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Cited by 110Muscle metabolism and nutritionMuscle Physiology and DisordersNutrition and Health in Aging

Influence of Amino Acids, Dietary Protein, and Physical Activity on Muscle Mass Development in Humans

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Dideriksen, Kasper, Reitelseder, Søren, Holm, Lars·2013·Nutrients
DOI 10.3390/nu5030852PMC PMC3705323
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Abstract

Ingestion of protein is crucial for maintenance of a variety of body functions and within the scope of this review we will specifically focus on the regulation of skeletal muscle mass. A quantitative limitation exists as to how much muscle protein the body can synthesize in response to protein intake. Ingestion of excess protein exerts an unwanted load to the body and therefore, it is important to find the least amount of protein that provides the maximal hypertrophic stimulus. Hence, research has focused on revealing the relationship between protein intake (dose) and its resulting stimulation of muscle protein synthesis (response). In addition to the protein amount, the protein digestibility and, hence, the availability of its constituent amino acids is decisive for the response. In this regard, recent studies have provided in-depth knowledge about the time-course of the muscle protein synthetic response dependent on the characteristics of the protein ingested. The effect of protein intake on muscle protein accretion can further be stimulated by prior exercise training. In the ageing population, physical training may counteract the development of “anabolic resistance” and restore the beneficial effect of protein feeding. Presently, our knowledge is based on measures obtained in standardized experimental settings or during long-term intervention periods. However, to improve coherence between these types of data and to further improve our knowledge of the effects of protein ingestion, other investigative approaches than those presently used are requested.

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Cited by

Sorted by citations

Authors
Dideriksen, K., Reitelseder, S., & Holm, L.
Affiliations
University of Copenhagen (DK)
Corresponding author
Dideriksen, Kasper
ORCID
Holm, Lars
Venue
Nutrients
Publisher
MDPI AG
Published
2013-03-13
Volume
5
Issue
3
Pages
852-876
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu5030852
PMC
PMC3705323
OpenAlex
W2071347293
Cited by
110
References
33
Citations by year
2026: 2 · 2025: 7 · 2024: 7 · 2023: 25 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 1
FWCI
1.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
  • Gigtforeningen
  • Arla Foods Ingredients Group
  • Mejeribrugets ForskningsFond
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
dietary protein, amino acids, muscle protein synthesis, muscle hypertrophy, muscle mass, protein digestibility, exercise training, anabolic resistance, aging, muscle protein accretion
MeSH terms
Amino Acids, Dietary Proteins, Humans, Motor Activity, Muscle, Skeletal

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