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Correlation between Testosterone and the Inflammatory Marker Soluble Interleukin-6 Receptor in Older Men
Abstract
CONTEXT: An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear. OBJECTIVE: We hypothesized that T and inflammatory markers are negatively correlated in older men. DESIGN: This was a cross-sectional study. SETTING: A population-based sample of older men was studied. PARTICIPANTS AND MEASURES: After excluding participants taking glucocorticoids or antibiotics or those with recent hospitalization, 467 men, aged 65 yr or older, had complete determinations of total T, bioavailable T, SHBG, albumin, IL-6, soluble IL-6 receptor (sIL-6r), TNF-alpha, IL-1beta, and C-reactive protein. RESULTS: After adjusting for potential confounders, sIL-6r was significantly and inversely correlated with total T (r = -0.20; P < 0.001) and bioavailable T (r = -0.12; P < 0.05). T was not correlated with any other inflammatory marker. CONCLUSIONS: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association.
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“Low sex hormone levels are associated with inflammation (62).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [62]
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“A variety of phenomena have been proposed to contribute to this age-related heightened inflammatory state including redox stress [46], immuno- and endocrine senescence [47, 48], DNA damage [49], epigenetic modification [50], and a distortion of gut microbial homeostasis [51] that is associated with increased levels of circulating endotoxin [42].”
From Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis (2018) · cites this paper as [48]
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Metadata
- Authors
- Maggio, M., Basaria, S., Ble, A., Lauretani, F., Bandinelli, S., Ceda, G. P., Valenti, G., Ling, S. M., & Ferrucci, L.
- Affiliations
- National Institutes of Health (US)
- Azienda Sanitaria di Firenze (IT)
- University of Parma (IT)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-01
- Volume
- 91
- Issue
- 1
- Pages
- 345-347
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2070468050
- Cited by
- 200
- References
- 20
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 5 · 2015: 12 · 2014: 16 · 2013: 13 · 2012: 17
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Minority Health and Health Disparities (263-MD-916413, 263MD 821336)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- testosterone, soluble IL-6 receptor, inflammation, older men, aging, bioavailable testosterone, sex hormone-binding globulin, inflammatory cytokines, C-reactive protein, TNF-α, IL-1β, age-related testosterone decline
- MeSH terms
- Aged, Aged, 80 and over, Aging, C-Reactive Protein, Humans, Interleukin-1, Italy, Male, Testosterone, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Cytokines, Inflammation Mediators, Receptors, Interleukin-6
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