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Cited by 200Hormonal and reproductive studiesAdipokines, Inflammation, and Metabolic DiseasesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Correlation between Testosterone and the Inflammatory Marker Soluble Interleukin-6 Receptor in Older Men

Maggio, Marcello, Basaria, Shehzad, Ble, Alessandro, Lauretani, Fulvio, Bandinelli, Stefania, Ceda, Gian Paolo, Valenti, Giorgio, Ling, Shari M., Ferrucci, Luigi·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-1097
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Abstract

CONTEXT: An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear. OBJECTIVE: We hypothesized that T and inflammatory markers are negatively correlated in older men. DESIGN: This was a cross-sectional study. SETTING: A population-based sample of older men was studied. PARTICIPANTS AND MEASURES: After excluding participants taking glucocorticoids or antibiotics or those with recent hospitalization, 467 men, aged 65 yr or older, had complete determinations of total T, bioavailable T, SHBG, albumin, IL-6, soluble IL-6 receptor (sIL-6r), TNF-alpha, IL-1beta, and C-reactive protein. RESULTS: After adjusting for potential confounders, sIL-6r was significantly and inversely correlated with total T (r = -0.20; P < 0.001) and bioavailable T (r = -0.12; P < 0.05). T was not correlated with any other inflammatory marker. CONCLUSIONS: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association.

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Metadata

Authors
Maggio, M., Basaria, S., Ble, A., Lauretani, F., Bandinelli, S., Ceda, G. P., Valenti, G., Ling, S. M., & Ferrucci, L.
Affiliations
  • National Institutes of Health (US)
  • Azienda Sanitaria di Firenze (IT)
  • University of Parma (IT)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-01
Volume
91
Issue
1
Pages
345-347
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-1097
OpenAlex
W2070468050
Cited by
200
References
20
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 5 · 2015: 12 · 2014: 16 · 2013: 13 · 2012: 17
FWCI
6.52
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Minority Health and Health Disparities (263-MD-916413, 263MD 821336)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
testosterone, soluble IL-6 receptor, inflammation, older men, aging, bioavailable testosterone, sex hormone-binding globulin, inflammatory cytokines, C-reactive protein, TNF-α, IL-1β, age-related testosterone decline
MeSH terms
Aged, Aged, 80 and over, Aging, C-Reactive Protein, Humans, Interleukin-1, Italy, Male, Testosterone, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Cytokines, Inflammation Mediators, Receptors, Interleukin-6

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