we performed RNA-Seq of muscle biopsy samples from older individuals before and after 10 days of complete bed rest (16, 56).”
BackgroundMethod
“Nutraceuticals” in relation to human skeletal muscle and exercise
Deane, C. S., Wilkinson, D. J., Phillips, B. E., Smith, K., Etheridge, T., & Atherton, P. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2016 · Cited by 73 · see citing works
“periods of disuse (65), while year long supplementation of HMB (plus arginine and 212”
Background
Skeletal Muscle Disuse Atrophy and the Rehabilitative Role of Protein in Recovery from Musculoskeletal Injury
Howard, E. E., Pasiakos, S. M., Fussell, M. A., & Rodriguez, N. R. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa015 · Cited by 73 · see citing works
Health Benefits of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis
Courel-Ibáñez, J., Vetrovsky, T., Dadova, K., Pallarés, J. G., & Steffl, M. (2019) · Nutrients · doi:10.3390/nu11092082 · Cited by 69 · see citing works
“Two studies [43,44] found positive effects in fat free mass using different techniq es, whilst three studies [37,40,41] found o differences between HMB and controls.”
BackgroundMethodInfluential
Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism
Wilkinson, D. J., Hossain, T., Limb, M. C., Phillips, B. E., Lund, J. N., Williams, J. P., Brook, M. S., Cegielski, J., Philp, A., Ashcroft, S. P., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.09.024 · Cited by 67 · see citing works
“In humans, HMB supplementation has been shown to reducemusclewasting in clinical populations (Cancer [17], COPD [18], AIDS [19]), whilst also increasing lean bodymass and protein turnover chronically in ageing cohorts when supplemented alongside the AAs arginine and lysine [20], in addition to attenuating muscle loss…”
Background
Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia
Damanti, S., Azzolino, D., Roncaglione, C., Arosio, B., Rossi, P., & Cesari, M. (2019) · Nutrients · doi:10.3390/nu11091991 · Cited by 62 · see citing works
Skeletal Muscle Recovery from Disuse Atrophy: Protein Turnover Signaling and Strategies for Accelerating Muscle Regrowth
Mirzoev, T. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217940 · Cited by 65 · see citing works
Nutritional Strategies to Offset Disuse-Induced Skeletal Muscle Atrophy and Anabolic Resistance in Older Adults: From Whole-Foods to Isolated Ingredients
Marshall, R. N., Smeuninx, B., Morgan, P. T., & Breen, L. (2020) · Nutrients · doi:10.3390/nu12051533 · Cited by 63 · see citing works
“5 g Ca-HMB, twice daily) has been shown to attenuate muscle anabolic resistance and atrophy compared with a placebo in healthy older adults [165].”
BackgroundInfluential
Metabolic phenotyping using kinetic measurements in young and older healthy adults
Deutz, N. E. P., Thaden, J. J., Have, G. A. M. T., Walker, D. K., & ENGELEN, M. P. K. J. (2017) · Metabolism · doi:10.1016/j.metabol.2017.09.015 · Cited by 63 · see citing works
Self-citation
Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial
Berton, L., Bano, G., Carraro, S., Veronese, N., Pizzato, S., Bolzetta, F., RUI, M. D., Valmorbida, E., Ronch, I. D., Perissinotto, E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141757 · Cited by 62 · see citing works
Nutritional Strategies in the Rehabilitation of Musculoskeletal Injuries in Athletes: A Systematic Integrative Review
Giraldo-Vallejo, J. E., Cardona-Guzmán, M. Á., Rodríguez-Alcivar, E. J., Kočí, J., Petro, J. L., Kreider, R. B., Cannataro, R., & Bonilla, D. A. (2023) · Nutrients · doi:10.3390/nu15040819 · Cited by 66 · see citing works
Impact of β−hydroxy-β−methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT
Viana, M. V., Becce, F., Pantet, O., Schmidt, S., Bagnoud, G., Thaden, J. J., Have, G. A. M. T., ENGELEN, M. P. K. J., Voidey, A., Deutz, N. E. P., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.07.018 · Cited by 60 · see citing works
Self-citation
Nutritional interventions in sarcopenia: a critical review
Hickson, M. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115002049 · Cited by 60 · see citing works
What Is the Role of Nutritional Supplements in Support of Total Hip Replacement and Total Knee Replacement Surgeries? A Systematic Review
Burgess, L. C., Phillips, S. M., & Wainwright, T. W. (2018) · Nutrients · doi:10.3390/nu10070820 · Cited by 60 · see citing works
“Supplementation with HMB is reported to enhance increases in the mass and strength of skeletal muscles in elderly subjects who are recovering from bed rest [47], and may, therefore, promote recovery post-THR and TKR.”
Background
Effects of β-hydroxy-β-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults
Standley, R. A., Distéfano, G., Pereira, S. L., Tian, M., Kelly, O. J., Coen, P. M., Deutz, N. E. P., Wolfe, R. R., & Goodpaster, B. H. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00192.2017 · Cited by 59 · see citing works
Self-citation
Factors influencing the efficacy of nutritional interventions on muscle mass in older adults: a systematic review and meta-analysis
Martin-Cantero, A., Reijnierse, E. M., Gill, B. M. T., & Maier, A. B. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuaa064 · Cited by 58 · see citing works
Reduced mortality risk in malnourished hospitalized older adult patients with COPD treated with a specialized oral nutritional supplement: Sub-group analysis of the NOURISH study
Deutz, N. E., Ziegler, T. R., Matheson, E. M., Matarese, L. E., Tappenden, K. A., Baggs, G. E., Nelson, J. L., Luo, M., Hegazi, R., & Jonnalagadda, S. S. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.031 · Cited by 63 · see citing works
Self-citation
Effects of exercise and/or β-hydroxy-β-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in older women with low muscle mass: a randomized, double-blind, placebo-controlled trial
Osuka, Y., Kojima, N., Sasai, H., Wakaba, K., Miyauchi, D., Tanaka, K., & Kim, H. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab176 · Cited by 53 · see citing works
Impact of dairy protein during limb immobilization and recovery on muscle size and protein synthesis; a randomized controlled trial.
Mitchell, C., D'Souza, R., Mitchell, S., Figueiredo, V., Miller, B., Hamilton, K., Peelor, F. F., Coronet, M., Pileggi, C., Durainayagam, B. R., et al. (2018) · Journal of applied physiology · doi:10.1152/japplphysiol.00803.2017 · Cited by 53 · see citing works
Sarcopenia and Nutrition
Laviano, A., Gori, C. S., & Rianda, S. (2014) · Advances in food and nutrition research · doi:10.1016/b978-0-12-800270-4.00003-1 · Cited by 55 · see citing works
Specialized oral nutritional supplement (ONS) improves handgrip strength in hospitalized, malnourished older patients with cardiovascular and pulmonary disease: A randomized clinical trial
Matheson, E. M., Nelson, J. L., Baggs, G. E., Luo, M., & Deutz, N. E. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.035 · Cited by 53 · see citing works
Self-citation
Interventional strategies to combat muscle disuse atrophy in humans: focus on neuromuscular electrical stimulation and dietary protein
Dirks, M. L., Wall, B. T., & van Loon, L. J. C. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00985.2016 · Cited by 53 · see citing works
“Similar suggestions have been made for supplementation with leucine’s metabolite -hydroxy -methylbutyric acid (HMB) (40).”
Amino acids and amino acid sensing: implication for aging and diseases
Dato, S., Hoxha, E., Crocco, P., Iannone, F., Passarino, G., & Rose, G. (2018) · Biogerontology (Dordrecht) · doi:10.1007/s10522-018-9770-8 · Cited by 44 · see citing works
Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Older Adults with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Study
Yang, C., Song, Y., Li, T., Chen, X., Zhou, J., Pan, Q., Jiang, W., Wang, M., & Jia, H. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1911-1 · Cited by 53 · see citing works
“Previous studies have indicated that the concentration of plasma HMB is positively associated with muscle mass and strength regardless of an older person’s health status (9-11).”
Background
Role of Oral Nutritional Supplements Enriched with B-hydroxy-B-Methylbutyrate in Maintaining Muscle Function and Improving Clinical Outcomes in Various Clinical Settings
Sanz‐París, A., Camprubí-Robles, M., López-Pedrosa, J. M., Pereira, S. L., Rueda, R., Ballesteros-Pomar, M. D., Almeida, J. M. G., & Cruz-Jentoft, A. J. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-0995-7 · Cited by 50 · see citing works
Self-citation
Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate (HMB) Improves Nutrition, Physical Performance and Ameliorates Intramuscular Adiposity in Pre-Frail Older Adults: A Randomized Controlled Trial
Peng, L., Cheng, Y., Yu, P.-C., Lee, W., Lin, M.-H., & Chen, L. (2021) · The journal of nutrition health & aging · doi:10.1007/s12603-021-1621-7 · Cited by 49 · see citing works
Effects of supplementation with a combination of β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine on postoperative recovery of quadriceps muscle strength after total knee arthroplasty.
Nishizaki, K., Ikegami, H., Tanaka, Y., 今井, 龍., & Matsumura, H. (2015) · PubMed · doi:10.6133/apjcn.2015.24.3.01 · Cited by 48 · see citing works
Acute Sarcopenia: Mechanisms and Management
Damanti, S., Senini, E., LORENZO, R. D., Merolla, A., Santoro, S., Festorazzi, C., Messina, M., Vitali, G., Sciorati, C., & Rovere, P. Q. (2024) · Nutrients · doi:10.3390/nu16203428 · Cited by 50 · see citing works
The Current Understanding of Sarcopenia
Delmonico, M., & Beck, D. T. (2017) · American Journal of Lifestyle Medicine · doi:10.1177/1559827615594343 · Cited by 31 · see citing works
“Additionally, HMB supplementation maintains LM in adults in their late 60s during 10 days of bed rest.(88) Despite some promising results of creatine and HMB as potential treatments for low LM and strength in older adults, data are sparse and further investigation is warranted to determine the benefits of nutritional…”
Background
Leucine Supplementation Does Not Attenuate Skeletal Muscle Loss during Leg Immobilization in Healthy, Young Men
Backx, E. M. P., Horstman, A. M. H., Marzuca-Nassr, G. N., van Kranenburg, J. M. X., Smeets, J. S. J., Fuchs, C. J., Janssen, A. A. W., de Groot, C. P. G. M., Snijders, T., Verdijk, L. B., et al. (2018) · Nutrients · doi:10.3390/nu10050635 · Cited by 47 · see citing works
Protein Intake Recommendation for Korean Older Adults to Prevent Sarcopenia: Expert Consensus by the Korean Geriatric Society and the Korean Nutrition Society
Jung, H., Kim, S., Kim, I., Lim, J., Park, H.-S., Song, W., Yoo, H. J., Jang, H. C., Kim, K., Park, Y., et al. (2018) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.18.0046 · Cited by 47 · see citing works
Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US task force recommendations
Vellas, B. J., Pahor, M., Manini, T. M., Rooks, D., Guralnik, J. M., Morley, J. E., Studenski, S. A., Evans, W. J., Asbrand, C., Fariello, R. G., et al. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0362-7 · Cited by 43 · see citing works
Self-citation
An umbrella review of systematic reviews of β‐hydroxy‐β‐methyl butyrate supplementation in ageing and clinical practice
Phillips, S. M., Lau, K. J., D'Souza, A. C., & Nunes, E. A. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.13030 · Cited by 42 · see citing works
The impact of disease-related immobilization on thigh muscle mass and strength in older hospitalized patients
Rommersbach, N., Wirth, R., Lueg, G., Klimek, C. N., Schnatmann, M., Liermann, D., Janssen, G., Müller, M. J., & Pourhassan, M. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01873-5 · Cited by 42 · see citing works
Nutrition as a Health Determinant in Elderly Patients
Mastronuzzi, T., & Grattagliano, I. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170523125806 · Cited by 42 · see citing works
Effects of Protein, Essential Amino Acids, B-Hydroxy B-Methylbutyrate, Creatine, Dehydroepiandrosterone and Fatty Acid Supplementation on Muscle Mass, Muscle Strength and Physical Performance in Older People Aged 60 Years and Over. A Systematic Review of the Literature
Beaudart, C., Rabenda, V., Simmons, M., Geerinck, A., de Carvalho, I. A., Reginster, J., Thiyagarajan, J. A., & Bruyère, O. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0934-z · Cited by 42 · see citing works
“Only two RCTs of good (39) and excellent (40) quality assessed the effects of HMB supplementation on muscle mass, muscle strength and physical performance in elderly subjects.”
Influential
Skeletal muscle dysfunction with advancing age
Pabla, P., Jones, E. J., Piasecki, M., & Phillips, B. E. (2024) · Clinical Science · doi:10.1042/cs20231197 · Cited by 47 · see citing works
“Further, in longer-term supplementation trials, HMB has been shown to improve SKM mass and function across the continuum of clinical care (i.e., in-patients, outpatients and community-dwelling [214–216]) with a focus on older adults.”
Background
Nutritional interventions during bed rest and spaceflight: prevention of muscle mass and strength loss, bone resorption, glucose intolerance, and cardiovascular problems
Gao, R., & Chilibeck, P. D. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.07.001 · Cited by 42 · see citing works
Disease-Related Malnutrition and Sarcopenia Predict Worse Outcome in Medical Inpatients: A Cohort Study
Ballesteros-Pomar, M., Gajete-Martín, L. M., de la Maza, B. P., Arnáiz, E. G., González-Roza, L., García-Pérez, M., González-Alonso, V., García-González, M., de Prado-Espinosa, R., Cuevas, M., et al. (2021) · Nutrients · doi:10.3390/nu13092937 · Cited by 35 · see citing works
“Loss of MM by prolonged bedrest decreases functional capacity and increases morbidity and hospital mortality in older adults [6].”
Background
The Potential of β-Hydroxy-β-Methylbutyrate as a New Strategy for the Management of Sarcopenia and Sarcopenic Obesity
Rossi, A., D'Introno, A., Rubele, S., Caliari, C., Gattazzo, S., Zoico, E., Mazzali, G., Fantin, F., & Zamboni, M. (2017) · Drugs & Aging · doi:10.1007/s40266-017-0496-0 · Cited by 39 · see citing works
Protecting Skeletal Muscle with Protein and Amino Acid during Periods of Disuse
Galvan, E., Arentson‐Lantz, E. J., Lamon, S., & Paddon‐Jones, D. (2016) · Nutrients · doi:10.3390/nu8070404 · Cited by 38 · see citing works
Age-related reduction of trunk muscle torque and prevalence of trunk sarcopenia in community-dwelling elderly: Validity of a portable trunk muscle torque measurement instrument and its application to a large sample cohort study
Sasaki, E., Sasaki, S., Chiba, D., Yamamoto, Y., Nawata, A., Tsuda, E., Nakaji, S., & Ishibashi, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192687 · Cited by 38 · see citing works
Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease
Singh, S. S., Kumar, A., Welch, N., Sekar, J., Mishra, S., Bellar, A., Gangadhariah, M. H., Attaway, A. H., Alkhafaji, H. A. A.-R., Wu, X., et al. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000327 · Cited by 38 · see citing works
The Effects of Protein and Supplements on Sarcopenia in Human Clinical Studies: How Older Adults Should Consume Protein and Supplements
Jang, Y. J. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2210.10014 · Cited by 39 · see citing works
Is β-hydroxy β-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations?
ENGELEN, M. P. K. J., & Deutz, N. E. P. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000459 · Cited by 37 · see citing works
Self-citation
Obesidad sarcopénica: un nuevo reto en la clínica práctica
Ciudin, A., Simó-Servat, A., Palmas-Candia, F. X., & Barahona, M. J. (2020) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2020.03.004 · Cited by 39 · see citing works
Sarcopenic obesity: A new challenge in the clinical practice
Ciudin, A., Simó-Servat, A., Palmas-Candia, F. X., & Barahona, M. J. (2020) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2020.03.007 · Cited by 37 · see citing works

Part I. Laparoscopic surgery for colon and rectal cancer
Zmora, O., & Wexner, S. D. (2001) · Current Problems in Cancer · doi:10.1067/mcn.2001.117697 · Cited by 8 · see citing works
Establishing exercise habit is important when assessing lean body mass in elderly
Safer, U., Taşçı, İ., Safer, V. B., & Doruk, H. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.04.022
Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis
Wu, H., Xia, Y., Jiang, J., Du, H., Guo, X., Liu, X., Li, C., Huang, G., & Niu, K. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.06.020 · Cited by 157 · see citing works
Leucine Supplementation Partially Protects Leg Lean Mass in Older Adults During Seven Days of Bed Rest (OR18-02-19)
Arentson‐Lantz, E. J., Galvan, F., Deer, R., Wacher, A., & Paddon‐Jones, D. (2019) · Current Developments in Nutrition · doi:10.1093/cdn/nzz028.or18-02-19
Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations
Fitschen, P. J., Wilson, G. J., Wilson, J. M., & Wilund, K. R. (2013) · Nutrition · doi:10.1016/j.nut.2012.05.005 · Cited by 97 · see citing works

Authors: Deutz, N. E. P., Pereira, S. L., Hays, N. P., Oliver, J. S., Edens, N. K., Evans, C. M., & Wolfe, R. R.
Affiliations: University of Arkansas for Medical Sciences (US)
Abbott Nutrition (United States) (US)
Corresponding author: Deutz, Nicolaas E.P.
ORCID: Deutz, Nicolaas E.P.
Pereira, Suzette L.
Hays, Nicholas P.
Wolfe, Robert R.
Venue: Clinical Nutrition
Publisher: Elsevier BV
Published: 2013-10
Volume: 32
Issue: 5
Pages: 704-712
ISSN: 0261-5614 (ISSN-L)
DOI: 10.1016/j.clnu.2013.02.011
OpenAlex: W2129894754
Cited by: 287
References: 43
Citations by year: 2026: 18 · 2025: 19 · 2024: 21 · 2023: 17 · 2022: 19 · 2021: 26 · 2020: 36 · 2019: 19 · 2018: 30 · 2017: 21 · 2016: 21 · 2015: 18 · 2014: 14 · 2013: 7 · 2012: 1
FWCI: 11.61
Type: journal article
Language: en
Open access: closed
Locations: Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Keywords: beta-hydroxy-beta-methylbutyrate, HMB supplementation, lean body mass, muscle mass loss, bed rest, disuse atrophy, older adults, leucine metabolites, body composition, sarcopenia prevention
MeSH terms: Aged, Aging, Bed Rest, Body Composition, Double-Blind Method, Female, Humans, Male, Middle Aged, Muscle Proteins, Musculoskeletal Physiological Phenomena, Valerates, Absorptiometry, Photon, Muscle, Skeletal, Dietary Supplements, Muscle Development, Whole Body Imaging, Muscle Strength, Resistance Training, Sarcopenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks